DE69402935D1 - Substituierte arylalkylaminobenzyl-aminopropanamide, ihre herstellung und verwendung als antiepileptische, neuroprotektive und antidepressive mittel - Google Patents

Substituierte arylalkylaminobenzyl-aminopropanamide, ihre herstellung und verwendung als antiepileptische, neuroprotektive und antidepressive mittel

Info

Publication number
DE69402935D1
DE69402935D1 DE69402935T DE69402935T DE69402935D1 DE 69402935 D1 DE69402935 D1 DE 69402935D1 DE 69402935 T DE69402935 T DE 69402935T DE 69402935 T DE69402935 T DE 69402935T DE 69402935 D1 DE69402935 D1 DE 69402935D1
Authority
DE
Germany
Prior art keywords
hydrogen
neuroprotective
pileptic
arylalkylaminobenzyl
aminopropanamides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69402935T
Other languages
English (en)
Other versions
DE69402935T2 (de
Inventor
Mario Varasi
Philippe Dostert
Paolo Pevarello
Alberto Bonsignori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Newron Pharmaceuticals SpA
Original Assignee
Pharmacia and Upjohn SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn SpA filed Critical Pharmacia and Upjohn SpA
Publication of DE69402935D1 publication Critical patent/DE69402935D1/de
Application granted granted Critical
Publication of DE69402935T2 publication Critical patent/DE69402935T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, ***e
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69402935T 1993-04-01 1994-03-15 Substituierte arylalkylaminobenzyl-aminopropanamide, ihre herstellung und verwendung als antiepileptische, neuroprotektive und antidepressive mittel Expired - Fee Related DE69402935T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939306899A GB9306899D0 (en) 1993-04-01 1993-04-01 Substituted (arylalkylaminobenzyl) aminopropionamide derivatives and process for their preparation
PCT/EP1994/000825 WO1994022809A1 (en) 1993-04-01 1994-03-15 Substituted (arylalkylaminobenzyl)aminopropionamide derivatives, their preparation and use anti-epileptic, neuroprotective and antidepressant agents

Publications (2)

Publication Number Publication Date
DE69402935D1 true DE69402935D1 (de) 1997-06-05
DE69402935T2 DE69402935T2 (de) 1997-11-20

Family

ID=10733226

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69402935T Expired - Fee Related DE69402935T2 (de) 1993-04-01 1994-03-15 Substituierte arylalkylaminobenzyl-aminopropanamide, ihre herstellung und verwendung als antiepileptische, neuroprotektive und antidepressive mittel

Country Status (21)

Country Link
US (1) US5449692A (de)
EP (1) EP0648202B1 (de)
JP (1) JP3542600B2 (de)
KR (1) KR950701905A (de)
CN (1) CN1035939C (de)
AT (1) ATE152442T1 (de)
AU (1) AU667169B2 (de)
CA (1) CA2136008C (de)
DE (1) DE69402935T2 (de)
DK (1) DK0648202T3 (de)
ES (1) ES2104370T3 (de)
FI (1) FI945582A0 (de)
GB (1) GB9306899D0 (de)
GR (1) GR3024150T3 (de)
HU (1) HUT70944A (de)
IL (1) IL108970A0 (de)
NZ (1) NZ263183A (de)
PL (1) PL306538A1 (de)
RU (1) RU94046144A (de)
WO (1) WO1994022809A1 (de)
ZA (1) ZA941964B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9515412D0 (en) * 1995-07-27 1995-09-27 Pharmacia Spa 2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives
IT1283489B1 (it) * 1996-07-23 1998-04-21 Chiesi Farma Spa Ammidi di alfa-amminoacidi,loro preparazione e loro impiego terapeutico
WO1999026614A1 (en) 1997-11-21 1999-06-03 Euro-Celtique S.A. Substituted 2-aminoacetamides and the use thereof
GB9727523D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
US6281211B1 (en) 1999-02-04 2001-08-28 Euro-Celtique S.A. Substituted semicarbazides and the use thereof
EP1169060B1 (de) * 1999-04-09 2005-08-31 Euro-Celtique S.A. Natrium kanalblocker zusammensetzungen und deren verwendung
DK1423168T3 (da) 2001-09-03 2006-05-15 Newron Pharm Spa Farmaceutisk præparat omfattende gabapentin eller en analog deraf og et alfa-aminoamid og dets analgetiske anvendelse
EP1438956A1 (de) * 2003-01-16 2004-07-21 Newron Pharmaceuticals S.p.A. Alpha-Aminoamidderivate die als Antimigränemittel nützlich sind
ES2347581T3 (es) * 2004-09-10 2010-11-02 Newron Pharmaceuticals S.P.A. Uso de (r)-(halobenciloxi)bencilamino-propanamidas como moduladores selectivos del canal de sodio y/o calcio.
EP1943231A1 (de) * 2005-10-26 2008-07-16 Boehringer Ingelheim International Gmbh (hetero)aryl-verbindungen mit mch-antagonistischer wirkung und medikamente mit diesen verbindungen

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1140748A (en) * 1966-06-23 1969-01-22 Ici Ltd New carboxylic acid derivatives
US4049663A (en) * 1972-06-06 1977-09-20 Allen & Hanburys Limited Ethylene diamine derivatives
DE3050800C2 (de) * 1979-03-22 1989-06-22 Continental Pharma Inc., Bruessel/Bruxelles, Be
FR2480747A1 (fr) * 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique
US4839369A (en) * 1985-04-16 1989-06-13 Rorer Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4631287A (en) * 1985-04-16 1986-12-23 Usv Pharmaceutical Corp. Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4725619A (en) * 1985-04-16 1988-02-16 Usv Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4728668A (en) * 1985-04-16 1988-03-01 Usv Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
IL94466A (en) * 1989-05-25 1995-01-24 Erba Carlo Spa Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation

Also Published As

Publication number Publication date
CN1035939C (zh) 1997-09-24
AU6377694A (en) 1994-10-24
JPH08504828A (ja) 1996-05-28
PL306538A1 (en) 1995-04-03
AU667169B2 (en) 1996-03-07
JP3542600B2 (ja) 2004-07-14
FI945582A (fi) 1994-11-28
FI945582A0 (fi) 1994-11-28
GR3024150T3 (en) 1997-10-31
CN1104018A (zh) 1995-06-21
IL108970A0 (en) 1994-06-24
EP0648202B1 (de) 1997-05-02
ZA941964B (en) 1994-10-19
WO1994022809A1 (en) 1994-10-13
CA2136008C (en) 2005-06-14
US5449692A (en) 1995-09-12
RU94046144A (ru) 1996-09-27
KR950701905A (ko) 1995-05-17
ATE152442T1 (de) 1997-05-15
CA2136008A1 (en) 1994-10-13
DK0648202T3 (da) 1997-10-27
DE69402935T2 (de) 1997-11-20
NZ263183A (en) 1996-02-27
ES2104370T3 (es) 1997-10-01
GB9306899D0 (en) 1993-05-26
HU9403809D0 (en) 1995-02-28
HUT70944A (en) 1995-11-28
EP0648202A1 (de) 1995-04-19

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NEWRON PHARMACEUTICALS S.P.A., GERENZANO (VARESE),

8339 Ceased/non-payment of the annual fee