DE60336265D1 - Inhibitoren der enzymaktivität der endooligopeptidase a (eopa) und ihre verwendungen - Google Patents

Inhibitoren der enzymaktivität der endooligopeptidase a (eopa) und ihre verwendungen

Info

Publication number
DE60336265D1
DE60336265D1 DE60336265T DE60336265T DE60336265D1 DE 60336265 D1 DE60336265 D1 DE 60336265D1 DE 60336265 T DE60336265 T DE 60336265T DE 60336265 T DE60336265 T DE 60336265T DE 60336265 D1 DE60336265 D1 DE 60336265D1
Authority
DE
Germany
Prior art keywords
eopa
inhibitors
activity
heopa
application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60336265T
Other languages
English (en)
Inventor
Antonio Camargo
Mirian Hayashi
Fernanda Portaro
Juliano Guerreiro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from BR0305688A external-priority patent/BR0305688A/pt
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of DE60336265D1 publication Critical patent/DE60336265D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
DE60336265T 2002-12-09 2003-12-08 Inhibitoren der enzymaktivität der endooligopeptidase a (eopa) und ihre verwendungen Expired - Lifetime DE60336265D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
BR0205000 2002-12-09
BR0305688A BR0305688A (pt) 2003-12-05 2003-12-05 Processo para a determinação da estrutura primária do rna mensageiro codificante para a endooligopeptidase a humana (heopa) [genbank acc n°af217798] e da sua sequência protéica [genbank acc n° aaf24516], para a determinação do gene da eopa humana, e para a produção da eopa humana recombinante; processo de geração de anticorpos anti-heopa; processo de padronização e utilização de substratos sintéticos para a determinação das propriedades bioquìmicas e proteolìticas da heopa; processo de identificação e produção de inibidores da eopa, obtenção de anticorpos com atividade inibitória sobre a atividade catalìtica e sobre a interação com oligopeptìdeos; método de identificação dessa proteìna em patologias congênitas, infecciosas e degenerativas do sistema nervoso central, e método de determinação do papel da eopa em processos imunológicos; método de diagnóstico imuno-quìmico e/ou enzimático, para a prevenção, evolução de patologias, prognóstico ou tratamento de doenças congênitas, infecciosas e degenerativas do sistema nervoso central; uso das propriedades de interação de ligantes com o centro ativo da eopa atuando quer como inibidores da sua ação enzimática e/ou alterando a sua associação com outras proteìnas intracelulares, úteis no tratamento de patologias neurológicas, psiquiátricas e degenerativas
PCT/BR2003/000189 WO2004053052A2 (en) 2002-12-09 2003-12-08 HUMAN RECOMBINANT ENDOOLIGOPEPTIDASE A (hEOPA)

Publications (1)

Publication Number Publication Date
DE60336265D1 true DE60336265D1 (de) 2011-04-14

Family

ID=37719837

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60336265T Expired - Lifetime DE60336265D1 (de) 2002-12-09 2003-12-08 Inhibitoren der enzymaktivität der endooligopeptidase a (eopa) und ihre verwendungen

Country Status (8)

Country Link
US (2) US20070031830A1 (de)
EP (1) EP1578953B1 (de)
JP (1) JP5272114B2 (de)
AT (1) ATE500324T1 (de)
AU (1) AU2003302901A1 (de)
CA (1) CA2507811C (de)
DE (1) DE60336265D1 (de)
WO (1) WO2004053052A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7985555B2 (en) 2004-06-25 2011-07-26 Washington University Markers for brain damage
RU2499599C2 (ru) 2007-09-28 2013-11-27 Интрексон Корпорейшн Конструкции терапевтического переключения генов и биореакторы для экспрессии биотерапевтических молекул и их применение
BRPI1004231A2 (pt) * 2010-11-09 2013-03-12 Universidade Federal De São Paulo- Unifesp mÉtodo e kit para diagnàstico de condiÇÕes neuropsiquiÁtricas, mÉtodo para avaliaÇço de tratamentos de condiÇÕes neuropsiquiÁtricas e mÉtodo de identificaÇço de fÁrmacos potencialmente éteis no tratamento de condiÇÕes neuropsiquiÁtricas
US10115661B2 (en) 2013-02-08 2018-10-30 Qualcomm Incorporated Substrate-less discrete coupled inductor structure
KR20200009126A (ko) * 2013-03-29 2020-01-29 인텔 아이피 코포레이션 셀 방식 네트워크에서의 인터넷에의 연결 확립

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6171790B1 (en) * 1998-05-01 2001-01-09 Incyte Pharmaceuticals, Inc. Human protease associated proteins
US6406891B1 (en) * 1998-09-28 2002-06-18 Board Of Regents, The University Of Texas System Dual RT procedure for cDNA synthesis
JP5058403B2 (ja) * 2000-06-27 2012-10-24 シスメックス株式会社 Ｃｋ−ｍｂ活性測定法およびｃｋ−ｍｂ活性測定試薬
JP2002065266A (ja) * 2000-08-28 2002-03-05 Teijin Ltd 気道特異的トリプシン様酵素およびその利用法

Also Published As

Publication number Publication date
EP1578953A4 (de) 2007-08-08
AU2003302901A1 (en) 2004-06-30
US20070031830A1 (en) 2007-02-08
US20090017042A1 (en) 2009-01-15
AU2003302901A8 (en) 2004-06-30
EP1578953B1 (de) 2011-03-02
CA2507811A1 (en) 2004-06-24
CA2507811C (en) 2013-11-05
JP2006524983A (ja) 2006-11-09
WO2004053052A2 (en) 2004-06-24
WO2004053052A3 (en) 2006-08-03
JP5272114B2 (ja) 2013-08-28
EP1578953A2 (de) 2005-09-28
ATE500324T1 (de) 2011-03-15

Similar Documents

Publication Publication Date Title
IL195338A (en) An antibody comprising an FC variant containing amino acid replaces d or e at position 239, a medicament containing it and its use
WO2007070671A3 (en) Therapeutic methods for inhibiting tumor growth with dll4 antagonists
DE502005009389D1 (de) Identifizierung und charakterisierung von funktionsblockierenden anti-ed-b-fibronektin antikörpern
WO2006002161A3 (en) Modulators of odorant receptors
NO20074374L (no) Fremgangsmate for fremstilling av polypeptidblandinger ved anvendelse av hydrogenolyse
NO2011003I1 (no) Dimensk fusjonsprotein bestående av de ligandbindende cfomener av de ekstacellulære deler av human type I interieukm-1 reseptor (IL-1R1) og IL-1 reseptor hjelpeprotein bundet (IL-I-RAcP) bundet i tinje til Fc-delen av humant IgG
DK1066380T3 (da) Opløselig T-cellereceptor
ATE465171T1 (de) Neue chemokine bindende peptide, die die biologische aktivität dieser chemokine modulieren
NZ615070A (en) Npp1 fusion proteins
BRPI0412607A (pt) método para aprimorar a eficácia de proteìnas modificantes de reação biológica e muteìnas resultantes
DE60336265D1 (de) Inhibitoren der enzymaktivität der endooligopeptidase a (eopa) und ihre verwendungen
MXPA05011085A (es) Composiciones y metodos relacionados a stop-1.
DK1234025T3 (da) Humane enzymer fra metalloproteasefamilien
DE60332579D1 (de) Prozess zur Immobilisierung von Polypeptiden über die Carboxylgruppe des C-terminus
ATE373717T1 (de) Pde8a und seine verwendung
ATE247130T1 (de) Inhibitoren für den urokinaserezeptor
DK1539221T3 (da) Transferrin-fusionsproteinbiblioteker
DK1863834T3 (da) Polypeptider og nukleinsyrer, der koder disse
DE69615185D1 (de) Faktor ix bindende peptide abgeleitet von faktor vii und ihre verwendung als inhibitoren der blutgerinnung
ATE466880T1 (de) Cytokinpolypeptidvarianten
ATE455849T1 (de) Rekombinante carboxypeptidase b und ihre aufreinigung
ATE512983T1 (de) Rezeptor für das tgr3-like protein
DE60032161D1 (de) P-glycoproteine und ihre verwendungen
SE9801530D0 (sv) Method for screening
ATE312941T1 (de) Test auf phosphoamidase