DE602004017478D1 - Substituierte thiophene und deren verwendungen - Google Patents

Substituierte thiophene und deren verwendungen

Info

Publication number
DE602004017478D1
DE602004017478D1 DE602004017478T DE602004017478T DE602004017478D1 DE 602004017478 D1 DE602004017478 D1 DE 602004017478D1 DE 602004017478 T DE602004017478 T DE 602004017478T DE 602004017478 T DE602004017478 T DE 602004017478T DE 602004017478 D1 DE602004017478 D1 DE 602004017478D1
Authority
DE
Germany
Prior art keywords
substituted thiophenes
thiophenes
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE602004017478T
Other languages
English (en)
Inventor
Susan Ashwell
Thomas Gero
Stophanos Ioannidis
James Janetka
Paul Lyne
Vibha Oza
Stephanie Springer
Mei Su
Dingwei Yu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of DE602004017478D1 publication Critical patent/DE602004017478D1/de
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D453/00Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D453/00Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE602004017478T 2003-08-15 2004-08-12 Substituierte thiophene und deren verwendungen Expired - Fee Related DE602004017478D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49558003P 2003-08-15 2003-08-15
US57641604P 2004-05-28 2004-05-28
PCT/GB2004/003473 WO2005016909A1 (en) 2003-08-15 2004-08-12 Substituted thiophenes and uses thereof

Publications (1)

Publication Number Publication Date
DE602004017478D1 true DE602004017478D1 (de) 2008-12-11

Family

ID=34198049

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004017478T Expired - Fee Related DE602004017478D1 (de) 2003-08-15 2004-08-12 Substituierte thiophene und deren verwendungen

Country Status (19)

Country Link
US (2) US7423061B2 (de)
EP (1) EP1660474B1 (de)
JP (1) JP2007502308A (de)
KR (1) KR20060080918A (de)
AR (1) AR045459A1 (de)
AT (1) ATE412645T1 (de)
AU (1) AU2004265140A1 (de)
BR (1) BRPI0413585A (de)
CA (1) CA2535652A1 (de)
DE (1) DE602004017478D1 (de)
ES (1) ES2314443T3 (de)
HK (1) HK1091487A1 (de)
IL (1) IL173619A0 (de)
IS (1) IS8344A (de)
MX (1) MXPA06001775A (de)
NO (1) NO20060718L (de)
RU (1) RU2006107782A (de)
TW (1) TW200524894A (de)
WO (1) WO2005016909A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10360369A1 (de) * 2003-12-22 2005-07-14 Bayer Cropscience Ag Amide
CN100584840C (zh) * 2004-01-05 2010-01-27 阿斯利康(瑞典)有限公司 取代杂环化合物及其应用
DE102005035742A1 (de) * 2005-07-29 2007-02-01 Merck Patent Gmbh Quadratsäurederivate II
DE102005039541A1 (de) * 2005-08-22 2007-03-22 Merck Patent Gmbh 3-Oxo-indazol-quadratsäurederivate
WO2008121592A2 (en) * 2007-03-30 2008-10-09 Takeda Pharmaceutical Company Limited Acetyl coenzyme a carboxylase inhibitors
CN101481380B (zh) * 2008-01-08 2012-10-17 浙江医药股份有限公司新昌制药厂 噻吩并哒嗪类化合物及其制备方法、药物组合物及其用途
JPWO2009096198A1 (ja) * 2008-02-01 2011-05-26 一般社団法人ファルマIp 新規ビアリール誘導体
ES2522628T3 (es) * 2008-06-11 2014-11-17 Genentech, Inc. Pirroles sustituidos y métodos de uso
EP3461480A1 (de) 2017-09-27 2019-04-03 Onxeo Kombination von checkpoint-hemmern des dna-schädigungsantwort-zellzyklus und belinostat zur behandlung von krebs
US20230293507A1 (en) * 2020-03-04 2023-09-21 Pharos Ibio Co., Ltd Use of 2,3,5-substituted thiophene compound for preventing, ameliorating, or treating ovarian cancer

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2291065C (en) * 1997-05-23 2010-02-09 Bayer Corporation Raf kinase inhibitors
DE69826695T2 (de) 1997-05-23 2006-02-02 Bayer Pharmaceuticals Corp., West Haven Arylharnstoffderivate zur behandlung von inflammatorischen oder immunomodulatorischen erkrankungen
GB0003154D0 (en) 2000-02-12 2000-04-05 Astrazeneca Uk Ltd Novel compounds
US6414013B1 (en) 2000-06-19 2002-07-02 Pharmacia & Upjohn S.P.A. Thiophene compounds, process for preparing the same, and pharmaceutical compositions containing the same background of the invention
AU2002211663A1 (en) 2000-10-12 2002-04-22 Smith Kline Beecham Corporation Nf-$g(k)b inhibitors
UA76977C2 (en) 2001-03-02 2006-10-16 Icos Corp Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers
SE0102616D0 (sv) * 2001-07-25 2001-07-25 Astrazeneca Ab Novel compounds
US7166639B2 (en) 2001-10-04 2007-01-23 Smithkline Beecham Corporation NF-κB inhibitors
WO2003028731A1 (en) * 2001-10-04 2003-04-10 Smithkline Beecham Corporation Chk1 kinase inhibitors
WO2003029241A1 (en) * 2001-10-04 2003-04-10 Smithkline Beecham Corporation Chk1 kinase inhibitors
JP2005531608A (ja) 2002-06-06 2005-10-20 スミスクライン・ビーチャム・コーポレイション NF−κB阻害剤
EP1569924A4 (de) 2002-12-06 2007-02-21 Smithkline Beecham Corp Nf-kb-inhibitoren
SE0300091D0 (sv) 2003-01-15 2003-01-15 Astrazeneca Ab Novel compounds
US20050085531A1 (en) 2003-10-03 2005-04-21 Hodge Carl N. Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
CN100584840C (zh) 2004-01-05 2010-01-27 阿斯利康(瑞典)有限公司 取代杂环化合物及其应用
WO2005105777A1 (en) 2004-05-05 2005-11-10 Pharmacia & Upjohn Company Llc Substituted thiophene amide compounds for the treatment of inflammation
US7741479B2 (en) 2004-12-07 2010-06-22 Locus Pharmaceuticals, Inc. Urea inhibitors of MAP kinases
WO2006062984A2 (en) 2004-12-07 2006-06-15 Locus Pharmaceuticals, Inc. Inhibitors of protein kinases

Also Published As

Publication number Publication date
HK1091487A1 (en) 2007-01-19
RU2006107782A (ru) 2006-08-10
WO2005016909A1 (en) 2005-02-24
EP1660474B1 (de) 2008-10-29
US20060281666A1 (en) 2006-12-14
JP2007502308A (ja) 2007-02-08
EP1660474A1 (de) 2006-05-31
IL173619A0 (en) 2006-07-05
ES2314443T3 (es) 2009-03-16
AU2004265140A1 (en) 2005-02-24
CA2535652A1 (en) 2005-02-24
AR045459A1 (es) 2005-10-26
US7423061B2 (en) 2008-09-09
ATE412645T1 (de) 2008-11-15
IS8344A (is) 2006-03-09
BRPI0413585A (pt) 2006-10-17
TW200524894A (en) 2005-08-01
US20090054396A1 (en) 2009-02-26
NO20060718L (no) 2006-03-01
KR20060080918A (ko) 2006-07-11
MXPA06001775A (es) 2006-05-17

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Legal Events

Date Code Title Description
8381 Inventor (new situation)

Inventor name: LYNE, PAUL, WALTHAM, MA 02451, US

Inventor name: OZA, VIBHA, WALTHAM, MA 02451, US

Inventor name: SPRINGER, STEPHANIE, BRADFORD, MA 01835, US

Inventor name: SU, MEI, WALTHAM, MA 02451, US

Inventor name: JANETKA, JAMES, WALTHAM, MA 02451, US

Inventor name: ASHWELL, SUSAN, WALTHAM, MA 02451, US

Inventor name: GERO, THOMAS, WALTHAM, MA 02451, US

Inventor name: IOANNIDIS, STEPHANOS, WALTHAM, MA 02451, US

Inventor name: YU, DINGWEI, WALTHAM, MA 02451, US

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee