GB1386584A - Method of preparation of purine sugar derivatives - Google Patents
Method of preparation of purine sugar derivativesInfo
- Publication number
- GB1386584A GB1386584A GB5450370A GB5450370A GB1386584A GB 1386584 A GB1386584 A GB 1386584A GB 5450370 A GB5450370 A GB 5450370A GB 5450370 A GB5450370 A GB 5450370A GB 1386584 A GB1386584 A GB 1386584A
- Authority
- GB
- United Kingdom
- Prior art keywords
- purine
- alkylamino
- compounds
- preparation
- give compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
Abstract
1386584 Purine-sugars WELLCOME FOUNDATION Ltd (Burroughs Wellcome Co) 16 Feb 1972 [16 Nov 1970] 54503/70 Heading C2C The invention comprises a process for making compounds (II) by acylating (V) to give compounds (IV), condensing (IV) with (VI) to give compounds (III) and subjecting (III) to basic hydrolysis; (II) may be reduced to give compounds (I) (R<SP>1</SP> is NH 2 , alkylamino or alkylthio, R<SP>2</SP> is H, NH 2 or alkylamino provided that one of R<SP>1</SP> and R<SP>2</SP> is NH 2 or alkylamino, Z is a blocking group or one or two of the Z's is/are H and at least one of Y<SP>1</SP> and Y<SP>2</SP> is a protected group R<SP>3</SP>CON(A)- wherein A is H or alkyl and R<SP>3</SP> is C 1 to C 20 alkyl and, when only one of Y<SP>1</SP> and Y<SP>2</SP> is R<SP>3</SP>CON(A), the other is R<SP>1</SP> or R<SP>2</SP>: the reduction gives I where R<SP>1</SP> is additionally SH or OH and R<SP>2</SP> is additionally OH with the proviso still being applicable). Compounds (II) where R<SP>1</SP> is NH 2 , lakylamino or alkylthio and R 2 is alkylamino are novel. The preparations of 2-amino-6-hydroxy-9-(#- D-arabinofuranosyl)purine and 2-hydroxy-6- amino-9-(#-D-arabinofuranosyl)purine are described.
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB5450370A GB1386584A (en) | 1970-11-16 | 1970-11-16 | Method of preparation of purine sugar derivatives |
ES397037A ES397037A1 (en) | 1970-11-16 | 1971-11-15 | Method of preparation of purine sugar derivatives |
CA127,718A CA983484A (en) | 1970-11-16 | 1971-11-15 | Method of preparation of purine sugar derivatives |
HUWE000452 HU163969B (en) | 1970-11-16 | 1971-11-15 | |
CS797071A CS176178B2 (en) | 1970-11-16 | 1971-11-15 | |
NL7115682A NL7115682A (en) | 1970-11-16 | 1971-11-15 | |
AT982371A AT339335B (en) | 1970-11-16 | 1971-11-15 | PROCESS FOR PRODUCING PURINE SUGAR DERIVATIVES |
CH1662871A CH561228A5 (en) | 1970-11-16 | 1971-11-16 | |
AR23906371A AR193229A1 (en) | 1970-11-16 | 1971-11-16 | A METHOD TO PREPARE PURINE SUGAR DERIVATIVES |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB5450370A GB1386584A (en) | 1970-11-16 | 1970-11-16 | Method of preparation of purine sugar derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1386584A true GB1386584A (en) | 1975-03-12 |
Family
ID=10471222
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB5450370A Expired GB1386584A (en) | 1970-11-16 | 1970-11-16 | Method of preparation of purine sugar derivatives |
Country Status (9)
Country | Link |
---|---|
AR (1) | AR193229A1 (en) |
AT (1) | AT339335B (en) |
CA (1) | CA983484A (en) |
CH (1) | CH561228A5 (en) |
CS (1) | CS176178B2 (en) |
ES (1) | ES397037A1 (en) |
GB (1) | GB1386584A (en) |
HU (1) | HU163969B (en) |
NL (1) | NL7115682A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4136175A (en) * | 1975-06-17 | 1979-01-23 | Burroughs Wellcome Co. | Purine nucleotide antiveral composition and methods of use |
US5262531A (en) * | 1988-07-05 | 1993-11-16 | Japan Tobacco, Inc. | Process for preparing 2'-deoxy-β-adenosine |
-
1970
- 1970-11-16 GB GB5450370A patent/GB1386584A/en not_active Expired
-
1971
- 1971-11-15 ES ES397037A patent/ES397037A1/en not_active Expired
- 1971-11-15 CA CA127,718A patent/CA983484A/en not_active Expired
- 1971-11-15 AT AT982371A patent/AT339335B/en not_active IP Right Cessation
- 1971-11-15 CS CS797071A patent/CS176178B2/cs unknown
- 1971-11-15 HU HUWE000452 patent/HU163969B/hu unknown
- 1971-11-15 NL NL7115682A patent/NL7115682A/xx not_active Application Discontinuation
- 1971-11-16 AR AR23906371A patent/AR193229A1/en active
- 1971-11-16 CH CH1662871A patent/CH561228A5/xx not_active IP Right Cessation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4136175A (en) * | 1975-06-17 | 1979-01-23 | Burroughs Wellcome Co. | Purine nucleotide antiveral composition and methods of use |
US5262531A (en) * | 1988-07-05 | 1993-11-16 | Japan Tobacco, Inc. | Process for preparing 2'-deoxy-β-adenosine |
Also Published As
Publication number | Publication date |
---|---|
HU163969B (en) | 1973-11-28 |
CH561228A5 (en) | 1975-04-30 |
ATA982371A (en) | 1977-02-15 |
CS176178B2 (en) | 1977-06-30 |
ES397037A1 (en) | 1975-03-01 |
CA983484A (en) | 1976-02-10 |
AT339335B (en) | 1977-10-10 |
AR193229A1 (en) | 1973-04-11 |
NL7115682A (en) | 1972-05-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |