DE68915067T2 - Verfahren zur Herstellung von 2'-Deoxy-beta-adenosin. - Google Patents

Verfahren zur Herstellung von 2'-Deoxy-beta-adenosin.

Info

Publication number
DE68915067T2
DE68915067T2 DE68915067T DE68915067T DE68915067T2 DE 68915067 T2 DE68915067 T2 DE 68915067T2 DE 68915067 T DE68915067 T DE 68915067T DE 68915067 T DE68915067 T DE 68915067T DE 68915067 T2 DE68915067 T2 DE 68915067T2
Authority
DE
Germany
Prior art keywords
deoxy
adenosine
beta
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68915067T
Other languages
English (en)
Other versions
DE68915067D1 (de
Inventor
Hiroshi Kawakami
Hajime Matsushita
Hajime Yoshikoshi
Kazuo Itoh
Yoshitake Naoi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
YUKI GOSEI YAKUHIN KOGYO KK
Japan Tobacco Inc
Original Assignee
YUKI GOSEI YAKUHIN KOGYO KK
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by YUKI GOSEI YAKUHIN KOGYO KK, Japan Tobacco Inc filed Critical YUKI GOSEI YAKUHIN KOGYO KK
Publication of DE68915067D1 publication Critical patent/DE68915067D1/de
Application granted granted Critical
Publication of DE68915067T2 publication Critical patent/DE68915067T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE68915067T 1988-07-05 1989-07-05 Verfahren zur Herstellung von 2'-Deoxy-beta-adenosin. Expired - Fee Related DE68915067T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP63166063A JPH0217199A (ja) 1988-07-05 1988-07-05 ２’−デオキシ−β−アデノシンの製造方法

Publications (2)

Publication Number Publication Date
DE68915067D1 DE68915067D1 (de) 1994-06-09
DE68915067T2 true DE68915067T2 (de) 1994-08-18

Family

ID=15824287

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68915067T Expired - Fee Related DE68915067T2 (de) 1988-07-05 1989-07-05 Verfahren zur Herstellung von 2'-Deoxy-beta-adenosin.

Country Status (4)

Country Link
US (1) US5262531A (de)
EP (1) EP0350292B1 (de)
JP (1) JPH0217199A (de)
DE (1) DE68915067T2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG94686A1 (en) * 1992-06-22 2003-03-18 Lilly Co Eli Stereoselective gylcosylation process
MX9303708A (es) * 1992-06-22 1994-05-31 Lilly Co Eli Proceso de glucosilacion anionica estereoselectiva para preparar 2'-desoxifluoro-beta nucleosidos.
UA41261C2 (uk) * 1992-06-22 2001-09-17 Елі Ліллі Енд Компані Спосіб одержання збагачених бета-аномером нуклеозидів
ATE332910T1 (de) * 2000-02-18 2006-08-15 Southern Res Inst Verfahren zur herstellung von 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofura osyl)-9h-purin-6-amin
US7528247B2 (en) * 2001-08-02 2009-05-05 Genzyme Corporation Process for preparing purine nucleosides
ATE394409T1 (de) 2001-08-02 2008-05-15 Ilex Oncology Inc Verfahren zur herstellung von purinnukleosiden
JP4603274B2 (ja) * 2004-02-24 2010-12-22 三井化学株式会社 ２’−デオキシ−５−トリフルオロメチルウリジンの製造方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3208997A (en) * 1962-11-15 1965-09-28 Sankyo Co Process for preparing purine and pyrimidine nucleosides
US3480613A (en) * 1967-07-03 1969-11-25 Merck & Co Inc 2-c or 3-c-alkylribofuranosyl - 1-substituted compounds and the nucleosides thereof
US3501456A (en) * 1967-08-08 1970-03-17 Merck & Co Inc Arabinofuranosyl nucleosides and intermediates
SU452961A3 (ru) * 1969-04-11 1974-12-05 Шеринг Аг. (Фирма) Способ получени пиримидиннуклеозидов
US3721664A (en) * 1970-01-27 1973-03-20 Hoffmann La Roche Preparation of 5-cytosine nucleosides
US3868373A (en) * 1970-01-27 1975-02-25 Hoffmann La Roche 4-Amino-5-fluoro-2-tri(lower alkyl) silyloxypyrimidines
GB1386584A (en) * 1970-11-16 1975-03-12 Wellcome Found Method of preparation of purine sugar derivatives
DE2757365A1 (de) * 1977-12-20 1979-06-21 Schering Ag Neues verfahren zur herstellung von nucleosiden
GB1601020A (en) * 1978-04-24 1981-10-21 Stichting Grega Vzw 2'-deoxy-5 (2-halogenovinyl)-uridines
US4782142A (en) * 1982-01-05 1988-11-01 The Research Foundation Of State University Of New York Novel 5-substituted 2-pyrimidinone nucleosides and methods of use
US4760137A (en) * 1984-08-06 1988-07-26 Brigham Young University Method for the production of 2'-deoxyadenosine compounds
CA1269659A (en) * 1984-08-06 1990-05-29 Brigham Young University Method for the production of 2'-deoxyadenosine compounds
US5047519A (en) * 1986-07-02 1991-09-10 E. I. Du Pont De Nemours And Company Alkynylamino-nucleotides
CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
CA1301166C (en) * 1987-07-21 1992-05-19 John Nicholas Freskos Process for preparing 2-deoxynucleosides
US4929723A (en) * 1987-07-21 1990-05-29 Ethyl Corporation Process for preparing 2-deoxynucleosides
JPH0217198A (ja) * 1988-07-05 1990-01-22 Japan Tobacco Inc ２’−デオキシ−β−シチジン誘導体およびその塩の製造法

Also Published As

Publication number Publication date
EP0350292B1 (de) 1994-05-04
DE68915067D1 (de) 1994-06-09
JPH0217199A (ja) 1990-01-22
US5262531A (en) 1993-11-16
EP0350292A2 (de) 1990-01-10
EP0350292A3 (en) 1990-12-19

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee