PT1289998E - Novo processo para a preparacao de derivados de vinil-pirrolidinona cefalosporina - Google Patents

Novo processo para a preparacao de derivados de vinil-pirrolidinona cefalosporina

Info

Publication number
PT1289998E
PT1289998E PT01936374T PT01936374T PT1289998E PT 1289998 E PT1289998 E PT 1289998E PT 01936374 T PT01936374 T PT 01936374T PT 01936374 T PT01936374 T PT 01936374T PT 1289998 E PT1289998 E PT 1289998E
Authority
PT
Portugal
Prior art keywords
preparation
vinastil
pyrolidinone
cephalosporin
derivatives
Prior art date
Application number
PT01936374T
Other languages
English (en)
Inventor
Paul Hebeisen
Hilpert Hans
Humm Roland
Original Assignee
Basilea Pharmaceutica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basilea Pharmaceutica Ag filed Critical Basilea Pharmaceutica Ag
Publication of PT1289998E publication Critical patent/PT1289998E/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/207-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/577-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with a further substituent in position 7, e.g. cephamycines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65613Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. cephalosporins and analogs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572Five-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/582Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT01936374T 2000-05-24 2001-05-18 Novo processo para a preparacao de derivados de vinil-pirrolidinona cefalosporina PT1289998E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00111164 2000-05-24
PCT/EP2001/005721 WO2001090111A1 (en) 2000-05-24 2001-05-18 New process for the preparation of vinyl-pyrrolidinone cephalosporine derivatives

Publications (1)

Publication Number Publication Date
PT1289998E true PT1289998E (pt) 2005-06-30

Family

ID=8168825

Family Applications (2)

Application Number Title Priority Date Filing Date
PT04002120T PT1435357E (pt) 2000-05-24 2001-05-18 Novo processo para a preparação de derivados de cefalosporina e vinil-pirrolidinona
PT01936374T PT1289998E (pt) 2000-05-24 2001-05-18 Novo processo para a preparacao de derivados de vinil-pirrolidinona cefalosporina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT04002120T PT1435357E (pt) 2000-05-24 2001-05-18 Novo processo para a preparação de derivados de cefalosporina e vinil-pirrolidinona

Country Status (16)

Country Link
US (1) US6504025B2 (pt)
EP (2) EP1289998B1 (pt)
JP (1) JP3994011B2 (pt)
KR (1) KR100528305B1 (pt)
CN (4) CN1301998C (pt)
AT (2) ATE292135T1 (pt)
AU (1) AU2001262299A1 (pt)
CA (2) CA2583727C (pt)
CY (1) CY1110298T1 (pt)
DE (2) DE60109771T2 (pt)
DK (2) DK1435357T3 (pt)
ES (2) ES2340273T3 (pt)
HK (3) HK1074620A1 (pt)
MX (1) MXPA02011530A (pt)
PT (2) PT1435357E (pt)
WO (1) WO2001090111A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE257136T1 (de) 2001-10-11 2004-01-15 Consortium Elektrochem Ind Verfahren zur oxidation von alkoholen unter katalyse von nitroxylverbindungen
SI1606293T1 (sl) * 2003-03-27 2009-10-31 Basilea Pharmaceutica Ag Cefalosporin v kristalni obliki
WO2009055696A1 (en) * 2007-10-25 2009-04-30 Achaogen, Inc. CARBACEPHEM β-LACTAM ANTIBIOTICS
AR071318A1 (es) * 2008-04-15 2010-06-09 Basilea Pharmaceutica Ag Benzhidril ester del acido (6r,7r)-7-{2-(5-amino-[1,2,4]tiadiazol-3-il)-2-[(z)-tritiloxiimino]-acetilamino}-3-[(r)-1'-terc-butoxicarbonil-2-oxo-[1,3']bipirrolidinil-(3e)-ilidenometil]-8-oxo-5-tia-1-aza-biciclo[4.2.0]oct-2-eno-2-carboxilico cristalino; su elaboracion y uso
WO2010030810A1 (en) * 2008-09-10 2010-03-18 Achaogen, Inc. Carbacephem beta-lactam antibiotics
WO2010072672A1 (en) 2008-12-24 2010-07-01 Basilea Pharmaceutica Ag New crystal polymorphs of ceftobiprole
US9096610B2 (en) * 2009-05-25 2015-08-04 Sandoz Ag Method for the production of ceftobiprole medocaril
ES2535822T3 (es) * 2010-05-10 2015-05-18 Basilea Pharmaceutica International Ltd. Procedimiento de oxidación para preparar derivados de 3-formil-cefem
CN103275104B (zh) * 2013-05-15 2015-05-20 苏州明锐医药科技有限公司 头孢托罗及头孢托罗酯的制备方法
CN105601648A (zh) * 2016-03-09 2016-05-25 上海宁瑞生化技术有限公司 一锅法制备头孢吡普的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT620225E (pt) * 1993-04-16 2003-03-31 Basilea Pharmaceutica Ag Derivados de cefalosporina
US5466811A (en) 1994-07-18 1995-11-14 Merck & Co., Inc. Dioxolenylmethyl carbamates pro moieties for amine drugs
US5631366A (en) * 1995-01-12 1997-05-20 Hoffmann-La Roche Inc. Process for making 3-formylcephem derivatives
KR100197788B1 (ko) 1995-06-30 1999-06-15 김충환 세펨 유도체의 제조방법
US5883247A (en) * 1996-06-10 1999-03-16 Hoffmann-La Roche Inc. Preparation of cephem and isooxacephem derivatives
TW415949B (en) 1996-12-19 2000-12-21 Hoffmann La Roche Vinyl pyrrolidine cephalosporin derivatives with basic substituents
KR100481143B1 (ko) * 1997-04-01 2005-04-08 바이오케미 게젤샤프트 엠베하 항균성 치환 7-아실아미노-3-(메틸히드라조노)메틸-세팔로스포린 및 중간체
AU754732B2 (en) 1998-06-15 2002-11-21 Basilea Pharmaceutica International Ag, Allschwil Derivatives of 3-(2-oxo-(1,3')bipyrrolidinyl-3-ylidenemethyl)-cephems

Also Published As

Publication number Publication date
US20020019381A1 (en) 2002-02-14
EP1435357A2 (en) 2004-07-07
DE60109771D1 (de) 2005-05-04
CN1430621A (zh) 2003-07-16
CY1110298T1 (el) 2015-04-29
ATE461203T1 (de) 2010-04-15
CA2583727A1 (en) 2001-11-29
CA2583727C (en) 2010-03-30
PT1435357E (pt) 2010-04-20
HK1096101A1 (en) 2007-05-25
DK1289998T3 (da) 2005-08-08
JP2003535059A (ja) 2003-11-25
CN1915997B (zh) 2010-06-16
CN1916006A (zh) 2007-02-21
MXPA02011530A (es) 2003-04-25
EP1289998A1 (en) 2003-03-12
KR20030005386A (ko) 2003-01-17
ES2340273T3 (es) 2010-06-01
KR100528305B1 (ko) 2005-11-15
CA2408941C (en) 2009-01-27
DK1435357T3 (da) 2010-05-03
AU2001262299A1 (en) 2001-12-03
CN1915997A (zh) 2007-02-21
ATE292135T1 (de) 2005-04-15
ES2238441T3 (es) 2005-09-01
WO2001090111A1 (en) 2001-11-29
CN1603327A (zh) 2005-04-06
US6504025B2 (en) 2003-01-07
EP1289998B1 (en) 2005-03-30
HK1074620A1 (en) 2005-11-18
CN1170831C (zh) 2004-10-13
EP1435357B1 (en) 2010-03-17
EP1435357A3 (en) 2006-05-03
CA2408941A1 (en) 2001-11-29
DE60141609D1 (de) 2010-04-29
JP3994011B2 (ja) 2007-10-17
HK1096091A1 (en) 2007-05-25
CN100567314C (zh) 2009-12-09
DE60109771T2 (de) 2006-02-16
CN1301998C (zh) 2007-02-28

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