DE60308387D1 - Pyrazolenthaltende zusammensetzungen und ihre verwendung als gsk-3 inhibitoren - Google Patents

Pyrazolenthaltende zusammensetzungen und ihre verwendung als gsk-3 inhibitoren

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Publication number
DE60308387D1
DE60308387D1 DE60308387T DE60308387T DE60308387D1 DE 60308387 D1 DE60308387 D1 DE 60308387D1 DE 60308387 T DE60308387 T DE 60308387T DE 60308387 T DE60308387 T DE 60308387T DE 60308387 D1 DE60308387 D1 DE 60308387D1
Authority
DE
Germany
Prior art keywords
gsk
pyrazole
inhibitors
containing compounds
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60308387T
Other languages
English (en)
Other versions
DE60308387T2 (de
Inventor
J Forster
C Park
W Wannamaker
Yung-Mae Yao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Application granted granted Critical
Publication of DE60308387D1 publication Critical patent/DE60308387D1/de
Publication of DE60308387T2 publication Critical patent/DE60308387T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
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    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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    • A—HUMAN NECESSITIES
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    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
DE60308387T 2002-08-02 2003-07-31 Pyrazolenthaltende zusammensetzungen und ihre verwendung als gsk-3 inhibitoren Expired - Lifetime DE60308387T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40096702P 2002-08-02 2002-08-02
US400967P 2002-08-02
PCT/US2003/023950 WO2004013140A1 (en) 2002-08-02 2003-07-31 Pyrazole compositions useful as inhibitors of gsk-3

Publications (2)

Publication Number Publication Date
DE60308387D1 true DE60308387D1 (de) 2006-10-26
DE60308387T2 DE60308387T2 (de) 2007-09-20

Family

ID=31495907

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60308387T Expired - Lifetime DE60308387T2 (de) 2002-08-02 2003-07-31 Pyrazolenthaltende zusammensetzungen und ihre verwendung als gsk-3 inhibitoren

Country Status (26)

Country Link
US (2) US7491730B2 (de)
EP (1) EP1532145B1 (de)
JP (3) JP4733388B2 (de)
KR (1) KR20050032105A (de)
CN (2) CN1319968C (de)
AR (1) AR040773A1 (de)
AT (1) ATE339419T1 (de)
AU (2) AU2003257078B2 (de)
BR (1) BR0313176A (de)
CA (1) CA2494100C (de)
CO (1) CO5700772A2 (de)
DE (1) DE60308387T2 (de)
DK (1) DK1532145T3 (de)
EA (1) EA200500299A1 (de)
EC (1) ECSP055640A (de)
ES (1) ES2273043T3 (de)
HK (1) HK1081186A1 (de)
IL (1) IL166620A (de)
MX (1) MXPA05001367A (de)
NO (1) NO20051100L (de)
NZ (2) NZ538426A (de)
PL (1) PL374967A1 (de)
PT (1) PT1532145E (de)
TW (1) TWI324157B (de)
WO (1) WO2004013140A1 (de)
ZA (1) ZA200501124B (de)

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ATE339419T1 (de) 2006-10-15
ZA200501124B (en) 2006-10-25
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MXPA05001367A (es) 2005-04-28
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US7872129B2 (en) 2011-01-18
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