BRPI0408716A - cefalosporina em forma cristalina - Google Patents

cefalosporina em forma cristalina

Info

Publication number
BRPI0408716A
BRPI0408716A BRPI0408716-0A BRPI0408716A BRPI0408716A BR PI0408716 A BRPI0408716 A BR PI0408716A BR PI0408716 A BRPI0408716 A BR PI0408716A BR PI0408716 A BRPI0408716 A BR PI0408716A
Authority
BR
Brazil
Prior art keywords
cephalosporin
formula
crystalline form
crystalline cephalosporin
crystalline
Prior art date
Application number
BRPI0408716-0A
Other languages
English (en)
Inventor
Joerg Berghausen
Original Assignee
Basilea Pharmaceutica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basilea Pharmaceutica Ag filed Critical Basilea Pharmaceutica Ag
Publication of BRPI0408716A publication Critical patent/BRPI0408716A/pt
Publication of BRPI0408716B1 publication Critical patent/BRPI0408716B1/pt
Publication of BRPI0408716B8 publication Critical patent/BRPI0408716B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/48—Methylene radicals, substituted by hetero rings
    • C07D501/56—Methylene radicals, substituted by hetero rings with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"CEFALOSPORINA EM FORMA CRISTALINA". A presente invenção refere-se à cefalosporina da fórmula (I) em forma cristalina. O composto da fórmula (I) na forma cristalina é útil como antibiótico tendo atividade antibacteriana potente e ampla; especialmente contra Staphylococci resistente à meticilina (MRSA) e Pseudomonas aeruginosa.
BRPI0408716-0A 2003-03-27 2004-03-15 Cefalosporin in crystalline form, process for its preparation and its uses, and preparation of cephalosporin BRPI0408716B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03006815 2003-03-27
EP03006815.9 2003-03-27
PCT/EP2004/002667 WO2004085444A1 (en) 2003-03-27 2004-03-15 Cephalosporin in crystalline form

Publications (3)

Publication Number Publication Date
BRPI0408716A true BRPI0408716A (pt) 2006-03-07
BRPI0408716B1 BRPI0408716B1 (pt) 2017-08-29
BRPI0408716B8 BRPI0408716B8 (pt) 2021-05-25

Family

ID=33040912

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0408716-0A BRPI0408716B1 (pt) 2003-03-27 2004-03-15 Cefalosporin in crystalline form, process for its preparation and its uses, and preparation of cephalosporin

Country Status (21)

Country Link
US (2) US7531650B2 (pt)
EP (1) EP1606293B1 (pt)
JP (1) JP5230934B2 (pt)
KR (1) KR101121942B1 (pt)
CN (1) CN1751051B (pt)
AT (1) ATE440101T1 (pt)
AU (1) AU2004224181B2 (pt)
BR (1) BRPI0408716B1 (pt)
CA (1) CA2519272C (pt)
CY (1) CY1109615T1 (pt)
DE (1) DE602004022643D1 (pt)
DK (1) DK1606293T3 (pt)
ES (1) ES2329244T3 (pt)
HK (1) HK1085479A1 (pt)
MX (1) MXPA05010083A (pt)
PL (1) PL1606293T3 (pt)
PT (1) PT1606293E (pt)
SI (1) SI1606293T1 (pt)
TW (1) TWI346117B (pt)
WO (1) WO2004085444A1 (pt)
ZA (1) ZA200507760B (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006059753A1 (en) * 2004-11-30 2006-06-08 Astellas Pharma Inc. Novel oral pharmaceutical suspension of cefdinir crystal

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE758350A (fr) * 1969-12-30 1971-05-03 Pfizer Procede de fabrication des sels mono- et bi-metalliques alcalins de l'alpha-carboxybenzylpenicilline
US3697506A (en) * 1970-08-07 1972-10-10 Pfizer Crystalline alkali metal salts of {60 -carboxybenzylpenicillin and process therefor
JPS5579393A (en) * 1978-12-11 1980-06-14 Takeda Chem Ind Ltd Cephalosporin derivative and its preparation
GR78221B (pt) 1980-02-01 1984-09-26 Ciba Geigy Ag
US4432987A (en) * 1982-04-23 1984-02-21 Pfizer Inc. Crystalline benzenesulfonate salts of sultamicillin
FR2532315A1 (fr) 1982-08-27 1984-03-02 Rhone Poulenc Sante Formes cristallisees de sels d'addition avec des acides, de l'((amino-2-thiazolyl-4)-2 methoxyimino-2 acetamido)-7 carboxy-2 (dioxo-5,6 formylmethyl-4 tetrahydro-1,4,5,6 triazine-1,2,4 yl-3) thio-2 vinyl)-3 oxo-8 thia-5 aza-1 bicyclo(4.2.0) octene-2 isomere syn, forme e et leur preparation
US4634556A (en) * 1985-05-10 1987-01-06 Schering Corporation Crystalline sodium (5R, 6S, 8R)-6-(1-hydroxyethyl)-2-(2-carbamoyloxyethylthio)-penem-3-carboxylate and process for making same
AU615966B2 (en) * 1987-12-04 1991-10-17 Takeda Chemical Industries Ltd. Crystals of cephem hydrochloride
JPH02101081A (ja) * 1988-10-08 1990-04-12 Meiji Seika Kaisha Ltd セファロスポリン誘導体結晶性二塩酸塩及びその製造法
CA2011116C (en) * 1989-03-06 1999-11-16 Murray A. Kaplan Lyophilized bmy-28142 dihydrochloride for parenteral use
US5492903A (en) * 1990-06-19 1996-02-20 Takeda Chemical Industries Ltd. Crystalline esters of (+)-(5R, 6S)-6-[(R)-1-hydroxyethyl]-3-(3-pyridyl)-7-oxo-4-thia-1-azabicyclo[3.2.0]he
JP2575590B2 (ja) * 1992-07-31 1997-01-29 塩野義製薬株式会社 トリアゾリルチオメチルチオセファロスポリン塩酸塩およびその水和物結晶ならびにそれらの製法
EP0581552B1 (en) 1992-07-31 1998-04-22 Shionogi & Co., Ltd. Triazolylthiomethylthio cephalosporin hyrochloride, its crystalline hydrate and the production of the same
KR100296810B1 (ko) * 1993-03-12 2001-10-24 로렌스 티. 마이젠헬더 결정성세프티오퍼유리산
HU224196B1 (hu) * 1996-09-20 2005-06-28 Meiji Seika Kaisha Ltd. Cefditoren-pivoxil kristályos formája, és eljárás annak előállítására
TW415949B (en) 1996-12-19 2000-12-21 Hoffmann La Roche Vinyl pyrrolidine cephalosporin derivatives with basic substituents
AU754732B2 (en) * 1998-06-15 2002-11-21 Basilea Pharmaceutica International Ag, Allschwil Derivatives of 3-(2-oxo-(1,3')bipyrrolidinyl-3-ylidenemethyl)-cephems
US6232306B1 (en) 1998-06-15 2001-05-15 Hoffmann-La Roche Inc. Derivatives of 3-(2-oxo-[1,3′]bipyrrolidinyl-3-ylidenemethyl)-cephams
US6504025B2 (en) * 2000-05-24 2003-01-07 Basilea Pharmaceutica Ag Process for the preparation of vinyl-pyrrolidinone cephalosporin derivatives
USRE40794E1 (en) * 2001-09-26 2009-06-23 Merck & Co., Inc. Crystalline forms of carbapenem antibiotics and methods of preparation

Also Published As

Publication number Publication date
MXPA05010083A (es) 2005-11-23
TW200502237A (en) 2005-01-16
DE602004022643D1 (de) 2009-10-01
CA2519272C (en) 2010-06-08
EP1606293A1 (en) 2005-12-21
ES2329244T3 (es) 2009-11-24
BRPI0408716B8 (pt) 2021-05-25
TWI346117B (en) 2011-08-01
US7531650B2 (en) 2009-05-12
CY1109615T1 (el) 2014-08-13
CN1751051A (zh) 2006-03-22
CA2519272A1 (en) 2004-10-07
AU2004224181B2 (en) 2011-06-02
JP5230934B2 (ja) 2013-07-10
KR101121942B1 (ko) 2012-03-09
PL1606293T3 (pl) 2010-01-29
WO2004085444A1 (en) 2004-10-07
HK1085479A1 (en) 2006-08-25
ZA200507760B (en) 2007-06-27
DK1606293T3 (da) 2009-10-05
EP1606293B1 (en) 2009-08-19
PT1606293E (pt) 2009-10-14
AU2004224181A1 (en) 2004-10-07
US20060167242A1 (en) 2006-07-27
SI1606293T1 (sl) 2009-10-31
JP2006521309A (ja) 2006-09-21
ATE440101T1 (de) 2009-09-15
CN1751051B (zh) 2010-06-09
BRPI0408716B1 (pt) 2017-08-29
US8093377B2 (en) 2012-01-10
US20090192306A1 (en) 2009-07-30
KR20050111787A (ko) 2005-11-28

Similar Documents

Publication Publication Date Title
HUP0400446A2 (hu) Azitromicin kristályformái
HK1090647A1 (en) Oxazolidinone-quinolone hybrid antibiotics
CY1116243T1 (el) Αναστολεiς βητα-λακταμασων
DE60221684D1 (de) Antibiotika mit doppelwirkung
PH12019500558A1 (en) Beta-lactamase inhibitor compounds
WO2004035569A3 (de) Neue verbindungen mit antibakterieller aktivität
WO2007064954A3 (en) Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents
WO2007004028A3 (en) Processes for the preparation of penems and its intermediate
ATE353894T1 (de) Acyloxymethylcarbamat-prodrugs von oxazolidinonen
ATE480538T1 (de) 2-arylmethylazetidincarbapenemderivate und deren herstellung
NZ545472A (en) 7-(4-substituted-3-cyclopropylaminomethyl-1-pyrrolidinyl)quinolonecarboxylic acid derivative
EP4272831A3 (en) Diazabicyclooctanones as inhibitors of serine beta-lactamases
CY1109615T1 (el) Κεφαλοσπορινη σε κρυσταλλικη μορφη
ATE449775T1 (de) Carbacephem beta-lactam-antibiotika
PT1289998E (pt) Novo processo para a preparacao de derivados de vinil-pirrolidinona cefalosporina
TW200745053A (en) 9-Aminocarbonylsubstituted derivatives of glycylcyclines
MX2010014248A (es) Nuevos antibioticos de trinem e inhibidores de beta-lactamasas.
EA202190444A1 (ru) Диазабициклооктаноны в качестве ингибиторов сериновых бета-лактамаз
DE60326710D1 (de) Trizyklische antibakterielle makrolidderivate
EA202190617A2 (ru) Соединения-ингибиторы бета-лактамаз
WO2003068791A3 (en) Macrolides with activity against methicillin-resistant staphylococcus aureus

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA INT.CL: C07D 501/56, A61K 31/545, A61K 31/04, A61P 31/00

Ipc: C07D 501/56 (2011.01), A61K 31/545 (2011.01), A61K

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]
B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/03/2004 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF