DE69816642D1 - Verfahren zur stereoselektiven synthese von prostacyclin-derivaten - Google Patents
Verfahren zur stereoselektiven synthese von prostacyclin-derivatenInfo
- Publication number
- DE69816642D1 DE69816642D1 DE69816642T DE69816642T DE69816642D1 DE 69816642 D1 DE69816642 D1 DE 69816642D1 DE 69816642 T DE69816642 T DE 69816642T DE 69816642 T DE69816642 T DE 69816642T DE 69816642 D1 DE69816642 D1 DE 69816642D1
- Authority
- DE
- Germany
- Prior art keywords
- stereoselective synthesis
- prostacyclin derivatives
- making
- stereoselective
- prostacyclin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 4
- 230000000707 stereoselective effect Effects 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- KAQKFAOMNZTLHT-VVUHWYTRSA-N epoprostenol Chemical class O1C(=CCCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-VVUHWYTRSA-N 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95773697A | 1997-10-24 | 1997-10-24 | |
| US957736 | 1997-10-24 | ||
| PCT/US1998/022585 WO1999021830A1 (en) | 1997-10-24 | 1998-10-26 | Process for stereoselective synthesis of prostacyclin derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69816642D1 true DE69816642D1 (de) | 2003-08-28 |
| DE69816642T2 DE69816642T2 (de) | 2004-06-09 |
Family
ID=25500067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69816642T Expired - Lifetime DE69816642T2 (de) | 1997-10-24 | 1998-10-26 | Verfahren zur stereoselektiven synthese von prostacyclin-derivaten |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1025083B1 (de) |
| JP (1) | JP3717053B2 (de) |
| KR (1) | KR100447022B1 (de) |
| CN (1) | CN1264819C (de) |
| AT (1) | ATE245628T1 (de) |
| CA (2) | CA2307163C (de) |
| DE (1) | DE69816642T2 (de) |
| DK (1) | DK1025083T3 (de) |
| ES (1) | ES2198760T3 (de) |
| PT (1) | PT1025083E (de) |
| WO (1) | WO1999021830A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6700025B2 (en) * | 2001-01-05 | 2004-03-02 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
| EP2792353B1 (de) | 2003-05-22 | 2018-02-28 | United Therapeutics Corporation | Polymorph von Treprostinil-Diethanolaminsalz |
| CA2698721A1 (en) | 2007-09-07 | 2009-03-12 | United Therapeutics Corporation | Buffer solutions having selective bactericidal activity against gram negative bacteria and methods of using same |
| CA2710205C (en) | 2007-12-17 | 2016-04-26 | United Therapeutics Corporation | An improved process to prepare treprostinil, the active ingredient in remodulin |
| CN101891596B (zh) * | 2009-05-22 | 2013-12-11 | 上海天伟生物制药有限公司 | 一种化合物及其制备方法和用途 |
| CN103261142B (zh) * | 2010-06-03 | 2014-12-10 | 联合治疗公司 | 曲前列环素的制备 |
| CA2710725C (en) | 2010-07-22 | 2017-08-01 | Alphora Research Inc. | Protected aldehydes for use as intermediates in chemical syntheses, and processes for their preparation |
| CA2726599C (en) | 2010-12-30 | 2017-07-25 | Alphora Research Inc. | Process for treprostinil salt preparation |
| ES2581762T3 (es) | 2011-03-02 | 2016-09-07 | United Therapeutics Corporation | Síntesis de producto intermedio para la producción de treprostinil |
| US8524939B2 (en) * | 2011-08-24 | 2013-09-03 | Chirogate International Inc. | Intermediates for the synthesis of benzindene prostaglandins and preparations thereof |
| CN103193626B (zh) * | 2012-01-10 | 2016-05-11 | 上海天伟生物制药有限公司 | 一种***素类似物的晶型及其制备方法和用途 |
| CN103193627B (zh) * | 2012-01-10 | 2016-04-20 | 上海天伟生物制药有限公司 | 一种***素类似物的晶型及其制备方法和用途 |
| EP2970091A4 (de) | 2013-03-14 | 2017-02-08 | United Therapeutics Corporation | Feste formen von treprostinil |
| HU231184B1 (hu) * | 2014-10-08 | 2021-07-28 | CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. | Treprostinil-nátrium-monohidrát és eljárás ennek előállítására |
| KR101890080B1 (ko) | 2014-10-20 | 2018-09-20 | 유나이티드 쎄러퓨틱스 코포레이션 | 프로스타시클린 유도체 제조를 위한 중간체의 합성 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4306075A (en) * | 1980-03-28 | 1981-12-15 | The Upjohn Company | Composition and process |
| US4486598A (en) * | 1982-02-22 | 1984-12-04 | The Upjohn Company | Carbacyclin analogs |
| DE19708496A1 (de) * | 1997-03-03 | 1998-09-10 | Hoechst Ag | Verfahren zur enantionmerenreinen Anthracylin-Synthese |
-
1998
- 1998-10-26 CN CNB988126397A patent/CN1264819C/zh not_active Expired - Lifetime
- 1998-10-26 ES ES98953972T patent/ES2198760T3/es not_active Expired - Lifetime
- 1998-10-26 JP JP2000517942A patent/JP3717053B2/ja not_active Expired - Fee Related
- 1998-10-26 WO PCT/US1998/022585 patent/WO1999021830A1/en active IP Right Grant
- 1998-10-26 DE DE69816642T patent/DE69816642T2/de not_active Expired - Lifetime
- 1998-10-26 DK DK98953972T patent/DK1025083T3/da active
- 1998-10-26 PT PT98953972T patent/PT1025083E/pt unknown
- 1998-10-26 AT AT98953972T patent/ATE245628T1/de active
- 1998-10-26 EP EP98953972A patent/EP1025083B1/de not_active Expired - Lifetime
- 1998-10-26 KR KR10-2000-7004300A patent/KR100447022B1/ko not_active IP Right Cessation
- 1998-10-26 CA CA2307163A patent/CA2307163C/en not_active Expired - Lifetime
- 1998-10-26 CA CA2847985A patent/CA2847985C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DK1025083T3 (da) | 2004-03-01 |
| CA2307163A1 (en) | 1999-05-06 |
| EP1025083B1 (de) | 2003-07-23 |
| WO1999021830A1 (en) | 1999-05-06 |
| PT1025083E (pt) | 2003-10-31 |
| ATE245628T1 (de) | 2003-08-15 |
| CA2847985A1 (en) | 1999-05-06 |
| CN1283184A (zh) | 2001-02-07 |
| EP1025083A1 (de) | 2000-08-09 |
| ES2198760T3 (es) | 2004-02-01 |
| JP2004500303A (ja) | 2004-01-08 |
| JP3717053B2 (ja) | 2005-11-16 |
| DE69816642T2 (de) | 2004-06-09 |
| KR20010031309A (ko) | 2001-04-16 |
| WO1999021830A8 (en) | 1999-07-22 |
| CA2307163C (en) | 2014-05-06 |
| CA2847985C (en) | 2015-02-03 |
| KR100447022B1 (ko) | 2004-09-07 |
| CN1264819C (zh) | 2006-07-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |