DE69019052D1 - Verfahren zur Herstellung von 2'Deoxy-5-trifluoromethyl-ss-uridin. - Google Patents

Verfahren zur Herstellung von 2'Deoxy-5-trifluoromethyl-ss-uridin.

Info

Publication number
DE69019052D1
DE69019052D1 DE69019052T DE69019052T DE69019052D1 DE 69019052 D1 DE69019052 D1 DE 69019052D1 DE 69019052 T DE69019052 T DE 69019052T DE 69019052 T DE69019052 T DE 69019052T DE 69019052 D1 DE69019052 D1 DE 69019052D1
Authority
DE
Germany
Prior art keywords
uridine
deoxy
trifluoromethyl
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69019052T
Other languages
English (en)
Other versions
DE69019052T2 (de
Inventor
Kazuo Itoh
Yoshitake Naoi
Hajime Life Science Matsushita
Takashi Ebata
Hiroshi Life Science Kawakami
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
YUKI GOSEI YAKUHIN KOGYO KK
Japan Tobacco Inc
Original Assignee
YUKI GOSEI YAKUHIN KOGYO KK
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by YUKI GOSEI YAKUHIN KOGYO KK, Japan Tobacco Inc filed Critical YUKI GOSEI YAKUHIN KOGYO KK
Application granted granted Critical
Publication of DE69019052D1 publication Critical patent/DE69019052D1/de
Publication of DE69019052T2 publication Critical patent/DE69019052T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69019052T 1989-02-22 1990-02-22 Verfahren zur Herstellung von 2'Deoxy-5-trifluoromethyl-ss-uridin. Expired - Lifetime DE69019052T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP4015689 1989-02-22
JP2007234A JPH02289595A (ja) 1989-02-22 1990-01-18 ２’―デオキシ―５―トリフルオロメチル―β―ウリジンの製造方法

Publications (2)

Publication Number Publication Date
DE69019052D1 true DE69019052D1 (de) 1995-06-08
DE69019052T2 DE69019052T2 (de) 1995-08-31

Family

ID=26341504

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69019052T Expired - Lifetime DE69019052T2 (de) 1989-02-22 1990-02-22 Verfahren zur Herstellung von 2'Deoxy-5-trifluoromethyl-ss-uridin.

Country Status (3)

Country Link
EP (1) EP0389110B1 (de)
JP (1) JPH02289595A (de)
DE (1) DE69019052T2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU207524B (en) * 1991-11-22 1993-04-28 Mta Koezponti Kemiai Kutato In Industrial process for producing 5-alkyl-2'-deoxy-beta-uridines with stereoselective synthesis
US5532349A (en) * 1993-07-20 1996-07-02 Mitsui Toatsu Chemicals, Inc. Process for producing 1-(2'-deoxy-β-D-erythro-pentofuranosyl)-5-trifluoromethyluracil derivatives
KR100441387B1 (ko) * 2000-02-10 2004-07-23 미쯔이카가쿠 가부시기가이샤 트리플루오로티미딘유도체의 제조방법
JP4603274B2 (ja) * 2004-02-24 2010-12-22 三井化学株式会社 ２’−デオキシ−５−トリフルオロメチルウリジンの製造方法
CN105198946A (zh) * 2014-06-11 2015-12-30 江苏豪森药业股份有限公司 新的曲氟尿苷晶型及其制备方法
CN105175467B (zh) * 2014-06-11 2020-07-17 江苏豪森药业集团有限公司 曲氟尿苷的新晶型及其制备方法
CN105198947B (zh) * 2014-06-27 2019-05-14 江苏奥赛康药业股份有限公司 一种Trifluridine化合物及其药物组合物
CN104761603B (zh) * 2014-12-06 2020-05-12 山东诚创医药技术开发有限公司 曲氟尿苷晶型b及其制备方法
CN106220699A (zh) * 2016-07-21 2016-12-14 嘉实（湖南）医药科技有限公司 高纯度曲氟尿苷的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1943428C3 (de) * 1969-08-23 1979-02-08 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von Pyrimidin- und 6-Azauracilnueleosiden
US3721664A (en) * 1970-01-27 1973-03-20 Hoffmann La Roche Preparation of 5-cytosine nucleosides
CA1301166C (en) * 1987-07-21 1992-05-19 John Nicholas Freskos Process for preparing 2-deoxynucleosides
JPH0217198A (ja) * 1988-07-05 1990-01-22 Japan Tobacco Inc ２’−デオキシ−β−シチジン誘導体およびその塩の製造法

Also Published As

Publication number Publication date
DE69019052T2 (de) 1995-08-31
EP0389110B1 (de) 1995-05-03
EP0389110A2 (de) 1990-09-26
JPH02289595A (ja) 1990-11-29
EP0389110A3 (en) 1990-12-19

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