DE60107435D1 - 2-adamantylethylamine und deren verwendung bei der behandlung von abnormalitäten in der glutamat transmission - Google Patents
2-adamantylethylamine und deren verwendung bei der behandlung von abnormalitäten in der glutamat transmissionInfo
- Publication number
- DE60107435D1 DE60107435D1 DE60107435T DE60107435T DE60107435D1 DE 60107435 D1 DE60107435 D1 DE 60107435D1 DE 60107435 T DE60107435 T DE 60107435T DE 60107435 T DE60107435 T DE 60107435T DE 60107435 D1 DE60107435 D1 DE 60107435D1
- Authority
- DE
- Germany
- Prior art keywords
- aryl
- alkyl
- aromatic heterocyclic
- adamantylethylamine
- heterocyclic groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- QQIDWRBNXQXUMI-UHFFFAOYSA-N 2-(2-adamantyl)ethanamine Chemical compound C1C(C2)CC3CC1C(CCN)C2C3 QQIDWRBNXQXUMI-UHFFFAOYSA-N 0.000 title 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 title 1
- 230000005540 biological transmission Effects 0.000 title 1
- 229930195712 glutamate Natural products 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 230000005856 abnormality Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 230000024587 synaptic transmission, glutamatergic Effects 0.000 abstract 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
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- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
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- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
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- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Psychology (AREA)
- Virology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Anesthesiology (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0018272 | 2000-07-25 | ||
GBGB0018272.5A GB0018272D0 (en) | 2000-07-25 | 2000-07-25 | Chemical compounds IV |
PCT/GB2001/003321 WO2002008219A2 (en) | 2000-07-25 | 2001-07-25 | 2-adamantylethylamines and their use in the treatment of conditions generally associated with abnormalities in glutamatergic transmission |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60107435D1 true DE60107435D1 (de) | 2004-12-30 |
DE60107435T2 DE60107435T2 (de) | 2005-12-15 |
Family
ID=9896338
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60107435T Expired - Fee Related DE60107435T2 (de) | 2000-07-25 | 2001-07-25 | 2-adamantylethylamine und deren verwendung bei der behandlung von abnormalitäten in der glutamat transmission |
Country Status (10)
Country | Link |
---|---|
US (1) | US6828318B2 (de) |
EP (1) | EP1305306B1 (de) |
JP (1) | JP2004504395A (de) |
AT (1) | ATE283268T1 (de) |
AU (1) | AU2001272666A1 (de) |
CA (1) | CA2415585A1 (de) |
DE (1) | DE60107435T2 (de) |
ES (1) | ES2233664T3 (de) |
GB (1) | GB0018272D0 (de) |
WO (1) | WO2002008219A2 (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200403066A (en) * | 2002-04-30 | 2004-03-01 | Novartis Ag | New uses of substituted aminoalkanephosphonic acids |
AU2003298514A1 (en) * | 2002-05-17 | 2004-05-04 | Eisai Co., Ltd. | Methods and compositions using cholinesterase inhibitors |
ATE411015T1 (de) * | 2003-10-22 | 2008-10-15 | Merz Pharma Gmbh & Co Kgaa | Verwendung von 1-aminocyclohexan-derivaten zur modifizierung der abscheidung von fibrillogenen as peptiden in amyloidpathien |
TW200531680A (en) * | 2004-03-03 | 2005-10-01 | Merz Pharma Gmbh & Co Kgaa | Therapy using 1-aminocyclohexane derivatives for the treatment of behavioral disorders associated with alzheimer's disease |
PT1820792E (pt) * | 2006-02-21 | 2012-04-10 | Hexal Ag | Processo para a preparação de adamantanaminas |
WO2008035049A1 (en) * | 2006-09-18 | 2008-03-27 | Merz Pharma Gmbh & Co. Kgaa | Adamantanyl-(cyclopropyl)-ketones as metabotropic glutamate receptor modulators |
MX2011003015A (es) | 2008-09-18 | 2011-11-18 | Univ Northwestern | Moduladores del receptor de n-metil-d-aspartato, y usos de los mismos. |
US8951968B2 (en) | 2009-10-05 | 2015-02-10 | Northwestern University | Methods of treating depression and other related diseases |
US9000047B2 (en) | 2010-05-24 | 2015-04-07 | Farmalider, S.A. | Compound inhibiting activation of the enzyme Erk 1/2 to be used in the treatment of neurodegenerative illnesses |
CA2834286A1 (en) * | 2011-04-27 | 2012-11-01 | Northwestern University | Methods of treating alzheimer's disease, huntington's disease, autism, and other disorders |
EA201591404A1 (ru) | 2013-01-29 | 2016-01-29 | Аптиникс Инк. | Спиролактамные модуляторы рецептора nmda и их применение |
WO2014120800A1 (en) | 2013-01-29 | 2014-08-07 | Naurex, Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
EA032153B1 (ru) | 2013-01-29 | 2019-04-30 | Аптиникс Инк. | Спиролактамные модуляторы nmda-рецептора и их применение |
LT3514158T (lt) | 2013-01-29 | 2023-02-10 | Aptinyx Inc. | Spirolaktaminiai nmda receptoriaus moduliatoriai ir jų panaudojimas |
BR112015018092A2 (pt) | 2013-01-29 | 2017-07-18 | Naurex Inc | moduladores de receptor de nmda de espiro-lactama e usos dos mesmos |
CN104844532A (zh) * | 2014-02-19 | 2015-08-19 | 周敬业 | 抗病毒化合物、其制备方法和用途 |
RU2605698C1 (ru) * | 2015-12-23 | 2016-12-27 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Волгоградский государственный технический университет" (ВолгГТУ) | Производные 2-(адамант-2-ил)этиламина, обладающие потенциальной противовирусной активностью |
WO2017201285A1 (en) | 2016-05-19 | 2017-11-23 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
MX2018014202A (es) | 2016-05-19 | 2019-06-20 | Aptinyx Inc | Moduladores del receptor espiro-lactama n-metil-d-aspartato y usos de los mismos. |
PE20190500A1 (es) | 2016-08-01 | 2019-04-10 | Aptinyx Inc | Moduladores del receptor nmda spiro-lactam y uso de los mismos |
BR112019001923A2 (pt) | 2016-08-01 | 2019-05-14 | Aptinyx Inc. | moduladores de nmda de espiro-lactama e métodos de sua utilização |
AU2017305240B2 (en) | 2016-08-01 | 2021-12-09 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
MX2019001322A (es) | 2016-08-01 | 2019-09-11 | Aptinyx Inc | Moduladores del receptor nmda spiro-lactam y bis-spiro-lactam y uso de los mismos. |
AU2017306152A1 (en) | 2016-08-01 | 2019-01-31 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
JP7210599B2 (ja) | 2018-01-31 | 2023-01-23 | アプティニックス インコーポレイテッド | スピロラクタム系nmda受容体修飾因子およびその使用 |
US12012413B2 (en) | 2019-11-11 | 2024-06-18 | Tenacia Biotechnology (Hong Kong) Co., Limited | Methods of treating painful diabetic peripheral neuropathy |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
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NL6900004A (de) | 1969-01-02 | 1970-07-06 | ||
WO1997023202A1 (en) * | 1995-12-22 | 1997-07-03 | STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of THE OREGON HEALTH SCIENCES UNIVERSITYA ND THE UNIVERSITY OF OREGON, EUGENE OREGON | Subtype-selective nmda receptor ligands and the use thereof |
CN1495160A (zh) * | 1997-12-16 | 2004-05-12 | ��ʲ | 1-取代-1-氨基甲基-环烷衍生物(=加巴喷丁类似物)、其制备及其在治疗神经病方面的用途 |
GB9802225D0 (en) | 1998-02-02 | 1998-04-01 | Cerebrus Ltd | Chemical compounds |
GB9901691D0 (en) | 1999-01-26 | 1999-03-17 | Cerebrus Ltd | Chemical compounds |
-
2000
- 2000-07-25 GB GBGB0018272.5A patent/GB0018272D0/en not_active Ceased
-
2001
- 2001-07-25 EP EP01951817A patent/EP1305306B1/de not_active Expired - Lifetime
- 2001-07-25 DE DE60107435T patent/DE60107435T2/de not_active Expired - Fee Related
- 2001-07-25 JP JP2002514125A patent/JP2004504395A/ja not_active Withdrawn
- 2001-07-25 ES ES01951817T patent/ES2233664T3/es not_active Expired - Lifetime
- 2001-07-25 US US10/333,952 patent/US6828318B2/en not_active Expired - Fee Related
- 2001-07-25 CA CA002415585A patent/CA2415585A1/en not_active Abandoned
- 2001-07-25 WO PCT/GB2001/003321 patent/WO2002008219A2/en active IP Right Grant
- 2001-07-25 AU AU2001272666A patent/AU2001272666A1/en not_active Abandoned
- 2001-07-25 AT AT01951817T patent/ATE283268T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO2002008219A3 (en) | 2002-06-13 |
CA2415585A1 (en) | 2002-01-31 |
DE60107435T2 (de) | 2005-12-15 |
US6828318B2 (en) | 2004-12-07 |
ATE283268T1 (de) | 2004-12-15 |
JP2004504395A (ja) | 2004-02-12 |
EP1305306B1 (de) | 2004-11-24 |
EP1305306A2 (de) | 2003-05-02 |
ES2233664T3 (es) | 2005-06-16 |
WO2002008219A2 (en) | 2002-01-31 |
GB0018272D0 (en) | 2000-09-13 |
US20030207881A1 (en) | 2003-11-06 |
AU2001272666A1 (en) | 2002-02-05 |
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