PT1025083E - Processo para a sintese estereo-selectiva de derivados da prostaciclina - Google Patents

Processo para a sintese estereo-selectiva de derivados da prostaciclina

Info

Publication number
PT1025083E
PT1025083E PT98953972T PT98953972T PT1025083E PT 1025083 E PT1025083 E PT 1025083E PT 98953972 T PT98953972 T PT 98953972T PT 98953972 T PT98953972 T PT 98953972T PT 1025083 E PT1025083 E PT 1025083E
Authority
PT
Portugal
Prior art keywords
prostaciclin
stereo
derivatives
selective synthesis
making
Prior art date
Application number
PT98953972T
Other languages
English (en)
Inventor
Robert M Moriarty
Raju Penmasta
Liang Guo
Munagala S Rao
James P Staszewski
Original Assignee
United Therapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by United Therapeutics Corp filed Critical United Therapeutics Corp
Publication of PT1025083E publication Critical patent/PT1025083E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
PT98953972T 1997-10-24 1998-10-26 Processo para a sintese estereo-selectiva de derivados da prostaciclina PT1025083E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95773697A 1997-10-24 1997-10-24

Publications (1)

Publication Number Publication Date
PT1025083E true PT1025083E (pt) 2003-10-31

Family

ID=25500067

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98953972T PT1025083E (pt) 1997-10-24 1998-10-26 Processo para a sintese estereo-selectiva de derivados da prostaciclina

Country Status (11)

Country Link
EP (1) EP1025083B1 (pt)
JP (1) JP3717053B2 (pt)
KR (1) KR100447022B1 (pt)
CN (1) CN1264819C (pt)
AT (1) ATE245628T1 (pt)
CA (2) CA2307163C (pt)
DE (1) DE69816642T2 (pt)
DK (1) DK1025083T3 (pt)
ES (1) ES2198760T3 (pt)
PT (1) PT1025083E (pt)
WO (1) WO1999021830A1 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6700025B2 (en) * 2001-01-05 2004-03-02 United Therapeutics Corporation Process for stereoselective synthesis of prostacyclin derivatives
EP2792353B1 (en) 2003-05-22 2018-02-28 United Therapeutics Corporation Polymorph of Treprostinil diethanolamine salt
CA2698721A1 (en) 2007-09-07 2009-03-12 United Therapeutics Corporation Buffer solutions having selective bactericidal activity against gram negative bacteria and methods of using same
CA2710205C (en) 2007-12-17 2016-04-26 United Therapeutics Corporation An improved process to prepare treprostinil, the active ingredient in remodulin
CN101891596B (zh) * 2009-05-22 2013-12-11 上海天伟生物制药有限公司 一种化合物及其制备方法和用途
CN103261142B (zh) * 2010-06-03 2014-12-10 联合治疗公司 曲前列环素的制备
CA2710725C (en) 2010-07-22 2017-08-01 Alphora Research Inc. Protected aldehydes for use as intermediates in chemical syntheses, and processes for their preparation
CA2726599C (en) 2010-12-30 2017-07-25 Alphora Research Inc. Process for treprostinil salt preparation
ES2581762T3 (es) 2011-03-02 2016-09-07 United Therapeutics Corporation Síntesis de producto intermedio para la producción de treprostinil
US8524939B2 (en) * 2011-08-24 2013-09-03 Chirogate International Inc. Intermediates for the synthesis of benzindene prostaglandins and preparations thereof
CN103193626B (zh) * 2012-01-10 2016-05-11 上海天伟生物制药有限公司 一种***素类似物的晶型及其制备方法和用途
CN103193627B (zh) * 2012-01-10 2016-04-20 上海天伟生物制药有限公司 一种***素类似物的晶型及其制备方法和用途
EP2970091A4 (en) 2013-03-14 2017-02-08 United Therapeutics Corporation Solid forms of treprostinil
HU231184B1 (hu) * 2014-10-08 2021-07-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Treprostinil-nátrium-monohidrát és eljárás ennek előállítására
KR101890080B1 (ko) 2014-10-20 2018-09-20 유나이티드 쎄러퓨틱스 코포레이션 프로스타시클린 유도체 제조를 위한 중간체의 합성

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4306075A (en) * 1980-03-28 1981-12-15 The Upjohn Company Composition and process
US4486598A (en) * 1982-02-22 1984-12-04 The Upjohn Company Carbacyclin analogs
DE19708496A1 (de) * 1997-03-03 1998-09-10 Hoechst Ag Verfahren zur enantionmerenreinen Anthracylin-Synthese

Also Published As

Publication number Publication date
DK1025083T3 (da) 2004-03-01
CA2307163A1 (en) 1999-05-06
DE69816642D1 (de) 2003-08-28
EP1025083B1 (en) 2003-07-23
WO1999021830A1 (en) 1999-05-06
ATE245628T1 (de) 2003-08-15
CA2847985A1 (en) 1999-05-06
CN1283184A (zh) 2001-02-07
EP1025083A1 (en) 2000-08-09
ES2198760T3 (es) 2004-02-01
JP2004500303A (ja) 2004-01-08
JP3717053B2 (ja) 2005-11-16
DE69816642T2 (de) 2004-06-09
KR20010031309A (ko) 2001-04-16
WO1999021830A8 (en) 1999-07-22
CA2307163C (en) 2014-05-06
CA2847985C (en) 2015-02-03
KR100447022B1 (ko) 2004-09-07
CN1264819C (zh) 2006-07-19

Similar Documents

Publication Publication Date Title
PT1025083E (pt) Processo para a sintese estereo-selectiva de derivados da prostaciclina
WO2002053517A3 (en) Process for stereoselective synthesis of prostacyclin derivatives
PT828717E (pt) Metodo de preparacao de 3-haloalquil-1h-pirazoles
EA199700170A1 (ru) Способ получения некоторых азациклогексапетидов
DE69525373D1 (de) Verfahren zur herstellung von alumosilikatderivaten
BR0109975A (pt) Método para produzir ansamitocinas
ATE187727T1 (de) Verfahren zur herstellung von imidazo- benzodiazepin-derivaten
ATE229021T1 (de) Verfahren zur herstellung von imidazochinazolinon-derivaten
BR9707404A (pt) Processo para produzir mosto fermentável
DE69628203D1 (de) Verfahren zur herstellung von phenylimidazolin-derivaten
AU6137496A (en) Process for producing guanidine derivatives, intermediates therefor and their production
ATE309230T1 (de) Verfahren zur herstellung von 2- chlorthiazolderivaten
EA199900027A1 (ru) Способ получения некоторых азациклогексапептидов
DE69928249D1 (de) Verbessertes verahren zur fermentativen herstellung von alkohol
BR9711104B1 (pt) processo para preparar uma composição polidispersada de sacarìdeos, composição polidispersada de sacarìdeos e produto compreendendo uma composição polidispersada de sacarìdeos.
PL329290A1 (en) Stereoselective method of obtaining amides exhibiting therapeutic action by an enzymatic process
AU7012498A (en) Method for producing cellulose shaped bodies
ZA957278B (en) Stereoselective process for producing dihydro-2,3-benzo-diazepine derivatives
AU9344298A (en) Method of producing substituted 2-nitroguanidine derivatives
BR9607371A (pt) Processo para produção de eletrodos de carbono
ATE242218T1 (de) Verfahren zur herstellung von imidazolinderivaten
AU1871797A (en) Method for producing cellulose derivatives
ATE198325T1 (de) Verfahren zur herstellung von dioxoazabiclohexanderivaten
ATE200675T1 (de) Verfahren zur herstellung von imidazodiazepinderivaten
PT1032580E (pt) Processo para a n-desmetilacao de eritromicinas e seus derivados