DE602004017478D1 - SUBSTITUTED THIOPHENES AND THEIR USES - Google Patents
SUBSTITUTED THIOPHENES AND THEIR USESInfo
- Publication number
- DE602004017478D1 DE602004017478D1 DE602004017478T DE602004017478T DE602004017478D1 DE 602004017478 D1 DE602004017478 D1 DE 602004017478D1 DE 602004017478 T DE602004017478 T DE 602004017478T DE 602004017478 T DE602004017478 T DE 602004017478T DE 602004017478 D1 DE602004017478 D1 DE 602004017478D1
- Authority
- DE
- Germany
- Prior art keywords
- substituted thiophenes
- thiophenes
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49558003P | 2003-08-15 | 2003-08-15 | |
| US57641604P | 2004-05-28 | 2004-05-28 | |
| PCT/GB2004/003473 WO2005016909A1 (en) | 2003-08-15 | 2004-08-12 | Substituted thiophenes and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602004017478D1 true DE602004017478D1 (en) | 2008-12-11 |
Family
ID=34198049
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004017478T Expired - Fee Related DE602004017478D1 (en) | 2003-08-15 | 2004-08-12 | SUBSTITUTED THIOPHENES AND THEIR USES |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7423061B2 (en) |
| EP (1) | EP1660474B1 (en) |
| JP (1) | JP2007502308A (en) |
| KR (1) | KR20060080918A (en) |
| AR (1) | AR045459A1 (en) |
| AT (1) | ATE412645T1 (en) |
| AU (1) | AU2004265140A1 (en) |
| BR (1) | BRPI0413585A (en) |
| CA (1) | CA2535652A1 (en) |
| DE (1) | DE602004017478D1 (en) |
| ES (1) | ES2314443T3 (en) |
| HK (1) | HK1091487A1 (en) |
| IL (1) | IL173619A0 (en) |
| IS (1) | IS8344A (en) |
| MX (1) | MXPA06001775A (en) |
| NO (1) | NO20060718L (en) |
| RU (1) | RU2006107782A (en) |
| TW (1) | TW200524894A (en) |
| WO (1) | WO2005016909A1 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10360369A1 (en) * | 2003-12-22 | 2005-07-14 | Bayer Cropscience Ag | amides |
| WO2005066163A2 (en) * | 2004-01-05 | 2005-07-21 | Astrazeneca Ab | Thiophene derivatives as chk 1 inihibitors |
| DE102005035742A1 (en) * | 2005-07-29 | 2007-02-01 | Merck Patent Gmbh | New cyclobut-3-ene-1,2-dione derivatives are kinase inhibitors useful for treating e.g. cancer, hypertension, diabetes, glaucoma and bacterial infections |
| DE102005039541A1 (en) * | 2005-08-22 | 2007-03-22 | Merck Patent Gmbh | 3-oxo-indazol-square acid derivatives |
| WO2008121592A2 (en) * | 2007-03-30 | 2008-10-09 | Takeda Pharmaceutical Company Limited | Acetyl coenzyme a carboxylase inhibitors |
| CN101481380B (en) * | 2008-01-08 | 2012-10-17 | 浙江医药股份有限公司新昌制药厂 | Thiofuran pyridazine compound, preparation thereof, pharmaceutical composition and uses thereof |
| WO2009096198A1 (en) * | 2008-02-01 | 2009-08-06 | Pharma Ip Limited Liability Intermediary Corporations | Novel biaryl derivative |
| KR20110015627A (en) * | 2008-06-11 | 2011-02-16 | 제넨테크, 인크. | Substituted pyrroles and methods of use |
| EP3461480A1 (en) | 2017-09-27 | 2019-04-03 | Onxeo | Combination of a dna damage response cell cycle checkpoint inhibitors and belinostat for treating cancer |
| WO2021177728A1 (en) * | 2020-03-04 | 2021-09-10 | (주)파로스아이바이오 | Use of 2,3,5-substituted thiophene compound for preventing, ameliorating, or treating ovarian cancer |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2153337T3 (en) * | 1997-05-23 | 2008-11-01 | Bayer Pharmaceuticals Corporation | QUINASA RAF INHIBITORS. |
| DE69826695T2 (en) | 1997-05-23 | 2006-02-02 | Bayer Pharmaceuticals Corp., West Haven | ARYLENE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY OR IMMUNOMODULATORY DISEASES |
| GB0003154D0 (en) | 2000-02-12 | 2000-04-05 | Astrazeneca Uk Ltd | Novel compounds |
| US6414013B1 (en) | 2000-06-19 | 2002-07-02 | Pharmacia & Upjohn S.P.A. | Thiophene compounds, process for preparing the same, and pharmaceutical compositions containing the same background of the invention |
| JP2004523476A (en) | 2000-10-12 | 2004-08-05 | スミスクライン・ビーチャム・コーポレイション | NF-κB inhibitor |
| UA76977C2 (en) * | 2001-03-02 | 2006-10-16 | Icos Corp | Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers |
| SE0102616D0 (en) * | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
| WO2003029241A1 (en) * | 2001-10-04 | 2003-04-10 | Smithkline Beecham Corporation | Chk1 kinase inhibitors |
| WO2003028731A1 (en) * | 2001-10-04 | 2003-04-10 | Smithkline Beecham Corporation | Chk1 kinase inhibitors |
| WO2003029242A1 (en) | 2001-10-04 | 2003-04-10 | Smithkline Beecham Corporation | NF-λB INHIBITORS |
| JP2005531608A (en) | 2002-06-06 | 2005-10-20 | スミスクライン・ビーチャム・コーポレイション | NF-κB inhibitor |
| US20060116419A1 (en) | 2002-12-06 | 2006-06-01 | Callahan James F | Nf-kb inhibitors |
| SE0300091D0 (en) | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
| US20050085531A1 (en) | 2003-10-03 | 2005-04-21 | Hodge Carl N. | Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof |
| WO2005066163A2 (en) * | 2004-01-05 | 2005-07-21 | Astrazeneca Ab | Thiophene derivatives as chk 1 inihibitors |
| WO2005105777A1 (en) | 2004-05-05 | 2005-11-10 | Pharmacia & Upjohn Company Llc | Substituted thiophene amide compounds for the treatment of inflammation |
| CA2589271A1 (en) | 2004-12-07 | 2006-06-15 | Locus Pharmaceuticals, Inc. | Urea inhibitors of map kinases |
| CA2589274A1 (en) | 2004-12-07 | 2006-06-15 | Locus Pharmaceuticals, Inc. | Inhibitors of protein kinases |
-
2004
- 2004-08-12 WO PCT/GB2004/003473 patent/WO2005016909A1/en active Search and Examination
- 2004-08-12 BR BRPI0413585-7A patent/BRPI0413585A/en not_active Application Discontinuation
- 2004-08-12 ES ES04768043T patent/ES2314443T3/en active Active
- 2004-08-12 AU AU2004265140A patent/AU2004265140A1/en not_active Abandoned
- 2004-08-12 DE DE602004017478T patent/DE602004017478D1/en not_active Expired - Fee Related
- 2004-08-12 JP JP2006523673A patent/JP2007502308A/en active Pending
- 2004-08-12 KR KR1020067003164A patent/KR20060080918A/en not_active Application Discontinuation
- 2004-08-12 US US10/568,380 patent/US7423061B2/en not_active Expired - Fee Related
- 2004-08-12 MX MXPA06001775A patent/MXPA06001775A/en not_active Application Discontinuation
- 2004-08-12 CA CA002535652A patent/CA2535652A1/en not_active Abandoned
- 2004-08-12 EP EP04768043A patent/EP1660474B1/en active Active
- 2004-08-12 AT AT04768043T patent/ATE412645T1/en not_active IP Right Cessation
- 2004-08-12 RU RU2006107782/04A patent/RU2006107782A/en not_active Application Discontinuation
- 2004-08-13 TW TW093124393A patent/TW200524894A/en unknown
- 2004-08-17 AR ARP040102946A patent/AR045459A1/en unknown
-
2006
- 2006-02-08 IL IL173619A patent/IL173619A0/en unknown
- 2006-02-14 NO NO20060718A patent/NO20060718L/en not_active Application Discontinuation
- 2006-03-09 IS IS8344A patent/IS8344A/en unknown
- 2006-11-01 HK HK06112029.4A patent/HK1091487A1/en not_active IP Right Cessation
-
2008
- 2008-09-08 US US12/206,317 patent/US20090054396A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20090054396A1 (en) | 2009-02-26 |
| ES2314443T3 (en) | 2009-03-16 |
| IS8344A (en) | 2006-03-09 |
| EP1660474B1 (en) | 2008-10-29 |
| AR045459A1 (en) | 2005-10-26 |
| RU2006107782A (en) | 2006-08-10 |
| NO20060718L (en) | 2006-03-01 |
| ATE412645T1 (en) | 2008-11-15 |
| TW200524894A (en) | 2005-08-01 |
| US7423061B2 (en) | 2008-09-09 |
| CA2535652A1 (en) | 2005-02-24 |
| EP1660474A1 (en) | 2006-05-31 |
| KR20060080918A (en) | 2006-07-11 |
| MXPA06001775A (en) | 2006-05-17 |
| IL173619A0 (en) | 2006-07-05 |
| JP2007502308A (en) | 2007-02-08 |
| HK1091487A1 (en) | 2007-01-19 |
| BRPI0413585A (en) | 2006-10-17 |
| US20060281666A1 (en) | 2006-12-14 |
| AU2004265140A1 (en) | 2005-02-24 |
| WO2005016909A1 (en) | 2005-02-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8381 | Inventor (new situation) |
Inventor name: LYNE, PAUL, WALTHAM, MA 02451, US Inventor name: OZA, VIBHA, WALTHAM, MA 02451, US Inventor name: SPRINGER, STEPHANIE, BRADFORD, MA 01835, US Inventor name: SU, MEI, WALTHAM, MA 02451, US Inventor name: JANETKA, JAMES, WALTHAM, MA 02451, US Inventor name: ASHWELL, SUSAN, WALTHAM, MA 02451, US Inventor name: GERO, THOMAS, WALTHAM, MA 02451, US Inventor name: IOANNIDIS, STEPHANOS, WALTHAM, MA 02451, US Inventor name: YU, DINGWEI, WALTHAM, MA 02451, US |
|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |