ATE480538T1 - 2-arylmethylazetidincarbapenemderivate und deren herstellung - Google Patents

2-arylmethylazetidincarbapenemderivate und deren herstellung

Info

Publication number
ATE480538T1
ATE480538T1 AT05721872T AT05721872T ATE480538T1 AT E480538 T1 ATE480538 T1 AT E480538T1 AT 05721872 T AT05721872 T AT 05721872T AT 05721872 T AT05721872 T AT 05721872T AT E480538 T1 ATE480538 T1 AT E480538T1
Authority
AT
Austria
Prior art keywords
arylmethylazetidinecarbapenem
derivatives
production
gram
activities against
Prior art date
Application number
AT05721872T
Other languages
English (en)
Inventor
Bong-Jin Kim
Jae-Hak Kim
Jae-Yang Kong
Heeyeong Cho
Young-Ro Choi
Chang-Seob Kim
Original Assignee
Korea Res Inst Chem Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Korea Res Inst Chem Tech filed Critical Korea Res Inst Chem Tech
Application granted granted Critical
Publication of ATE480538T1 publication Critical patent/ATE480538T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT05721872T 2004-08-31 2005-02-24 2-arylmethylazetidincarbapenemderivate und deren herstellung ATE480538T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020040068821A KR100599876B1 (ko) 2004-08-31 2004-08-31 2-아릴메틸아제티딘 카바페넴 유도체 및 그의 제조방법
PCT/KR2005/000509 WO2006025634A1 (en) 2004-08-31 2005-02-24 2-arylmethylazetidine carbapenem derivatives and preparation thereof

Publications (1)

Publication Number Publication Date
ATE480538T1 true ATE480538T1 (de) 2010-09-15

Family

ID=36000255

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05721872T ATE480538T1 (de) 2004-08-31 2005-02-24 2-arylmethylazetidincarbapenemderivate und deren herstellung

Country Status (8)

Country Link
US (1) US7662810B2 (de)
EP (1) EP1784407B1 (de)
JP (1) JP4801049B2 (de)
KR (1) KR100599876B1 (de)
CN (1) CN100494200C (de)
AT (1) ATE480538T1 (de)
DE (1) DE602005023492D1 (de)
WO (1) WO2006025634A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2004043961A1 (ja) * 2002-11-13 2006-03-09 株式会社カネカ 経口投与用カルバペネム化合物の製造方法
CN103275081A (zh) * 2007-09-12 2013-09-04 黄振华 培南类抗菌素
CN101848911A (zh) * 2007-09-20 2010-09-29 国际药品工业株式会社 碳青霉烯类抗生素的合成中间体的酸加成盐及其制备方法
KR101050976B1 (ko) * 2007-09-20 2011-07-21 국제약품공업주식회사 카바페넴계 항생제의 합성 중간체의 산부가염 및 그의 제조방법
KR101044559B1 (ko) * 2007-09-20 2011-06-28 국제약품공업주식회사 티올 화합물의 산부가염 및 그의 제조방법
KR100950699B1 (ko) * 2008-03-28 2010-03-31 국제약품공업주식회사 2-아릴메틸아제티딘-카바페넴-3-카복실산 에스테르유도체의 산부가염, 이의 제조방법 및 이를 포함하는 약학조성물
KR100930586B1 (ko) * 2007-11-23 2009-12-09 한국화학연구원 2-아릴메틸아제티딘-카바페넴-3-카복실산 에스테르 유도체,이의 제조방법 및 이를 포함하는 약학 조성물
JP2011504495A (ja) * 2007-11-23 2011-02-10 クジェ ファーマシューティカル インダストリアル カンパニー リミテッド ２−アリールメチルアゼチジン−カルバペネム−３−カルボン酸エステル誘導体またはその塩、その製造方法及びそれを含む医薬組成物
MX2011009532A (es) 2009-03-13 2011-10-24 Daewoong Bio Inc Metodo mejorado para preparar meropenem usando polvo de zinc.
IL312087A (en) * 2021-10-20 2024-06-01 Assembly Biosciences Inc process

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4552873A (en) * 1981-08-19 1985-11-12 Sankyo Company Limited Carbapenem compounds, and compositions containing them
JPS5916892A (ja) * 1982-07-19 1984-01-28 Sankyo Co Ltd カルバペネム−３−カルボン酸誘導体およびその製法
US4698339A (en) * 1983-09-28 1987-10-06 Takeda Chemical Industries, Ltd. Carbapenems, their production and use
JPS60233076A (ja) * 1984-05-03 1985-11-19 Sumitomo Chem Co Ltd 新規なβ−ラクタム化合物およびその製造法
DE3617626A1 (de) * 1986-05-26 1987-12-03 Bayer Ag Substituierte 6-hydroxymethyl-carbapenem-antibiotika, verfahren zu ihrer herstellung und ihre verwendung
AU644008B2 (en) 1990-08-10 1993-12-02 Sumitomo Pharmaceuticals Company, Limited Beta-lactam compounds, and their production and use
JP3242677B2 (ja) * 1990-08-10 2001-12-25 住友製薬株式会社 新規なβ−ラクタム化合物及びその製造法
AU682510B2 (en) 1993-07-01 1997-10-09 Pfizer Japan Inc. 2-(1-(1,3-thiazolin-2-yl)azetidin-3-yl)thio-carbapenem derivatives
AU680736B2 (en) * 1994-02-25 1997-08-07 Banyu Pharmaceutical Co., Ltd. Carbapenem derivative
US5496816A (en) * 1994-03-14 1996-03-05 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
JP3209675B2 (ja) * 1994-12-12 2001-09-17 日本ワイスレダリー株式会社 チオール化合物
JPH09202789A (ja) * 1995-11-20 1997-08-05 Suntory Ltd ペネム誘導体およびこれを含有する抗菌剤
TW420681B (en) * 1995-12-08 2001-02-01 Lederle Japan Ltd Carbapenem-3-carboxylic acid ester derivatives
JPH1059970A (ja) * 1996-08-16 1998-03-03 Suntory Ltd カルバペネム誘導体およびこれを含有する抗菌剤
PT1021404E (pt) * 1997-10-07 2003-04-30 Boehringer Ingelheim Ca Ltd Derivados de azetidinona para o tratamento de infeccoes pelo hcmv
KR20010079713A (ko) * 1998-09-10 2001-08-22 마쓰자와 도로, 하야시 지로 카르바페넴 화합물
JP4260941B2 (ja) * 1998-11-09 2009-04-30 株式会社片山製薬所 アゼチジン−３−オール
JP2002212182A (ja) * 2000-11-16 2002-07-31 Sankyo Co Ltd １−メチルカルバペネム誘導体
BR0115454A (pt) * 2000-11-16 2003-09-23 Sankyo Co Composto de 1-metilcarbapenem ou um sal ou derivado de éster deste farmaceuticamente aceitável, composição farmacêutica, e, uso de um composto ou de um sal ou derivado de éster deste farmaceuticamente aceitável
JP2003183282A (ja) * 2001-12-21 2003-07-03 Wyeth Lederle Japan Ltd カルバペネム化合物

Also Published As

Publication number Publication date
EP1784407A1 (de) 2007-05-16
EP1784407B1 (de) 2010-09-08
KR100599876B1 (ko) 2006-07-13
CN1946724A (zh) 2007-04-11
CN100494200C (zh) 2009-06-03
KR20060020081A (ko) 2006-03-06
WO2006025634A1 (en) 2006-03-09
EP1784407A4 (de) 2009-02-11
US20070244089A1 (en) 2007-10-18
WO2006025634A8 (en) 2006-08-24
JP4801049B2 (ja) 2011-10-26
JP2007532693A (ja) 2007-11-15
US7662810B2 (en) 2010-02-16
DE602005023492D1 (de) 2010-10-21

Similar Documents

Publication Publication Date Title
ATE480538T1 (de) 2-arylmethylazetidincarbapenemderivate und deren herstellung
WO2012134184A3 (ko) 신규한 세파로스포린 유도체 및 이를 함유하는 의약 조성물
WO2005070945A8 (ja) メチシリン耐性黄色ブドウ球菌（ｍｒｓａ）に有効な新規アミノグリコシド系抗生物質
PA8678901A1 (es) Derivados de quinolina como agentes antibacteriales
WO2010047737A3 (en) Antimicrobial indoline compounds for treatment of bacterial infections
WO2008143343A1 (ja) １４位置換基に複素芳香環カルボン酸構造を有するムチリン誘導体
NZ545472A (en) 7-(4-substituted-3-cyclopropylaminomethyl-1-pyrrolidinyl)quinolonecarboxylic acid derivative
WO2011073112A3 (en) Mannose derivatives as antagonists of bacterial adhesion
WO2012031298A3 (en) Ethynylbenzene derivatives
WO2005014585A8 (en) Halogenated quinazolinyl nitrofurans as antibacterial agents
WO2007067559A3 (en) Antibacterial agents
GEP20156370B (en) Fluoro-pyridinone derivatives useful as antibacterial agents
WO2007001335A3 (en) Ramoplanin derivatives possessing antibacterial activity
WO2006055070A3 (en) Novel lincomycin derivatives possessing antibacterial activity
NZ594675A (en) Actagardine derivatives
MX2010004407A (es) Antibioticos de carbacefem beta-lactama.
MX2022007412A (es) Compuestos novedosos y sus usos.
RS20050931A (en) Novel lincomycin derivatives possessing antimicro bial activity
WO2015024011A3 (en) Antibacterial compounds
SG166798A1 (en) Quinolone derivatives as antibacterial agents
WO2005070922A3 (en) Bis-indole pyrroles useful as antimicrobials agents
WO2009066917A3 (en) 2-arylmethylazetidine-carbapenem-3-carboxylic acid ester derivative or its salt, process for the preparation thereof and pharmaceutical composition comprising the same
WO2010036000A3 (en) Novel oxazolidinone derivatives with cyclic amidoxime or cyclic amidrazone and pharmaceutical compositions thereof
WO2005016936A3 (en) Process for selective preparation of z-isomer of cefditoren and pharmaceutically acceptable salts and esters thereof
WO2010030811A3 (en) CARBACEPHEM β-LACTAM ANTIBIOTICS

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties