DE60205937T2 - Homogen beschichtete vorrichtung mit osteoinduktiven und osteokonduktiven eigenschaften - Google Patents
Homogen beschichtete vorrichtung mit osteoinduktiven und osteokonduktiven eigenschaften Download PDFInfo
- Publication number
- DE60205937T2 DE60205937T2 DE60205937T DE60205937T DE60205937T2 DE 60205937 T2 DE60205937 T2 DE 60205937T2 DE 60205937 T DE60205937 T DE 60205937T DE 60205937 T DE60205937 T DE 60205937T DE 60205937 T2 DE60205937 T2 DE 60205937T2
- Authority
- DE
- Germany
- Prior art keywords
- osteoinductive
- relates
- osteoconductive properties
- homogen
- coated device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/108—Specific proteins or polypeptides not covered by groups A61L24/102 - A61L24/106
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Surgery (AREA)
- Inorganic Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Glass Compositions (AREA)
- Apparatuses And Processes For Manufacturing Resistors (AREA)
- Dental Preparations (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Prostheses (AREA)
- Permanent Magnet Type Synchronous Machine (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01127573 | 2001-11-19 | ||
EP01127573 | 2001-11-19 | ||
EP02803343.9A EP1448246B2 (de) | 2001-11-19 | 2002-03-27 | Methode zur herstellung einer homogen beschichtete vorrichtung mit osteoinduktiven und osteokonduktiven eigenschaften |
PCT/EP2002/003463 WO2003043673A1 (en) | 2001-11-19 | 2002-03-27 | Device having osteoinductive and osteoconductive properties |
Publications (3)
Publication Number | Publication Date |
---|---|
DE60205937D1 DE60205937D1 (de) | 2005-10-06 |
DE60205937T2 true DE60205937T2 (de) | 2006-06-14 |
DE60205937T3 DE60205937T3 (de) | 2016-01-21 |
Family
ID=8179288
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60205937.2T Expired - Lifetime DE60205937T3 (de) | 2001-11-19 | 2002-03-27 | Methode zur Herstellung einer homogen beschichtete Vorrichtung mit osteoinduktiven und osteokonduktiven Eigenschaft |
Country Status (16)
Country | Link |
---|---|
US (2) | US8546334B2 (de) |
EP (1) | EP1448246B2 (de) |
JP (2) | JP4473576B2 (de) |
CN (1) | CN100425285C (de) |
AT (1) | ATE303169T1 (de) |
AU (1) | AU2002308204B9 (de) |
BR (1) | BR0214275A (de) |
CA (1) | CA2466947C (de) |
CY (1) | CY1105664T1 (de) |
DE (1) | DE60205937T3 (de) |
DK (1) | DK1448246T4 (de) |
ES (1) | ES2247423T5 (de) |
HK (1) | HK1071315A1 (de) |
PT (1) | PT1448246E (de) |
SI (1) | SI1448246T2 (de) |
WO (1) | WO2003043673A1 (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1462126A1 (de) * | 2003-03-28 | 2004-09-29 | BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH | Verbesserte osteoinduktive Materialien |
ES2350939T3 (es) | 2004-03-10 | 2011-01-28 | Scil Technology Gmbh | Implantes recubiertos, su fabricación y uso de los mismos. |
EP1604694A1 (de) * | 2004-06-09 | 2005-12-14 | Scil Technology GmbH | Kompositvorrichtung mit osteoinduktiven und osteokonduktiven Eigenschaften |
EP1604693A1 (de) | 2004-06-09 | 2005-12-14 | Scil Technology GmbH | In-situ hergestelltes Gerüst, dessen Herstellungsverfahren und dessen Verwendung |
EP1753396A2 (de) * | 2004-06-09 | 2007-02-21 | Scil Technology GmbH | Verbundmaterial zur verwendung als proteinträger |
US20060286171A1 (en) * | 2005-06-17 | 2006-12-21 | Tianhong Zhou | Bone morphogenetic protein formulations |
EP1960008A2 (de) * | 2005-12-14 | 2008-08-27 | Scil Technology GmbH | Formbares biologisches material für die knochenregeneration |
US20070299520A1 (en) * | 2006-06-26 | 2007-12-27 | Warsaw Orthopedic, Inc. | Surface treatment of implantable devices |
AU2007234612B2 (en) | 2006-12-14 | 2013-06-27 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein stabilization formulations |
DE102006060958A1 (de) * | 2006-12-20 | 2008-06-26 | Jennissen, Herbert P., Prof. Dr. | Verfahren zur Herstellung einer Polymermatrix, daraus bestehende Implantate sowie deren Verwendung |
US20080221681A1 (en) * | 2007-03-09 | 2008-09-11 | Warsaw Orthopedic, Inc. | Methods for Improving Fatigue Performance of Implants With Osteointegrating Coatings |
US7678764B2 (en) | 2007-06-29 | 2010-03-16 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein formulations for use at elevated temperatures |
EP2187932B1 (de) * | 2007-08-07 | 2015-01-28 | DePuy Synthes Products, LLC | Proteinformulierungen mit gdf-5 in wässriger saurer lösung |
US20090061002A1 (en) * | 2007-09-05 | 2009-03-05 | Venbrocks Rudolf A | Calcium phospate based delivery of growth and differentiation factors to compromised bone |
DE102007051914A1 (de) * | 2007-10-29 | 2009-05-07 | Herbert Prof. Dr. Jennissen | Verfahren zur Herstellung von mit Wachstumsfaktoren beladenen Partikeln sowie die so erhaltenen Partikel |
CA2720845A1 (en) * | 2008-04-14 | 2009-10-22 | Advanced Technologies And Regenerative Medicine, Llc | Liquid buffered gdf-5 formulations |
US20110059149A1 (en) * | 2008-06-16 | 2011-03-10 | Little Marisa A | Process for depositing calcium phosphate therapeutic coatings with different release rates and a prosthesis coated via the process |
JP2012528149A (ja) * | 2009-05-28 | 2012-11-12 | アドビオ・アーベー | 多層タンパク質フィルム、該フィルムの製造方法、ならびに該フィルムを使用した薬物送達装置および医用インプラント |
EP2598177B1 (de) * | 2010-07-30 | 2015-06-17 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH | Wirkstofffreisetzungsvorrichtungen und wachstumsfaktorformulierungen für beschleunigte wundheilung |
WO2012093939A1 (en) | 2011-01-05 | 2012-07-12 | Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg | Particles comprising calcium phosphate and use thereof |
BR112021006752A2 (pt) * | 2018-10-12 | 2021-07-13 | Theradaptive, Inc. | polipeptídeos incluindo uma sequência de ligação de betafosfato tricálcico e usos dos mesmos |
EP3682931A1 (de) * | 2019-01-21 | 2020-07-22 | Universitätsklinikum Hamburg-Eppendorf | Thorakaler katheter |
Family Cites Families (139)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3329128A1 (de) | 1983-08-11 | 1985-02-28 | Bayer Ag, 5090 Leverkusen | 3-cycloalkyl-1-(1,3-dioxan-5-yl)-2-(1,2,4-triazol-1-yl)-propan-1-one und -propan-1-ole |
US4596574A (en) * | 1984-05-14 | 1986-06-24 | The Regents Of The University Of California | Biodegradable porous ceramic delivery system for bone morphogenetic protein |
US5108922A (en) | 1986-07-01 | 1992-04-28 | Genetics Institute, Inc. | DNA sequences encoding BMP-1 products |
US6432919B1 (en) | 1986-07-01 | 2002-08-13 | Genetics Institute, Inc. | Bone morphogenetic protein-3 and compositions |
US5631142A (en) | 1986-07-01 | 1997-05-20 | Genetics Institute, Inc. | Compositions comprising bone morphogenetic protein-2 (BMP-2) |
US6150328A (en) | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
US5013649A (en) | 1986-07-01 | 1991-05-07 | Genetics Institute, Inc. | DNA sequences encoding osteoinductive products |
US5939388A (en) | 1986-07-01 | 1999-08-17 | Rosen; Vicki A. | Methods of administering BMP-5 compositions |
US5366875A (en) | 1986-07-01 | 1994-11-22 | Genetics Institute, Inc. | Methods for producing BMP-7 proteins |
US5459047A (en) | 1986-07-01 | 1995-10-17 | Genetics Institute, Inc. | BMP-6 proteins |
US5106748A (en) | 1986-07-01 | 1992-04-21 | Genetics Institute, Inc. | Dna sequences encoding 5 proteins |
US4877864A (en) | 1987-03-26 | 1989-10-31 | Genetics Institute, Inc. | Osteoinductive factors |
US5543394A (en) | 1986-07-01 | 1996-08-06 | Genetics Institute, Inc. | Bone morphogenetic protein 5(BMP-5) compositions |
ZA874681B (en) | 1986-07-01 | 1988-04-27 | Genetics Inst | Novel osteoinductive factors |
IL83003A (en) | 1986-07-01 | 1995-07-31 | Genetics Inst | Factors that soak bone formation |
US5187076A (en) | 1986-07-01 | 1993-02-16 | Genetics Institute, Inc. | DNA sequences encoding BMP-6 proteins |
ATE231523T1 (de) | 1988-04-08 | 2003-02-15 | Stryker Corp | Osteogene vorrichtungen |
US5266683A (en) | 1988-04-08 | 1993-11-30 | Stryker Corporation | Osteogenic proteins |
US5162114A (en) | 1989-02-23 | 1992-11-10 | Stryker Corporation | Bone collagen matrix for xenogenic implants |
US5354557A (en) | 1988-04-08 | 1994-10-11 | Stryker Corporation | Osteogenic devices |
US5324819A (en) | 1988-04-08 | 1994-06-28 | Stryker Corporation | Osteogenic proteins |
US5670336A (en) | 1988-04-08 | 1997-09-23 | Stryker Corporation | Method for recombinant production of osteogenic protein |
US4975526A (en) | 1989-02-23 | 1990-12-04 | Creative Biomolecules, Inc. | Bone collagen matrix for zenogenic implants |
US6586388B2 (en) | 1988-04-08 | 2003-07-01 | Stryker Corporation | Method of using recombinant osteogenic protein to repair bone or cartilage defects |
US5258494A (en) | 1988-04-08 | 1993-11-02 | Stryker Corporation | Osteogenic proteins |
US5011691A (en) | 1988-08-15 | 1991-04-30 | Stryker Corporation | Osteogenic devices |
US5344654A (en) | 1988-04-08 | 1994-09-06 | Stryker Corporation | Prosthetic devices having enhanced osteogenic properties |
US5258029A (en) | 1988-09-29 | 1993-11-02 | Collagen Corporation | Method for improving implant fixation |
US5108436A (en) | 1988-09-29 | 1992-04-28 | Collagen Corporation | Implant fixation |
US5207710A (en) | 1988-09-29 | 1993-05-04 | Collagen Corporation | Method for improving implant fixation |
ATE162223T1 (de) | 1989-03-28 | 1998-01-15 | Genetics Inst | Osteoinduktive zusammensetzungen |
US5158934A (en) | 1989-09-01 | 1992-10-27 | Genentech, Inc. | Method of inducing bone growth using TGF-β |
US5422340A (en) | 1989-09-01 | 1995-06-06 | Ammann; Arthur J. | TGF-βformulation for inducing bone growth |
DK0448704T3 (da) | 1989-10-17 | 1999-04-06 | Stryker Corp | Osteogene anordninger |
DK27390D0 (da) | 1990-02-02 | 1990-02-02 | Troels Torp Andreassen | Fremgangsmaade og apparat til administration af biologisk aktive stoffer |
DE69129865T2 (de) | 1990-10-18 | 1999-03-04 | Stryker Corp., Kalamazoo, Mich. | Osteogene peptide |
US6495513B1 (en) | 1991-03-11 | 2002-12-17 | Curis, Inc. | Morphogen-enhanced survival and repair of neural cells |
CA2363965C (en) | 1991-03-11 | 2010-05-18 | Curis, Inc. | Protein-induced morphogenesis |
US5652337A (en) | 1991-03-11 | 1997-07-29 | Creative Biomolecules, Inc. | OP-3-induced morphogenesis |
US5674844A (en) | 1991-03-11 | 1997-10-07 | Creative Biomolecules, Inc. | Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases |
US6506729B1 (en) | 1991-03-11 | 2003-01-14 | Curis, Inc. | Methods and compositions for the treatment and prevention of Parkinson's disease |
US6723698B2 (en) | 1991-03-11 | 2004-04-20 | Curis, Inc. | Methods and compositions for the treatment of motor neuron injury and neuropathy |
WO1992015323A1 (en) | 1991-03-11 | 1992-09-17 | Creative Biomolecules, Inc. | Protein-induced morphogenesis |
US5652118A (en) | 1991-03-11 | 1997-07-29 | Creative Biomolecules, Inc. | Nucleic acid encoding a novel morphogenic protein, OP-3 |
US5650276A (en) | 1991-03-11 | 1997-07-22 | Creative Biomolecules, Inc. | Morphogenic protein screening method |
US6077823A (en) | 1991-03-11 | 2000-06-20 | Creative Biomolecules, Inc. | Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury |
US6395883B1 (en) | 1991-03-11 | 2002-05-28 | Curis, Inc. | Soluble morphogenic protein complex compositions of matter |
US5656593A (en) | 1991-03-11 | 1997-08-12 | Creative Biomolecules, Inc. | Morphogen induced periodontal tissue regeneration |
US6800603B2 (en) | 1991-03-11 | 2004-10-05 | Curis, Inc. | Morphogen-induced neural cell adhesion |
US5972884A (en) | 1991-03-11 | 1999-10-26 | Creative Biomolecules, Inc. | Morphogen treatment of gastrointestinal ulcers |
US6194376B1 (en) | 1991-03-11 | 2001-02-27 | Creative Biomolecules, Inc. | Method for modulating inflammatory response comprising administering morphogen |
US6211146B1 (en) | 1991-03-11 | 2001-04-03 | Curis, Inc. | 60A protein-induced morphogenesis |
US5849686A (en) | 1991-03-11 | 1998-12-15 | Creative Biomolecules, Inc. | Morphogen-induced liver regeneration |
US6090776A (en) | 1991-03-11 | 2000-07-18 | Creative Bio Molecules, Inc. | Morphogen treatment of organ implants |
US5707810A (en) | 1991-03-11 | 1998-01-13 | Creative Biomolecules, Inc. | Method of diagnosing renal tissue damage or disease |
US5739107A (en) | 1991-03-11 | 1998-04-14 | Creative Biomolecules, Inc. | Morphogen treatment of gastrointestinal ulcers |
US5290763A (en) | 1991-04-22 | 1994-03-01 | Intermedics Orthopedics/Denver, Inc. | Osteoinductive protein mixtures and purification processes |
US5563124A (en) | 1991-04-22 | 1996-10-08 | Intermedics Orthopedics/ Denver, Inc. | Osteogenic product and process |
US5177406A (en) | 1991-04-29 | 1993-01-05 | General Motors Corporation | Active matrix vacuum fluorescent display with compensation for variable phosphor efficiency |
DE4121043A1 (de) | 1991-06-26 | 1993-01-07 | Merck Patent Gmbh | Knochenersatzmaterial mit fgf |
EP0523926A3 (en) | 1991-07-15 | 1993-12-01 | Smith & Nephew Richards Inc | Prosthetic implants with bioabsorbable coating |
US6022853A (en) | 1991-08-30 | 2000-02-08 | Creative Biomolecules, Inc. | Morphogen-enriched dietary composition |
EP0601106B2 (de) | 1991-08-30 | 2003-11-05 | Curis, Inc. | Morphogen-induzierte Modulation von entzündlichen Antworten |
DE69233559T2 (de) | 1991-08-30 | 2006-08-31 | Curis, Inc., Cambridge | Osteogenische proteine in der behandlung von metabolischen knochenkrankheiten |
SE469653B (sv) | 1992-01-13 | 1993-08-16 | Lucocer Ab | Poroest implantat |
WO1993016099A2 (en) | 1992-02-12 | 1993-08-19 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Dna sequences encoding novel growth/differentiation factors |
US6120760A (en) | 1992-02-12 | 2000-09-19 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung | Growth/differentiation factors of the TGF-β family |
US5876452A (en) | 1992-02-14 | 1999-03-02 | Board Of Regents, University Of Texas System | Biodegradable implant |
US6013853A (en) | 1992-02-14 | 2000-01-11 | The University Of Texas System | Continuous release polymeric implant carrier |
EP0625891B1 (de) | 1992-02-14 | 1997-01-08 | Board Of Regents The University Of Texas System | Mehrphasiges, biologisch abbaubares implantat/träger und verfahren zu seiner herstellung |
US5610021A (en) | 1992-02-21 | 1997-03-11 | Creative Biomolecules, Inc. | Compositions and methods for identification and use of soluble complex forms of osteogenic proteins |
US6071695A (en) | 1992-02-21 | 2000-06-06 | Creative Biomolecules, Inc. | Methods and products for identification of modulators of osteogenic protein-1 gene expression |
US5397235A (en) | 1993-07-02 | 1995-03-14 | Dental Marketing Specialists, Inc. | Method for installation of dental implant |
DK0679097T3 (da) | 1993-01-12 | 1997-12-22 | Genentech Inc | TGF-Beta-præparat til fremkaldelse af knoglevækst |
CA2153654A1 (en) | 1993-01-12 | 1994-07-21 | Se-Jin Lee | Growth differentiation factor-5 |
US5385887A (en) * | 1993-09-10 | 1995-01-31 | Genetics Institute, Inc. | Formulations for delivery of osteogenic proteins |
US6027919A (en) | 1993-12-07 | 2000-02-22 | Genetics Institute, Inc. | BMP-12 and BMP-13 proteins and DNA encoding them |
WO1995016035A2 (en) | 1993-12-07 | 1995-06-15 | Genetics Institute, Inc. | Bmp-12, bmp-13 and tendon-inducing compositions thereof |
US6013517A (en) | 1994-05-09 | 2000-01-11 | Chiron Corporation | Crossless retroviral vectors |
US5681746A (en) | 1994-12-30 | 1997-10-28 | Chiron Viagene, Inc. | Retroviral delivery of full length factor VIII |
ATE197250T1 (de) | 1995-03-01 | 2000-11-15 | Stryker Corp | Morphogeninduzierte regenerierung der dentin |
US5782919A (en) * | 1995-03-27 | 1998-07-21 | Sdgi Holdings, Inc. | Interbody fusion device and method for restoration of normal spinal anatomy |
US5635372A (en) | 1995-05-18 | 1997-06-03 | Genetics Institute, Inc. | BMP-15 compositions |
US5676976A (en) | 1995-05-19 | 1997-10-14 | Etex Corporation | Synthesis of reactive amorphous calcium phosphates |
US6287341B1 (en) | 1995-05-19 | 2001-09-11 | Etex Corporation | Orthopedic and dental ceramic implants |
US6027742A (en) | 1995-05-19 | 2000-02-22 | Etex Corporation | Bioresorbable ceramic composites |
US6117456A (en) | 1995-05-19 | 2000-09-12 | Etex Corporation | Methods and products related to the physical conversion of reactive amorphous calcium phosphate |
US6541037B1 (en) | 1995-05-19 | 2003-04-01 | Etex Corporation | Delivery vehicle |
US6132463A (en) | 1995-05-19 | 2000-10-17 | Etex Corporation | Cell seeding of ceramic compositions |
US8333996B2 (en) | 1995-05-19 | 2012-12-18 | Etex Corporation | Calcium phosphate delivery vehicle and adjuvant |
HU222664B1 (hu) | 1995-06-05 | 2003-09-29 | Genetics Institute, Llc | Csont morfogenetikus protein (BMP) alkalmazása csont és ín vagy szalag funkcionális összeköttetésének regenerálására |
ES2225870T3 (es) * | 1996-02-29 | 2005-03-16 | Bioactive Bone Substitute Oy, Ab | Dispositivo osteogenico y su procedimiento de preparacion. |
CA2205104A1 (en) | 1996-05-10 | 1997-11-10 | Eugenia Ribeiro De Sousa Fidalgo Leitao | Device for incorporation and release of biologically active agents |
US6143948A (en) | 1996-05-10 | 2000-11-07 | Isotis B.V. | Device for incorporation and release of biologically active agents |
EP0806212B1 (de) † | 1996-05-10 | 2003-04-02 | IsoTis N.V. | Vorrichtung zur Aufnahme und Freigabe von biologisch aktiven Substanzen |
EP0806211B1 (de) | 1996-05-10 | 2002-10-23 | IsoTis N.V. | Implantatwerkstoff und Verfahren zu seiner Herstellung |
US6953594B2 (en) | 1996-10-10 | 2005-10-11 | Etex Corporation | Method of preparing a poorly crystalline calcium phosphate and methods of its use |
ATE269720T1 (de) | 1996-10-16 | 2004-07-15 | Etex Corp | Verfahren zur herstellung von niedrigkristallinen calciumphosphat und verfahren zu dessen verwendung |
DE19647853A1 (de) | 1996-11-19 | 1998-05-20 | Bioph Biotech Entw Pharm Gmbh | Verbindungen mit verbesserter knorpel- und/oder knocheninduzierender Aktivität |
US20020082224A1 (en) | 1997-01-14 | 2002-06-27 | Douglas J. Jolly | Non-immunogenic prodrugs and selectable markers for use in gene therapy |
SI0972520T1 (sl) | 1997-01-30 | 2006-02-28 | Bioph Biotech Entw Pharm Gmbh | Liofiliziran sestavek humanega kostnega morfogenetskega proteina MP52 |
DE69814352T3 (de) | 1997-02-07 | 2009-08-13 | Stryker Corp., Kalamazoo | Matrixlose osteogene vorrichtungen und implantate und verfahren zu deren verwendung |
US20020098222A1 (en) | 1997-03-13 | 2002-07-25 | John F. Wironen | Bone paste |
US20030032586A1 (en) | 1997-05-15 | 2003-02-13 | David C. Rueger | Compositions for morphogen-induced osteogenesis |
WO1999011202A1 (en) | 1997-09-05 | 1999-03-11 | Icet, Inc. | Biomimetic calcium phosphate implant coatings and methods for making the same |
WO1999015641A1 (en) | 1997-09-24 | 1999-04-01 | The Regents Of The University Of California | Non-primate lentiviral vectors and packaging systems |
US20020048805A1 (en) | 1998-01-16 | 2002-04-25 | Julie C. Johnston | Feline immunodeficiency virus gene therapy vectors |
CA2318575A1 (en) | 1998-01-16 | 1999-07-22 | Chiron Corporation | Feline immunodeficiency virus gene therapy vectors |
AU3988799A (en) | 1998-05-13 | 1999-11-29 | Genetix Pharmaceuticals, Inc. | Novel lentiviral packaging cells |
US6261322B1 (en) | 1998-05-14 | 2001-07-17 | Hayes Medical, Inc. | Implant with composite coating |
KR100298178B1 (ko) | 1998-06-29 | 2001-08-07 | 박종섭 | 이미지센서의포토다이오드 |
US6328765B1 (en) | 1998-12-03 | 2001-12-11 | Gore Enterprise Holdings, Inc. | Methods and articles for regenerating living tissue |
US6423544B1 (en) | 1998-12-31 | 2002-07-23 | Chiron Corporation | Compositions and methods for producing recombinant virions |
ES2209820T3 (es) | 1999-02-04 | 2004-07-01 | Sdgi Holdings, Inc. | Composiciones esponjosas osteogenicas altamente mineralizadas, y usos de las mismas. |
AU770196B2 (en) | 1999-02-04 | 2004-02-12 | Warsaw Orthopedic, Inc. | Osteogenic paste compositions and uses thereof |
US6730297B1 (en) | 1999-05-28 | 2004-05-04 | Chiron Corporation | Use of recombinant gene delivery vectors for treating or preventing lysosomal storage disorders |
SE514202C2 (sv) | 1999-05-31 | 2001-01-22 | Nobel Biocare Ab | På implantat till ben- eller vävnadsstruktur anordnat skikt samt sådant implantat och förfarande för applicering av skiktet |
SE514323C2 (sv) | 1999-05-31 | 2001-02-12 | Nobel Biocare Ab | Implantat samt förfarande och användning vid implantat |
SE515695C2 (sv) | 1999-05-31 | 2001-09-24 | Nobel Biocare Ab | Implantat med beläggning av bentillväxtstimulerande substans för applicering i ben och förfarande vid sådant implantat |
WO2001008715A1 (en) * | 1999-07-28 | 2001-02-08 | Regeneration Technologies, Inc. | Reduced antigenicity tissue (rat) implants |
US6696410B1 (en) * | 1999-09-27 | 2004-02-24 | Stryker Corporation | Compositions and therapeutic methods using morphogenic proteins, hormones and hormone receptors |
WO2001028603A1 (en) | 1999-10-15 | 2001-04-26 | Genetics Institute, Inc. | Formulations for delivery of osteogenic proteins |
JP4703926B2 (ja) | 1999-10-15 | 2011-06-15 | ジェネティクス インスティテュート,エルエルシー | 骨形成蛋白をデリバリーするためのヒアルロン酸の処方 |
DE19950386A1 (de) | 1999-10-19 | 2001-05-10 | Miladin Lazarov | Biokompatibler Gegenstand |
ES2206407T3 (es) † | 2000-02-04 | 2004-05-16 | Chienna B.V. | Revestimiento proteico. |
US20020022885A1 (en) * | 2000-05-19 | 2002-02-21 | Takahiro Ochi | Biomaterial |
WO2001091801A2 (en) | 2000-05-26 | 2001-12-06 | Chiron Corporation | Methods of transducing neural cells using lentivirus vectors |
US6533821B1 (en) | 2000-06-22 | 2003-03-18 | Thomas Lally | Bio-adhesive composition, method for adhering objects to bone |
US7419829B2 (en) | 2000-10-06 | 2008-09-02 | Oxford Biomedica (Uk) Limited | Vector system |
US20030003565A1 (en) | 2000-11-27 | 2003-01-02 | Dubensky Thomas W. | Functional lentiviral vector from an MLV-based backbone |
US20020082679A1 (en) | 2000-12-22 | 2002-06-27 | Avantec Vascular Corporation | Delivery or therapeutic capable agents |
CA2433657A1 (en) | 2001-01-05 | 2002-07-11 | Duke University | Contrast enhancement agent for magnetic resonance imaging |
US20030049328A1 (en) | 2001-03-02 | 2003-03-13 | Dalal Paresh S. | Porous beta-tricalcium phosphate granules and methods for producing same |
US6949251B2 (en) | 2001-03-02 | 2005-09-27 | Stryker Corporation | Porous β-tricalcium phosphate granules for regeneration of bone tissue |
CA2447683A1 (en) | 2001-04-16 | 2002-10-24 | James J. Cassidy | Dense/porous structures for use as bone substitutes |
EP2055267B1 (de) | 2001-05-01 | 2013-04-17 | Amedica Corporation | Röntgendurchlässiges Knochentransplantat |
WO2002087341A1 (en) | 2001-05-01 | 2002-11-07 | Genetix Pharmaceuticals, Inc. | Novel self-inactivating (sin) lentiviral vectors |
SE519566C2 (sv) | 2001-07-04 | 2003-03-11 | Nobel Biocare Ab | Förfarande för behandling av implantat genom beläggning med kalciumfosfat och bentillväxtstimulerande medel |
SE519564C2 (sv) | 2001-07-04 | 2003-03-11 | Nobel Biocare Ab | Implantat, t ex dentalt implantat, belagt med bentillväxtstimulerande medel |
-
2002
- 2002-03-27 BR BR0214275-9A patent/BR0214275A/pt not_active IP Right Cessation
- 2002-03-27 AT AT02803343T patent/ATE303169T1/de active
- 2002-03-27 SI SI200230206T patent/SI1448246T2/sl unknown
- 2002-03-27 CN CNB028192745A patent/CN100425285C/zh not_active Expired - Fee Related
- 2002-03-27 WO PCT/EP2002/003463 patent/WO2003043673A1/en active IP Right Grant
- 2002-03-27 DE DE60205937.2T patent/DE60205937T3/de not_active Expired - Lifetime
- 2002-03-27 ES ES02803343.9T patent/ES2247423T5/es not_active Expired - Lifetime
- 2002-03-27 AU AU2002308204A patent/AU2002308204B9/en not_active Ceased
- 2002-03-27 DK DK02803343.9T patent/DK1448246T4/en active
- 2002-03-27 EP EP02803343.9A patent/EP1448246B2/de not_active Expired - Lifetime
- 2002-03-27 US US10/496,399 patent/US8546334B2/en not_active Expired - Fee Related
- 2002-03-27 CA CA2466947A patent/CA2466947C/en not_active Expired - Fee Related
- 2002-03-27 PT PT02803343T patent/PT1448246E/pt unknown
- 2002-03-27 JP JP2003545351A patent/JP4473576B2/ja not_active Expired - Fee Related
-
2005
- 2005-05-13 HK HK05104014.9A patent/HK1071315A1/xx not_active IP Right Cessation
- 2005-11-04 CY CY20051101348T patent/CY1105664T1/el unknown
-
2009
- 2009-12-29 JP JP2009299102A patent/JP5054091B2/ja not_active Expired - Fee Related
-
2013
- 2013-09-27 US US14/040,500 patent/US20150080303A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1448246B1 (de) | 2005-08-31 |
DK1448246T4 (en) | 2015-12-21 |
CN1561235A (zh) | 2005-01-05 |
JP2010075737A (ja) | 2010-04-08 |
JP5054091B2 (ja) | 2012-10-24 |
CA2466947C (en) | 2012-05-22 |
HK1071315A1 (en) | 2005-07-15 |
ES2247423T5 (es) | 2015-12-30 |
ES2247423T3 (es) | 2006-03-01 |
WO2003043673A1 (en) | 2003-05-30 |
EP1448246A1 (de) | 2004-08-25 |
DE60205937T3 (de) | 2016-01-21 |
PT1448246E (pt) | 2005-11-30 |
ATE303169T1 (de) | 2005-09-15 |
DE60205937D1 (de) | 2005-10-06 |
SI1448246T1 (sl) | 2005-12-31 |
US20060088565A1 (en) | 2006-04-27 |
CY1105664T1 (el) | 2010-12-22 |
BR0214275A (pt) | 2004-09-21 |
US8546334B2 (en) | 2013-10-01 |
AU2002308204A1 (en) | 2003-06-10 |
AU2002308204B2 (en) | 2007-09-27 |
CN100425285C (zh) | 2008-10-15 |
JP2005509494A (ja) | 2005-04-14 |
JP4473576B2 (ja) | 2010-06-02 |
EP1448246B2 (de) | 2015-09-09 |
US20150080303A1 (en) | 2015-03-19 |
SI1448246T2 (sl) | 2015-12-31 |
CA2466947A1 (en) | 2003-05-30 |
AU2002308204B9 (en) | 2008-06-12 |
DK1448246T3 (da) | 2005-12-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1071315A1 (en) | Device having osteoinductive and osteoconductive properties | |
Hing et al. | Effect of silicon level on rate, quality and progression of bone healing within silicate-substituted porous hydroxyapatite scaffolds | |
HUP0401357A2 (hu) | Kalcium-foszfát hordozóanyagok csontképződést serkentő fehérjék bejuttatásához | |
Xiao et al. | Hollow hydroxyapatite microspheres: A novel bioactive and osteoconductive carrier for controlled release of bone morphogenetic protein-2 in bone regeneration | |
Hu et al. | Cerium-doped whitlockite nanohybrid scaffolds promote new bone regeneration via SMAD signaling pathway | |
Bayani et al. | Main properties of nanocrystalline hydroxyapatite as a bone graft material in treatment of periodontal defects. A review of literature | |
Verron et al. | Controlling the biological function of calcium phosphate bone substitutes with drugs | |
Cabrejos-Azama et al. | Magnesium substitution in brushite cements for enhanced bone tissue regeneration | |
US20110112654A1 (en) | Bone implant application | |
Li et al. | Sr-doped nanowire modification of Ca–Si-based coatings for improved osteogenic activities and reduced inflammatory reactions | |
BRPI0516105B8 (pt) | material de implante consistindo em fosfato de cálcio poroso ou colágeno e fosfato de cálcio poroso, material de implante consistindo em aloenxerto ou colágeno e aloenxerto, método de preparação dos mesmos, uso de fosfato de cálcio poroso ou colágeno e fosfato de cálcio poroso na preparação do referido material de implante e uso de aloenxerto ou colágeno e aloenxerto na preparação do referido material de implante | |
ATE536855T1 (de) | Gewebegerüste zusamensetzungen zur behandlung von zahnerkrankungen | |
Galli et al. | Osteoconductive potential of mesoporous titania implant surfaces loaded with magnesium: an experimental study in the rabbit | |
LeGeros et al. | Introduction to synthetic and biologic apatites | |
Vater et al. | Modifications of a calcium phosphate cement with biomolecules—Influence on nanostructure, material, and biological properties | |
Lee et al. | Bone formation and remodeling of three different dental implant surfaces with Escherichia coli-derived recombinant human bone morphogenetic protein 2 in a rabbit model | |
Kumar et al. | Quantitative assessment of degradation, cytocompatibility, and in vivo bone regeneration of silicon-incorporated magnesium phosphate bioceramics | |
Cuylear et al. | Calcium phosphate delivery systems for regeneration and biomineralization of mineralized tissues of the craniofacial complex | |
He et al. | Osteogenesis-inducing calcium phosphate nanoparticle precursors applied to titanium surfaces | |
Parisi et al. | Aptamers recognizing fibronectin confer improved bioactivity to biomaterials and promote new bone formation in a periodontal defect in rats | |
Salma et al. | Early morphofunctional response of contact tissue after intraosal implantation in rabbit jaw of pure synthetic hydroxyapatite (HAp) bioceramic materials and HAp saturated with lidocaine | |
Wang et al. | Ascorbate–apatite composite and ascorbate–FGF-2–apatite composite layers formed on external fixation rods and their effects on cell activity in vitro | |
Qiu et al. | Copper‐deposited diatom‐biosilica enhanced osteogenic potential in periodontal ligament stem cells and rat cranium | |
NL2021794B1 (en) | Bioactive bone repair particles | |
Chung et al. | Investigation of collagen/tricalcium silicate/carboxymethyl cellulose composite bone glue for drug controlled release |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent |