DE69716449T2 - Substituierte zyklische amine als metalloproteaseinhibitoren - Google Patents

Substituierte zyklische amine als metalloproteaseinhibitoren

Info

Publication number
DE69716449T2
DE69716449T2 DE69716449T DE69716449T DE69716449T2 DE 69716449 T2 DE69716449 T2 DE 69716449T2 DE 69716449 T DE69716449 T DE 69716449T DE 69716449 T DE69716449 T DE 69716449T DE 69716449 T2 DE69716449 T2 DE 69716449T2
Authority
DE
Germany
Prior art keywords
inhibitors
metalloproteas
cyclic amines
substituted cyclic
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69716449T
Other languages
English (en)
Other versions
DE69716449D1 (de
Inventor
George Natchus
Biswanath De
Stanislaw Pikul
Gregory Almstead
Gunnard Bookland
Olabisi Taiwo
Menyan Cheng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Application granted granted Critical
Publication of DE69716449D1 publication Critical patent/DE69716449D1/de
Publication of DE69716449T2 publication Critical patent/DE69716449T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/42—Nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
DE69716449T 1996-08-28 1997-08-22 Substituierte zyklische amine als metalloproteaseinhibitoren Expired - Fee Related DE69716449T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2484296P 1996-08-28 1996-08-28
PCT/US1997/014555 WO1998008815A1 (en) 1996-08-28 1997-08-22 Substituted cyclic amine metalloprotease inhibitors

Publications (2)

Publication Number Publication Date
DE69716449D1 DE69716449D1 (de) 2002-11-21
DE69716449T2 true DE69716449T2 (de) 2003-08-07

Family

ID=21822685

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69716449T Expired - Fee Related DE69716449T2 (de) 1996-08-28 1997-08-22 Substituierte zyklische amine als metalloproteaseinhibitoren

Country Status (30)

Country Link
US (6) US6417219B1 (de)
EP (1) EP0927161B1 (de)
JP (2) JP3541043B2 (de)
KR (1) KR100323272B1 (de)
CN (1) CN1232451A (de)
AT (1) ATE226193T1 (de)
AU (1) AU741893B2 (de)
BR (1) BR9713465A (de)
CA (1) CA2263928A1 (de)
CO (1) CO4900036A1 (de)
CZ (1) CZ63199A3 (de)
DE (1) DE69716449T2 (de)
DK (1) DK0927161T3 (de)
ES (1) ES2201318T3 (de)
HK (1) HK1020962A1 (de)
HU (1) HUP0000478A3 (de)
ID (1) ID18143A (de)
IL (1) IL128666A (de)
MY (1) MY116959A (de)
NO (1) NO315371B1 (de)
NZ (1) NZ334256A (de)
PE (1) PE109098A1 (de)
PL (1) PL331802A1 (de)
PT (1) PT927161E (de)
RU (1) RU2221782C2 (de)
SK (1) SK25099A3 (de)
TR (1) TR199900431T2 (de)
TW (1) TWI232218B (de)
WO (1) WO1998008815A1 (de)
ZA (1) ZA977698B (de)

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Also Published As

Publication number Publication date
CO4900036A1 (es) 2000-03-27
NZ334256A (en) 2000-11-24
NO990855L (no) 1999-04-23
US20020061877A1 (en) 2002-05-23
ID18143A (id) 1998-03-05
US20050101567A1 (en) 2005-05-12
US20050154019A1 (en) 2005-07-14
JP2000516955A (ja) 2000-12-19
DE69716449D1 (de) 2002-11-21
PL331802A1 (en) 1999-08-02
WO1998008815A1 (en) 1998-03-05
HUP0000478A2 (hu) 2000-09-28
CZ63199A3 (cs) 1999-08-11
JP3541043B2 (ja) 2004-07-07
JP2004115531A (ja) 2004-04-15
US20030191163A1 (en) 2003-10-09
ATE226193T1 (de) 2002-11-15
ES2201318T3 (es) 2004-03-16
HK1020962A1 (en) 2000-05-26
TR199900431T2 (xx) 1999-04-21
DK0927161T3 (da) 2003-02-17
US20020072517A1 (en) 2002-06-13
ZA977698B (en) 1998-02-23
IL128666A0 (en) 2000-01-31
TWI232218B (en) 2005-05-11
AU741893B2 (en) 2001-12-13
KR20000035922A (ko) 2000-06-26
US6858628B2 (en) 2005-02-22
EP0927161A1 (de) 1999-07-07
KR100323272B1 (ko) 2002-02-06
US6569855B2 (en) 2003-05-27
EP0927161B1 (de) 2002-10-16
MY116959A (en) 2004-04-30
RU2221782C2 (ru) 2004-01-20
PT927161E (pt) 2003-12-31
NO990855D0 (no) 1999-02-23
AU4074197A (en) 1998-03-19
NO315371B1 (no) 2003-08-25
IL128666A (en) 2005-09-25
PE109098A1 (es) 1999-02-19
CN1232451A (zh) 1999-10-20
CA2263928A1 (en) 1998-03-05
SK25099A3 (en) 2000-02-14
HUP0000478A3 (en) 2000-10-30
BR9713465A (pt) 2000-03-28
US6417219B1 (en) 2002-07-09

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