ES2120039T3 - Nuevos acildipeptidos heterociclicos, procedimientos de preparacion y composiciones farmaceuticas que los contienen. - Google Patents

Nuevos acildipeptidos heterociclicos, procedimientos de preparacion y composiciones farmaceuticas que los contienen.

Info

Publication number
ES2120039T3
ES2120039T3 ES94914681T ES94914681T ES2120039T3 ES 2120039 T3 ES2120039 T3 ES 2120039T3 ES 94914681 T ES94914681 T ES 94914681T ES 94914681 T ES94914681 T ES 94914681T ES 2120039 T3 ES2120039 T3 ES 2120039T3
Authority
ES
Spain
Prior art keywords
pct
group
acildipeptides
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94914681T
Other languages
English (en)
Inventor
Danijel Kikelj
Elizabeta Suhadolc
Alenka Rutar
Slavko Pecar
Alesa Puncuh
Uros Urleb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LJUBLJANI, University of
Lek Pharmaceuticals dd
Univerza Ljubljana v Fakulteta za Farmazijo
Original Assignee
LJUBLJANI, University of
Univerza Ljubljana v Fakulteta za Farmazijo
Lek Pharmaceuticals and Chemical Co dd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LJUBLJANI, University of, Univerza Ljubljana v Fakulteta za Farmazijo, Lek Pharmaceuticals and Chemical Co dd filed Critical LJUBLJANI, University of
Application granted granted Critical
Publication of ES2120039T3 publication Critical patent/ES2120039T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

LOS NUEVOS ACILDIPEPTIDOS HETEROCICLICOS DE LA FORMULA (I) EN LA QUE Z REPRESENTA UN ATOMO DE OXIGENO O DE AZUFRE O UN GRUPO CH2-R1 REPRESENTA HIDROGENO, UN GRUPO ALQUILO C1-4 DE CADENA LINEAL O RAMIFICADA, CICLOALQUILO, CICLOALQUILALQUILO, TRIFLUOMETILO O BENCILO; R2 REPRESENTA HIDROGENO, UN GRUPO ALQUILO C1-4 DE CADENA LINEAL O RAMIFICADA, CICLOALQUILO, ALQUILCICLOALQUILO, DIALQUILAMINOALQUILO, ACILAMINOALQUILO O BENCILO; R3 REPRESENTA HIDROGENO, UN GRUPO ALQUILO C1-12 DE CADENA LINEAL O RAMIFICADA O TRIFLUOMETILO; R4 Y R5, QUE SON IDENTICOS O DIFERENTES, REPRESENTAN UN GRUPO OR6 O NHR6, EN DONDE R6 ES HIDROGENO, UN GRUPO ALQUILO C1-8 DE CADENA LINEAL O RAMIFICADA O BENCILO; Y REPRESENTA UN GRUPO -CH2-, =CH- O =N-; A REPRESENTA UN GRUPO -(CH2,3- CUANDO Y ES -CH2-, LOS DOS ANILLOS ESTAN TRANS-CONDENSADOS, O UN GRUPO (A) O (B), EN DONDE R7 REPRESENTA H, F, BR, CL, UN GRUPO ALQUILO C1-4 DE CADENA LINEAL O RAMIFICADA, ALCOXI C1-4, TRIFLUOMETILO, NITRO, AMINO, ALQUILAMINO O DIALQUILAMINO, CUANDO Y ES =CH- O =N-; SE PREPARAN HACIENDO REACCIONAR EL ACIDO CARBOXILICO HETEROCICLICO CORRESPONDIENTE CON LOS DIPEPTIDOS CORRESPONDIENTES UTILIZANDO REACTIVOS COMUNES PARA LA FORMACION DEL ENLACE PEPTIDO. LOS ACILDIPEPTIDOS HETEROCICLICOS DE LA FORMULA (I) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES SON UTILES COMO COMPUESTOS ACTIVOS PARA MEDICAMENTOS PUES POSEEN UNA ACTIVIDAD INMUNOESTIMULADORA Y ANTITUMORAL.
ES94914681T 1993-04-22 1994-04-21 Nuevos acildipeptidos heterociclicos, procedimientos de preparacion y composiciones farmaceuticas que los contienen. Expired - Lifetime ES2120039T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SI9300212A SI9300212A (en) 1993-04-22 1993-04-22 Novel N-acyldipeptides, process for the preparation thereof and pharmaceutical composition containing the same

Publications (1)

Publication Number Publication Date
ES2120039T3 true ES2120039T3 (es) 1998-10-16

Family

ID=20431165

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94914681T Expired - Lifetime ES2120039T3 (es) 1993-04-22 1994-04-21 Nuevos acildipeptidos heterociclicos, procedimientos de preparacion y composiciones farmaceuticas que los contienen.

Country Status (8)

Country Link
US (1) US5824652A (es)
EP (1) EP0695308B1 (es)
JP (1) JP2886987B2 (es)
AT (1) ATE167873T1 (es)
DE (1) DE69411380T2 (es)
ES (1) ES2120039T3 (es)
SI (1) SI9300212A (es)
WO (1) WO1994024152A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009010606A1 (es) * 2007-07-19 2009-01-22 Universidad De Cádiz Derivados 2-alquil-2h-1,4-benzoxacin-3(4h)-ona y 2-alcoxicarbonil-2h-1,4- benzoxacin-3(4h)-ona, con actividad fítotóxica

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2326930A1 (fr) * 1975-10-09 1977-05-06 Anvar Agents hydrosolubles depresseurs non specifiques des reponses immunitaires
US4322341A (en) * 1980-05-13 1982-03-30 Fujisawa Pharmaceutical Co Peptide, process for preparation thereof and use thereof
YU183090A (sh) * 1990-09-27 1992-12-21 Lek Novi n-acildipeptidi, postopki za njihovo pripravo in farmacevtski pripravki, kojih vsebujejo
US5321216A (en) * 1991-04-09 1994-06-14 Otis Elevator Company Restraining elevator car motion while the doors are open

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009010606A1 (es) * 2007-07-19 2009-01-22 Universidad De Cádiz Derivados 2-alquil-2h-1,4-benzoxacin-3(4h)-ona y 2-alcoxicarbonil-2h-1,4- benzoxacin-3(4h)-ona, con actividad fítotóxica

Also Published As

Publication number Publication date
WO1994024152A1 (en) 1994-10-27
DE69411380D1 (de) 1998-08-06
EP0695308A1 (en) 1996-02-07
SI9300212A (en) 1994-12-31
US5824652A (en) 1998-10-20
ATE167873T1 (de) 1998-07-15
JPH09506856A (ja) 1997-07-08
JP2886987B2 (ja) 1999-04-26
EP0695308B1 (en) 1998-07-01
DE69411380T2 (de) 1999-04-01

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