ATE500324T1 - Inhibitoren der enzymaktivität der endooligopeptidase a (eopa) und ihre verwendungen - Google Patents
Inhibitoren der enzymaktivität der endooligopeptidase a (eopa) und ihre verwendungenInfo
- Publication number
- ATE500324T1 ATE500324T1 AT03812536T AT03812536T ATE500324T1 AT E500324 T1 ATE500324 T1 AT E500324T1 AT 03812536 T AT03812536 T AT 03812536T AT 03812536 T AT03812536 T AT 03812536T AT E500324 T1 ATE500324 T1 AT E500324T1
- Authority
- AT
- Austria
- Prior art keywords
- eopa
- activity
- heopa
- application
- endooligopeptidase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR0205000 | 2002-12-09 | ||
BR0305688A BR0305688A (pt) | 2003-12-05 | 2003-12-05 | Processo para a determinação da estrutura primária do rna mensageiro codificante para a endooligopeptidase a humana (heopa) [genbank acc n°af217798] e da sua sequência protéica [genbank acc n° aaf24516], para a determinação do gene da eopa humana, e para a produção da eopa humana recombinante; processo de geração de anticorpos anti-heopa; processo de padronização e utilização de substratos sintéticos para a determinação das propriedades bioquìmicas e proteolìticas da heopa; processo de identificação e produção de inibidores da eopa, obtenção de anticorpos com atividade inibitória sobre a atividade catalìtica e sobre a interação com oligopeptìdeos; método de identificação dessa proteìna em patologias congênitas, infecciosas e degenerativas do sistema nervoso central, e método de determinação do papel da eopa em processos imunológicos; método de diagnóstico imuno-quìmico e/ou enzimático, para a prevenção, evolução de patologias, prognóstico ou tratamento de doenças congênitas, infecciosas e degenerativas do sistema nervoso central; uso das propriedades de interação de ligantes com o centro ativo da eopa atuando quer como inibidores da sua ação enzimática e/ou alterando a sua associação com outras proteìnas intracelulares, úteis no tratamento de patologias neurológicas, psiquiátricas e degenerativas |
PCT/BR2003/000189 WO2004053052A2 (en) | 2002-12-09 | 2003-12-08 | HUMAN RECOMBINANT ENDOOLIGOPEPTIDASE A (hEOPA) |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE500324T1 true ATE500324T1 (de) | 2011-03-15 |
Family
ID=37719837
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03812536T ATE500324T1 (de) | 2002-12-09 | 2003-12-08 | Inhibitoren der enzymaktivität der endooligopeptidase a (eopa) und ihre verwendungen |
Country Status (8)
Country | Link |
---|---|
US (2) | US20070031830A1 (de) |
EP (1) | EP1578953B1 (de) |
JP (1) | JP5272114B2 (de) |
AT (1) | ATE500324T1 (de) |
AU (1) | AU2003302901A1 (de) |
CA (1) | CA2507811C (de) |
DE (1) | DE60336265D1 (de) |
WO (1) | WO2004053052A2 (de) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5190261B2 (ja) | 2004-06-25 | 2013-04-24 | ワシントン・ユニバーシティ | 脳損傷に対するマーカー |
CN101868241A (zh) * | 2007-09-28 | 2010-10-20 | 英特瑞克斯顿股份有限公司 | 表达生物治疗分子的治疗基因开关构建物和生物反应器以及它们的应用 |
BRPI1004231A2 (pt) * | 2010-11-09 | 2013-03-12 | Universidade Federal De São Paulo- Unifesp | mÉtodo e kit para diagnàstico de condiÇÕes neuropsiquiÁtricas, mÉtodo para avaliaÇço de tratamentos de condiÇÕes neuropsiquiÁtricas e mÉtodo de identificaÇço de fÁrmacos potencialmente éteis no tratamento de condiÇÕes neuropsiquiÁtricas |
US10115661B2 (en) | 2013-02-08 | 2018-10-30 | Qualcomm Incorporated | Substrate-less discrete coupled inductor structure |
KR102453739B1 (ko) * | 2013-03-29 | 2022-10-11 | 애플 인크. | 셀 방식 네트워크에서의 인터넷에의 연결 확립 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6171790B1 (en) * | 1998-05-01 | 2001-01-09 | Incyte Pharmaceuticals, Inc. | Human protease associated proteins |
US6406891B1 (en) * | 1998-09-28 | 2002-06-18 | Board Of Regents, The University Of Texas System | Dual RT procedure for cDNA synthesis |
JP5058403B2 (ja) * | 2000-06-27 | 2012-10-24 | シスメックス株式会社 | Ck−mb活性測定法およびck−mb活性測定試薬 |
JP2002065266A (ja) * | 2000-08-28 | 2002-03-05 | Teijin Ltd | 気道特異的トリプシン様酵素およびその利用法 |
-
2003
- 2003-12-08 JP JP2004557687A patent/JP5272114B2/ja not_active Expired - Fee Related
- 2003-12-08 US US10/538,071 patent/US20070031830A1/en not_active Abandoned
- 2003-12-08 AT AT03812536T patent/ATE500324T1/de not_active IP Right Cessation
- 2003-12-08 WO PCT/BR2003/000189 patent/WO2004053052A2/en active Application Filing
- 2003-12-08 CA CA2507811A patent/CA2507811C/en not_active Expired - Fee Related
- 2003-12-08 AU AU2003302901A patent/AU2003302901A1/en not_active Abandoned
- 2003-12-08 DE DE60336265T patent/DE60336265D1/de not_active Expired - Lifetime
- 2003-12-08 EP EP03812536A patent/EP1578953B1/de not_active Expired - Lifetime
-
2008
- 2008-04-14 US US12/102,821 patent/US20090017042A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE60336265D1 (de) | 2011-04-14 |
JP2006524983A (ja) | 2006-11-09 |
WO2004053052A2 (en) | 2004-06-24 |
JP5272114B2 (ja) | 2013-08-28 |
WO2004053052A3 (en) | 2006-08-03 |
CA2507811A1 (en) | 2004-06-24 |
EP1578953B1 (de) | 2011-03-02 |
EP1578953A2 (de) | 2005-09-28 |
US20070031830A1 (en) | 2007-02-08 |
CA2507811C (en) | 2013-11-05 |
EP1578953A4 (de) | 2007-08-08 |
AU2003302901A1 (en) | 2004-06-30 |
AU2003302901A8 (en) | 2004-06-30 |
US20090017042A1 (en) | 2009-01-15 |
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Legal Events
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |