DE69715448T2 - Benzothiophenecarboxamid-derivate und diese enthaltende pgd2 antagonisten - Google Patents

Benzothiophenecarboxamid-derivate und diese enthaltende pgd2 antagonisten

Info

Publication number
DE69715448T2
DE69715448T2 DE69715448T DE69715448T DE69715448T2 DE 69715448 T2 DE69715448 T2 DE 69715448T2 DE 69715448 T DE69715448 T DE 69715448T DE 69715448 T DE69715448 T DE 69715448T DE 69715448 T2 DE69715448 T2 DE 69715448T2
Authority
DE
Germany
Prior art keywords
antagonists containing
pgd2 antagonists
benzothiophenecarboxamide
derivatives
benzothiophenecarboxamide derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69715448T
Other languages
English (en)
Other versions
DE69715448D1 (de
Inventor
Tsunetoshi Honma
Yoshiharu Hiramatsu
Akinori Arimura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of DE69715448D1 publication Critical patent/DE69715448D1/de
Application granted granted Critical
Publication of DE69715448T2 publication Critical patent/DE69715448T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69715448T 1996-12-13 1997-12-10 Benzothiophenecarboxamid-derivate und diese enthaltende pgd2 antagonisten Expired - Lifetime DE69715448T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP33349596 1996-12-13
JP25400197 1997-09-19
PCT/JP1997/004527 WO1998025919A1 (en) 1996-12-13 1997-12-10 Benzothiophenecarboxamide derivatives and pgd2 antagonists comprising them

Publications (2)

Publication Number Publication Date
DE69715448D1 DE69715448D1 (de) 2002-10-17
DE69715448T2 true DE69715448T2 (de) 2003-08-07

Family

ID=26541496

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69715448T Expired - Lifetime DE69715448T2 (de) 1996-12-13 1997-12-10 Benzothiophenecarboxamid-derivate und diese enthaltende pgd2 antagonisten

Country Status (26)

Country Link
US (1) US6083974A (de)
EP (1) EP0944614B1 (de)
JP (1) JP3215441B2 (de)
KR (1) KR100433568B1 (de)
CN (2) CN1105112C (de)
AR (1) AR008939A1 (de)
AT (1) ATE223911T1 (de)
AU (1) AU718958B2 (de)
BR (1) BR9714016A (de)
CA (1) CA2274591C (de)
CZ (1) CZ297324B6 (de)
DE (1) DE69715448T2 (de)
DK (1) DK0944614T3 (de)
ES (1) ES2181039T3 (de)
HK (1) HK1020045A1 (de)
HU (1) HU226458B1 (de)
ID (1) ID22753A (de)
IL (1) IL130660A (de)
NO (1) NO992838L (de)
NZ (1) NZ336143A (de)
PL (1) PL191760B1 (de)
PT (1) PT944614E (de)
RU (1) RU2161617C1 (de)
TR (1) TR199901280T2 (de)
TW (1) TW438790B (de)
WO (1) WO1998025919A1 (de)

Families Citing this family (37)

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HUP0101728A3 (en) * 1998-03-31 2002-04-29 Shionogi & Co 5-hydroxybenzo[b]thiophene-3-carboxylic acid and their derivatives and methods for producing them
RU2185380C1 (ru) 1998-03-31 2002-07-20 Сионоги Энд Ко., Лтд. Способ получения производных бензотиофенкарбоксамида и аминоспиртов (варианты)
ATE295183T1 (de) * 1998-06-03 2005-05-15 Shionogi & Co Mittel zur linderung von juckreiz, enthaltend pgd2- antagonisten
WO2001002334A1 (fr) * 1999-07-02 2001-01-11 Shionogi & Co., Ltd. Nouveau procede de production d'amino-alcool bicyclique
CA2402174A1 (en) 2000-03-09 2001-09-13 Ono Pharmaceutical Co., Ltd. Indole derivatives, process for preparation of the same and use thereof
ATE311200T1 (de) * 2000-04-12 2005-12-15 Merck Frosst Canada Inc Verfahren und zusammensetzungen zur behandlung von allergischen zuständen mit pgd2 rezeptor antagonisten
US6410583B1 (en) * 2000-07-25 2002-06-25 Merck Frosst Canada & Co. Cyclopentanoindoles, compositions containing such compounds and methods of treatment
US7273883B2 (en) 2000-09-14 2007-09-25 Allergan, Inc. Prostaglandin EP4 antagonist
US7217725B2 (en) 2000-09-14 2007-05-15 Allergan, Inc. Prostaglandin D2 antagonist
WO2002032892A1 (en) * 2000-10-17 2002-04-25 Shionogi & Co., Ltd Process for the preparation of pgd2 antagonist
EP1338594A4 (de) * 2000-11-01 2004-06-16 Shionogi & Co Pharmazeutische zusammensetzungen mit pgd2-rezeptor-antagonistischer wirkung
AR038136A1 (es) 2002-01-24 2004-12-29 Merck Frosst Canada Inc Cicloalcanindoles con sustitucion con fluor composiciones que contienen estos compuestos y metodos de tratamiento
BR0308518A (pt) * 2002-03-19 2005-02-22 Ono Pharmaceutical Co Compostos ácidos carboxìlicos e drogas contendo os compostos como o ingrediente ativo
EP1535629A4 (de) * 2002-07-12 2008-05-21 Japan Science & Tech Agency Arzneimittel zur verbesserung der prognose von gehirnverletzungen und verfahren zur untersuchung
EP1547598A1 (de) * 2002-09-30 2005-06-29 Shionogi & Co., Ltd. NEUE VERWENDUNGEN DES PROSTAGLANDIN D sb 2 /sb , PROSTAGLANDIN D sb 2 /sb AGONISTEN UND DES PROSTAGLANDIN D sb 2 /sb ANTAGONISTEN
CA2503767C (en) 2002-10-30 2009-09-22 Merck Frosst Canada & Co./Merck Frosst Canada & Cie Pyridopyrrolizine and pyridoindolizine derivatives
NZ550365A (en) 2004-03-11 2010-09-30 Actelion Pharmaceuticals Ltd Tetrahydropyridoindole derivatives
JPWO2006068162A1 (ja) * 2004-12-24 2008-06-12 塩野義製薬株式会社 慢性閉塞性肺疾患の治療剤
TW200716093A (en) * 2005-04-28 2007-05-01 Shionogi & Co An antiasthmatic agent containing PGD2 receptor antagonist and leukotriene receptor antagonist
TWI410410B (zh) 2007-08-10 2013-10-01 Ono Pharmaceutical Co Phenylacetic acid compounds
TW201130810A (en) 2009-12-23 2011-09-16 Ironwood Pharmaceuticals Inc CRTH2 modulators
WO2011115804A1 (en) 2010-03-17 2011-09-22 Ironwood Pharmaceuticals, Inc. Sgc stimulators
CN107021951B (zh) 2010-06-30 2020-10-20 赛克里翁治疗有限公司 sGC刺激物
US20130259830A1 (en) 2010-07-12 2013-10-03 Ironwood Pharmaceuticals, Inc. Crth2 modulators
US20130216552A1 (en) 2010-07-12 2013-08-22 Ironwood Pharmaceuticals, Inc. Crth2 modulators
WO2012064559A1 (en) 2010-11-09 2012-05-18 Ironwood Pharmaceuticals, Inc. Sgc stimulators
US9139564B2 (en) 2011-12-27 2015-09-22 Ironwood Pharmaceuticals, Inc. 2-benzyl, 3-(pyrimidin-2-yl) substituted pyrazoles useful as sGC stimulators
WO2014047111A1 (en) 2012-09-18 2014-03-27 Ironwood Pharmaceuticals, Inc. Sgc stimulators
US9487508B2 (en) 2012-09-19 2016-11-08 Ironwood Pharmaceuticals, Inc. SGC stimulators
CN108912111B (zh) 2013-03-15 2021-09-14 赛克里翁治疗有限公司 化合物及药用组合物
JP2016540017A (ja) 2013-12-11 2016-12-22 アイアンウッド ファーマシューティカルズ インコーポレイテッド ｓＧＣ刺激物質
US20160324856A1 (en) 2014-01-13 2016-11-10 Ironwood Pharmaceuticals, Inc. Use of sgc stimulators for the treatment of neuromuscular disorders
WO2016044445A2 (en) 2014-09-17 2016-03-24 Ironwood Pharmaceuticals, Inc. sGC STIMULATORS
WO2016044447A1 (en) 2014-09-17 2016-03-24 Ironwood Pharmaceuticals, Inc. Pyrazole derivatives as sgc stimulators
WO2016044446A2 (en) 2014-09-17 2016-03-24 Ironwood Pharmaceuticals, Inc. Sgc stimulators
BR112019000290B1 (pt) 2016-07-07 2022-10-18 Cyclerion Therapeutics, Inc Prófármacos de fósforo dos estimuladores da sgc
WO2018009609A1 (en) 2016-07-07 2018-01-11 Ironwood Pharmaceuticals, Inc. Solid forms of an sgc stimulator

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4560343A (en) * 1984-06-11 1985-12-24 Honeywell Inc. Functional check for a hot surface ignitor element
JPS6149A (ja) * 1984-06-12 1986-01-06 Ono Pharmaceut Co Ltd 新規な１３―アザ―１４―オキソ―ＴｘＡ２類似化合物およびそれらを有効成分として含有するトロンボキサン起因疾患治療剤
NZ218115A (en) * 1985-11-18 1990-02-26 Shionogi & Co Bicyclic sulphonamides and pharmaceutical compositions
CA1294974C (en) * 1987-05-08 1992-01-28 Sanji Hagishita Bicyclic sulfonamide derivatives and process therefor
US5356926A (en) * 1992-02-24 1994-10-18 Warner-Lambert Company 3-alkyloxy-, aryloxy-, or arylalkyloxy-benzo [β]thiophene-2-carboxamides as inhibitors of cell adhesion
CA2113787A1 (en) * 1993-01-29 1994-07-30 Nobuyuki Hamanaka Carbocyclic sulfonamides
DE4317076A1 (de) * 1993-05-21 1994-11-24 Bayer Ag Benzthiophencarbonsäureamid-S-oxide
US5863936A (en) * 1995-04-18 1999-01-26 Geron Corporation Telomerase inhibitors
DK0837052T3 (da) * 1995-06-21 2007-01-02 Shionogi & Co Bicykliske aminoderivater og PGD2-antagonist indeholdende disse
WO1998015545A1 (en) * 1996-10-08 1998-04-16 Eli Lilly And Company New serotonin 5-ht1f agonists

Also Published As

Publication number Publication date
KR100433568B1 (ko) 2004-05-31
RU2161617C1 (ru) 2001-01-10
CN1185226C (zh) 2005-01-19
CZ206599A3 (cs) 1999-11-17
CZ297324B6 (cs) 2006-11-15
CA2274591A1 (en) 1998-06-18
DE69715448D1 (de) 2002-10-17
CN1105112C (zh) 2003-04-09
DK0944614T3 (da) 2003-01-13
CN1445225A (zh) 2003-10-01
JP2000514824A (ja) 2000-11-07
PL334072A1 (en) 2000-01-31
AU5409798A (en) 1998-07-03
TW438790B (en) 2001-06-07
WO1998025919A1 (en) 1998-06-18
NO992838D0 (no) 1999-06-10
NO992838L (no) 1999-07-20
PL191760B1 (pl) 2006-06-30
ATE223911T1 (de) 2002-09-15
HU226458B1 (en) 2008-12-29
EP0944614A1 (de) 1999-09-29
AR008939A1 (es) 2000-02-23
HUP0002869A2 (hu) 2001-06-28
CA2274591C (en) 2005-06-14
JP3215441B2 (ja) 2001-10-09
IL130660A0 (en) 2000-06-01
BR9714016A (pt) 2000-02-29
AU718958B2 (en) 2000-05-04
HK1020045A1 (en) 2000-03-10
NZ336143A (en) 2002-05-31
US6083974A (en) 2000-07-04
ES2181039T3 (es) 2003-02-16
TR199901280T2 (xx) 1999-10-21
PT944614E (pt) 2003-01-31
EP0944614B1 (de) 2002-09-11
ID22753A (id) 1999-12-09
HUP0002869A3 (en) 2003-01-28
IL130660A (en) 2002-03-10
CN1240438A (zh) 2000-01-05
KR20000069402A (ko) 2000-11-25

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Legal Events

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8364 No opposition during term of opposition