DE60117043D1 - Behandlung von mukositis - Google Patents

Behandlung von mukositis

Info

Publication number
DE60117043D1
DE60117043D1 DE60117043T DE60117043T DE60117043D1 DE 60117043 D1 DE60117043 D1 DE 60117043D1 DE 60117043 T DE60117043 T DE 60117043T DE 60117043 T DE60117043 T DE 60117043T DE 60117043 D1 DE60117043 D1 DE 60117043D1
Authority
DE
Germany
Prior art keywords
mucositis
treatment
therapeutic composition
treating
biocompatible
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60117043T
Other languages
English (en)
Other versions
DE60117043T2 (de
Inventor
J Rosenthal
B Etter
C Rodell
H Schauer
Adrian Samaniego
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RxKinetix Inc
Original Assignee
RxKinetix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RxKinetix Inc filed Critical RxKinetix Inc
Application granted granted Critical
Publication of DE60117043D1 publication Critical patent/DE60117043D1/de
Publication of DE60117043T2 publication Critical patent/DE60117043T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
DE60117043T 2000-11-22 2001-11-21 Behandlung von mukositis Expired - Lifetime DE60117043T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72151600A 2000-11-22 2000-11-22
US721516 2000-11-22
PCT/US2001/044186 WO2002041837A2 (en) 2000-11-22 2001-11-21 Treatment of mucositis

Publications (2)

Publication Number Publication Date
DE60117043D1 true DE60117043D1 (de) 2006-04-13
DE60117043T2 DE60117043T2 (de) 2006-07-13

Family

ID=24898290

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60117043T Expired - Lifetime DE60117043T2 (de) 2000-11-22 2001-11-21 Behandlung von mukositis

Country Status (11)

Country Link
US (5) US6685917B2 (de)
EP (2) EP1343492B1 (de)
JP (1) JP4822652B2 (de)
AT (1) ATE316786T1 (de)
AU (1) AU2002239342A1 (de)
BR (1) BRPI0115531B1 (de)
DE (1) DE60117043T2 (de)
DK (1) DK1343492T3 (de)
ES (1) ES2254523T3 (de)
MX (1) MXPA03004546A (de)
WO (1) WO2002041837A2 (de)

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6525018B1 (en) * 1999-05-17 2003-02-25 The General Hospital Corp. Treating eye disorders using intestinal trefoil proteins
US20030186882A1 (en) * 2001-07-31 2003-10-02 Podolsky Daniel K. Methods and compositions for treating and preventing distal bowel lesions
US20030185838A1 (en) * 2001-11-28 2003-10-02 Podolsky Daniel K. Methods and compositions for treating lesions of the respiratory epithelium
DE60117043T2 (de) * 2000-11-22 2006-07-13 Rxkinetix, Inc., Louisville Behandlung von mukositis
US20030105016A1 (en) * 2001-09-06 2003-06-05 Podolsky Daniel K. Methods and compositions for treating vaginal, cervical, and uterine epithelial lesions
US20060189526A1 (en) * 2002-04-24 2006-08-24 Podolsky Daniel K Compositions containing an intestinal trefoil peptide and a mucoadhesive
US20040171544A1 (en) * 2001-04-24 2004-09-02 Barker Nicholas P. Trefoil domain-containing polypeptides and uses thereof
US7538082B2 (en) * 2001-04-24 2009-05-26 The General Hospital Corporation Methods and compositions for treating oral and esophageal lesions
MXPA03009772A (es) * 2001-04-24 2004-02-23 Gen Hospital Corp Metodos y composiciones para tratar lesiones orales y del esofago.
US20030181384A1 (en) * 2001-09-06 2003-09-25 Podolsky Daniel K. Methods and compositions for treating vaginal, cervical, and uterine epithelial lesions
US20030185839A1 (en) * 2001-10-05 2003-10-02 Podolsky Daniel K. Methods and compositions for treating dermal lesions
JP2005508937A (ja) * 2001-10-05 2005-04-07 ザ ジェネラル ホスピタル コーポレーション 皮膚病変を治療するための方法および組成物
US6620405B2 (en) 2001-11-01 2003-09-16 3M Innovative Properties Company Delivery of hydrogel compositions as a fine mist
MXPA04009363A (es) * 2002-03-26 2005-01-25 Gen Hospital Corp Terapia de combinacion usando peptidos trifolios.
FR2837709B1 (fr) * 2002-03-26 2005-05-13 Innovations Pharma Ag Composition thermoreversible destinee a compenser les hyposialies et asialies provoquees par les xerostomies
US20060275370A1 (en) * 2002-07-25 2006-12-07 Yih-Lin Chung Method and compositions for treatment of epithelial damage
US20040057983A1 (en) 2002-09-25 2004-03-25 David Schmidt Biomolecular wearable apparatus
KR20040028336A (ko) * 2002-09-30 2004-04-03 김종국 신규한 질내 투여용 항균 온도감응성 겔 조성물
US20060188471A1 (en) * 2002-10-31 2006-08-24 Podolsky Daniel K Methods of treating epithelial lesions
US7591999B2 (en) 2003-03-04 2009-09-22 Mitsubishi Tanabe Pharma Corporation Powdery preparation for nasal administration
WO2004080429A2 (en) * 2003-03-13 2004-09-23 Oregon Health & Science University Use of thiol-based compositions in ameliorating mucosal injury
US20050118261A1 (en) * 2003-06-12 2005-06-02 Oien Hal J. Compositions and methods of administering doxepin to mucosal tissue
US6984628B2 (en) 2003-07-15 2006-01-10 Allergan, Inc. Ophthalmic compositions comprising trefoil factor family peptides
BRPI0415480B1 (pt) * 2003-10-16 2019-09-17 Nestec S.A. Composição nutricional contra efeitos colaterais de quimioterapia ou radioterapia
US20050090551A1 (en) * 2003-10-27 2005-04-28 Board Of Trustees Of Southern Illinois University Therapeutic use of methionine for the treatment or prevention of mucositis
US20070003582A1 (en) * 2003-11-25 2007-01-04 Heng Madalene C Medicine for the treatment of acne and for reversing the signs of age and sun damage and method for using same
PT1708722E (pt) 2004-01-28 2014-09-12 Univ California Nova terapia interstciial para o alívio imediato dos sintomas e terapia crónica na cistite intersticial
US7901707B2 (en) * 2004-03-15 2011-03-08 Christine Allen Biodegradable biocompatible implant and method of manufacturing same
ES2660172T3 (es) * 2004-05-19 2018-03-21 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Composición inyectable que comprende desoxicolato de sodio
US20060127468A1 (en) * 2004-05-19 2006-06-15 Kolodney Michael S Methods and related compositions for reduction of fat and skin tightening
US7754230B2 (en) * 2004-05-19 2010-07-13 The Regents Of The University Of California Methods and related compositions for reduction of fat
EP1848427A1 (de) * 2005-02-16 2007-10-31 Wyeth a Corporation of the State of Delaware Verwendung von östrogenrezeptor-b-selektiven agonisten für strahlungs- oder chemotherapieinduzierte mucositis und strhalungscystitis
US8075771B2 (en) * 2005-02-17 2011-12-13 E. I. Du Pont De Nemours And Company Apparatus for magnetic field gradient enhanced centrifugation
JP4732784B2 (ja) * 2005-04-21 2011-07-27 興和株式会社 パンテノール含有口腔内粘膜付着製剤
JP5032003B2 (ja) * 2005-06-15 2012-09-26 株式会社琉球バイオリソース開発 口腔粘膜用の鎮痛・抗炎症トローチ剤
US20090028951A1 (en) * 2005-07-13 2009-01-29 Al Czap Compositions for Oral Administration of Sustained Release Glutathione, Methods for Their Production and Uses Thereof
US8324192B2 (en) 2005-11-12 2012-12-04 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
US8497258B2 (en) 2005-11-12 2013-07-30 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
US8679545B2 (en) 2005-11-12 2014-03-25 The Regents Of The University Of California Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract
PT1965787E (pt) * 2005-11-30 2013-07-05 Endo Pharmaceuticals Inc Tratamento de xerostomia com um antioxidante que contém enxofre
EP2001528A4 (de) * 2006-03-23 2012-04-04 Citagenix Inc Osteokonduktive umkehrphasen-zusammensetzung
JP2009538913A (ja) * 2006-05-30 2009-11-12 ハーレイ,ジェフリー,ティー. コバラミン調合物および粘膜炎の治療法または予防法
PT2035006E (pt) 2006-06-01 2010-04-22 Nobera Pharma Sl Utilização de alopurinol para o tratamento da eritrodisestesia palmo-plantar
US20090047336A1 (en) * 2007-08-17 2009-02-19 Hong Kong Baptist University novel formulation of dehydrated lipid vesicles for controlled release of active pharmaceutical ingredient via inhalation
EP2203152A4 (de) * 2007-10-03 2011-05-25 Myrex Pharmaceuticals Inc Mundspülung und verfahren zu ihrer anwendung zur behandlung von mucositis oder stomatitis
WO2009053892A1 (en) * 2007-10-22 2009-04-30 Koninklijke Philips Electronics, N.V. Interproximal teeth cleaning apparatus with an air-driven spray
CN101156834B (zh) * 2007-10-30 2010-08-11 深圳南粤药业有限公司 氨来呫诺温度敏感型凝胶及其制备方法
US20090131386A1 (en) * 2007-11-13 2009-05-21 Meritage Pharma, Inc. Compositions for the treatment of inflammation of the gastrointestinal tract
US20100216754A1 (en) * 2007-11-13 2010-08-26 Meritage Pharma, Inc. Compositions for the treatment of inflammation of the gastrointestinal tract
WO2009064458A2 (en) * 2007-11-13 2009-05-22 Meritage Pharma, Inc. Compositions for the treatment of inflammation of the gastrointestinal tract
US20090123551A1 (en) * 2007-11-13 2009-05-14 Meritage Pharma, Inc. Gastrointestinal delivery systems
US20090148530A1 (en) 2007-12-08 2009-06-11 Jamie Koufman Method for prevention and treatment of reflux injury in the aerodigestive tract and laryngopharynx caused by pepsin
US20110201926A1 (en) * 2008-02-29 2011-08-18 Pluromed, Inc. Local embolization via heating of thermosensitive polymers
JP5836592B2 (ja) * 2008-02-29 2015-12-24 プルーロームド インコーポレイテッドPluromed, Inc. 感熱性ポリマーを使用する局所塞栓
US20090264392A1 (en) * 2008-04-21 2009-10-22 Meritage Pharma, Inc. Treating eosinophilic esophagitis
US8602961B2 (en) * 2008-05-15 2013-12-10 Lifewave Products Llc Apparatus and method of stimulating elevation of glutathione levels in a subject
US20100204286A1 (en) 2009-02-12 2010-08-12 Donahue Stephen R Method for reducing gastrointestinal adverse effects of cytotoxic agents
US8101593B2 (en) 2009-03-03 2012-01-24 Kythera Biopharmaceuticals, Inc. Formulations of deoxycholic acid and salts thereof
EP2246057A1 (de) * 2009-04-29 2010-11-03 Nobera Pharma, S.L. Verwendung von Allopurinol zur Behandlung der Hand-Fuß-Hautreaktion
AU2010249047A1 (en) * 2009-05-13 2011-11-24 Protein Delivery Solutions, Llc Pharmaceutical system for trans-membrane delivery
WO2011094504A2 (en) * 2010-01-28 2011-08-04 Ora, Inc. Antimicrobial sinus irrigation compositions, methods, and devices
WO2012031123A2 (en) * 2010-09-01 2012-03-08 Trythisfirst, Inc. Method of treating ear infections
IT1401895B1 (it) * 2010-10-18 2013-08-28 Straccia Presidio farmacologico naturale per la prevenzione delle malattie infiammatorie del parodonto.
IT1401894B1 (it) 2010-10-18 2013-08-28 Straccia Presidio farmacologico per la prevenzione della lesione cariosa incipiente e dell' ipersensibilita' dentinale
IT1405758B1 (it) * 2010-11-03 2014-01-24 Stewart Italia Srl Preparazione farmaceutica a base nac in soluzione ipertonica per il trattamento di affezioni rinofaringee
JP2012116818A (ja) * 2010-12-03 2012-06-21 Feng Chia Univ 泌尿器系疾患を治療する医薬組成物
EP2675460A4 (de) 2011-02-18 2014-07-09 Kythera Biopharmaceuticals Inc Behandlung von fettgewebe unter dem kinn
FR2972327B1 (fr) * 2011-03-11 2017-08-11 Laboratoires Le Stum Composition nutraceutique mucoadhesive comprenant une association d'antioxydants
US8653058B2 (en) 2011-04-05 2014-02-18 Kythera Biopharmaceuticals, Inc. Compositions comprising deoxycholic acid and salts thereof suitable for use in treating fat deposits
DK2701681T3 (en) 2011-04-29 2017-01-09 Moberg Pharma Ab PHARMACEUTICAL COMPOSITIONS COMPRISING A LOCAL ANESTHETICS as bupivacaine for local administration to the mouth or throat
ITMI20110954A1 (it) * 2011-05-26 2012-11-27 Professional Dietetics Srl Combinazioni per il trattamento delle mucositi vaginali o rettali
ITMI20111151A1 (it) * 2011-06-24 2012-12-25 Lo Li Pharma Srl N-acetil cisteina e sua composizione per uso nel trattamento di patologie vaginali.
FI20115680L (fi) * 2011-06-29 2012-12-30 Biohit Oyj Nestemäisiä farmaseuttisia koostumuksia tai yhdistelmätuotteita
US20130177599A1 (en) * 2012-01-06 2013-07-11 Insite Vision Incorporated Methods and kits for extending contact lens use
JP2013170156A (ja) * 2012-02-22 2013-09-02 Terumo Corp 固形組成物
CN104583182A (zh) * 2012-05-23 2015-04-29 塞利克斯比奥私人有限公司 用于治疗粘膜炎的组合物和方法
KR101320945B1 (ko) * 2012-07-03 2013-10-23 주식회사파마킹 에스-알릴-엘-시스테인을 유효성분으로 포함하는 대장염 예방 또는 치료용 조성물 및 이를 포함하는 의약제제
KR101423631B1 (ko) * 2012-08-17 2014-07-25 주식회사파마킹 에스-알릴엘-시스테인을 유효성분으로 포함하는 안질환 예방 또는 치료용 조성물 및 이를 포함하는 의약제제
CN103027891A (zh) * 2012-11-25 2013-04-10 天津坤健生物制药有限公司 用于治疗口腔溃疡的乙酰半胱氨酸含漱液及制备方法
KR102265488B1 (ko) * 2013-07-31 2021-06-17 아지노모토 가부시키가이샤 암 화학 요법시의 부작용 경감제
US9457011B2 (en) * 2014-02-25 2016-10-04 Muslim D. Shahid Compositions and methods for the treatment of acid-related gastrointestinal disorders containing a dithiolane compound and a gastric acid secretion inhibitor
WO2015143310A1 (en) 2014-03-21 2015-09-24 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods for preparation of a terminally sterilized hydrogel derived from extracellular matrix
EP3265070B1 (de) * 2015-03-06 2019-07-03 Repoceuticals ApS Melatonin zur vorbeugung und behandlung von strahlungsvaginitis und strahlungsproktitis
WO2016146573A1 (en) * 2015-03-13 2016-09-22 Repoceuticals Aps Melatonin for preventing and treating radiation cystitis
CA2981757C (en) 2015-05-14 2023-06-27 Professional Dietetics S.P.A. Compositions comprising amino acids for use in the treatment of mucositides in neoplasia patients undergoing radiation therapy and/or chemotherapy
PE20181153A1 (es) 2015-08-05 2018-07-17 Childrens Medical Center Composiciones con potenciadores de premiacion para suministro de farmacos
CN105380957A (zh) * 2015-12-04 2016-03-09 天津坤健生物制药有限公司 一种乙酰半胱氨酸凝胶剂及制备方法与应用
US10239847B1 (en) 2016-03-03 2019-03-26 Cellactin Method for 2-oxothiazolidine-4-carboxylic acid for cellular glutathione
CA3031691A1 (en) 2016-09-13 2018-03-22 Rasna Research Inc. Dactinomycin compositions and methods for the treatment of myelodysplastic syndrome and acute myeloid leukemia
JP7277360B2 (ja) * 2016-09-14 2023-05-18 ザ チルドレンズ メディカル センター コーポレーション 薬物送達のための透過促進剤を有する組成物
EP3330251A1 (de) * 2016-11-30 2018-06-06 Clevexel Pharma Verfahren zur herstellung von gefriergetrocknetem 2-[(3-aminopropyl)amino]ethanethiol
CA3052489A1 (en) * 2017-03-02 2018-09-07 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Ecm hydrogel for treating esophageal inflammation
EP3628314B1 (de) * 2017-04-19 2023-07-26 Otsuka Pharmaceutical Factory, Inc. Olanexidine als entzündungshemmender wirkstoff
IT201700124424A1 (it) * 2017-10-31 2019-05-01 Sofar Swiss Sa Compressa da succhiare e/o sciogliere in bocca a base di acido ialuronico e condroitina solfato e loro sali
WO2019124605A1 (ko) * 2017-12-22 2019-06-27 경상대학교병원 알파리포산을 유효성분으로 함유하는 구강염 예방 또는 치료용 약학 조성물
WO2019124609A1 (ko) * 2017-12-22 2019-06-27 경상대학교병원 알파리포산을 유효성분으로 함유하는 침샘염 예방 또는 치료용 약학 조성물
EP3834887A1 (de) * 2019-12-12 2021-06-16 Koninklijke Philips N.V. Topische orale zusammensetzung
WO2022040584A1 (en) * 2020-08-21 2022-02-24 Neuronasal, Inc. Methods of administering glutathione precursors

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3091569A (en) * 1960-08-26 1963-05-28 Mead Johnson & Co Mucolytic-nu-acylated sulfhydryl compositions and process for treating animal mucus
US3591686A (en) * 1967-08-01 1971-07-06 Mead Johnson & Co Anti-inflammatory compositions and methods utilizing n-acylcysteines and the beta-alkyl and carboxyl derivatives thereof
US4188373A (en) * 1976-02-26 1980-02-12 Cooper Laboratories, Inc. Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes
US4176197A (en) * 1978-02-03 1979-11-27 Dominion Pharmacal, Inc. Method for treating acne vulgaris
US4512968A (en) * 1982-11-30 1985-04-23 Lion Corporation Oral compositions
US4615697A (en) * 1983-11-14 1986-10-07 Bio-Mimetics, Inc. Bioadhesive compositions and methods of treatment therewith
US4724239A (en) * 1985-09-16 1988-02-09 Morgan Lee R Method of treating chemical ulcers with N,N'-diacetylcystine, N-acetyl homocysteine and N-acetyl cysteine
US4708965A (en) * 1985-09-16 1987-11-24 Morgan Lee R Method of treating herpes virus infections with N,N'-diacetylcystine and derivatives
US4946870A (en) * 1986-06-06 1990-08-07 Union Carbide Chemicals And Plastics Company Inc. Delivery systems for pharmaceutical or therapeutic actives
US5300494A (en) 1986-06-06 1994-04-05 Union Carbide Chemicals & Plastics Technology Corporation Delivery systems for quaternary and related compounds
US5508031A (en) * 1986-11-21 1996-04-16 Cetus Oncology Corporation Method for treating biological damage using a free-radial scavenger and interleukin-2
DE3727896A1 (de) * 1987-08-21 1989-03-02 Degussa Verfahren zur herstellung von salzen des n-acetylcysteins oder -homocysteins
US5061729A (en) * 1988-06-08 1991-10-29 Biogal Gyogyszergyar Pharmaceutical composition and process for preparing the same
SE462779B (sv) * 1988-10-10 1990-09-03 Lejus Medical Ab Farmaceutisk komposition innehaallande n-acetylcystein i en kaerna belagd med hydroxipropylmetylcellulosaftalat
US5221722A (en) * 1988-11-28 1993-06-22 The B. F. Goodrich Company Crosslinked polyacrylic acid
US5580577A (en) * 1990-01-11 1996-12-03 Herzenberg; Leonard A. Method of treating the symptoms of human rhinovirus infection
US5256396A (en) * 1990-01-24 1993-10-26 Colgate-Palmolive Company Topical composition
US5593683A (en) * 1990-05-01 1997-01-14 Mdv Technologies, Inc. Method of making thermoreversible polyoxyalkylene gels
US5071644A (en) * 1990-08-07 1991-12-10 Mediventures, Inc. Topical drug delivery with thermo-irreversible gels
US5143731A (en) * 1990-08-07 1992-09-01 Mediventures Incorporated Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels
US5346703A (en) * 1990-08-07 1994-09-13 Mediventures, Inc. Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels
IT1250421B (it) * 1991-05-30 1995-04-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato con proprieta' bio-adesive.
US5296500A (en) * 1991-08-30 1994-03-22 The Procter & Gamble Company Use of N-acetyl-cysteine and derivatives for regulating skin wrinkles and/or skin atrophy
WO1993007856A1 (en) * 1991-10-16 1993-04-29 Richardson-Vicks, Inc. LOW pH AQUEOUS COSMETIC GEL CONTAINING NON-IONIC POLYACRYLAMIDE DERIVATIVES
US5318780A (en) * 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
IT1258781B (it) * 1992-01-16 1996-02-29 Zambon Spa Composizione farmaceutica oftalmica contenente n-acetilcisteina e polivinilalcol
US5466680A (en) * 1992-03-26 1995-11-14 Cytologics, Inc. Method and compositions for enhancing white blood cell functioning on a mucosal or cutaneous surface
US5286480A (en) 1992-06-29 1994-02-15 The Procter & Gamble Company Use of N-acetylated amino acid complexes in oral care compositions
IT1255460B (it) * 1992-07-28 1995-11-02 Poli Ind Chimica Spa Composizioni farmaceutiche in forma di microemulsioni o di dispersioni liposomiali bioadesive per la somministrazione transmucosale di sostanze peptidiche e di proteine farmacologicamente attive
US5817625A (en) * 1992-09-21 1998-10-06 Oncogene Science, Inc. Methods of prevention of oral mucositis with transforming growth factor beta
US5807894A (en) * 1992-12-02 1998-09-15 Zambon Group S.P.A. Syrup containing N-acetyl-cysteine
US5324746A (en) * 1993-02-12 1994-06-28 Mckee Rex N Method of treating damaged mucosal and epithelial tissues with misoprostol
US5637616A (en) * 1993-06-18 1997-06-10 Arcturus Pharmaceutical Corporation Method for treating diseases mediated by proteases
US5744155A (en) * 1993-08-13 1998-04-28 Friedman; Doron Bioadhesive emulsion preparations for enhanced drug delivery
US5490978A (en) * 1993-10-15 1996-02-13 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Block copolymers of polysaccharides and polyalkylene oxides
US5447712A (en) * 1993-12-09 1995-09-05 Free Radical Sciences Method of reducing cyclophosphamide induced hemorrhagic cystitis
US5458879A (en) * 1994-03-03 1995-10-17 The Procter & Gamble Company Oral vehicle compositions
US5541181A (en) * 1994-05-26 1996-07-30 Bristol-Myers Squibb Company Compound produced by a strain of micromonospora
US5597849A (en) * 1994-11-14 1997-01-28 Medical Polymer Technologies, Inc. Stick formulations for topical drug delivery of therapeutic agents and uses thereof
DE69509124T2 (de) * 1994-12-23 1999-11-25 Cookson Group Plc Verfahren zur korrosionshemmung von kupfer- und kupferlegierungen
US5939485A (en) * 1995-06-19 1999-08-17 Medlogic Global Corporation Responsive polymer networks and methods of their use
US6025326A (en) * 1995-07-07 2000-02-15 Intrabiotics Pharmaceuticals, Inc. Compositions and methods for the prevention and treatment of oral mucositis
US6150472A (en) * 1995-12-22 2000-11-21 Holland Biomaterials Group B.V. Multi-functional site containing polymers, and applications thereof
SE9601527D0 (sv) * 1996-04-23 1996-04-23 Pharmacia Ab Transdermally alministered acetylcysteine as mucolytic agent
US5869029A (en) * 1996-06-21 1999-02-09 Hercules Incorporated Dispersible water-soluble or water-swellable polymers and process for making toothpastes containing them
US6797729B1 (en) * 1996-06-28 2004-09-28 Baxter International Inc. Therapeutic glutamine and N-actyl-cysteine composition
CN1230123A (zh) * 1996-07-11 1999-09-29 荷兰发马克有限公司 含碱性药物的酸加成盐的药物组合物
US5861174A (en) * 1996-07-12 1999-01-19 University Technology Corporation Temperature sensitive gel for sustained delivery of protein drugs
EP1007533B1 (de) * 1996-08-27 2005-06-22 University Of Utah Research Foundation Biokonjugate und verabreichung von bioaktiven substanzen
US6743422B1 (en) * 1996-10-15 2004-06-01 Amgen, Inc. Keratinocyte growth factor-2 products
SE9604610D0 (sv) * 1996-12-16 1996-12-16 Noviscens Ab Medical composition
GB2320431B (en) * 1996-12-20 2000-08-30 Johnson & Johnson Medical Compositions for the treatment of chronic wounds
US6458373B1 (en) * 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
JP4578578B2 (ja) * 1997-01-13 2010-11-10 エモリー、ユニバーシティ インフルエンザ感染の治療用化合物及びそれらの組み合わせ
US6126930A (en) * 1997-02-13 2000-10-03 The Procter & Gamble Company Spray compositions
US5843881A (en) * 1997-02-13 1998-12-01 The Procter & Gamble Company Spray compositions
US20020198161A1 (en) * 1997-02-20 2002-12-26 Douglas E. Brash Therapeutic uses of antioxidants
US5904927A (en) * 1997-03-14 1999-05-18 Northeastern University Drug delivery using pH-sensitive semi-interpenetrating network hydrogels
US6197331B1 (en) * 1997-07-24 2001-03-06 Perio Products Ltd. Pharmaceutical oral patch for controlled release of pharmaceutical agents in the oral cavity
BR9814615A (pt) 1997-10-22 2001-10-16 Jens Ponikau Métodos e materiais para o tratamento e prevenção de inflamação do tecido da mucosa
WO1999026657A1 (en) * 1997-11-25 1999-06-03 Musc Foundation For Research Development Inhibitors of nitric oxide synthase
US6228347B1 (en) * 1997-12-01 2001-05-08 Thione International, Inc. Antioxidant gel for gingival conditions
US5994409A (en) * 1997-12-09 1999-11-30 U.S. Bioscience, Inc. Methods for treatment of neuro--and nephro--disorders and therapeutic toxicities using aminothiol compounds
US6238888B1 (en) * 1997-12-22 2001-05-29 Human Genone Sciences, Inc. Keratinocyte growth factor-2 formulations
EP0938896A1 (de) * 1998-01-15 1999-09-01 Novartis AG In Autoklaven behandelbare pharmazeutische Zusammensetzungen mit Komplexbildner
GB9812426D0 (en) * 1998-06-10 1998-08-05 Reckitt & Colmann Prod Ltd Improvements in or relating to organic compositions
FR2781156B1 (fr) * 1998-07-20 2001-06-29 Lafon Labor Composition pharmaceutique destinee notamment a la prevention et au traitement des radiomucites et des chimiomucites
AU747611B2 (en) * 1998-07-30 2002-05-16 E-Nutriceuticals, Inc. Novel chitosan-containing liquid compositions and methods for their preparation and use
WO2000007603A2 (en) * 1998-08-04 2000-02-17 Madash Llp End modified thermal responsive hydrogels
US6319513B1 (en) * 1998-08-24 2001-11-20 The Procter & Gamble Company Oral liquid mucoadhesive compounds
US6231889B1 (en) * 1998-09-21 2001-05-15 Chronorx, Llc Unit dosage forms for the treatment of herpes simplex
US5945089A (en) * 1998-11-05 1999-08-31 I-Dent International Corporation Method of treating mucositis
US6669927B2 (en) * 1998-11-12 2003-12-30 3M Innovative Properties Company Dental compositions
US20030229141A1 (en) * 1999-01-08 2003-12-11 Yu Ruey J. N-acetyl cysteine and its topical use
US6159485A (en) * 1999-01-08 2000-12-12 Yugenic Limited Partnership N-acetyl aldosamines, n-acetylamino acids and related n-acetyl compounds and their topical use
US6270781B1 (en) 1999-01-08 2001-08-07 Maxim Pharmaceuticals, Inc. Method and compositions for topical treatment of damaged tissue using reactive oxygen metabolite production or release inhibitors
US6159491A (en) * 1999-02-12 2000-12-12 Biovector Technologies, Inc. Prolonged release bioadhesive vaginal gel dosage form
US6194382B1 (en) * 1999-03-03 2001-02-27 Albert Einstein College Of Medicine Of Yeshiva University Method and composition for treating irritable bowel syndrome using low doses of opioid receptor antagonists
US6297337B1 (en) * 1999-05-19 2001-10-02 Pmd Holdings Corp. Bioadhesive polymer compositions
US6117415A (en) * 1999-06-17 2000-09-12 Alpharx Inc. Toothpaste comprising bioadhesive submicron emulsion for improved delivery of antibacterial and anticaries agents
US6309663B1 (en) * 1999-08-17 2001-10-30 Lipocine Inc. Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents
US6391860B1 (en) * 1999-09-09 2002-05-21 Mcgrath Patrick D. Method for preparation and use of paste formed by controlled reaction of sucralfate with hydrochloric acid
JP2003509350A (ja) * 1999-09-11 2003-03-11 ザ、プロクター、エンド、ギャンブル、カンパニー 注加可能な液体賦形剤
US6258342B1 (en) * 1999-11-03 2001-07-10 Hercules Incorporated Process for making toothpaste using agglomerated dispersible polymers
US6432415B1 (en) * 1999-12-17 2002-08-13 Axrix Laboratories, Inc. Pharmaceutical gel and aerosol formulations and methods to administer the same to skin and mucosal surfaces
US20010025027A1 (en) 2000-03-07 2001-09-27 Sonis Stephen T. Inhibition of ceramide for the prevention and treatment of oral mucositis induced by antineoplastic drugs or radiation
IT1318447B1 (it) 2000-04-04 2003-08-25 Paolo Farina Formulazioni per la rimozione della placca dentale e del tartaro.
DE60118172T2 (de) * 2000-04-26 2007-03-08 Oregon Health Sciences University, Portland Verabreichung von einer chemoschützenden verbindung,welche eine thiolgruppe enthält
PT1395289E (pt) * 2000-06-08 2011-03-16 Sang Dr Christine Tratamento da dor neuropática com antagonistas do receptor de n-metil-d-aspartato (nmda)
US20020013331A1 (en) * 2000-06-26 2002-01-31 Williams Robert O. Methods and compositions for treating pain of the mucous membrane
US6479068B1 (en) * 2000-06-30 2002-11-12 Baxter International Inc. Therapeutic nutrient regimen for alleviating mucositis, stomatitis and cachexia in oncology patients
FI121528B (fi) 2000-10-30 2010-12-31 Biohit Oyj Farmaseuttinen koostumus syöpään sairastumisen riskin vähentämiseen paikallisesti sitomalla asetaldehydi syljessä, mahalaukussa tai paksusuolessa
DE60117043T2 (de) * 2000-11-22 2006-07-13 Rxkinetix, Inc., Louisville Behandlung von mukositis
WO2002064113A1 (en) 2001-02-15 2002-08-22 Access Pharmaceuticals, Inc. Liquid formulations for the prevention and treatment of mucosal diseases and disorders
US6623754B2 (en) * 2001-05-21 2003-09-23 Noveon Ip Holdings Corp. Dosage form of N-acetyl cysteine
WO2003024391A2 (en) 2001-08-16 2003-03-27 Mucosal Therapeutics, Inc. Treatment and prevention of mucositis in cancer patients
US20040062764A1 (en) * 2001-08-30 2004-04-01 Neuwelt Edward A Chemoprotectant for gastric toxicity
US6857784B2 (en) * 2002-09-30 2005-02-22 Reliance Electric Technologies, Llc. Adapter mounted bearing assembly

Also Published As

Publication number Publication date
WO2002041837A3 (en) 2003-03-06
AU2002239342A1 (en) 2002-06-03
US20070071824A1 (en) 2007-03-29
EP1609468A3 (de) 2006-01-25
BR0115531A (pt) 2004-02-03
EP1609468A2 (de) 2005-12-28
WO2002041837A2 (en) 2002-05-30
EP1343492A2 (de) 2003-09-17
ATE316786T1 (de) 2006-02-15
US20070014861A1 (en) 2007-01-18
DK1343492T3 (da) 2006-03-06
US20070014860A1 (en) 2007-01-18
BRPI0115531B1 (pt) 2015-10-13
DE60117043T2 (de) 2006-07-13
MXPA03004546A (es) 2003-09-10
ES2254523T3 (es) 2006-06-16
US20040141949A1 (en) 2004-07-22
JP2004513957A (ja) 2004-05-13
JP4822652B2 (ja) 2011-11-24
EP1343492B1 (de) 2006-02-01
US20020119104A1 (en) 2002-08-29
US6685917B2 (en) 2004-02-03
EP1343492A4 (de) 2004-05-06

Similar Documents

Publication Publication Date Title
ATE316786T1 (de) Behandlung von mukositis
DE60235083D1 (de) Substituierte tetracyclin-verbindungen zur behandlung von malaria
ATE457166T1 (de) Orale zusammensetzungen zur behandlung von diabetes
DE60239707D1 (de) Antimikrobielle kationische peptide und diese enthaltende formulierungen
EE05419B1 (et) Asendatud oksasolidinoonid kombineeritud raviks
DE60023043D1 (de) (S,S)-Reboxetin zur Behandlung von Inkontinenz
AR020055A1 (es) Una composicion farmaceutica o cosmetica que contiene una sustancia de esmalte activa, usos de dicha composicion y un metodo para preparar la misma.
BR0207961A (pt) Combinação de análogos da epotilona e agentes quimioterápicos para o tratamento de doenças proliferativas
ATE444086T1 (de) Therapeutische zusammensetzungen und verfahren zur behandlung von periodontitis mit entzündunshemmenden mitteln
ATE220918T1 (de) Matrixprotein enthaltende zusammensetzungen zur wundheilung
CY1109361T1 (el) Υποκατεστημενες 4-αμινοκυκλοεξανολες
DE69116380T2 (de) Pharmazeutische zubereitung zur behandlung verlängerter gerinnungszeit
DE59813162D1 (de) Pharmazeutische zusammensetzung enthaltend clindamycin und clotrimazol, zur behandlung vaginaler infektionen
RS50148B (sr) Upotreba docetaksela za lečenje hepatoćelijskog karcinoma
BRPI0407178A (pt) Composição farmacêutica osteogênica
PT1001775E (pt) Medicamento contendo ioimbina e arginina para tratamento de disfuncao erectil
DE60031016D1 (de) Verwendung von Antiseptika zur Herstellung von Arzneimitteln zur Prophylaxe und Behandlung von Entzündungen im Korperinneren des Menschen
ATE321553T1 (de) Arzneimittel für hinterstrangataxie und zusammensetzung zur behandlung von hinterstrangataxie
ATE337790T1 (de) Verwendung von cortisol-sequestriermitteln zur behandlung von hypercortisolaemie-verwandten erkrankungen
DE60113895D1 (de) Verwendung von Tiludronsäure beim Geflügel zur Herstellung eines Arzneimittels zur Prophylaxe und Behandlung von Osteoporose
RU2002128309A (ru) Полимерная композиция для лечения гнойных ран
LT2002105A (en) Novel use of siberian fir oil

Legal Events

Date Code Title Description
8364 No opposition during term of opposition