WO2007004028A3 - Processes for the preparation of penems and its intermediate - Google Patents
Processes for the preparation of penems and its intermediate Download PDFInfo
- Publication number
- WO2007004028A3 WO2007004028A3 PCT/IB2006/001821 IB2006001821W WO2007004028A3 WO 2007004028 A3 WO2007004028 A3 WO 2007004028A3 IB 2006001821 W IB2006001821 W IB 2006001821W WO 2007004028 A3 WO2007004028 A3 WO 2007004028A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- preparation
- gram
- formula
- protecting group
- lactam antibiotics
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The present invention relates to a process for the preparation of 4-acetoxy azetidinone of Formula I, wherein R2 is hydrogen or a suitable amino protecting group and P is suitable hydroxy protecting group, and to the use of these compounds as intermediates for the preparation of ß-lactam antibiotics that possess the carbapenem and penem ring systems. 4-acetoxy azetidinone of Formula I is a key intermediate in the synthesis of ß-lactam antibiotics which are commonly prescribed antimicrobial agents having activity against a wide range of both Gram-positive and Gram-negative bacteria.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1702DE2005 | 2005-06-30 | ||
IN1702/DEL/2005 | 2005-06-30 |
Publications (2)
Publication Number | Publication Date |
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WO2007004028A2 WO2007004028A2 (en) | 2007-01-11 |
WO2007004028A3 true WO2007004028A3 (en) | 2007-03-29 |
Family
ID=37205705
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2006/001821 WO2007004028A2 (en) | 2005-06-30 | 2006-06-30 | Processes for the preparation of penems and its intermediate |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2007004028A2 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8952034B2 (en) | 2009-07-27 | 2015-02-10 | Gilead Sciences, Inc. | Fused heterocyclic compounds as ion channel modulators |
US8962610B2 (en) | 2011-07-01 | 2015-02-24 | Gilead Sciences, Inc. | Fused heterocyclic compounds as ion channel modulators |
US9115096B2 (en) | 2011-05-10 | 2015-08-25 | Gilead Sciences, Inc. | Fused heterocyclic compounds as ion channel modulators |
US9193694B2 (en) | 2011-07-01 | 2015-11-24 | Gilead Sciences, Inc. | Fused heterocyclic compounds as ion channel modulators |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101265271B (en) * | 2008-04-30 | 2013-06-05 | 寿光富康制药有限公司 | Method for synthesizing penem-like pharmaceutical intermediate 4AA |
CN101747250B (en) * | 2008-12-16 | 2012-09-05 | 上海医药工业研究院 | Method for preparing 4 - acyloxo heterocyclic ketone compounds |
WO2011048583A1 (en) | 2009-10-23 | 2011-04-28 | Ranbaxy Laboratories Limited | Process for the preparation of carbapenem compounds |
MX2012015096A (en) | 2010-07-02 | 2013-05-28 | Gilead Sciences Inc | Fused heterocyclic compounds as ion channel modulators. |
CN102432632A (en) * | 2011-09-16 | 2012-05-02 | 上海悦昂化学有限公司 | Method for preparing (3R,4R)-3-[(1R)tert-butyl-dimethyl-silyloxyethyl]-4-acetoxyl-2-azetidinone |
CN102827199A (en) * | 2012-08-28 | 2012-12-19 | 三峡大学 | Synthetic method for penem and carbapenem antibiotic type key intermediate 4AA |
CN102936262A (en) * | 2012-11-07 | 2013-02-20 | 凯莱英医药集团(天津)股份有限公司 | Preparation method for imipenem medicine intermediate 4AA |
WO2014071565A1 (en) * | 2012-11-07 | 2014-05-15 | 凯莱英医药集团(天津)股份有限公司 | Preparation method for intermediate 4aa of imipenem drugs |
CN103242361A (en) * | 2013-05-23 | 2013-08-14 | 浙江海翔川南药业有限公司 | Preparation method of penem antibiotic intermediate |
CN109721521A (en) * | 2018-11-26 | 2019-05-07 | 广东药科大学 | A kind of preparation method of optical activity clausenamide ketone and its derivative |
CN115385950B (en) * | 2022-10-27 | 2023-04-28 | 天津凯莱英医药科技发展有限公司 | System and method for preparing 4-acetoxyazetidinone by continuous ozone oxidation |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0126587A1 (en) * | 1983-05-09 | 1984-11-28 | Sumitomo Pharmaceuticals Company, Limited | Carboxylic thio-pyrrolidinyl beta-lactam compounds and production thereof |
EP0367722A1 (en) * | 1988-11-04 | 1990-05-09 | Ciba-Geigy Ag | Process for preparing optically active acyloxyazetidinones |
EP0371875A2 (en) * | 1988-11-29 | 1990-06-06 | Takasago International Corporation | Process for preparing 4-acetoxyazetidinones |
EP0528678A1 (en) * | 1991-08-20 | 1993-02-24 | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. | A pyrrolidylthiocarbapenem derivative |
WO1998007691A1 (en) * | 1996-08-24 | 1998-02-26 | Choongwae Pharmaceutical Co., Ltd. | Process for stereoselective preparation of trans-azetidinones |
-
2006
- 2006-06-30 WO PCT/IB2006/001821 patent/WO2007004028A2/en active Application Filing
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0126587A1 (en) * | 1983-05-09 | 1984-11-28 | Sumitomo Pharmaceuticals Company, Limited | Carboxylic thio-pyrrolidinyl beta-lactam compounds and production thereof |
US4943569A (en) * | 1983-05-09 | 1990-07-24 | Sumitomo Pharmaceuticals Co., Ltd. | B-lactam compounds |
EP0367722A1 (en) * | 1988-11-04 | 1990-05-09 | Ciba-Geigy Ag | Process for preparing optically active acyloxyazetidinones |
EP0371875A2 (en) * | 1988-11-29 | 1990-06-06 | Takasago International Corporation | Process for preparing 4-acetoxyazetidinones |
US5081239A (en) * | 1988-11-29 | 1992-01-14 | Takasago International Corporation | Ruthenium catalyzed process for preparing 4-acetoxyazetidinones |
EP0528678A1 (en) * | 1991-08-20 | 1993-02-24 | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. | A pyrrolidylthiocarbapenem derivative |
US5317016A (en) * | 1991-08-20 | 1994-05-31 | Shionogi Seiyaku Kabushiki Kaisha | Pyrrolidylthiocarbapenem derivative |
WO1998007691A1 (en) * | 1996-08-24 | 1998-02-26 | Choongwae Pharmaceutical Co., Ltd. | Process for stereoselective preparation of trans-azetidinones |
WO1998007690A1 (en) * | 1996-08-24 | 1998-02-26 | Choongwae Pharmaceutical Co., Ltd. | Process for stereoselective preparation of 4-acetoxyazetidinones |
Non-Patent Citations (6)
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8952034B2 (en) | 2009-07-27 | 2015-02-10 | Gilead Sciences, Inc. | Fused heterocyclic compounds as ion channel modulators |
US9371329B2 (en) | 2009-07-27 | 2016-06-21 | Gilead Sciences, Inc. | Fused heterocyclic compounds as ion channel modulators |
US9115096B2 (en) | 2011-05-10 | 2015-08-25 | Gilead Sciences, Inc. | Fused heterocyclic compounds as ion channel modulators |
US9403782B2 (en) | 2011-05-10 | 2016-08-02 | Gilead Sciences, Inc. | Fused heterocyclic compounds as ion channel modulators |
US8962610B2 (en) | 2011-07-01 | 2015-02-24 | Gilead Sciences, Inc. | Fused heterocyclic compounds as ion channel modulators |
US9193694B2 (en) | 2011-07-01 | 2015-11-24 | Gilead Sciences, Inc. | Fused heterocyclic compounds as ion channel modulators |
Also Published As
Publication number | Publication date |
---|---|
WO2007004028A2 (en) | 2007-01-11 |
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