LT3514158T - Spirolaktaminiai nmda receptoriaus moduliatoriai ir jų panaudojimas - Google Patents

Spirolaktaminiai nmda receptoriaus moduliatoriai ir jų panaudojimas

Info

Publication number
LT3514158T
LT3514158T LTEP19161143.3T LT19161143T LT3514158T LT 3514158 T LT3514158 T LT 3514158T LT 19161143 T LT19161143 T LT 19161143T LT 3514158 T LT3514158 T LT 3514158T
Authority
LT
Lithuania
Prior art keywords
spiro
nmda receptor
receptor modulators
lactam nmda
lactam
Prior art date
Application number
LTEP19161143.3T
Other languages
English (en)
Inventor
John A. Lowe Iii
M. Amin Khan
Original Assignee
Aptinyx Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aptinyx Inc. filed Critical Aptinyx Inc.
Publication of LT3514158T publication Critical patent/LT3514158T/lt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
LTEP19161143.3T 2013-01-29 2014-01-29 Spirolaktaminiai nmda receptoriaus moduliatoriai ir jų panaudojimas LT3514158T (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361757903P 2013-01-29 2013-01-29

Publications (1)

Publication Number Publication Date
LT3514158T true LT3514158T (lt) 2023-02-10

Family

ID=50071821

Family Applications (2)

Application Number Title Priority Date Filing Date
LTEP19161143.3T LT3514158T (lt) 2013-01-29 2014-01-29 Spirolaktaminiai nmda receptoriaus moduliatoriai ir jų panaudojimas
LTEP14703747.7T LT2951183T (lt) 2013-01-29 2014-01-29 Spiro-laktamo nmda receptorių moduliatoriai ir jų panaudojimas

Family Applications After (1)

Application Number Title Priority Date Filing Date
LTEP14703747.7T LT2951183T (lt) 2013-01-29 2014-01-29 Spiro-laktamo nmda receptorių moduliatoriai ir jų panaudojimas

Country Status (28)

Country Link
US (8) US9512134B2 (lt)
EP (2) EP2951183B1 (lt)
JP (2) JP2016506958A (lt)
KR (1) KR102280616B1 (lt)
CN (1) CN105229011B (lt)
AU (1) AU2014212484B2 (lt)
BR (1) BR112015018087B1 (lt)
CA (1) CA2898861C (lt)
CL (2) CL2015002121A1 (lt)
CY (1) CY1121675T1 (lt)
DK (1) DK2951183T3 (lt)
EA (1) EA032649B1 (lt)
ES (2) ES2935352T3 (lt)
HK (1) HK1218417A1 (lt)
HR (2) HRP20221545T1 (lt)
HU (1) HUE043843T2 (lt)
IL (1) IL240163B (lt)
LT (2) LT3514158T (lt)
MX (1) MX2015009786A (lt)
MY (1) MY188450A (lt)
PE (1) PE20151416A1 (lt)
PH (1) PH12015501601B1 (lt)
PL (1) PL2951183T3 (lt)
PT (2) PT3514158T (lt)
SG (1) SG11201505860XA (lt)
SI (2) SI2951183T1 (lt)
TR (1) TR201908596T4 (lt)
WO (1) WO2014120783A1 (lt)

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AU2014212501A1 (en) 2013-01-29 2015-07-30 Aptinyx, Inc. Spiro-lactam NMDA receptor modulators and uses thereof
AU2014212485C1 (en) 2013-01-29 2018-10-25 Aptinyx, Inc. Spiro-lactam NMDA receptor modulators and uses thereof
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WO2019152696A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
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WO2019152685A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and methods of using same
WO2019152687A1 (en) 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
WO2019152688A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
EP3986399A4 (en) * 2019-06-24 2023-06-07 Naurex Inc. SOLID FORMS OF TERT-BUTYL (S)-2-((2S,3R)-1-AMINO-3-HYDROXY-1-OXOBU TAN-2-YL)-1-OXO -2, 5-DIAZASPIRO[3,4 ]OCTANE-5-CARBOXYLATE AND METHODS FOR THE PREPARATION THEREOF
EP3986400A4 (en) * 2019-06-24 2023-05-17 Naurex Inc. METHODS AND INTERMEDIATES FOR THE PRODUCTION OF DIAZASPIROLACTAM COMPOUNDS
AU2020323543A1 (en) * 2019-08-01 2022-02-24 Aptinyx Inc. Methods of treating disorders associated with elevated levels of antibodies that interact with the NMDA receptor
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Also Published As

Publication number Publication date
PH12015501601A1 (en) 2015-10-19
MX2015009786A (es) 2015-12-11
LT2951183T (lt) 2019-05-27
EP2951183A1 (en) 2015-12-09
US20160289240A1 (en) 2016-10-06
WO2014120783A1 (en) 2014-08-07
PL2951183T3 (pl) 2019-08-30
DK2951183T3 (da) 2019-06-03
US10441572B2 (en) 2019-10-15
IL240163A0 (en) 2015-09-24
PH12015501601B1 (en) 2015-10-19
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HRP20190613T1 (hr) 2019-06-28
CL2015002121A1 (es) 2015-12-04
EA201591401A1 (ru) 2018-01-31
HK1218417A1 (zh) 2017-02-17
EP3514158B1 (en) 2022-10-12
AU2014212484B2 (en) 2018-01-04
US20170231956A1 (en) 2017-08-17
SI2951183T1 (sl) 2019-07-31
CN105229011B (zh) 2018-02-06
AU2014212484A1 (en) 2015-07-30
KR20150110790A (ko) 2015-10-02
SG11201505860XA (en) 2015-08-28
US20200206189A1 (en) 2020-07-02
EP3514158A1 (en) 2019-07-24
KR102280616B1 (ko) 2021-07-21
US20220151992A1 (en) 2022-05-19
CA2898861A1 (en) 2014-08-07
PT3514158T (pt) 2023-01-13
BR112015018087B1 (pt) 2022-09-20
US20180250268A1 (en) 2018-09-06
SI3514158T1 (sl) 2023-03-31
CL2015002125A1 (es) 2015-12-04
US20160122359A1 (en) 2016-05-05
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US10052308B2 (en) 2018-08-21
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US9504670B2 (en) 2016-11-29
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EA032649B1 (ru) 2019-06-28
US9579304B2 (en) 2017-02-28
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US9512134B2 (en) 2016-12-06

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