HUP0401357A2 - Kalcium-foszfát hordozóanyagok csontképződést serkentő fehérjék bejuttatásához - Google Patents
Kalcium-foszfát hordozóanyagok csontképződést serkentő fehérjék bejuttatásáhozInfo
- Publication number
- HUP0401357A2 HUP0401357A2 HU0401357A HUP0401357A HUP0401357A2 HU P0401357 A2 HUP0401357 A2 HU P0401357A2 HU 0401357 A HU0401357 A HU 0401357A HU P0401357 A HUP0401357 A HU P0401357A HU P0401357 A2 HUP0401357 A2 HU P0401357A2
- Authority
- HU
- Hungary
- Prior art keywords
- calcium phosphate
- bone
- delivery vehicles
- osteoinductive proteins
- preparation
- Prior art date
Links
- 229910000389 calcium phosphate Inorganic materials 0.000 title abstract 2
- 239000001506 calcium phosphate Substances 0.000 title abstract 2
- 235000011010 calcium phosphates Nutrition 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 title abstract 2
- 230000002138 osteoinductive effect Effects 0.000 title 1
- 210000000988 bone and bone Anatomy 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 229940088623 biologically active substance Drugs 0.000 abstract 1
- 230000007547 defect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001009 osteoporotic effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/005—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/14—Post-treatment to improve physical properties
- A61L17/145—Coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/108—Specific proteins or polypeptides not covered by groups A61L24/102 - A61L24/106
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Materials Engineering (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Inorganic Chemistry (AREA)
- Transplantation (AREA)
- Rheumatology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Prostheses (AREA)
- Medicinal Preparation (AREA)
- Dental Prosthetics (AREA)
Abstract
A találmány tárgya csontdefektussal rendelkező emlős kezelséreszolgáló készítmény. A készítmény tartalmaz csontképző fehérjét mintelsődleges biológiailag aktív anyagot, kalcium-foszfátot minthordozót, és hatékony mennyiségű effervescens anyagot. Feltárnaktovábbá eljárásokat a készítmény elkészítésére és a csontképzőkészítmény csontritkulásos és/vagy csontfelpuhulásos csont kezelésérevaló alkalmazására. Ó
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29681801P | 2001-06-08 | 2001-06-08 | |
US60/296,818 | 2001-06-08 | ||
PCT/US2002/017798 WO2002100331A2 (en) | 2001-06-08 | 2002-06-06 | Calcium phosphate delivery vehicles for osteoinductive proteins |
Publications (3)
Publication Number | Publication Date |
---|---|
HUP0401357A2 true HUP0401357A2 (hu) | 2004-10-28 |
HUP0401357A3 HUP0401357A3 (en) | 2009-11-30 |
HU230046B1 HU230046B1 (hu) | 2015-06-29 |
Family
ID=23143697
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0401357A HU230046B1 (hu) | 2001-06-08 | 2002-06-06 | Kalcium-foszfát hordozóanyagok csontképződést serkentő fehérjék bejuttatásához |
Country Status (19)
Country | Link |
---|---|
US (3) | US7413753B2 (hu) |
EP (2) | EP2260860B1 (hu) |
JP (5) | JP4414218B2 (hu) |
KR (3) | KR101105908B1 (hu) |
CN (2) | CN100379424C (hu) |
AR (1) | AR034347A1 (hu) |
AU (1) | AU2002314928B2 (hu) |
BR (1) | BRPI0210282B8 (hu) |
CA (2) | CA2852202A1 (hu) |
HK (2) | HK1062530A1 (hu) |
HU (1) | HU230046B1 (hu) |
IL (3) | IL159136A0 (hu) |
MX (1) | MXPA03011236A (hu) |
NO (1) | NO333548B1 (hu) |
NZ (1) | NZ530435A (hu) |
PL (1) | PL216040B1 (hu) |
TW (1) | TWI267378B (hu) |
WO (1) | WO2002100331A2 (hu) |
ZA (1) | ZA200400066B (hu) |
Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7687462B2 (en) | 1999-10-05 | 2010-03-30 | The Regents Of The University Of California | Composition for promoting cartilage formation or repair comprising a nell gene product and method of treating cartilage-related conditions using such composition |
DE10032220A1 (de) | 2000-07-03 | 2002-01-24 | Sanatis Gmbh | Magnesium-ammonium-phosphat-Zemente, deren Herstellung und Verwendung |
TWI267378B (en) * | 2001-06-08 | 2006-12-01 | Wyeth Corp | Calcium phosphate delivery vehicles for osteoinductive proteins |
EP1578348A4 (en) * | 2002-02-08 | 2011-03-16 | Wyeth Llc | FORMULATION WITH BIOACTIVE AGENTS AND METHOD OF USE THEREOF |
TW200400062A (en) * | 2002-04-03 | 2004-01-01 | Mathys Medizinaltechnik Ag | Kneadable, pliable bone replacement material |
US7273523B2 (en) | 2002-06-07 | 2007-09-25 | Kyphon Inc. | Strontium-apatite-cement-preparations, cements formed therefrom, and uses thereof |
US20070026069A1 (en) * | 2003-03-28 | 2007-02-01 | Shastri Venkatram P | Biommetic hierarchies using functionalized nanoparticles as building blocks |
US20040199256A1 (en) * | 2003-04-04 | 2004-10-07 | Chao-Jan Wang | Support device for supporting between spinal vertebrae |
EP1615596B1 (en) * | 2003-04-11 | 2016-11-02 | Etex Corporation | Osteoinductive bone material |
EP1675608B1 (en) * | 2003-09-12 | 2007-03-21 | Wyeth | Injectable calcium phosphate solid rods for delivery of osteogenic proteins |
WO2005089127A2 (en) * | 2004-03-05 | 2005-09-29 | The Trustees Of Columbia University In The City Of New York | Polymer-ceramic-hydrogel composite scaffold for osteochondral repair |
US7767221B2 (en) | 2004-03-05 | 2010-08-03 | The Trustees Of Columbia University In The City Of New York | Multi-phased, biodegradable and osteointegrative composite scaffold for biological fixation of musculoskeletal soft tissue to bone |
WO2005117919A2 (en) | 2004-04-15 | 2005-12-15 | Etex Corporation | Delayed-setting calcium phosphate pastes |
EP1742680B1 (en) | 2004-04-27 | 2012-10-24 | Kyphon SÀRL | Bone substitute compositions and method of use |
US20060074422A1 (en) * | 2004-09-27 | 2006-04-06 | Story Brooks J | Suture anchor and void filler combination |
US20060089723A1 (en) * | 2004-10-25 | 2006-04-27 | Murphy Kieran P | Method for bone augmentation |
US8852240B2 (en) * | 2004-10-25 | 2014-10-07 | Kieran Murphy, Llc | Methods and compositions for fostering and preserving bone growth |
US7651701B2 (en) * | 2005-08-29 | 2010-01-26 | Sanatis Gmbh | Bone cement composition and method of making the same |
US20070248675A1 (en) * | 2005-09-08 | 2007-10-25 | Gwangju Institute Of Science And Technology | Composite comprising polysaccharide-functionalized nanoparticle and hydrogel matrix, a drug delivery system and a bone defect replacement matrix for sustained release comprising the same, and the preparation method thereof |
US8920827B2 (en) * | 2005-10-21 | 2014-12-30 | Wake Forest University Health Sciences | Keratin bioceramic compositions |
US8147860B2 (en) * | 2005-12-06 | 2012-04-03 | Etex Corporation | Porous calcium phosphate bone material |
US10300167B2 (en) | 2006-03-24 | 2019-05-28 | Cabertech, Inc. | Functionalized calcium phosphate artificial bone and joint compositions and methods of use and manufacture |
JP5538881B2 (ja) * | 2006-04-25 | 2014-07-02 | テレフレックス・メディカル・インコーポレイテッド | リン酸カルシウムポリマー複合材料および方法 |
US7754005B2 (en) | 2006-05-02 | 2010-07-13 | Kyphon Sarl | Bone cement compositions comprising an indicator agent and related methods thereof |
US7507286B2 (en) * | 2006-06-08 | 2009-03-24 | Sanatis Gmbh | Self-foaming cement for void filling and/or delivery systems |
US8101198B2 (en) * | 2006-07-26 | 2012-01-24 | The Regents Of The University Of California | Osteogenic enhancer composition |
JP2010511751A (ja) * | 2006-11-30 | 2010-04-15 | スミス アンド ネフュー インコーポレーテッド | 繊維強化複合材料 |
US20100047309A1 (en) * | 2006-12-06 | 2010-02-25 | Lu Helen H | Graft collar and scaffold apparatuses for musculoskeletal tissue engineering and related methods |
WO2009131553A2 (en) | 2006-12-29 | 2009-10-29 | Osteogenex Inc. | Methods of altering bone growth by administration of sost or wise antagonist or agonist |
US8753391B2 (en) * | 2007-02-12 | 2014-06-17 | The Trustees Of Columbia University In The City Of New York | Fully synthetic implantable multi-phased scaffold |
US20080241256A1 (en) * | 2007-03-30 | 2008-10-02 | Liisa Kuhn | Targeted active agent delivery system based on calcium phosphate nanoparticles |
AU2007352435B2 (en) * | 2007-04-27 | 2012-01-19 | Unigene Laboratories, Inc. | Methods and compositions for fostering and preserving bone growth |
US20090081276A1 (en) * | 2007-08-13 | 2009-03-26 | Eben Alsberg | Bioresorbable implant composition |
US20090061002A1 (en) * | 2007-09-05 | 2009-03-05 | Venbrocks Rudolf A | Calcium phospate based delivery of growth and differentiation factors to compromised bone |
US7968616B2 (en) * | 2008-04-22 | 2011-06-28 | Kyphon Sarl | Bone cement composition and method |
TWI381857B (zh) * | 2008-12-10 | 2013-01-11 | Univ Taipei Medical | 口腔保健用之非晶性磷酸鈣之製備方法及其組成物 |
CN102448983A (zh) | 2009-05-26 | 2012-05-09 | 加州大学董事会 | 纤调蛋白肽 |
US9636109B2 (en) * | 2009-07-22 | 2017-05-02 | Wisconsin Alumni Research Foundation | Biologically active sutures for regenerative medicine |
US9937128B2 (en) | 2009-08-03 | 2018-04-10 | The University Of North Carolina At Chapel Hill | Liposomes comprising a calcium phosphate-containing precipitate |
US20110046241A1 (en) * | 2009-08-24 | 2011-02-24 | Keizer Timothy S | Calcium based carrier particles |
US20110046240A1 (en) * | 2009-08-24 | 2011-02-24 | Keizer Timothy S | Calcium-based carrier particles |
US20110046238A1 (en) * | 2009-08-24 | 2011-02-24 | Keiser Bruce A | Calcium based carrier particles |
US20110046239A1 (en) * | 2009-08-24 | 2011-02-24 | Keiser Bruce A | Calcium based carrier particles |
WO2011058443A1 (en) * | 2009-11-13 | 2011-05-19 | Barralet Jake E | Method and device to induce collagen biomineralisation |
US9180137B2 (en) | 2010-02-09 | 2015-11-10 | Bone Support Ab | Preparation of bone cement compositions |
US8388887B2 (en) | 2010-04-12 | 2013-03-05 | Biomet Manufacturing Corp. | Methods for making textured ceramic implants |
TWI579007B (zh) | 2010-07-02 | 2017-04-21 | 艾格諾福斯保健公司 | 骨再生材料之用途 |
EP2606121B1 (en) | 2010-08-19 | 2016-05-11 | The Regents of The University of California | Compositions comrpising perivascular stem cells and nell-1 protein |
US8551525B2 (en) | 2010-12-23 | 2013-10-08 | Biostructures, Llc | Bone graft materials and methods |
WO2012093939A1 (en) | 2011-01-05 | 2012-07-12 | Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg | Particles comprising calcium phosphate and use thereof |
US8998925B2 (en) | 2011-06-20 | 2015-04-07 | Rdc Holdings, Llc | Fixation system for orthopedic devices |
WO2012177759A1 (en) | 2011-06-20 | 2012-12-27 | Rdc Holdings, Llc | System and method for repairing joints |
CN106748951B (zh) | 2012-07-19 | 2020-07-24 | 开曼化学股份有限公司 | 作为在治疗ep4介导的疾病和病状中使用的ep4受体选择性激动剂的二氟内酰胺化合物 |
PL2958603T3 (pl) | 2013-02-20 | 2018-10-31 | Bone Support Ab | Ulepszone zestalanie utwardzalnego materiału zastępczego kości |
CN105120863B (zh) | 2013-03-14 | 2021-06-04 | 奥斯特克有限公司 | 促进骨生长的烷基胺骆驼蓬碱衍生物 |
US20160296664A1 (en) | 2013-04-12 | 2016-10-13 | The Trustees Of Columbia University In The City Of New York | Methods for host cell homing and dental pulp regeneration |
KR20160048054A (ko) * | 2013-07-19 | 2016-05-03 | 카이맨 케미칼 컴파니 인코포레이티드 | 골 성장의 촉진을 위한 방법, 시스템 및 조성물 |
JP6145366B2 (ja) * | 2013-09-10 | 2017-06-07 | HOYA Technosurgical株式会社 | リン酸カルシウム硬化性組成物 |
AU2015319796A1 (en) * | 2014-08-28 | 2017-03-02 | Bioventus, Llc | Improved osteoinductive substrates and methods of making the same |
KR101597203B1 (ko) * | 2014-09-26 | 2016-02-24 | 한국화학연구원 | 생분해성 폴리머 및 수산화아파타이트를 포함하는 복합 소재 및 이의 제조방법 |
CA2977625A1 (en) | 2014-12-29 | 2016-07-07 | Bioventus, Llc | Systems and methods for improved delivery of osteoinductive molecules in bone repair |
US10238507B2 (en) | 2015-01-12 | 2019-03-26 | Surgentec, Llc | Bone graft delivery system and method for using same |
US20160374904A1 (en) * | 2015-06-23 | 2016-12-29 | South Dakota Board Of Regents | Sequential Material Deposition for Remineralization and Desensitization of Teeth |
ES2672265B1 (es) | 2016-11-07 | 2019-04-10 | Inst Biomecanico De Barcelona S L | Dispositivo para fusion intervertebral que comprende un tornillo de estabilizacion intervertebral y una composicion para remodelacion osea |
CN106822991B (zh) * | 2017-03-13 | 2019-09-27 | 深圳市英汉斯科技有限公司 | 小分子肽生物骨修复材料及其制备方法 |
BR112019020373A2 (pt) * | 2017-04-03 | 2020-04-28 | Wisconsin Alumni Res Found | micropartículas revestidas com minerais para liberação sustentada de moléculas biologicamente ativas |
US10687828B2 (en) | 2018-04-13 | 2020-06-23 | Surgentec, Llc | Bone graft delivery system and method for using same |
US11116647B2 (en) | 2018-04-13 | 2021-09-14 | Surgentec, Llc | Bone graft delivery system and method for using same |
CN108815580B (zh) * | 2018-07-23 | 2019-11-12 | 吴容思 | 一种可调控降解的磷酸钙骨水泥及其制备方法 |
SG11202101151SA (en) | 2018-08-14 | 2021-03-30 | Osteoqc Inc | Pyrrolo - dipyridine compounds |
AU2019320773A1 (en) | 2018-08-14 | 2021-03-04 | Osteoqc Inc. | Fluoro β-carboline compounds |
WO2020118011A1 (en) | 2018-12-06 | 2020-06-11 | Alexion Pharmaceuticals, Inc. | Anti-alk2 antibodies and uses thereof |
CN110064071B (zh) * | 2019-04-12 | 2021-09-10 | 西安理工大学 | 一种可膨胀无机骨水泥的制备方法 |
CN114569732B (zh) * | 2022-01-24 | 2023-09-01 | 国家纳米科学中心 | 一种纳米药物及其制备方法和应用 |
Family Cites Families (187)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2465357A (en) * | 1944-08-14 | 1949-03-29 | Upjohn Co | Therapeutic sponge and method of making |
CH563767A5 (hu) * | 1973-01-30 | 1975-07-15 | Pheulpin Jean | |
US4468464A (en) | 1974-11-04 | 1984-08-28 | The Board Of Trustees Of The Leland Stanford Junior University | Biologically functional molecular chimeras |
DE2657370C2 (de) * | 1976-12-17 | 1982-11-11 | Hans Dr.med. Dr.med.dent. 8000 München Scheicher | Mittel zum Bedecken und/oder Ausfüllen von Knochendefekten |
US4159358A (en) * | 1977-05-19 | 1979-06-26 | Board Of Regents, State Of Florida | Method of bonding a bioglass to metal |
DE2732848A1 (de) * | 1977-07-18 | 1979-02-08 | Schering Ag | Diurethane, herbizide mittel enthaltend diese verbindungen sowie verfahren zu ihrer herstellung |
US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US4294753A (en) | 1980-08-04 | 1981-10-13 | The Regents Of The University Of California | Bone morphogenetic protein process |
US4761471A (en) | 1980-08-04 | 1988-08-02 | The Regents Of The University Of California | Bone morphogenetic protein composition |
US4619989A (en) | 1981-05-05 | 1986-10-28 | The Regents Of The University Of Cal. | Bone morphogenetic protein composition |
US4455256A (en) * | 1981-05-05 | 1984-06-19 | The Regents Of The University Of California | Bone morphogenetic protein |
US4419446A (en) | 1980-12-31 | 1983-12-06 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant DNA process utilizing a papilloma virus DNA as a vector |
IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
US4727028A (en) * | 1981-06-22 | 1988-02-23 | Eli Lilly And Company | Recombinant DNA cloning vectors and the eukaryotic and prokaryotic transformants thereof |
US4394370A (en) * | 1981-09-21 | 1983-07-19 | Jefferies Steven R | Bone graft material for osseous defects and method of making same |
US4472840A (en) | 1981-09-21 | 1984-09-25 | Jefferies Steven R | Method of inducing osseous formation by implanting bone graft material |
US4474181A (en) | 1982-02-18 | 1984-10-02 | Schenck Robert R | Method and apparatus for anastomosing small blood vessels |
USRE33161E (en) | 1982-04-29 | 1990-02-06 | American Dental Association Health Foundation | Combinations of sparingly soluble calcium phosphates in slurries and pastes as mineralizers and cements |
USRE33221E (en) | 1982-04-29 | 1990-05-22 | American Dental Association Health Foundation | Dental restorative cement pastes |
IL68218A (en) * | 1983-03-23 | 1985-12-31 | Univ Ramot | Compositions for cartilage repair comprising embryonal chondrocytes |
US4434094A (en) * | 1983-04-12 | 1984-02-28 | Collagen Corporation | Partially purified osteogenic factor and process for preparing same from demineralized bone |
US4795804A (en) * | 1983-08-16 | 1989-01-03 | The Regents Of The University Of California | Bone morphogenetic agents |
US4923805A (en) * | 1983-11-02 | 1990-05-08 | Integrated Genetics, Inc. | Fsh |
US4703008A (en) | 1983-12-13 | 1987-10-27 | Kiren-Amgen, Inc. | DNA sequences encoding erythropoietin |
GB8334498D0 (en) * | 1983-12-24 | 1984-02-01 | Beecham Group Plc | Compounds |
US4804744A (en) * | 1984-01-04 | 1989-02-14 | International Genetic Engineering, Inc. | Osteogenic factors |
US4563489A (en) * | 1984-02-10 | 1986-01-07 | University Of California | Biodegradable organic polymer delivery system for bone morphogenetic protein |
US4608199A (en) | 1984-03-20 | 1986-08-26 | Arnold Caplan | Bone protein purification process |
US4662884A (en) * | 1984-04-25 | 1987-05-05 | University Of Utah Research Foundation | Prostheses and methods for promoting nerve regeneration |
US4596574A (en) * | 1984-05-14 | 1986-06-24 | The Regents Of The University Of California | Biodegradable porous ceramic delivery system for bone morphogenetic protein |
CA1341617C (en) * | 1984-06-08 | 2011-06-28 | Henry George Burger | Inhibin isolated from ovarian follicular fluid |
US4868161A (en) | 1984-06-29 | 1989-09-19 | City Of Hope | Method for promoting nerve regeneration |
US4843063A (en) * | 1984-07-16 | 1989-06-27 | Collagen Corporation | Polypeptide cartilage-inducing factors found in bone |
EP0169016B2 (en) * | 1984-07-16 | 2004-04-28 | Celtrix Pharmaceuticals, Inc. | Polypeptide cartilage-inducing factors found in bone |
US4627982A (en) | 1984-07-16 | 1986-12-09 | Collagen Corporation | Partially purified bone-inducing factor |
US5187263A (en) * | 1984-10-12 | 1993-02-16 | Zymogenetics, Inc. | Expression of biologically active PDGE analogs in eucaryotic cells |
US4769328A (en) | 1984-10-12 | 1988-09-06 | Zymogenetics Inc. | Expression of biologically active PDGF analogs in yeast |
US4563350A (en) * | 1984-10-24 | 1986-01-07 | Collagen Corporation | Inductive collagen based bone repair preparations |
AU598455B2 (en) * | 1984-12-27 | 1990-06-28 | Suntory Limited | Method for purifying an interferon |
US4886747A (en) | 1985-03-22 | 1989-12-12 | Genentech, Inc. | Nucleic acid encoding TGF-β and its uses |
US4766067A (en) | 1985-05-31 | 1988-08-23 | President And Fellows Of Harvard College | Gene amplification |
US4681763A (en) * | 1985-06-11 | 1987-07-21 | University Of Medicine And Dentistry Of New Jersey | Composition for stimulating bone growth |
US4851521A (en) * | 1985-07-08 | 1989-07-25 | Fidia, S.P.A. | Esters of hyaluronic acid |
US4798885A (en) * | 1986-02-07 | 1989-01-17 | Genentech, Inc. | Compositions of hormonally active human and porcine inhibin containing an α chain and 62 chain |
US5215893A (en) * | 1985-10-03 | 1993-06-01 | Genentech, Inc. | Nucleic acid encoding the ba chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid |
US5089396A (en) * | 1985-10-03 | 1992-02-18 | Genentech, Inc. | Nucleic acid encoding β chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid |
US4737578A (en) * | 1986-02-10 | 1988-04-12 | The Salk Institute For Biological Studies | Human inhibin |
US4758233A (en) * | 1986-04-22 | 1988-07-19 | N.J. Phillips TPY. Limited | Cream applicator |
NL8601328A (nl) * | 1986-05-23 | 1987-12-16 | Langen Research | Inrichting voor het met een massa, in het bijzonder pasteuze massa, injekteren van vlees. |
US4839215A (en) * | 1986-06-09 | 1989-06-13 | Ceramed Corporation | Biocompatible particles and cloth-like article made therefrom |
US5108922A (en) * | 1986-07-01 | 1992-04-28 | Genetics Institute, Inc. | DNA sequences encoding BMP-1 products |
US5106748A (en) * | 1986-07-01 | 1992-04-21 | Genetics Institute, Inc. | Dna sequences encoding 5 proteins |
US4877864A (en) | 1987-03-26 | 1989-10-31 | Genetics Institute, Inc. | Osteoinductive factors |
US6432919B1 (en) * | 1986-07-01 | 2002-08-13 | Genetics Institute, Inc. | Bone morphogenetic protein-3 and compositions |
US5543394A (en) * | 1986-07-01 | 1996-08-06 | Genetics Institute, Inc. | Bone morphogenetic protein 5(BMP-5) compositions |
US5459047A (en) * | 1986-07-01 | 1995-10-17 | Genetics Institute, Inc. | BMP-6 proteins |
US5013649A (en) * | 1986-07-01 | 1991-05-07 | Genetics Institute, Inc. | DNA sequences encoding osteoinductive products |
US5187076A (en) | 1986-07-01 | 1993-02-16 | Genetics Institute, Inc. | DNA sequences encoding BMP-6 proteins |
US6150328A (en) * | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
ZA874681B (en) | 1986-07-01 | 1988-04-27 | Genetics Inst | Novel osteoinductive factors |
US5366875A (en) | 1986-07-01 | 1994-11-22 | Genetics Institute, Inc. | Methods for producing BMP-7 proteins |
US5019087A (en) * | 1986-10-06 | 1991-05-28 | American Biomaterials Corporation | Nerve regeneration conduit |
US5124316A (en) * | 1986-11-14 | 1992-06-23 | President And Fellows Of Harvard College | Method for periodontal regeneration |
US5041538A (en) | 1987-08-28 | 1991-08-20 | The Salk Institute For Biological Studies | Mammalian follistatin |
US5202120A (en) * | 1987-09-11 | 1993-04-13 | Case Western Reserve University | Methods of reducing glial scar formation and promoting axon and blood vessel growth and/or regeneration through the use of activated immature astrocytes |
US5147399A (en) | 1988-02-01 | 1992-09-15 | Dellon Arnold L | Method of treating nerve defects through use of a bioabsorbable surgical device |
IT1215881B (it) | 1988-02-16 | 1990-02-22 | Giancarlo Foresti | Sussidio chirurgico ad azione osteotropa. |
US5011691A (en) * | 1988-08-15 | 1991-04-30 | Stryker Corporation | Osteogenic devices |
US5258494A (en) * | 1988-04-08 | 1993-11-02 | Stryker Corporation | Osteogenic proteins |
US5354557A (en) | 1988-04-08 | 1994-10-11 | Stryker Corporation | Osteogenic devices |
US5108753A (en) * | 1988-04-08 | 1992-04-28 | Creative Biomolecules | Osteogenic devices |
US5266683A (en) | 1988-04-08 | 1993-11-30 | Stryker Corporation | Osteogenic proteins |
US4968590A (en) | 1988-04-08 | 1990-11-06 | Stryker Corporation | Osteogenic proteins and polypeptides |
US5129905A (en) | 1988-04-20 | 1992-07-14 | Norian Corporation | Methods for in situ prepared calcium phosphate minerals |
US5053212A (en) | 1988-04-20 | 1991-10-01 | Norian Corporation | Intimate mixture of calcium and phosphate sources as precursor to hydroxyapatite |
US5962028A (en) | 1988-04-20 | 1999-10-05 | Norian Corporation | Carbonated hydroxyapatite compositions and uses |
US6005162A (en) | 1988-04-20 | 1999-12-21 | Norian Corporation | Methods of repairing bone |
US6002065A (en) * | 1988-04-20 | 1999-12-14 | Norian Corporation | Kits for preparing calcium phosphate minerals |
US5024841A (en) * | 1988-06-30 | 1991-06-18 | Collagen Corporation | Collagen wound healing matrices and process for their production |
US5071834A (en) | 1988-09-16 | 1991-12-10 | Genentech, Inc. | Purified activin B composition |
US5106626A (en) * | 1988-10-11 | 1992-04-21 | International Genetic Engineering, Inc. | Osteogenic factors |
US5284756A (en) * | 1988-10-11 | 1994-02-08 | Lynn Grinna | Heterodimeric osteogenic factor |
US4955892A (en) | 1988-10-24 | 1990-09-11 | Louisiana State University | Neural cell adhesion protein nerve prosthesis |
US5457038A (en) * | 1988-11-10 | 1995-10-10 | Genetics Institute, Inc. | Natural killer stimulatory factor |
US5011486A (en) * | 1988-11-18 | 1991-04-30 | Brown University Research Foundation | Composite nerve guidance channels |
US5162430A (en) * | 1988-11-21 | 1992-11-10 | Collagen Corporation | Collagen-polymer conjugates |
US4920962A (en) * | 1988-11-23 | 1990-05-01 | Claude Proulx | Splint-like element for use in end-to-end nerve suture |
US5217867A (en) * | 1988-11-30 | 1993-06-08 | The Salk Institute For Biological Studies | Receptors: their identification, characterization, preparation and use |
US5026381A (en) * | 1989-04-20 | 1991-06-25 | Colla-Tec, Incorporated | Multi-layered, semi-permeable conduit for nerve regeneration comprised of type 1 collagen, its method of manufacture and a method of nerve regeneration using said conduit |
US4963146A (en) | 1989-04-20 | 1990-10-16 | Colla-Tec Incorporated | Multi-layered, semi-permeable conduit for nerve regeneration |
US5166322A (en) | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
US5399346A (en) * | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
WO1991000103A1 (en) * | 1989-06-29 | 1991-01-10 | The United States Of America, Represented By The Secretary, United States Department Of Commerce | Method for protecting bone marrow against chemotherapeutic drugs and radiation therapy using transforming growth factor beta 1 |
US5324519A (en) * | 1989-07-24 | 1994-06-28 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
US5422340A (en) * | 1989-09-01 | 1995-06-06 | Ammann; Arthur J. | TGF-βformulation for inducing bone growth |
US5236456A (en) * | 1989-11-09 | 1993-08-17 | Osteotech, Inc. | Osteogenic composition and implant containing same |
US5166190A (en) | 1990-01-08 | 1992-11-24 | Genentech, Inc. | Method for increasing fertility in males |
US5187086A (en) * | 1990-01-26 | 1993-02-16 | Scripps Clinic And Research Foundation | Molecules with antibody combining sites that catalyze hydrolysis reactions through use of a charged hapten |
US5492697A (en) * | 1990-03-05 | 1996-02-20 | Board Of Regents, Univ. Of Texas System | Biodegradable implant for fracture nonunions |
US5256418A (en) | 1990-04-06 | 1993-10-26 | Organogenesis, Inc. | Collagen constructs |
CA2040475C (en) * | 1990-04-18 | 1995-08-22 | Motohiko Hayashi | Facsimile apparatus comprising cordless telephone set |
US5290271A (en) * | 1990-05-14 | 1994-03-01 | Jernberg Gary R | Surgical implant and method for controlled release of chemotherapeutic agents |
DE69132823T2 (de) | 1990-05-16 | 2002-07-18 | Genetics Institute, Inc. | Knochen- und knorpel-bildung hervorrufende proteine |
WO1991017777A2 (en) | 1990-05-22 | 1991-11-28 | University Of Florida | Injectable bioactive glass compositions and methods for tissue reconstruction |
US5168050A (en) | 1990-05-24 | 1992-12-01 | Genentech, Inc. | Mammalian expression of the bone morphogenetic protein-2b using bmp2a/bmp2b fusion |
US5218090A (en) * | 1990-06-12 | 1993-06-08 | Warner-Lambert Company | EGF receptor truncates |
US5364839A (en) | 1990-06-18 | 1994-11-15 | Genetics Institute, Inc. | Osteoinductive pharmaceutical formulations |
ATE253589T1 (de) * | 1990-09-26 | 2003-11-15 | Inst Genetics Llc | Bmp-5-derivate |
US5206028A (en) * | 1991-02-11 | 1993-04-27 | Li Shu Tung | Dense collagen membrane matrices for medical uses |
US5208219A (en) * | 1991-02-14 | 1993-05-04 | Celtrix Pharmaceuticals Inc. | Method for inducing bone growth |
US5318898A (en) * | 1991-04-02 | 1994-06-07 | Genetics Institute, Inc. | Production of recombinant bone-inducing proteins |
US5118667A (en) * | 1991-05-03 | 1992-06-02 | Celtrix Pharmaceuticals, Inc. | Bone growth factors and inhibitors of bone resorption for promoting bone formation |
US5229495A (en) * | 1991-06-18 | 1993-07-20 | Ludwig Institute For Cancer Research | Substantially pure receptor like TGF-β 1 binding molecules and uses thereof |
US5216126A (en) * | 1991-06-19 | 1993-06-01 | Genentech, Inc. | Receptor polypeptides and their production and uses |
AU663328B2 (en) | 1991-06-21 | 1995-10-05 | Genetics Institute, Llc | Pharmaceutical formulations of osteogenic proteins |
KR100255415B1 (ko) | 1991-06-25 | 2000-05-01 | 브루스 엠. 에이센 | 비엠피-9 조성물 |
US6287816B1 (en) * | 1991-06-25 | 2001-09-11 | Genetics Institute, Inc. | BMP-9 compositions |
US5356629A (en) | 1991-07-12 | 1994-10-18 | United States Surgical Corporation | Composition for effecting bone repair |
US5306307A (en) * | 1991-07-22 | 1994-04-26 | Calcitek, Inc. | Spinal disk implant |
US5270300A (en) | 1991-09-06 | 1993-12-14 | Robert Francis Shaw | Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone |
US5171579A (en) | 1991-10-11 | 1992-12-15 | Genetics Institute, Inc. | Formulations of blood clot-polymer matrix for delivery of osteogenic proteins |
ATE238417T1 (de) * | 1991-11-04 | 2003-05-15 | Inst Genetics Llc | Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung |
SE469653B (sv) * | 1992-01-13 | 1993-08-16 | Lucocer Ab | Poroest implantat |
WO1993016099A2 (en) | 1992-02-12 | 1993-08-19 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Dna sequences encoding novel growth/differentiation factors |
JPH07504106A (ja) | 1992-02-28 | 1995-05-11 | コラーゲン コーポレイション | 注射可能なセラミック組成物及びそれらの製造及び使用のための方法 |
AU3920693A (en) * | 1992-03-18 | 1993-10-21 | General Hospital Corporation, The | Four novel receptors of the TGF-beta receptor family |
US5550176A (en) * | 1992-04-17 | 1996-08-27 | Ucar Carbon Technology Corporation | Room temperature setting carbonaceous cement with increased electrical conductivity and flexural strength |
IT1259090B (it) | 1992-04-17 | 1996-03-11 | Fidia Spa | Biomaterialli per protesi d'osso |
IT1259100B (it) * | 1992-05-20 | 1996-03-11 | Lanfranco Callegaro | Uso di idrogeli per il bloccaggio di sistemi protesici |
IL106278A0 (en) | 1992-07-13 | 1993-11-15 | Sumitomo Metal Ind | Bone formation-inducing protein |
AU5125693A (en) | 1992-09-03 | 1994-03-29 | Regents Of The University Of California, The | Dorsal tissue affecting factor and compositions |
EP1475440A3 (en) | 1993-01-12 | 2004-11-17 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-3 |
CA2153654A1 (en) | 1993-01-12 | 1994-07-21 | Se-Jin Lee | Growth differentiation factor-5 |
CA2153653C (en) | 1993-01-12 | 2010-12-07 | Se-Jin Lee | Growth differentiation factor-9 |
US5420243A (en) * | 1993-01-26 | 1995-05-30 | Celtrix Pharmaceuticals, Inc. | Biologically active TGF-β2 peptides |
CA2157577C (en) | 1993-03-19 | 2009-11-17 | Se-Jin Lee | Growth differentiation factor-8 |
GB9308060D0 (en) * | 1993-04-19 | 1993-06-02 | Cancer Res Campaign Tech | Stem cell inhibitor |
KR100231640B1 (ko) | 1993-05-12 | 1999-12-01 | 토마스 제이 데스로저 | Bmp-10 조성물 |
US5637480A (en) * | 1993-05-12 | 1997-06-10 | Genetics Institute, Inc. | DNA molecules encoding bone morphogenetic protein-10 |
EP2272959A1 (en) | 1993-05-12 | 2011-01-12 | Genetics Institute, LLC | BMP-11 compositions |
US5447725A (en) * | 1993-06-11 | 1995-09-05 | The Procter & Gamble Company | Methods for aiding periodontal tissue regeneration |
JPH09503904A (ja) | 1993-07-09 | 1997-04-22 | ザ ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン | 増殖分化因子−7 |
CA2165776A1 (en) | 1993-07-09 | 1995-01-19 | Se-Jin Lee | Growth differentiation factor-6 |
ATE326234T1 (de) * | 1993-08-26 | 2006-06-15 | Genetics Inst Llc | Menschliche knochen-morphogenetische proteine zur verwendung bei neuronaler regeneration |
US6291206B1 (en) | 1993-09-17 | 2001-09-18 | Genetics Institute, Inc. | BMP receptor proteins |
EP0725796A4 (en) | 1993-10-08 | 1999-12-01 | Univ Johns Hopkins | GROWTH DIFFERENTIATION FACTOR-10 |
US5789543A (en) * | 1993-12-30 | 1998-08-04 | President And Fellows Of Harvard College | Vertebrate embryonic pattern-inducing proteins and uses related thereto |
AU8095694A (en) * | 1993-10-28 | 1995-05-22 | Thm Biomedical, Inc. | Improved process and device for treating and healing a bone void |
WO1995016035A2 (en) | 1993-12-07 | 1995-06-15 | Genetics Institute, Inc. | Bmp-12, bmp-13 and tendon-inducing compositions thereof |
US5399677A (en) * | 1993-12-07 | 1995-03-21 | Genetics Institute, Inc. | Mutants of bone morphogenetic proteins |
US6027919A (en) * | 1993-12-07 | 2000-02-22 | Genetics Institute, Inc. | BMP-12 and BMP-13 proteins and DNA encoding them |
CA2179029C (en) | 1993-12-30 | 2009-02-24 | Philip W. Ingham | Vertebrate embryonic pattern-inducing hedgehog-like proteins |
JPH07250688A (ja) | 1994-01-28 | 1995-10-03 | Sagami Chem Res Center | TGF−βスーパーファミリー蛋白質をコードするヒト新規cDNA |
JP3424049B2 (ja) | 1994-03-09 | 2003-07-07 | 山之内製薬株式会社 | 骨形成用移植体 |
WO1996001845A1 (en) | 1994-07-08 | 1996-01-25 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-11 |
DE69518760T2 (de) | 1994-07-13 | 2001-05-23 | The Johns Hopkins University School Of Medicine, Baltimore | Wachstumsdifferenzierungsfaktor-12 |
US5520923A (en) * | 1994-09-19 | 1996-05-28 | Genetics Institute, Inc. | Formulations for delivery of osteogenic proteins |
US6281332B1 (en) | 1994-12-02 | 2001-08-28 | The Johns Hopkins University School Of Medicine | Hedgehog-derived polypeptides |
US5635372A (en) * | 1995-05-18 | 1997-06-03 | Genetics Institute, Inc. | BMP-15 compositions |
US5676976A (en) | 1995-05-19 | 1997-10-14 | Etex Corporation | Synthesis of reactive amorphous calcium phosphates |
US6027742A (en) | 1995-05-19 | 2000-02-22 | Etex Corporation | Bioresorbable ceramic composites |
US6117456A (en) | 1995-05-19 | 2000-09-12 | Etex Corporation | Methods and products related to the physical conversion of reactive amorphous calcium phosphate |
US6132463A (en) * | 1995-05-19 | 2000-10-17 | Etex Corporation | Cell seeding of ceramic compositions |
HU222664B1 (hu) * | 1995-06-05 | 2003-09-29 | Genetics Institute, Llc | Csont morfogenetikus protein (BMP) alkalmazása csont és ín vagy szalag funkcionális összeköttetésének regenerálására |
CN1192700A (zh) | 1995-06-06 | 1998-09-09 | 基因科学再生实验室有限公司 | 改性成骨材料 |
US5674292A (en) * | 1995-06-07 | 1997-10-07 | Stryker Corporation | Terminally sterilized osteogenic devices and preparation thereof |
US5752974A (en) * | 1995-12-18 | 1998-05-19 | Collagen Corporation | Injectable or implantable biomaterials for filling or blocking lumens and voids of the body |
EP2311471A3 (en) * | 1996-04-19 | 2013-05-15 | Osiris Therapeutics, Inc. | Regeneration and augmentation of bone using mesenchymal stem cells |
US5939323A (en) * | 1996-05-28 | 1999-08-17 | Brown University | Hyaluronan based biodegradable scaffolds for tissue repair |
IT1288290B1 (it) | 1996-06-21 | 1998-09-11 | Fidia Spa In Amministrazione S | Acido ialuronico autoreticolato e relative composizioni farmaceutiche per il trattamento delle artropatie |
US5965403A (en) | 1996-09-18 | 1999-10-12 | Genetics Institute, Inc. | Nucleic acids encoding bone morphogenic protein-16 (BMP-16) |
AU734691B2 (en) | 1996-10-16 | 2001-06-21 | Life Science Enterprises, Inc. | Bioceramic compositions |
AU6245898A (en) | 1997-01-21 | 1998-08-07 | Genetics Institute Inc. | Injectable formulations for treatment of osteoporotic bone |
US20020098222A1 (en) | 1997-03-13 | 2002-07-25 | John F. Wironen | Bone paste |
US6034062A (en) * | 1997-03-13 | 2000-03-07 | Genetics Institute, Inc. | Bone morphogenetic protein (BMP)-9 compositions and their uses |
US5972368A (en) * | 1997-06-11 | 1999-10-26 | Sdgi Holdings, Inc. | Bone graft composites and spacers |
IT1296689B1 (it) | 1997-11-06 | 1999-07-14 | Fidia Advanced Biopolymers Srl | Derivati esterei dell'acido ialuronico aventi proprieta viscoelastiche e loro uso in campo biomedico-sanitario |
WO1999030632A1 (en) * | 1997-12-18 | 1999-06-24 | Comfort Biomedical, Inc. | Bone augmentation for prosthetic implants and the like |
US20020076429A1 (en) | 1998-01-28 | 2002-06-20 | John F. Wironen | Bone paste subjected to irradiative and thermal treatment |
IT1302534B1 (it) | 1998-12-21 | 2000-09-05 | Fidia Advanced Biopolymers Srl | Composizioni iniettabili, biocompatibili e biodegradabili comprendentialmeno un derivato dell'acido ialuronico, cellule condrogeniche, per |
AU770196B2 (en) * | 1999-02-04 | 2004-02-12 | Warsaw Orthopedic, Inc. | Osteogenic paste compositions and uses thereof |
JP4703926B2 (ja) * | 1999-10-15 | 2011-06-15 | ジェネティクス インスティテュート,エルエルシー | 骨形成蛋白をデリバリーするためのヒアルロン酸の処方 |
WO2001028603A1 (en) | 1999-10-15 | 2001-04-26 | Genetics Institute, Inc. | Formulations for delivery of osteogenic proteins |
US6822421B2 (en) * | 2000-09-29 | 2004-11-23 | Honda Giken Kogyo Kabushiki Kaisha | Bipedal robot with position for energy storage device |
CA2436162A1 (en) | 2001-01-25 | 2002-08-01 | John F. Wironen | Injectable porous bone graft materials |
TWI267378B (en) * | 2001-06-08 | 2006-12-01 | Wyeth Corp | Calcium phosphate delivery vehicles for osteoinductive proteins |
JP4879482B2 (ja) | 2002-05-17 | 2012-02-22 | ワイス・エルエルシー | 骨原性タンパク質を送達するための注入可能な固体ヒアルロン酸キャリア |
-
2002
- 2002-05-23 TW TW091110889A patent/TWI267378B/zh not_active IP Right Cessation
- 2002-05-29 AR ARP020102004A patent/AR034347A1/es not_active Application Discontinuation
- 2002-05-31 US US10/160,607 patent/US7413753B2/en not_active Expired - Lifetime
- 2002-06-06 CN CNB028156390A patent/CN100379424C/zh not_active Expired - Lifetime
- 2002-06-06 KR KR1020107014777A patent/KR101105908B1/ko active IP Right Grant
- 2002-06-06 NZ NZ530435A patent/NZ530435A/en not_active IP Right Cessation
- 2002-06-06 MX MXPA03011236A patent/MXPA03011236A/es active IP Right Grant
- 2002-06-06 AU AU2002314928A patent/AU2002314928B2/en not_active Expired
- 2002-06-06 EP EP10183027.1A patent/EP2260860B1/en not_active Expired - Lifetime
- 2002-06-06 CA CA2852202A patent/CA2852202A1/en not_active Abandoned
- 2002-06-06 CN CN2008100096136A patent/CN101239182B/zh not_active Expired - Lifetime
- 2002-06-06 CA CA2449713A patent/CA2449713C/en not_active Expired - Lifetime
- 2002-06-06 WO PCT/US2002/017798 patent/WO2002100331A2/en active Application Filing
- 2002-06-06 IL IL15913602A patent/IL159136A0/xx unknown
- 2002-06-06 KR KR10-2003-7016020A patent/KR20040019300A/ko active Application Filing
- 2002-06-06 EP EP02741855.7A patent/EP1404346B1/en not_active Expired - Lifetime
- 2002-06-06 JP JP2003503158A patent/JP4414218B2/ja not_active Expired - Lifetime
- 2002-06-06 PL PL367224A patent/PL216040B1/pl unknown
- 2002-06-06 KR KR1020087018671A patent/KR100980164B1/ko active IP Right Grant
- 2002-06-06 BR BRPI0210282A patent/BRPI0210282B8/pt not_active IP Right Cessation
- 2002-06-06 HU HU0401357A patent/HU230046B1/hu unknown
-
2003
- 2003-11-30 IL IL159136A patent/IL159136A/en active IP Right Grant
- 2003-12-03 NO NO20035383A patent/NO333548B1/no not_active IP Right Cessation
-
2004
- 2004-01-06 ZA ZA200400066A patent/ZA200400066B/en unknown
- 2004-07-23 HK HK04105479.5A patent/HK1062530A1/zh not_active IP Right Cessation
-
2007
- 2007-12-17 US US11/957,691 patent/US7622139B2/en not_active Expired - Lifetime
-
2009
- 2009-02-13 HK HK09101399.6A patent/HK1123502A1/xx not_active IP Right Cessation
- 2009-05-11 JP JP2009115064A patent/JP5091188B2/ja not_active Expired - Lifetime
- 2009-09-23 US US12/565,159 patent/US8003133B2/en not_active Expired - Fee Related
-
2010
- 2010-07-02 JP JP2010152516A patent/JP2010207653A/ja not_active Withdrawn
-
2013
- 2013-08-16 JP JP2013169050A patent/JP2013226469A/ja not_active Withdrawn
-
2014
- 2014-02-16 IL IL230994A patent/IL230994A0/en unknown
-
2016
- 2016-02-04 JP JP2016019546A patent/JP2016084361A/ja not_active Withdrawn
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUP0401357A2 (hu) | Kalcium-foszfát hordozóanyagok csontképződést serkentő fehérjék bejuttatásához | |
HK1071315A1 (en) | Device having osteoinductive and osteoconductive properties | |
ATE539701T1 (de) | Zusammengesetzte schlinge zur behandlung von inkontinenz | |
AU2002361860A1 (en) | Calcium phosphate bone replacement materials and methods of use thereof | |
DE60137430D1 (de) | Gewebeimplant zur wiederherstellung von knorpelgewebe | |
WO2003055443A3 (en) | Bone morphogenic proteins (bmp), bmp receptors and bmp binding proteins and their use in the diagnosis and treatment of glaucoma | |
DE69911609D1 (de) | Verfahren zur beschleunigen den zuwachs und heilen von knochen und knorpel | |
NO2014010I1 (no) | Radium 223 salt slik som Radium 223 diklorid | |
YU37304A (sh) | Specifični agensi koji vezuju humani angiopoetin-2 | |
DE60214477D1 (de) | Implantat zur Regeneration von Knorpelgewebe | |
DE50008238D1 (de) | Aktiver marknagel zur distraktion von knochenteilen | |
DE69118535D1 (de) | Osteo-induktive pharmazeutische formulierungen | |
WO2005117919A3 (en) | Delayed-setting calcium phosphate pastes | |
DE602004031134D1 (de) | Pharmazeutische zusammensetzungen und verfahren zur verwendung von levodopa und carbidopa | |
ATE448775T1 (de) | Rifalazil zur behandlung von infektionen mit clostridium difficile | |
DE60027209D1 (de) | Arzneimittel enthaltend hydroxyapatite zur behandlung von knochengewebserkrankungen | |
ATE275425T1 (de) | Zusammensetzung zur wiederherstellung von knochengewebe | |
WO2007002469A3 (en) | Therapeutic compositions and methods using transforming growth factor-beta mimics | |
Lind et al. | Transforming growth factor-β1 adsorbed to tricalciumphosphate coated implants increases peri-implant bone remodeling | |
DE60025830D1 (de) | Fusions-polypeptide zur gewebegeneration und wundheilung zur gezielten matrixanwendung | |
ATE255920T1 (de) | Methoden und zusammensetzungen zur heilung und reparatur von gelenkknorpeln | |
WO2005020846A3 (en) | Artificial bone and joint compositions and methods of use and manufacture | |
NO20001799L (no) | FremgangsmÕte for rensing av kirurgiske instrumenter | |
AU2003251729A1 (en) | Use of antibodies against flt-1 for the treatment of osteoporosis | |
DE60223707D1 (de) | Calcium-l-threonat zur behandlung von knochenfrakturen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
GB9A | Succession in title |
Owner name: ETEX CORPORATION, US Free format text: FORMER OWNER(S): WYETH, US; WYETH, US; WYETH LLC,, US Owner name: WYETH LLC,, US Free format text: FORMER OWNER(S): WYETH, US; WYETH, US; WYETH LLC,, US |
|
HC9A | Change of name, address |
Owner name: WYETH LLC,, US Free format text: FORMER OWNER(S): WYETH, US; WYETH, US; WYETH LLC,, US Owner name: ETEX CORPORATION, US Free format text: FORMER OWNER(S): WYETH, US; WYETH, US; WYETH LLC,, US |