ATE332910T1 - Verfahren zur herstellung von 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofura osyl)-9h-purin-6-amin - Google Patents

Verfahren zur herstellung von 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofura osyl)-9h-purin-6-amin

Info

Publication number
ATE332910T1
ATE332910T1 AT01910961T AT01910961T ATE332910T1 AT E332910 T1 ATE332910 T1 AT E332910T1 AT 01910961 T AT01910961 T AT 01910961T AT 01910961 T AT01910961 T AT 01910961T AT E332910 T1 ATE332910 T1 AT E332910T1
Authority
AT
Austria
Prior art keywords
deoxy
fluoro
chloro
beta
amine
Prior art date
Application number
AT01910961T
Other languages
English (en)
Inventor
John A Montgomery
Anita T Fowler
John A Secrist Iii
Original Assignee
Southern Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Southern Res Inst filed Critical Southern Res Inst
Application granted granted Critical
Publication of ATE332910T1 publication Critical patent/ATE332910T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT01910961T 2000-02-18 2001-02-16 Verfahren zur herstellung von 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofura osyl)-9h-purin-6-amin ATE332910T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18342200P 2000-02-18 2000-02-18

Publications (1)

Publication Number Publication Date
ATE332910T1 true ATE332910T1 (de) 2006-08-15

Family

ID=22672724

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01910961T ATE332910T1 (de) 2000-02-18 2001-02-16 Verfahren zur herstellung von 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofura osyl)-9h-purin-6-amin

Country Status (15)

Country Link
US (2) US6949640B2 (de)
EP (1) EP1261350B1 (de)
JP (2) JP4555536B2 (de)
KR (1) KR100695717B1 (de)
AT (1) ATE332910T1 (de)
AU (2) AU2001238516B2 (de)
CA (1) CA2400470C (de)
CY (1) CY1105636T1 (de)
DE (1) DE60121425T2 (de)
DK (1) DK1261350T3 (de)
ES (1) ES2267725T3 (de)
MX (1) MXPA02008075A (de)
NZ (1) NZ520852A (de)
PT (1) PT1261350E (de)
WO (1) WO2001060383A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE332910T1 (de) * 2000-02-18 2006-08-15 Southern Res Inst Verfahren zur herstellung von 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofura osyl)-9h-purin-6-amin
US7528247B2 (en) * 2001-08-02 2009-05-05 Genzyme Corporation Process for preparing purine nucleosides
ATE394409T1 (de) 2001-08-02 2008-05-15 Ilex Oncology Inc Verfahren zur herstellung von purinnukleosiden
US6884880B2 (en) * 2002-08-21 2005-04-26 Ash Stevens, Inc. Process for the preparation of 9-β-anomeric nucleoside analogs
CN101257797B (zh) * 2005-06-14 2013-06-12 布里格姆·扬大学 嘌呤类化合物的选择性n-9糖基化的方法
EP2070938A1 (de) 2007-12-13 2009-06-17 Heidelberg Pharma AG Clofarabin-Dietherphospholipid-Derivate
CN101497640B (zh) * 2008-01-30 2011-09-14 江苏正大天晴药业股份有限公司 一种氯法拉滨的晶型
CN102311472B (zh) 2010-07-09 2014-09-03 神隆(昆山)生化科技有限公司 2-氯-9-(2’-脱氧-2’-氟-β-D-***呋喃糖基)-腺嘌呤的制备
CN102060899B (zh) * 2010-12-27 2012-07-25 江苏奥赛康药业股份有限公司 一种奈拉滨N-9位α型异构体、其制备方法及其应用
WO2015118558A2 (en) * 2014-02-04 2015-08-13 Msn Laboratories Private Limited Process for the preparation of clofarabine
EP2937420A1 (de) 2014-04-23 2015-10-28 Synbias Pharma AG Verfahren zur Synthese von Clofarabin
US11021510B2 (en) * 2016-11-03 2021-06-01 Laurence I. Wu Prodrugs of clofarabine

Family Cites Families (21)

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Publication number Priority date Publication date Assignee Title
US3903073A (en) * 1973-12-26 1975-09-02 Abbott Lab 2-Substituted adenosine-5{40 {0 carboxylates
US4625020A (en) * 1983-11-18 1986-11-25 Bristol-Myers Company Nucleoside process
US4751221A (en) * 1985-10-18 1988-06-14 Sloan-Kettering Institute For Cancer Research 2-fluoro-arabinofuranosyl purine nucleosides
US5310732A (en) * 1986-02-03 1994-05-10 The Scripps Research Institute 2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis
EP0267878A1 (de) * 1986-11-14 1988-05-18 Ciba-Geigy Ag N9-Cyclopentylsubstituierte Adeninderivate
GB8712745D0 (en) * 1987-05-30 1987-07-01 Wellcome Found Antiviral compounds
NZ226672A (en) 1987-10-30 1991-07-26 Hoffmann La Roche 6-amino-9-(2,3-dideoxy-2-fluoro-b-d-threopentofuranosyl)-9h-purine derivatives and pharmaceutical compositions
ATE128141T1 (de) 1988-03-16 1995-10-15 Scripps Research Inst Als therapeutische mittel verwendbare substituierte adeninderivate.
JPH0217199A (ja) * 1988-07-05 1990-01-22 Japan Tobacco Inc ２’−デオキシ−β−アデノシンの製造方法
US5384310A (en) * 1989-05-23 1995-01-24 Southern Research Institute 2'-fluoro-2-haloarabinoadinosines and their pharmaceutical compositions
HU906976D0 (en) * 1989-11-13 1991-05-28 Bristol Myers Squibb Co Process for producing 2', 3'-didesoxy-2'-fluoarabinonucleoside analogues
US5110919A (en) * 1989-12-04 1992-05-05 Ash Stevens, Inc. Process for the preparation of 2-amino-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine and novel intermediates
CS276072B6 (en) * 1990-08-06 1992-03-18 Ustav Organicke Chemie A Bioch (2R)-2-/DI(2-PROPYL)PHOSPHONYLMETHOXY/-3-p-TOLUENESULFONYLOXY -1- TRIMETHYLACETOXYPROPANE AND PROCESS FOR PREPARING THEREOF
US5180824A (en) 1990-11-29 1993-01-19 Berlex Biosciences Inc. 6-azido-2-fluoropurine, useful in the synthesis of nucleosides
US5332814A (en) * 1991-11-12 1994-07-26 Ciba-Geigy Corporation Process for the preparation of carbacyclic nucleosides, and intermediates
US5821357A (en) * 1992-06-22 1998-10-13 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoropurine and triazole nucleosides
UA41261C2 (uk) 1992-06-22 2001-09-17 Елі Ліллі Енд Компані Спосіб одержання збагачених бета-аномером нуклеозидів
MX9303708A (es) * 1992-06-22 1994-05-31 Lilly Co Eli Proceso de glucosilacion anionica estereoselectiva para preparar 2'-desoxifluoro-beta nucleosidos.
US5401838A (en) 1992-06-22 1995-03-28 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5753789A (en) * 1996-07-26 1998-05-19 Yale University Oligonucleotides containing L-nucleosides
ATE332910T1 (de) * 2000-02-18 2006-08-15 Southern Res Inst Verfahren zur herstellung von 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofura osyl)-9h-purin-6-amin

Also Published As

Publication number Publication date
DK1261350T3 (da) 2006-11-13
US20050288500A1 (en) 2005-12-29
CA2400470A1 (en) 2001-08-23
AU3851601A (en) 2001-08-27
EP1261350A4 (de) 2003-04-16
CA2400470C (en) 2008-11-18
AU2001238516B2 (en) 2005-08-04
JP4555536B2 (ja) 2010-10-06
JP2010070560A (ja) 2010-04-02
KR100695717B1 (ko) 2007-03-15
DE60121425D1 (de) 2006-08-24
CY1105636T1 (el) 2010-12-22
EP1261350A1 (de) 2002-12-04
WO2001060383A1 (en) 2001-08-23
KR20030032920A (ko) 2003-04-26
US7470784B2 (en) 2008-12-30
MXPA02008075A (es) 2005-06-06
DE60121425T2 (de) 2007-02-01
NZ520852A (en) 2004-03-26
ES2267725T3 (es) 2007-03-16
EP1261350B1 (de) 2006-07-12
US20030023078A1 (en) 2003-01-30
JP2003522798A (ja) 2003-07-29
PT1261350E (pt) 2006-11-30
US6949640B2 (en) 2005-09-27

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