DE602004022643D1 - Cephalosporin in kristalliner form - Google Patents

Cephalosporin in kristalliner form

Info

Publication number: DE602004022643D1
Authority: DE; Germany
Prior art keywords: crystalline form; cephalosporin; formula; mrsa; potent
Prior art date: 2003-03-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE602004022643T

Other languages

English (en)

Inventor

Joerg Berghausen

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Basilea Pharmaceutica AG

Original Assignee

Basilea Pharmaceutica AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-03-27

Filing date

2004-03-15

Publication date

2009-10-01

2004-03-15 Application filed by Basilea Pharmaceutica AG filed Critical Basilea Pharmaceutica AG

2009-10-01 Publication of DE602004022643D1 publication Critical patent/DE602004022643D1/de

2024-03-16 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

229930186147 Cephalosporin Natural products 0.000 title abstract 2
229940124587 cephalosporin Drugs 0.000 title abstract 2
150000001780 cephalosporins Chemical class 0.000 title abstract 2
RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 abstract 1
241000589517 Pseudomonas aeruginosa Species 0.000 abstract 1
241000295644 Staphylococcaceae Species 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
230000000844 anti-bacterial effect Effects 0.000 abstract 1
229940088710 antibiotic agent Drugs 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229960003085 meticillin Drugs 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/48—Methylene radicals, substituted by hetero rings
- C07D501/56—Methylene radicals, substituted by hetero rings with the 7-amino radical acylated by carboxylic acids containing hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DE602004022643T 2003-03-27 2004-03-15 Cephalosporin in kristalliner form Expired - Lifetime DE602004022643D1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP03006815		2003-03-27
PCT/EP2004/002667 WO2004085444A1 (en)	2003-03-27	2004-03-15	Cephalosporin in crystalline form

Publications (1)

Publication Number	Publication Date
DE602004022643D1 true DE602004022643D1 (de)	2009-10-01

Family

ID=33040912

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE602004022643T Expired - Lifetime DE602004022643D1 (de)	2003-03-27	2004-03-15	Cephalosporin in kristalliner form

Country Status (21)

Country	Link
US (2)	US7531650B2 (de)
EP (1)	EP1606293B1 (de)
JP (1)	JP5230934B2 (de)
KR (1)	KR101121942B1 (de)
CN (1)	CN1751051B (de)
AT (1)	ATE440101T1 (de)
AU (1)	AU2004224181B2 (de)
BR (1)	BRPI0408716B1 (de)
CA (1)	CA2519272C (de)
CY (1)	CY1109615T1 (de)
DE (1)	DE602004022643D1 (de)
DK (1)	DK1606293T3 (de)
ES (1)	ES2329244T3 (de)
HK (1)	HK1085479A1 (de)
MX (1)	MXPA05010083A (de)
PL (1)	PL1606293T3 (de)
PT (1)	PT1606293E (de)
SI (1)	SI1606293T1 (de)
TW (1)	TWI346117B (de)
WO (1)	WO2004085444A1 (de)
ZA (1)	ZA200507760B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2006059753A1 (en) *	2004-11-30	2006-06-08	Astellas Pharma Inc.	Novel oral pharmaceutical suspension of cefdinir crystal

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE758350A (fr) *	1969-12-30	1971-05-03	Pfizer	Procede de fabrication des sels mono- et bi-metalliques alcalins de l'alpha-carboxybenzylpenicilline
US3697506A (en) *	1970-08-07	1972-10-10	Pfizer	Crystalline alkali metal salts of {60 -carboxybenzylpenicillin and process therefor
JPS5579393A (en) *	1978-12-11	1980-06-14	Takeda Chem Ind Ltd	Cephalosporin derivative and its preparation
GR78221B (de)	1980-02-01	1984-09-26	Ciba Geigy Ag
US4432987A (en) *	1982-04-23	1984-02-21	Pfizer Inc.	Crystalline benzenesulfonate salts of sultamicillin
FR2532315A1 (fr)	1982-08-27	1984-03-02	Rhone Poulenc Sante	Formes cristallisees de sels d'addition avec des acides, de l'((amino-2-thiazolyl-4)-2 methoxyimino-2 acetamido)-7 carboxy-2 (dioxo-5,6 formylmethyl-4 tetrahydro-1,4,5,6 triazine-1,2,4 yl-3) thio-2 vinyl)-3 oxo-8 thia-5 aza-1 bicyclo(4.2.0) octene-2 isomere syn, forme e et leur preparation
US4634556A (en) *	1985-05-10	1987-01-06	Schering Corporation	Crystalline sodium (5R, 6S, 8R)-6-(1-hydroxyethyl)-2-(2-carbamoyloxyethylthio)-penem-3-carboxylate and process for making same
AU615966B2 (en) *	1987-12-04	1991-10-17	Takeda Chemical Industries Ltd.	Crystals of cephem hydrochloride
JPH02101081A (ja) *	1988-10-08	1990-04-12	Meiji Seika Kaisha Ltd	セファロスポリン誘導体結晶性二塩酸塩及びその製造法
CA2011116C (en) *	1989-03-06	1999-11-16	Murray A. Kaplan	Lyophilized bmy-28142 dihydrochloride for parenteral use
US5492903A (en) *	1990-06-19	1996-02-20	Takeda Chemical Industries Ltd.	Crystalline esters of (+)-(5R, 6S)-6-[(R)-1-hydroxyethyl]-3-(3-pyridyl)-7-oxo-4-thia-1-azabicyclo[3.2.0]he
JP2575590B2 (ja) *	1992-07-31	1997-01-29	塩野義製薬株式会社	トリアゾリルチオメチルチオセファロスポリン塩酸塩およびその水和物結晶ならびにそれらの製法
EP0581552B1 (de)	1992-07-31	1998-04-22	Shionogi & Co., Ltd.	Triazolylthiomethylthiocephalosporin-Hydrochlorid, sein kristallines Hydrat und seine Herstellung
KR100296810B1 (ko) *	1993-03-12	2001-10-24	로렌스 티. 마이젠헬더	결정성세프티오퍼유리산
HU224196B1 (hu) *	1996-09-20	2005-06-28	Meiji Seika Kaisha Ltd.	Cefditoren-pivoxil kristályos formája, és eljárás annak előállítására
TW415949B (en)	1996-12-19	2000-12-21	Hoffmann La Roche	Vinyl pyrrolidine cephalosporin derivatives with basic substituents
AU754732B2 (en) *	1998-06-15	2002-11-21	Basilea Pharmaceutica International Ag, Allschwil	Derivatives of 3-(2-oxo-(1,3')bipyrrolidinyl-3-ylidenemethyl)-cephems
US6232306B1 (en)	1998-06-15	2001-05-15	Hoffmann-La Roche Inc.	Derivatives of 3-(2-oxo-[1,3′]bipyrrolidinyl-3-ylidenemethyl)-cephams
US6504025B2 (en) *	2000-05-24	2003-01-07	Basilea Pharmaceutica Ag	Process for the preparation of vinyl-pyrrolidinone cephalosporin derivatives
USRE40794E1 (en) *	2001-09-26	2009-06-23	Merck & Co., Inc.	Crystalline forms of carbapenem antibiotics and methods of preparation

2004
- 2004-03-15 SI SI200431215T patent/SI1606293T1/sl unknown
- 2004-03-15 CN CN2004800042140A patent/CN1751051B/zh not_active Expired - Lifetime
- 2004-03-15 PL PL04720595T patent/PL1606293T3/pl unknown
- 2004-03-15 BR BRPI0408716-0A patent/BRPI0408716B1/pt active IP Right Grant
- 2004-03-15 US US10/547,648 patent/US7531650B2/en active Active
- 2004-03-15 AT AT04720595T patent/ATE440101T1/de active
- 2004-03-15 JP JP2006504690A patent/JP5230934B2/ja not_active Expired - Lifetime
- 2004-03-15 PT PT04720595T patent/PT1606293E/pt unknown
- 2004-03-15 EP EP04720595A patent/EP1606293B1/de not_active Expired - Lifetime
- 2004-03-15 DK DK04720595T patent/DK1606293T3/da active
- 2004-03-15 CA CA2519272A patent/CA2519272C/en not_active Expired - Fee Related
- 2004-03-15 MX MXPA05010083A patent/MXPA05010083A/es active IP Right Grant
- 2004-03-15 ES ES04720595T patent/ES2329244T3/es not_active Expired - Lifetime
- 2004-03-15 AU AU2004224181A patent/AU2004224181B2/en not_active Ceased
- 2004-03-15 WO PCT/EP2004/002667 patent/WO2004085444A1/en active Application Filing
- 2004-03-15 DE DE602004022643T patent/DE602004022643D1/de not_active Expired - Lifetime
- 2004-03-26 TW TW093108308A patent/TWI346117B/zh not_active IP Right Cessation
2005
- 2005-09-26 ZA ZA200507760A patent/ZA200507760B/en unknown
- 2005-09-26 KR KR1020057018075A patent/KR101121942B1/ko active IP Right Grant
2006
- 2006-05-15 HK HK06105568.5A patent/HK1085479A1/xx not_active IP Right Cessation
2009
- 2009-04-01 US US12/416,461 patent/US8093377B2/en active Active
- 2009-11-12 CY CY20091101186T patent/CY1109615T1/el unknown

Also Published As

Publication number	Publication date
MXPA05010083A (es)	2005-11-23
TW200502237A (en)	2005-01-16
CA2519272C (en)	2010-06-08
EP1606293A1 (de)	2005-12-21
ES2329244T3 (es)	2009-11-24
BRPI0408716B8 (de)	2021-05-25
TWI346117B (en)	2011-08-01
US7531650B2 (en)	2009-05-12
CY1109615T1 (el)	2014-08-13
BRPI0408716A (pt)	2006-03-07
CN1751051A (zh)	2006-03-22
CA2519272A1 (en)	2004-10-07
AU2004224181B2 (en)	2011-06-02
JP5230934B2 (ja)	2013-07-10
KR101121942B1 (ko)	2012-03-09
PL1606293T3 (pl)	2010-01-29
WO2004085444A1 (en)	2004-10-07
HK1085479A1 (en)	2006-08-25
ZA200507760B (en)	2007-06-27
DK1606293T3 (da)	2009-10-05
EP1606293B1 (de)	2009-08-19
PT1606293E (pt)	2009-10-14
AU2004224181A1 (en)	2004-10-07
US20060167242A1 (en)	2006-07-27
SI1606293T1 (sl)	2009-10-31
JP2006521309A (ja)	2006-09-21
ATE440101T1 (de)	2009-09-15
CN1751051B (zh)	2010-06-09
BRPI0408716B1 (pt)	2017-08-29
US8093377B2 (en)	2012-01-10
US20090192306A1 (en)	2009-07-30
KR20050111787A (ko)	2005-11-28

Legal Events

Date	Code	Title	Description
2010-09-09	8364	No opposition during term of opposition

Publication	Publication Date	Title
HK1090647A1 (en)	2006-12-29	Oxazolidinone-quinolone hybrid antibiotics
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DE60221684D1 (de)	2007-09-20	Antibiotika mit doppelwirkung
WO2004035569A3 (de)	2004-09-02	Neue verbindungen mit antibakterieller aktivität
WO2007004028A3 (en)	2007-03-29	Processes for the preparation of penems and its intermediate
MX2019003060A (es)	2019-07-08	Compuestos inhibidores de beta-lactamasa.
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ATE480538T1 (de)	2010-09-15	2-arylmethylazetidincarbapenemderivate und deren herstellung
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EP4272831A3 (de)	2024-02-21	Diazabicyclooctanones als inhibitoren von serin-beta-lactamasen
ATE339424T1 (de)	2006-10-15	3-substituierte 7-alkylidene-3-cephem-4- carbonsäuren als beta-lactamase inhibitoren
CY1109615T1 (el)	2014-08-13	Κεφαλοσπορινη σε κρυσταλλικη μορφη
PT1289998E (pt)	2005-06-30	Novo processo para a preparacao de derivados de vinil-pirrolidinona cefalosporina
ATE449775T1 (de)	2009-12-15	Carbacephem beta-lactam-antibiotika
TW200745053A (en)	2007-12-16	9-Aminocarbonylsubstituted derivatives of glycylcyclines
EP0911030A3 (de)	1999-10-13	Antimikrobielle Zusammensetzungen welche Vinylpyrrolidinon-Cephalosporin-Derivate und ein Carbapenemantibiotikum oder ein beta-lactamaseinhibitor enthaten
EA202190444A1 (ru)	2021-06-18	Диазабициклооктаноны в качестве ингибиторов сериновых бета-лактамаз
DE60326710D1 (de)	2009-04-30	Trizyklische antibakterielle makrolidderivate
EA202190617A2 (ru)	2021-06-30	Соединения-ингибиторы бета-лактамаз
WO2003068791A3 (en)	2004-01-22	Macrolides with activity against methicillin-resistant staphylococcus aureus