DE60041255D1 - Polyionische beschichtungen für analytische und sensor-vorrichtungen - Google Patents

Polyionische beschichtungen für analytische und sensor-vorrichtungen

Info

Publication number
DE60041255D1
DE60041255D1 DE60041255T DE60041255T DE60041255D1 DE 60041255 D1 DE60041255 D1 DE 60041255D1 DE 60041255 T DE60041255 T DE 60041255T DE 60041255 T DE60041255 T DE 60041255T DE 60041255 D1 DE60041255 D1 DE 60041255D1
Authority
DE
Germany
Prior art keywords
analyte
multifunctional
side chains
polyionic
copolymers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60041255T
Other languages
English (en)
Inventor
Jeffrey A Hubbell
Marcus Textor
Donald L Elbert
Stephanie Finken
Laurence Ruiz-Taylor
Nicholas D Spencer
Rolf Hofer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eidgenoessische Technische Hochschule Zurich ETHZ
Universitaet Zuerich
Original Assignee
Eidgenoessische Technische Hochschule Zurich ETHZ
Universitaet Zuerich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eidgenoessische Technische Hochschule Zurich ETHZ, Universitaet Zuerich filed Critical Eidgenoessische Technische Hochschule Zurich ETHZ
Application granted granted Critical
Publication of DE60041255D1 publication Critical patent/DE60041255D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y10S435/815—Enzyme separation or purification by sorption
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/961—Chemistry: molecular biology and microbiology including a step of forming, releasing, or exposing the antigen or forming the hapten-immunogenic carrier complex or the antigen per se
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/969—Multiple layering of reactants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/819—Multifunctional antigen or antibody
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/823—Immunogenic carrier or carrier per se
DE60041255T 1999-04-28 2000-04-28 Polyionische beschichtungen für analytische und sensor-vorrichtungen Expired - Lifetime DE60041255D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US13139199P 1999-04-28 1999-04-28
US13140299P 1999-04-28 1999-04-28
US18461600P 2000-02-24 2000-02-24
PCT/US2000/011708 WO2000065352A1 (en) 1999-04-28 2000-04-28 Polyionic coatings in analytic and sensor devices

Publications (1)

Publication Number Publication Date
DE60041255D1 true DE60041255D1 (de) 2009-02-12

Family

ID=27384152

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60041255T Expired - Lifetime DE60041255D1 (de) 1999-04-28 2000-04-28 Polyionische beschichtungen für analytische und sensor-vorrichtungen

Country Status (8)

Country Link
US (1) US6884628B2 (de)
EP (1) EP1190252B1 (de)
JP (1) JP4647792B2 (de)
AT (1) ATE419528T1 (de)
AU (1) AU769571B2 (de)
CA (1) CA2371011C (de)
DE (1) DE60041255D1 (de)
WO (1) WO2000065352A1 (de)

Families Citing this family (241)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
DE60027309T2 (de) 1999-07-02 2006-08-31 Symyx Technologies, Inc., Santa Clara Polymerverzweigungen zur immobilisierung von molekülen auf oberflächen oder substraten, wobei die polymere wasserlösliche oder wasserdispergierbare segmente und sonden aufweisen
US20030059809A1 (en) * 1999-12-17 2003-03-27 Todor Vujasinovic Biochips,preparation and uses
US7163712B2 (en) * 2000-03-03 2007-01-16 Duke University Microstamping activated polymer surfaces
US6406777B1 (en) * 2000-06-14 2002-06-18 The United States Of America As Represented By The Secretary Of The Navy Metal and glass structure for use in surface enhanced Raman spectroscopy and method for fabricating same
DE10036907B4 (de) * 2000-07-28 2012-03-22 Xantec Bioanalytics Gmbh Verfahren zur Herstellung einer Beschichtung auf einem mit Gold bedampften Glassubstrat, Beschichtung hergestellt nach diesem Verfahren und deren Verwendung
US7678539B2 (en) * 2000-08-10 2010-03-16 Corning Incorporated Arrays of biological membranes and methods and use thereof
US7393698B2 (en) * 2000-08-21 2008-07-01 National Institute Of Advanced Industrial Science And Technology Magnetic fine particles and process for producing the same
US7205161B2 (en) 2001-01-10 2007-04-17 Symyx Technologies, Inc. Polymer brushes for immobilizing molecules to a surface or substrate having improved stability
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
CA2440656A1 (en) * 2001-03-09 2002-09-19 Apollo Biotechnology, Inc. Conjugate probes and optical detection of analytes
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US6844028B2 (en) 2001-06-26 2005-01-18 Accelr8 Technology Corporation Functional surface coating
US7501157B2 (en) * 2001-06-26 2009-03-10 Accelr8 Technology Corporation Hydroxyl functional surface coating
US6989267B2 (en) 2001-07-02 2006-01-24 Agilent Technologies, Inc. Methods of making microarrays with substrate surfaces having covalently bound polyelectrolyte films
CA2453141A1 (en) * 2001-07-09 2003-01-23 Arizona Board Of Regents A Body Corporate Acting On Behalf Of Arizona State University Afinity biosensor for monitoring of biological process
AU2002338007A1 (en) * 2001-08-27 2003-03-18 Zeptosens Ag Surface for the immobilisation of nucleic acids
AU2002361223A1 (en) * 2001-08-27 2003-03-18 Zeptosens Ag Bioanalytical recognition surface with optimised recognition element density
US9671396B2 (en) * 2001-09-05 2017-06-06 Joon Won Park Solid substrate comprising array of dendrons and methods for using the same
EP1425583A1 (de) * 2001-09-12 2004-06-09 Eidgenössische Technische Hochschule Zürich Vorrichtung mit chemisch strukturierten oberflächen
WO2003027674A1 (fr) * 2001-09-21 2003-04-03 Takara Bio Inc. Support pour l'immobilisation des ligands
FI118061B (fi) 2001-09-24 2007-06-15 Beanor Oy Menetelmä ja bioanturi analyysiä varten
ATE337546T1 (de) * 2001-12-21 2006-09-15 Imec Inter Uni Micro Electr Verfahren zum nachweis eines analyten
US8043868B2 (en) * 2001-12-21 2011-10-25 Imec Method and apparatus for detecting an analyte
JP2005513479A (ja) * 2001-12-21 2005-05-12 センス プロテオミック リミテッド 質量分析用のプローブ
FI115166B (fi) 2001-12-31 2005-03-15 Biofons Oy Diagnostisia menetelmiä
US7635463B2 (en) 2002-02-27 2009-12-22 Pharmain Corporation Compositions for delivery of therapeutics and other materials
US7138105B2 (en) * 2002-02-27 2006-11-21 Pharmain Compositions for delivery of therapeutics and other materials, and methods of making and using the same
US20050260259A1 (en) * 2004-04-23 2005-11-24 Bolotin Elijah M Compositions for treatment with glucagon-like peptide, and methods of making and using the same
WO2003072156A1 (en) * 2002-02-28 2003-09-04 Eidgenössische Technische Hochschule Zürich Oberflächentechnik Biomedical implant surfaces with osteogenic properties
WO2003087823A1 (de) * 2002-04-12 2003-10-23 Micronas Gmbh Verfahren zum immobilisieren von molekülen auf oberflächen
WO2003089551A2 (en) * 2002-04-16 2003-10-30 Eidgenossisch Technische Hochschule Zurich Environmentally compatible additives for aqueous lubricants
US20030198967A1 (en) * 2002-04-23 2003-10-23 Matson Robert S. Multi-functional microarrays and methods
US7010182B2 (en) * 2002-07-31 2006-03-07 Luna Innovations Incorporated Biosensors having enhanced environmental sensitivity
US7998699B2 (en) 2002-08-15 2011-08-16 University Of South Florida Early detection of pathogens in blood
US7384742B2 (en) * 2002-08-16 2008-06-10 Decision Biomarkers, Inc. Substrates for isolating reacting and microscopically analyzing materials
US20090118605A1 (en) * 2002-08-30 2009-05-07 Northwestern University Surface-enhanced raman nanobiosensor
US20040043508A1 (en) * 2002-09-03 2004-03-04 Frutos Anthony G. Polymer-coated substrates for binding biological molecules
US20040062882A1 (en) * 2002-09-30 2004-04-01 Andrea Liebmann-Vinson Cell adhesion resisting surfaces
ES2208121B1 (es) * 2002-11-29 2005-08-16 Consejo Sup. Investig. Cientificas Anticuerpos y antigenos inmovilizados sobre particulas magneticas de silice como biosensores.
US7070922B2 (en) * 2002-12-04 2006-07-04 International Business Machines Corporation Surface treatment
US20040121339A1 (en) * 2002-12-19 2004-06-24 Jizhong Zhou Special film-coated substrate for bio-microarray fabrication and use thereof
CN100347545C (zh) * 2003-04-08 2007-11-07 成都夸常科技有限公司 一种对样品中的目标物进行定性和/或定量分析的方法及其检测装置
JP4006523B2 (ja) * 2003-04-10 2007-11-14 独立行政法人産業技術総合研究所 タンパク質アレイ及びその作製方法
CA2515850A1 (en) * 2003-04-14 2004-10-28 Caliper Life Sciences, Inc. Reduction of migration shift assay interference
DE10320312A1 (de) * 2003-05-06 2004-12-02 Friz Biochem Gmbh Substrat als Träger von Ligaten
US20040228766A1 (en) * 2003-05-14 2004-11-18 Witty Thomas R. Point of care diagnostic platform
US7160867B2 (en) * 2003-05-16 2007-01-09 Isotechnika, Inc. Rapamycin carbohydrate derivatives
WO2005011867A2 (en) 2003-07-31 2005-02-10 Handylab, Inc. Processing particle-containing samples
US9206414B2 (en) * 2003-08-13 2015-12-08 Axcelon Biopolymers Corporation Anisotropic nanocomposite hydrogel
DE602004020999D1 (de) 2003-08-15 2009-06-18 Univ South Florida Materialien und verfahren zum einfangen von krankheitserregern und zur abtrennung von aurintricarbonsäure aus einer probe
US20050070027A1 (en) * 2003-09-30 2005-03-31 Jacques Gollier Double resonance interrogation of grating-coupled waveguides
JP2006514299A (ja) * 2003-10-27 2006-04-27 センス プロテオミック リミテッド 酵素アレイ及びアッセイ
WO2005051905A2 (en) * 2003-11-19 2005-06-09 Massachusetts Institute Of Technology Large-area two-dimensional non-adhesive cell arrays for sensing and cell-sorting applications
US7510942B2 (en) * 2003-11-25 2009-03-31 Arizona Board Of Regents, Acting For And On Behalf Of Arizona State University Molecular modifications of metal/dielectric interfaces
US20050131513A1 (en) * 2003-12-16 2005-06-16 Cook Incorporated Stent catheter with a permanently affixed conductor
WO2005072764A2 (en) * 2004-01-16 2005-08-11 Novocell, Inc. Fibrin-bound angiogenic factors to stimulate vascularization of transplant site of encapsulated cells
US7723126B2 (en) * 2004-03-24 2010-05-25 Wisconsin Alumni Research Foundation Plasma-enhanced functionalization of inorganic oxide surfaces
JP4535490B2 (ja) * 2004-04-09 2010-09-01 株式会社資生堂 蛋白質吸着防止方法
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
CA2994321C (en) 2004-05-03 2023-08-08 Handylab, Inc. A microfluidic device and methods for processing polynucleotide-containing samples
CA2566897A1 (en) * 2004-05-21 2005-12-01 Mds Inc. Doing Business Through Its Mds Pharma Services Division Method of quantifying the cell-binding properties of a medical device
ATE462451T1 (de) * 2004-06-16 2010-04-15 Affinergy Inc Grenzflächenbiomaterialien zur förderung der anhaftung von zielanalyten
US10150945B2 (en) * 2004-07-23 2018-12-11 Jnc Corporation Cell culture device and manufacturing method therof
US20060029961A1 (en) * 2004-08-04 2006-02-09 Goh M C Patterned surfaces and their use in diffraction-based sensing
US7595157B2 (en) * 2004-08-19 2009-09-29 Biocept, Inc. Microarrays utilizing hydrogels
EP1799626B1 (de) * 2004-10-12 2012-01-18 Schott AG Gemultiplexter proteinadsorptions-assay
US20060110594A1 (en) * 2004-11-24 2006-05-25 Frutos Anthony G Polymer-coated substrates for binding biomolecules and methods of making and using thereof
JP4585523B2 (ja) 2004-12-28 2010-11-24 独立行政法人科学技術振興機構 自己組織化材料または微粒子を基板上に固定化する方法、および当該方法を用いて作製した基板
US20060141527A1 (en) * 2004-12-29 2006-06-29 Caracci Stephen J Method for creating a reference region and a sample region on a biosensor and the resulting biosensor
US7604984B2 (en) * 2004-12-29 2009-10-20 Corning Incorporated Spatially scanned optical reader system and method for using same
US7629173B2 (en) 2004-12-29 2009-12-08 Corning Incorporated Optical reader system and method for monitoring and correcting lateral and angular misalignments of label independent biosensors
US20060240478A1 (en) * 2005-02-23 2006-10-26 Fuji Photo Film Co., Ltd. Biosensor
JP2006335912A (ja) * 2005-06-03 2006-12-14 Fujifilm Holdings Corp 生理活性物質固定化剤
WO2006102756A1 (en) 2005-03-30 2006-10-05 University Western Ontario Anisotropic hydrogels
JP2006271860A (ja) * 2005-03-30 2006-10-12 Japan Lifeline Co Ltd 医療用具及びその製造方法
WO2006113785A2 (en) * 2005-04-18 2006-10-26 Brigham Young University Laser modification and functionalization of substrates
ES2525324T3 (es) 2005-04-26 2014-12-22 Bayer Intellectual Property Gmbh Nuevo aparato y procedimiento de recubrimiento de sustratos portadores para la detección de analitos mediante un procedimiento de detección por afinidad
US7723438B2 (en) * 2005-04-28 2010-05-25 International Business Machines Corporation Surface-decorated polymeric amphiphile porogens for the templation of nanoporous materials
US20070009568A1 (en) * 2005-06-03 2007-01-11 Bhatnagar Rajendra S Methods for immobilizing molecules on surfaces
US8475886B2 (en) * 2005-08-05 2013-07-02 Corning Incorporated Methods for producing surfaces that resist non-specific protein binding and cell attachment
US7713689B2 (en) * 2005-09-15 2010-05-11 Duke University Non-fouling polymeric surface modification and signal amplification method for biomolecular detection
US7763423B2 (en) * 2005-09-30 2010-07-27 Pacific Biosciences Of California, Inc. Substrates having low density reactive groups for monitoring enzyme activity
JP4818056B2 (ja) * 2005-10-07 2011-11-16 キヤノン株式会社 標的物質を捕捉する捕捉分子を結合させるための結合用官能基を基体上に備えた構造体
US20090148346A1 (en) * 2005-10-07 2009-06-11 Canon Kabushiki Kaisha Substrate with binding functional group
US20090221441A1 (en) * 2005-11-01 2009-09-03 Rensselaer Polytechnic Institute Three-dimensional cellular array chip and platform for toxicology assays
US20070117152A1 (en) * 2005-11-08 2007-05-24 Fujifilm Corporation Biosensor
CA2628915A1 (en) * 2005-11-08 2007-05-18 Smart Holograms Limited Novel boronate complex and its use in a glucose sensor
US20070224164A1 (en) * 2005-11-14 2007-09-27 Maciej Radosz Degradable nanogel for drug delivery
US20070110786A1 (en) * 2005-11-15 2007-05-17 Boston Scientific Scimed, Inc. Medical articles having enhanced therapeutic agent binding
JP2009523406A (ja) * 2005-11-15 2009-06-25 オクソニカ・インコーポレーテッド 生体剤（ｂｉｏａｇｅｎｔｓ）の検出のためのＳＥＲＳに基づく方法
KR100738083B1 (ko) * 2005-12-20 2007-07-12 삼성전자주식회사 마이크로어레이용 기판 및 그의 제조방법
US7723422B2 (en) * 2005-12-23 2010-05-25 Boston Scientific Scimed, Inc. Functionalized block copolymers
US8455088B2 (en) * 2005-12-23 2013-06-04 Boston Scientific Scimed, Inc. Spun nanofiber, medical devices, and methods
US7674864B2 (en) * 2005-12-23 2010-03-09 Boston Scientific Scimed, Inc. Polymeric hybrid precursors, polymeric hybrid precursor composite matrices, medical devices, and methods
US7781203B2 (en) * 2005-12-29 2010-08-24 Corning Incorporated Supports for assaying analytes and methods of making and using thereof
US8834912B2 (en) * 2005-12-30 2014-09-16 Boston Scientific Scimed, Inc. Medical devices having multiple charged layers
EP1808187A1 (de) * 2006-01-11 2007-07-18 Straumann Holding AG Zell-selektive Implantatoberflächen mit kontrollierter bioaktiver Freisetzung von Wirkstoffen
US20090155811A1 (en) * 2006-01-27 2009-06-18 Oxonica, Inc. Lateral Flow Immunoassay With Encapsulated Detection Modality
US8349349B2 (en) * 2006-02-28 2013-01-08 Covidien Lp Tissue adhesives and sealants and method for their use
WO2007100882A2 (en) * 2006-02-28 2007-09-07 Tyco Healthcare Group Lp Tissue adhesives and sealants and methods for their use
US8835513B2 (en) 2006-02-28 2014-09-16 Covidien Lp Drug delivery devices
EP1997877B1 (de) * 2006-03-17 2014-03-05 Sanyo Chemical Industries, Ltd. Zellkultursubstrat
US20100111917A1 (en) * 2006-03-21 2010-05-06 Ying Jackie Y Cell-adhesive polyelectrolyte material for use as membrane and coating
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
DK3088083T3 (en) 2006-03-24 2018-11-26 Handylab Inc Method of carrying out PCR down a multi-track cartridge
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US8088616B2 (en) 2006-03-24 2012-01-03 Handylab, Inc. Heater unit for microfluidic diagnostic system
US8545865B2 (en) * 2006-03-24 2013-10-01 Boston Scientific Scimed, Inc. Medical devices having polymer brushes
US8975216B2 (en) * 2006-03-30 2015-03-10 Pacific Biosciences Of California Articles having localized molecules disposed thereon and methods of producing same
US20080050747A1 (en) * 2006-03-30 2008-02-28 Pacific Biosciences Of California, Inc. Articles having localized molecules disposed thereon and methods of producing and using same
US20080076189A1 (en) * 2006-03-30 2008-03-27 Visigen Biotechnologies, Inc. Modified surfaces for the detection of biomolecules at the single molecule level
WO2007118714A1 (en) * 2006-04-19 2007-10-25 Universiteit Gent Integrated surface mode biosensor
US8330951B2 (en) * 2006-04-28 2012-12-11 Hewlett-Packard Development Company, L.P. Nano-enhanced Raman spectroscopy substrate packaging structure
US10741034B2 (en) 2006-05-19 2020-08-11 Apdn (B.V.I.) Inc. Security system and method of marking an inventory item and/or person in the vicinity
US9790538B2 (en) 2013-03-07 2017-10-17 Apdn (B.V.I.) Inc. Alkaline activation for immobilization of DNA taggants
WO2008014223A2 (en) * 2006-07-24 2008-01-31 Becton, Dickinson And Company Assay particle concentration and imaging apparatus and method
WO2008019381A1 (en) * 2006-08-07 2008-02-14 University Of Washington Mixed charge copolymers and hydrogels
JPWO2008018355A1 (ja) * 2006-08-08 2009-12-24 シャープ株式会社 バイオセンサ及びその製造方法並びに当該バイオセンサを用いた検出方法
JP5001015B2 (ja) * 2006-09-28 2012-08-15 富士フイルム株式会社 非特異吸着を抑制した表面を有する生化学用器具
EP2091647A2 (de) 2006-11-14 2009-08-26 Handylab, Inc. Mikrofluidisches system für parallele amplifikation und erkennung von polynukleotiden
WO2008064291A2 (en) * 2006-11-21 2008-05-29 Applera Corporation Intermediates and methods for forming passivated surfaces on oxide layers and articles produced thereby
US8029902B2 (en) * 2006-12-11 2011-10-04 Wisconsin Alumni Research Foundation Plasma-enhanced functionalization of substrate surfaces with quaternary ammonium and quaternary phosphonium groups
EP2104846A2 (de) * 2006-12-29 2009-09-30 The University of Washington Nichtverschmutzende oberflächen und materialien mit zwei funktionen
JP2008185494A (ja) * 2007-01-31 2008-08-14 Fujifilm Corp 生理活性物質固定化基板
EP2076774A1 (de) * 2007-02-28 2009-07-08 Corning Incorporated Oberflächen und verfahren für zelluläre biosensortests
JP2008249502A (ja) * 2007-03-30 2008-10-16 Fujifilm Corp 生理活性物質を固定化した固体基板
US8093039B2 (en) * 2007-04-10 2012-01-10 The Trustees Of The Stevens Institute Of Technology Surfaces differentially adhesive to eukaryotic cells and non-eukaryotic cells
US8084077B2 (en) 2007-05-25 2011-12-27 Abbott Laboratories One-step phosphorylcholine-linked polymer coating and drug loading of stent
WO2009006445A2 (en) * 2007-06-29 2009-01-08 Applied Biosystems Systems and methods for electronic detection with nanofets
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8324372B2 (en) 2007-07-13 2012-12-04 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US7960336B2 (en) 2007-08-03 2011-06-14 Pharmain Corporation Composition for long-acting peptide analogs
JP2009057549A (ja) * 2007-08-06 2009-03-19 Canon Inc 構造体およびその製造方法
US8563527B2 (en) * 2007-08-20 2013-10-22 Pharmain Corporation Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same
KR101050690B1 (ko) 2007-09-07 2011-07-20 광주과학기술원 다기능성 고분자막 및 그의 용도
WO2009031804A2 (en) * 2007-09-07 2009-03-12 Gwangju Institute Of Science And Technology Multi-functional polymeric layers and its uses
US8445217B2 (en) 2007-09-20 2013-05-21 Vanderbilt University Free solution measurement of molecular interactions by backscattering interferometry
DE102007049013A1 (de) * 2007-10-11 2009-04-16 Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG Sensor mit Langzeitstabilität für Bio-Prozesse
US20090130746A1 (en) * 2007-10-25 2009-05-21 Canon U.S. Life Sciences, Inc. Microchannel surface coating
US20110092768A1 (en) * 2007-10-31 2011-04-21 Given Imaging Ltd. Device, system and method for in-vivo analysis
JP5345335B2 (ja) * 2007-12-03 2013-11-20 国立大学法人九州大学 新規双性イオン型多分岐樹脂、並びに、蛋白質チップ表面調節剤
WO2009076235A2 (en) 2007-12-05 2009-06-18 Zyomyx, Inc. Cell assay kit and method
US8796184B2 (en) 2008-03-28 2014-08-05 Sentilus, Inc. Detection assay devices and methods of making and using the same
US8815611B2 (en) * 2008-04-10 2014-08-26 Corning Incorporated Surface for label independent detection and method thereof
US8877298B2 (en) * 2008-05-27 2014-11-04 The Hong Kong University Of Science And Technology Printing using a structure coated with ultraviolet radiation responsive material
JP2009286968A (ja) * 2008-05-30 2009-12-10 Canon Inc グラフトポリマー含有基体、その製造方法および磁気バイオセンサ
US20090311540A1 (en) * 2008-06-11 2009-12-17 Yoram Cohen Highly Sensitive and Selective Nano-Structured Grafted Polymer Layers
EP2339951A1 (de) * 2008-07-10 2011-07-06 Given Imaging Ltd. Vorrichtung, verfahren und kit für den in-vivo-nachweis eines biomarkers
WO2010005444A1 (en) * 2008-07-11 2010-01-14 Handylab, Inc. Polynucleotide capture materials, and methods of using same
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
US8173198B2 (en) * 2008-07-23 2012-05-08 Life Technologies Corporation Deposition of metal oxides onto surfaces as an immobilization vehicle for carboxylated or phophated particles or polymers
US20100034704A1 (en) * 2008-08-06 2010-02-11 Honeywell International Inc. Microfluidic cartridge channel with reduced bubble formation
US8076529B2 (en) 2008-09-26 2011-12-13 Abbott Cardiovascular Systems, Inc. Expandable member formed of a fibrous matrix for intraluminal drug delivery
US8226603B2 (en) 2008-09-25 2012-07-24 Abbott Cardiovascular Systems Inc. Expandable member having a covering formed of a fibrous matrix for intraluminal drug delivery
US8049061B2 (en) 2008-09-25 2011-11-01 Abbott Cardiovascular Systems, Inc. Expandable member formed of a fibrous matrix having hydrogel polymer for intraluminal drug delivery
US8500687B2 (en) 2008-09-25 2013-08-06 Abbott Cardiovascular Systems Inc. Stent delivery system having a fibrous matrix covering with improved stent retention
US20100099203A1 (en) * 2008-10-03 2010-04-22 Molecular Sensing, Inc. Substrates with surfaces modified with PEG
DE102008053270A1 (de) 2008-10-27 2010-05-12 Medizinische Hochschule Hannover Vorrichtung und Verfahren zur Analyse von Zellen
US8580240B1 (en) 2008-11-19 2013-11-12 University Of Kentucky Research Foundation Compounds and methods for reducing the occurrence of post-surgical adhesions
AU2009324879A1 (en) * 2008-11-25 2010-06-17 The Regents Of The University Of California Functionalized titanium implants and related regenerative materials
EP2192410B1 (de) * 2008-11-26 2012-07-11 Corning Incorporated Erfassung der Nanoteilchenaffinität für etikettenunabhängige Detektionssysteme
EP2204650B1 (de) * 2008-12-31 2012-06-27 DWI an der RWTH Aachen e.V. Neuartiges Biosensorsystem basierend auf der Erkennung von induzierter Doppelbrechung (RIB)
WO2010080710A2 (en) * 2009-01-12 2010-07-15 Molecular Sensing, Inc. Sample collection and measurement in a single container by back scattering interferometry
CN102356315A (zh) * 2009-03-20 2012-02-15 安塔纳公司 含有在其表面固定的细胞的质量敏感性传感器及利用所述传感器检测配体结合的方法
WO2010117460A1 (en) * 2009-04-08 2010-10-14 Michigan Molecular Institute Surface modification of reverse osmosis membranes by hydrophilic dendritic polymers
WO2010123448A1 (en) * 2009-04-21 2010-10-28 Gyros Patent Ab Method for reducing adsorption losses on metal oxide surfaces
US20120208291A1 (en) * 2009-05-01 2012-08-16 Univeristy Of Utah Research Foundation Methods and compositions for measuring high affinity interactions with kinetic imaging of single molecule interaction (kismi)
US8501406B1 (en) 2009-07-14 2013-08-06 Pacific Biosciences Of California, Inc. Selectively functionalized arrays
US20120150015A1 (en) * 2009-09-02 2012-06-14 Mayo Foundation For Medical Education And Research System and method for detecting healing adjacent to implanted medical device
US20110225809A1 (en) * 2010-03-17 2011-09-22 Alan Francis Daher Apparatus for removably attaching an item to a surface
CN106691462B (zh) 2010-05-17 2020-11-10 申提留斯控股有限公司 检测装置和相关使用方法
WO2011156713A1 (en) 2010-06-11 2011-12-15 Vanderbilt University Multiplexed interferometric detection system and method
EP2409766A1 (de) * 2010-07-23 2012-01-25 F. Hoffmann-La Roche AG Verfahren zur Hydrophilisierung von Oberflächen fluidischer Komponenten und derartige Komponenten enthaltende Bauteile
US9562853B2 (en) 2011-02-22 2017-02-07 Vanderbilt University Nonaqueous backscattering interferometric methods
BR112013026451B1 (pt) 2011-04-15 2021-02-09 Becton, Dickinson And Company sistema e método para realizar ensaios de diagnóstico molecular em várias amostras em paralelo e simultaneamente amplificação em tempo real em pluralidade de câmaras de reação de amplificação
EP2541250A1 (de) 2011-06-30 2013-01-02 Koninklijke Philips Electronics N.V. Molekulare Architektur von magnetischen Partikeln für Affinitätsprüfungen mit geringer nicht spezifischer Bindung
US8507294B2 (en) * 2011-07-13 2013-08-13 Empire Technology Development Llc Method and system for analyte monitoring using surface plasmons with a refreshable surface
WO2013012666A2 (en) * 2011-07-15 2013-01-24 The University Of Georgia Research Foundation, Inc. Compounds, methods of making, and methods of use
US9599613B2 (en) 2011-07-20 2017-03-21 University Of Washington Through Its Center For Commercialization Photonic blood typing
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
JP6117217B2 (ja) 2011-09-30 2017-04-19 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ ユニット化された試薬ストリップ
DK2773958T3 (en) 2011-11-02 2018-03-12 Univ Cape Town Method for identifying an analyte in a biological sample
EP2773892B1 (de) 2011-11-04 2020-10-07 Handylab, Inc. Vorrichtung zur vorbereitung von polynukleotidproben
US10031138B2 (en) * 2012-01-20 2018-07-24 University Of Washington Through Its Center For Commercialization Hierarchical films having ultra low fouling and high recognition element loading properties
US10822644B2 (en) 2012-02-03 2020-11-03 Becton, Dickinson And Company External files for distribution of molecular diagnostic tests and determination of compatibility between tests
US9161756B2 (en) 2012-03-16 2015-10-20 Covidien Lp Closure tape dispenser
US9572580B2 (en) 2012-03-16 2017-02-21 Covidien Lp Closure tape dispenser
JP5844195B2 (ja) * 2012-03-29 2016-01-13 三洋化成工業株式会社 磁性シリカ粒子並びにこれを用いた免疫測定法及び免疫測定用試薬
US20140102899A1 (en) * 2012-04-09 2014-04-17 Applied Dna Sciences, Inc. Plasma treatment for dna binding
US9273949B2 (en) 2012-05-11 2016-03-01 Vanderbilt University Backscattering interferometric methods
WO2014014788A2 (en) * 2012-07-18 2014-01-23 President And Fellows Of Harvard College Modification of surfaces for simulataneous repellency and targeted binding of desired moieties
WO2014022365A1 (en) * 2012-07-31 2014-02-06 The Trustees Of Columbia University In The City Of New York Cyclopropenium polymers and methods for making the same
US9758606B2 (en) 2012-07-31 2017-09-12 The Trustees Of Columbia University In The City Of New York Cyclopropenium polymers and methods for making the same
US9297032B2 (en) 2012-10-10 2016-03-29 Apdn (B.V.I.) Inc. Use of perturbants to facilitate incorporation and recovery of taggants from polymerized coatings
US9266370B2 (en) 2012-10-10 2016-02-23 Apdn (B.V.I) Inc. DNA marking of previously undistinguished items for traceability
US8994077B2 (en) * 2012-12-21 2015-03-31 International Business Machines Corporation Field effect transistor-based bio sensor
TWI535750B (zh) 2013-01-14 2016-06-01 國立臺灣大學 基材上的聚合物組成物以及表面改質方法
US10060851B2 (en) * 2013-03-05 2018-08-28 Plexense, Inc. Surface plasmon detection apparatuses and methods
US9963740B2 (en) 2013-03-07 2018-05-08 APDN (B.V.I.), Inc. Method and device for marking articles
KR101592241B1 (ko) 2013-04-15 2016-02-05 (주)플렉센스 나노 입자 어레이의 제조 방법, 표면 플라즈몬 공명 기반의 센서, 및 이를 이용한 분석 방법
US10544449B2 (en) 2013-06-14 2020-01-28 Pacific Biosciences Of California, Inc. Bis-biotinylation tags
DE102013211837A1 (de) * 2013-06-21 2014-12-24 Gilupi Gmbh Katheter mit Detektionsvorrichtung zum Echtzeitnachweis eines Probenmaterials
DE102013211850A1 (de) * 2013-06-21 2014-12-24 Gilupi Gmbh Schnelltest zum Nachweisen von Erregermaterial, insbesondere zur Unterstützung der Diagnose einer Sepsis, sowie Kit und Vorrichtung zur Durchführung eines Sepsistests
US9366651B2 (en) 2013-07-03 2016-06-14 Matrix Sensors, Inc. Array of sensors with surface modifications
CA2926436A1 (en) 2013-10-07 2015-04-16 Judith Murrah Multimode image and spectral reader
US10745825B2 (en) 2014-03-18 2020-08-18 Apdn (B.V.I.) Inc. Encrypted optical markers for security applications
WO2015142990A1 (en) 2014-03-18 2015-09-24 Apdn (B.V.I.) Inc. Encryped optical markers for security applications
EP3164701A1 (de) 2014-07-02 2017-05-10 Life Technologies Corporation Behandlung der oberfläche von halbleitersensoren
US11754563B2 (en) 2014-11-20 2023-09-12 Global Life Sciences Solutions Operations UK Ltd Porous membranes with a polymer grafting, methods and uses thereof
US10760182B2 (en) 2014-12-16 2020-09-01 Apdn (B.V.I.) Inc. Method and device for marking fibrous materials
EP3247988A4 (de) 2015-01-23 2018-12-19 Vanderbilt University Robustes interferometer und verfahren zur verwendung davon
TWI585401B (zh) * 2015-12-17 2017-06-01 長庚大學 光定址電位感測元件
US10627396B2 (en) 2016-01-29 2020-04-21 Vanderbilt University Free-solution response function interferometry
WO2017180302A1 (en) 2016-04-11 2017-10-19 Apdn (B.V.I.) Inc. Method of marking cellulosic products
US10995371B2 (en) 2016-10-13 2021-05-04 Apdn (B.V.I.) Inc. Composition and method of DNA marking elastomeric material
US9999899B2 (en) 2016-11-01 2018-06-19 International Business Machines Corporation Controlled exposure of in-vivo sensors
WO2018156352A1 (en) 2017-02-21 2018-08-30 Apdn (B.V.I) Inc. Nucleic acid coated submicron particles for authentication
WO2018222034A1 (en) * 2017-05-30 2018-12-06 Jurriaan Huskens Surface with poly-cationic polymers and functionalized using coupling chemistry, biosensor comprising the same and use thereof in bio-sensing
WO2018234564A1 (en) * 2017-06-22 2018-12-27 Paris Sciences Et Lettres - Quartier Latin OXYDO-REDUCABLE CLADABLE COMB COPOLYMER FOR REGULATED ADHESION BETWEEN CELLS AND SUBSTRATES
EP3778653A4 (de) 2018-03-28 2021-12-29 Mochida Pharmaceutical Co., Ltd. Neuartiges reaktives alginsäurederivat
US11357542B2 (en) 2019-06-21 2022-06-14 Covidien Lp Valve assembly and retainer for surgical access assembly
WO2021060336A1 (ja) 2019-09-25 2021-04-01 持田製薬株式会社 新規な架橋アルギン酸構造体
JP2022551523A (ja) 2019-10-11 2022-12-09 クアンタム－エスアイ インコーポレイテッド 気相における表面修飾
JP7343924B2 (ja) * 2019-11-05 2023-09-13 国立大学法人東海国立大学機構 ポリペプチド
WO2023205353A1 (en) * 2022-04-21 2023-10-26 Ultima Genomics, Inc. Self assembly of beads on substrates
EP4299596A1 (de) * 2022-06-30 2024-01-03 betaSENSE GmbH Funktionalisiertes element einer molekularen sonde

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4822867A (en) * 1987-02-02 1989-04-18 Semih Erhan Protein polymer grafts
US4886836A (en) * 1987-06-03 1989-12-12 Pall Corporation Activated medium with low non-specific protein adsorption
US5866322A (en) 1988-01-29 1999-02-02 Abbott Laboratories Method for performing Rubella assay
EP0335308B1 (de) * 1988-03-31 1993-12-08 W.R. Grace & Co.-Conn. Mit Protein nichtabsorbierend polyureum-urethan-polymerbeschichtete Gegenstände
JP2570408B2 (ja) * 1988-11-29 1997-01-08 東ソー株式会社 抗原，抗体又は生理活性物質固定化用の担体
US5330911A (en) * 1989-09-28 1994-07-19 Board Of Regents, The University Of Texas System Surfaces having desirable cell adhesive effects
US5459054A (en) * 1989-12-05 1995-10-17 Neocrin Company Cells encapsulated in alginate containing a high content of a- l- guluronic acid
US5380536A (en) * 1990-10-15 1995-01-10 The Board Of Regents, The University Of Texas System Biocompatible microcapsules
US5462990A (en) 1990-10-15 1995-10-31 Board Of Regents, The University Of Texas System Multifunctional organic polymers
US5626863A (en) 1992-02-28 1997-05-06 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5529914A (en) * 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
SE467308B (sv) * 1990-10-22 1992-06-29 Berol Nobel Ab Fast yta belagd med ett hydrofilt ytterskikt med kovalent bundna biopolymerer, saett att framstaella en saadan yta och ett konjugat daerfoer
US6093558A (en) * 1991-07-25 2000-07-25 Edge Biosystems, Inc. Binding protein of biologically active compositions to an adhesive formulation on a substrate
US5573934A (en) 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
DE4208645A1 (de) 1992-03-18 1993-09-23 Bayer Ag Optischer festphasenbiosensor auf basis fluoreszenzfarbstoffmarkierter polyionischer schichten
US5578442A (en) * 1992-03-23 1996-11-26 Vivorx, Inc. Graft copolymers of polycationic species and water-soluble polymers, and use therefor
US6113946A (en) * 1992-04-03 2000-09-05 The Regents Of The University Of California Self-assembling polynucleotide delivery system comprising dendrimer polycations
ATE154526T1 (de) * 1992-04-16 1997-07-15 Merck Patent Gmbh Aktivierte trägermaterialien, ihre herstellung und verwendung
CA2135769A1 (en) * 1992-05-29 1993-12-09 Kent C. Cochrum Coated transplant and method for making same
US5344455A (en) * 1992-10-30 1994-09-06 Medtronic, Inc. Graft polymer articles having bioactive surfaces
US5414075A (en) * 1992-11-06 1995-05-09 Bsi Corporation Restrained multifunctional reagent for surface modification
SE509662C2 (sv) * 1993-04-29 1999-02-22 Tetra Laval Holdings & Finance Förpackningslaminat belagt med en vattenolöslig chitosanförening samt sätt att tillverka förpackningslaminatet
US5512492A (en) * 1993-05-18 1996-04-30 University Of Utah Research Foundation Waveguide immunosensor with coating chemistry providing enhanced sensitivity
EP0700514B1 (de) * 1993-05-18 2001-11-28 University of Utah Research Foundation Vorrichtung und verfahren fuer homogene multianalyt-immuno-assays
US6284503B1 (en) * 1993-08-20 2001-09-04 University Of Utah Research Foundation Composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces
US5543326A (en) * 1994-03-04 1996-08-06 Heller; Adam Biosensor including chemically modified enzymes
EP0767819A4 (de) * 1994-06-28 1997-09-24 Tri Point Medical Corp Ph-modifiziertes, biokompatibles monomer und polymerzusammensetzung
US5858747A (en) * 1994-07-20 1999-01-12 Cytotherapeutics, Inc. Control of cell growth in a bioartificial organ with extracellular matrix coated microcarriers
US5507804A (en) * 1994-11-16 1996-04-16 Alcon Laboratories, Inc. Cross-linked polyethylene oxide coatings to improve the biocompatibility of implantable medical devices
US5932462A (en) * 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US6017577A (en) * 1995-02-01 2000-01-25 Schneider (Usa) Inc. Slippery, tenaciously adhering hydrophilic polyurethane hydrogel coatings, coated polymer substrate materials, and coated medical devices
US5629213A (en) * 1995-03-03 1997-05-13 Kornguth; Steven E. Analytical biosensor
DE19530078A1 (de) * 1995-08-16 1997-02-20 Bayer Ag Optischer Festphasenbiosensor auf Basis von Streptavidin und Biotin
US5916585A (en) * 1996-06-03 1999-06-29 Gore Enterprise Holdings, Inc. Materials and method for the immobilization of bioactive species onto biodegradable polymers
BR9710054A (pt) * 1996-06-28 2000-01-11 Caliper Techn Corp Aparelhos para separar compostos de teste para um efeito sobre um sistema bioquìmico e para detectar ummefeito de um composto de teste sobre um sistema bioquìmico, processos de determinação de se uma amostra contém um composto capaz de afetar um sistema bioquìmico, de separação de uma pluralidade de compostos de teste para um efeito sobre um sistema bioquìmico e usos de um sistema microfluido e de um substrato de ensaio.
CA2202424A1 (en) * 1997-04-11 1998-10-11 Donald E. Brooks A tethered polymer macromolecule-excluding surface, its mode of synthesis and use
ES2353840T3 (es) * 1997-04-21 2011-03-07 California Institute Of Technology Recubrimientos tisulares poliméricos multifuncionales.
US6287558B1 (en) * 1997-08-01 2001-09-11 Biohybrio Technologies Llc Devices containing cells or tissue and an agent that inhibits damage by a host cell molecule
US6121027A (en) * 1997-08-15 2000-09-19 Surmodics, Inc. Polybifunctional reagent having a polymeric backbone and photoreactive moieties and bioactive groups
US6348322B1 (en) * 1997-10-17 2002-02-19 Duke University Method of screening for specific binding interactions
WO1999052574A1 (en) * 1998-04-10 1999-10-21 Massachusetts Institute Of Technology Biopolymers resistant coatings
US6303136B1 (en) * 1998-04-13 2001-10-16 Neurotech S.A. Cells or tissue attached to a non-degradable filamentous matrix encapsulated by a semi-permeable membrane
AU752942B2 (en) * 1998-04-13 2002-10-03 Massachusetts Institute Of Technology Comb copolymers for regulating cell-surface interactions
US6248127B1 (en) * 1998-08-21 2001-06-19 Medtronic Ave, Inc. Thromboresistant coated medical device
US6303179B1 (en) * 1999-02-08 2001-10-16 Medtronic, Inc Method for attachment of biomolecules to surfaces through amine-functional groups

Also Published As

Publication number Publication date
AU769571B2 (en) 2004-01-29
US20020128234A1 (en) 2002-09-12
CA2371011A1 (en) 2000-11-02
AU4684600A (en) 2000-11-10
CA2371011C (en) 2009-12-22
EP1190252A1 (de) 2002-03-27
WO2000065352A1 (en) 2000-11-02
EP1190252B1 (de) 2008-12-31
JP2003516519A (ja) 2003-05-13
JP4647792B2 (ja) 2011-03-09
ATE419528T1 (de) 2009-01-15
US6884628B2 (en) 2005-04-26

Similar Documents

Publication Publication Date Title
DE60041255D1 (de) Polyionische beschichtungen für analytische und sensor-vorrichtungen
WO2006101798A3 (en) Polymer compound for biomedical use and biochip substrate using such a polymer compound
US20190285623A1 (en) Detection and assay devices and methods of making and using the same
EP1893979B1 (de) Molekular geprägte polymere und ihre verwendung bei diagnosevorrichtungen
Bi et al. Deposition of PEG onto PMMA microchannel surface to minimize nonspecific adsorption
EP1650565A4 (de) Oberfläche eines bei nichtspezifischer adsorption inhibierten basismaterials
Sung et al. Toward immunoassay chips: Facile immobilization of antibodies on cyclic olefin copolymer substrates through pre-activated polymer adlayers
DE602006018477D1 (de) Dna und antikörpern sowie verwendungen davon
WO2002056021A3 (en) Polymer brushes for immobilizing molecules to a surface
WO2006116111A3 (en) Interdigitated chemical sensors, and methods of making and using the same
WO2001042508A3 (en) Methods and compositions relating to electrical detection of nucleic acid reactions
Sakai-Kato et al. An enzyme-immobilization method for integration of biofunctions on a microchip using a water-soluble amphiphilic phospholipid polymer having a reacting group
Zhou et al. Potentiometric sensor for dipicolinic acid
WO2000039325A3 (de) Affinitätssensor für den nachweis spezifischer molekularer bindungsereignisse und dessen verwendung
CN104583765A (zh) 酶电极
Wang et al. Microfluidic immunosensor based on stable antibody-patterned surface in PMMA microchip
US10077379B2 (en) Silane copolymers and uses thereof
WO2010001876A1 (ja) バイオチップ用基板及びその製造方法
Uygun et al. Molecularly imprinted sensors—New sensing technologies
EP1798250A3 (de) Zur Bindung an Metallschichten geeignete Moleküle zur kovalenten Immobilisierung von Biomolekülen
WO2002079268A3 (en) Tuning the properties of conjugated polyelectrolytes and application in a biosensor platform
Horsch et al. Fish and clips: A convenient strategy to identify tyrosinase substrates with rapid activation behavior for materials science applications
EP1726939A3 (de) Detektor für molekulare Interaktion und Molekülgewinnungsvorrichtung damit
WO2005059507A3 (en) Biosensor and method of making same
DE60037734D1 (de) Photo-pfropfungs-elektropolymere, ihre herstellung und deren verwendung als träger für erkennungssonden spezifisch in biosensorsystemen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition