DE602006018477D1 - Dna und antikörpern sowie verwendungen davon - Google Patents
Dna und antikörpern sowie verwendungen davonInfo
- Publication number
- DE602006018477D1 DE602006018477D1 DE602006018477T DE602006018477T DE602006018477D1 DE 602006018477 D1 DE602006018477 D1 DE 602006018477D1 DE 602006018477 T DE602006018477 T DE 602006018477T DE 602006018477 T DE602006018477 T DE 602006018477T DE 602006018477 D1 DE602006018477 D1 DE 602006018477D1
- Authority
- DE
- Germany
- Prior art keywords
- capture probes
- capture
- bound
- antibodies
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54386—Analytical elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/0054—Means for coding or tagging the apparatus or the reagents
- B01J2219/00547—Bar codes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/0054—Means for coding or tagging the apparatus or the reagents
- B01J2219/00572—Chemical means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/0061—The surface being organic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00632—Introduction of reactive groups to the surface
- B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
- B01J2219/00641—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being continuous, e.g. porous oxide substrates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00702—Processes involving means for analysing and characterising the products
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00722—Nucleotides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00725—Peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Nanotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Food Science & Technology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Medical Informatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Crystallography & Structural Chemistry (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70961305P | 2005-08-19 | 2005-08-19 | |
PCT/US2006/032301 WO2007024676A2 (en) | 2005-08-19 | 2006-08-18 | Methods for preparing hybrid substrates comprising dna and antibodies and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602006018477D1 true DE602006018477D1 (de) | 2011-01-05 |
Family
ID=37533338
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602006018477T Active DE602006018477D1 (de) | 2005-08-19 | 2006-08-18 | Dna und antikörpern sowie verwendungen davon |
Country Status (6)
Country | Link |
---|---|
US (1) | US20090111094A1 (de) |
EP (1) | EP1915466B1 (de) |
JP (1) | JP2009505106A (de) |
AT (1) | ATE489482T1 (de) |
DE (1) | DE602006018477D1 (de) |
WO (1) | WO2007024676A2 (de) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101634608B1 (ko) * | 2007-07-17 | 2016-06-29 | 소마로직, 인크. | 개선된 오프―레이트를 갖는 압타머를 생성하는 방법 |
US8852893B2 (en) * | 2007-09-14 | 2014-10-07 | Physicians Choice Laboratory Services, Llc | Detection of nucleic acids and proteins |
JP2009085619A (ja) * | 2007-09-27 | 2009-04-23 | Tdk Corp | バイオセンサ |
JP2010099061A (ja) * | 2008-09-26 | 2010-05-06 | Sekisui Chem Co Ltd | 検出用カートリッジ及び被検出物質の検出方法 |
EP2389585A2 (de) * | 2009-01-22 | 2011-11-30 | Li-Cor, Inc. | Einzelmolekül-proteomik mit dynamischen sonden |
JP5626673B2 (ja) * | 2009-03-12 | 2014-11-19 | 国立大学法人東京農工大学 | ジンクフィンガーを用いた新規標識方法及び被検物質の測定方法 |
CN101967517B (zh) * | 2010-03-19 | 2012-11-07 | 黄乐群 | 一种无需借助pcr的基因检测方法 |
EP2591107A2 (de) * | 2010-07-06 | 2013-05-15 | Aptateck Bio Ltd. | Auf nukleinsäureaptamer basierendes diagnostisches verfahren mit neuen verfahren zur signalverstärkung |
CN102147414B (zh) * | 2010-12-30 | 2013-07-03 | 中国科学院上海微***与信息技术研究所 | 基于纳米探针的微流体芯片检测微量蛋白的方法 |
CN102520189A (zh) * | 2011-12-16 | 2012-06-27 | 首都医科大学 | 一个基于纳米技术的psa高敏感检测方法 |
JP5566543B2 (ja) | 2012-03-30 | 2014-08-06 | 国立大学法人九州大学 | センサ、検出方法、検出システム、及び、検出装置 |
KR101460439B1 (ko) | 2012-05-14 | 2014-11-12 | 서울대학교산학협력단 | 나노프로브 및 이를 이용한 표적 물질 검출방법 |
WO2013184788A1 (en) * | 2012-06-05 | 2013-12-12 | Predictive Biosciences, Inc. | Detection of nucleic acids and proteins |
WO2014007034A1 (ja) * | 2012-07-06 | 2014-01-09 | 株式会社 日立ハイテクノロジーズ | 分析装置及び分析方法 |
KR101470730B1 (ko) * | 2013-04-24 | 2014-12-09 | 경희대학교 산학협력단 | 파장-의존성 플라즈몬 공명산란을 이용한 나노바이오칩 키트 및 이를 이용한 생체분자의 검출방법 |
CN104458710B (zh) * | 2014-12-09 | 2017-11-14 | 山东省海盟生化科技有限公司 | 肿瘤早期高通量电化学发光检测方法的构建 |
KR102489353B1 (ko) | 2015-06-01 | 2023-01-17 | 캘리포니아 인스티튜트 오브 테크놀로지 | 특정 집단에 대한 항원으로 t 세포를 스크리닝하기 위한 조성물 및 방법 |
US11041850B2 (en) | 2015-07-07 | 2021-06-22 | The Regents Of The University Of California | Method for detecting protein-specific glycosylation |
CN105132533B (zh) * | 2015-07-24 | 2018-11-23 | 清华大学深圳研究生院 | 一种靶分子浓度的检测方法 |
CA3043639A1 (en) | 2016-12-09 | 2018-06-14 | Ultivue, Inc. | Improved methods for multiplex imaging using labeled nucleic acid imaging agents |
WO2018183876A1 (en) | 2017-03-31 | 2018-10-04 | Ultivue, Inc. | Dna-antigen exchange and amplification |
BR112020024727A2 (pt) * | 2018-06-11 | 2021-03-23 | Foundation Medicine, Inc. | composições e métodos para avaliação de alterações genômicas |
AU2020235929A1 (en) * | 2019-03-13 | 2021-09-23 | Evorion Biotechnologies Gmbh | Methods and kits for determining cell secreted biomolecules |
AU2020267119A1 (en) * | 2019-04-30 | 2021-11-18 | Encodia, Inc. | Methods for preparing analytes and related kits |
WO2020235607A1 (ja) * | 2019-05-21 | 2020-11-26 | 凸版印刷株式会社 | 標的分子の検出方法 |
CN110361433B (zh) * | 2019-07-04 | 2021-09-24 | 章毅 | 电化学检测细胞的方法及其组合物 |
EP4200250A1 (de) * | 2020-08-18 | 2023-06-28 | Regenacellx.SL | Zusammensetzungen und verfahren zum nachweis von sars-cov-2-spike-protein |
US20230357822A1 (en) * | 2020-09-17 | 2023-11-09 | Evorion Biotechnologies Gmbh | Method for analyzing cell released biomolecules |
EP4356134A1 (de) * | 2021-06-17 | 2024-04-24 | Roche Diagnostics GmbH | Verfahren zur immundetektion auf einer lipidschicht mittels magnetischer tunnelübergänge |
CN117546023A (zh) * | 2021-06-17 | 2024-02-09 | 豪夫迈·罗氏有限公司 | 用于在脂质层上进行免疫传感的方法 |
JP2024522765A (ja) * | 2021-06-17 | 2024-06-21 | エフ. ホフマン-ラ ロシュ アーゲー | 磁気トンネル接合部を使用して脂質層上で免疫センシングするための方法ii |
CN114199816B (zh) * | 2021-11-22 | 2023-11-03 | 湖北大学 | 基于近红外光激发检测生物标志物的光热传感器及其制备方法、在标志物检测中的应用 |
CN117871873A (zh) * | 2024-02-18 | 2024-04-12 | 河南省科学院物理研究所 | 一种基于高分子微球的显微暗场生物检测方法 |
Family Cites Families (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4193983A (en) * | 1978-05-16 | 1980-03-18 | Syva Company | Labeled liposome particle compositions and immunoassays therewith |
NL7807532A (nl) * | 1978-07-13 | 1980-01-15 | Akzo Nv | Metaal-immunotest. |
US4318707A (en) * | 1978-11-24 | 1982-03-09 | Syva Company | Macromolecular fluorescent quencher particle in specific receptor assays |
US4256834A (en) * | 1979-04-09 | 1981-03-17 | Syva Company | Fluorescent scavenger particle immunoassay |
US4261968A (en) * | 1979-05-10 | 1981-04-14 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
US4650770A (en) * | 1981-04-27 | 1987-03-17 | Syntex (U.S.A.) Inc. | Energy absorbing particle quenching in light emitting competitive protein binding assays |
US4713348A (en) * | 1983-04-05 | 1987-12-15 | Syntex (U.S.A.) Inc. | Fluorescent multiparameter particle analysis |
US5288609A (en) * | 1984-04-27 | 1994-02-22 | Enzo Diagnostics, Inc. | Capture sandwich hybridization method and composition |
US4868104A (en) * | 1985-09-06 | 1989-09-19 | Syntex (U.S.A.) Inc. | Homogeneous assay for specific polynucleotides |
US4996143A (en) * | 1985-12-23 | 1991-02-26 | Syngene, Inc. | Fluorescent stokes shift probes for polynucleotide hybridization |
US5137827A (en) * | 1986-03-25 | 1992-08-11 | Midwest Research Technologies, Inc. | Diagnostic element for electrical detection of a binding reaction |
US5514602A (en) * | 1986-06-09 | 1996-05-07 | Ortho Diagnostic Systems, Inc. | Method of producing a metal sol reagent containing colloidal metal particles |
US5360895A (en) * | 1987-04-22 | 1994-11-01 | Associated Universities, Inc. | Derivatized gold clusters and antibody-gold cluster conjugates |
US4853335A (en) * | 1987-09-28 | 1989-08-01 | Olsen Duane A | Colloidal gold particle concentration immunoassay |
US5151510A (en) * | 1990-04-20 | 1992-09-29 | Applied Biosystems, Inc. | Method of synethesizing sulfurized oligonucleotide analogs |
US5270163A (en) | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
US5567588A (en) * | 1990-06-11 | 1996-10-22 | University Research Corporation | Systematic evolution of ligands by exponential enrichment: Solution SELEX |
US5460831A (en) * | 1990-06-22 | 1995-10-24 | The Regents Of The University Of California | Targeted transfection nanoparticles |
AU8951191A (en) * | 1990-10-29 | 1992-05-26 | Dekalb Plant Genetics | Isolation of biological materials using magnetic particles |
US5665582A (en) * | 1990-10-29 | 1997-09-09 | Dekalb Genetics Corp. | Isolation of biological materials |
US5294369A (en) * | 1990-12-05 | 1994-03-15 | Akzo N.V. | Ligand gold bonding |
US5840867A (en) * | 1991-02-21 | 1998-11-24 | Gilead Sciences, Inc. | Aptamer analogs specific for biomolecules |
JPH07502479A (ja) * | 1991-11-22 | 1995-03-16 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 自己集合性単一層を使って固体無機表面に共有結合した半導体微少結晶 |
US5225064A (en) * | 1992-01-15 | 1993-07-06 | Enzyme Technology Research Group, Inc. | Peroxidase colloidal gold oxidase biosensors for mediatorless glucose determination |
US5472881A (en) * | 1992-11-12 | 1995-12-05 | University Of Utah Research Foundation | Thiol labeling of DNA for attachment to gold surfaces |
US5637508A (en) * | 1993-03-26 | 1997-06-10 | Geo-Centers, Inc. | Biomolecules bound to polymer or copolymer coated catalytic inorganic particles, immunoassays using the same and kits containing the same |
US5384265A (en) * | 1993-03-26 | 1995-01-24 | Geo-Centers, Inc. | Biomolecules bound to catalytic inorganic particles, immunoassays using the same |
US5681943A (en) * | 1993-04-12 | 1997-10-28 | Northwestern University | Method for covalently linking adjacent oligonucleotides |
US5543158A (en) * | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
US5521289A (en) * | 1994-07-29 | 1996-05-28 | Nanoprobes, Inc. | Small organometallic probes |
US5599668A (en) * | 1994-09-22 | 1997-02-04 | Abbott Laboratories | Light scattering optical waveguide method for detecting specific binding events |
US5609907A (en) * | 1995-02-09 | 1997-03-11 | The Penn State Research Foundation | Self-assembled metal colloid monolayers |
US6025202A (en) * | 1995-02-09 | 2000-02-15 | The Penn State Research Foundation | Self-assembled metal colloid monolayers and detection methods therewith |
US6004806A (en) * | 1995-06-07 | 1999-12-21 | Commonwealth Scientific And Industrial Research Organization | Optimized minizymes and miniribozymes and uses thereof |
ATE357663T1 (de) * | 1996-04-25 | 2007-04-15 | Genicon Sciences Corp | Teilchenförmiges markierungsmittel verwendendes analytassay |
DE69737598T2 (de) * | 1996-07-29 | 2007-12-27 | Nanosphere Inc., Skokie | Nanopartikel mit daran angehefteten oligonukleotiden sowie deren verwendungen |
US6582921B2 (en) * | 1996-07-29 | 2003-06-24 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses thereof |
US6750016B2 (en) * | 1996-07-29 | 2004-06-15 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US6506564B1 (en) * | 1996-07-29 | 2003-01-14 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US6361944B1 (en) * | 1996-07-29 | 2002-03-26 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US7169556B2 (en) * | 1996-07-29 | 2007-01-30 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US6984491B2 (en) * | 1996-07-29 | 2006-01-10 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US5922537A (en) * | 1996-11-08 | 1999-07-13 | N.o slashed.AB Immunoassay, Inc. | Nanoparticles biosensor |
US5939021A (en) * | 1997-01-23 | 1999-08-17 | Hansen; W. Peter | Homogeneous binding assay |
US6001570A (en) * | 1997-02-18 | 1999-12-14 | Invitro Diagnostics, Inc. | Compositions, methods, kits and apparatus for determining the presence or absence of target molecules |
US20050037397A1 (en) * | 2001-03-28 | 2005-02-17 | Nanosphere, Inc. | Bio-barcode based detection of target analytes |
US6974669B2 (en) * | 2000-03-28 | 2005-12-13 | Nanosphere, Inc. | Bio-barcodes based on oligonucleotide-modified nanoparticles |
US6149868A (en) * | 1997-10-28 | 2000-11-21 | The Penn State Research Foundation | Surface enhanced raman scattering from metal nanoparticle-analyte-noble metal substrate sandwiches |
US5990479A (en) * | 1997-11-25 | 1999-11-23 | Regents Of The University Of California | Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes |
US6225058B1 (en) * | 1998-01-13 | 2001-05-01 | Invitro Diagnostics, Inc. | Compositions, methods, kits and apparatus for determining the presence or absence of target molecules |
US5972615A (en) * | 1998-01-21 | 1999-10-26 | Urocor, Inc. | Biomarkers and targets for diagnosis, prognosis and management of prostate disease |
US6290839B1 (en) * | 1998-06-23 | 2001-09-18 | Clinical Micro Sensors, Inc. | Systems for electrophoretic transport and detection of analytes |
US6270163B1 (en) * | 1998-09-14 | 2001-08-07 | Holmes Limestone Co. | Mining machine with moveable cutting assembly and method of using the same |
WO2000075132A1 (en) * | 1999-06-03 | 2000-12-14 | Eli Lilly And Company | Process for preparing a 10,11-methanodibenzosuberane derivative |
WO2001051665A2 (en) * | 2000-01-13 | 2001-07-19 | Nanosphere Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US20020001810A1 (en) * | 2000-06-05 | 2002-01-03 | Farrell Michael Patrick | Q-beta replicase based assays; the use of chimeric DNA-RNA molecules as probes from which efficient Q-beta replicase templates can be generated in a reverse transcriptase dependent manner |
AU7687001A (en) * | 2000-07-11 | 2002-01-21 | Nanospherre Inc | Method of detection by enhancement of silver staining |
DE60141171D1 (de) * | 2000-11-27 | 2010-03-11 | Intelligent Medical Devices Ll | Klinische intelligente diagnostische vorrichtungen und verfahren |
WO2002046483A2 (en) * | 2000-12-06 | 2002-06-13 | Northwestern University | Silver stain removal from dna detection chips by cyanide etching or sonication |
WO2002079490A2 (en) * | 2001-03-28 | 2002-10-10 | Nanosphere, Inc. | Bio-barcodes based on oligonucleotide-modified particles |
US20030113740A1 (en) * | 2001-04-26 | 2003-06-19 | Mirkin Chad A. | Oligonucleotide-modified ROMP polymers and co-polymers |
US7147687B2 (en) * | 2001-05-25 | 2006-12-12 | Nanosphere, Inc. | Non-alloying core shell nanoparticles |
WO2002096262A2 (en) * | 2001-05-25 | 2002-12-05 | Northwestern University | Non-alloying core shell nanoparticles |
US20050287560A1 (en) * | 2001-07-13 | 2005-12-29 | Nanosphere, Inc. | Method for preparing substrates having immobilized molecules and substrates |
US7110585B2 (en) * | 2001-08-03 | 2006-09-19 | Nanosphere, Inc. | Nanoparticle imaging system and method |
ATE403751T1 (de) * | 2001-11-09 | 2008-08-15 | Nanosphere Inc | Biokonjugat-nanopartikelsonden |
US20030211488A1 (en) * | 2002-05-07 | 2003-11-13 | Northwestern University | Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection |
WO2004004647A2 (en) * | 2002-07-02 | 2004-01-15 | Nanosphere Inc. | Nanoparticle polyanion conjugates and methods of use thereof in detecting analytes |
US20040115794A1 (en) * | 2002-12-12 | 2004-06-17 | Affymetrix, Inc. | Methods for detecting transcriptional factor binding sites |
CA2508359A1 (en) * | 2002-12-12 | 2004-06-24 | Nanosphere, Inc. | Direct snp detection with unamplified dna |
DE602004028445D1 (de) | 2003-02-24 | 2010-09-16 | Pritest Inc | Lichtdurchlässige festmatrix-prüfvorrichtung zur mikroarray-analyse |
GB0305656D0 (en) * | 2003-03-12 | 2003-04-16 | Bioinvent Int Ab | Screening assay |
US20050250094A1 (en) * | 2003-05-30 | 2005-11-10 | Nanosphere, Inc. | Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes |
AU2004254367B2 (en) * | 2003-06-27 | 2008-06-19 | Nanosphere, Inc. | Bio-barcode based detection of target analytes |
-
2006
- 2006-08-18 WO PCT/US2006/032301 patent/WO2007024676A2/en active Application Filing
- 2006-08-18 US US11/506,280 patent/US20090111094A1/en not_active Abandoned
- 2006-08-18 JP JP2008527164A patent/JP2009505106A/ja active Pending
- 2006-08-18 AT AT06801832T patent/ATE489482T1/de not_active IP Right Cessation
- 2006-08-18 EP EP06801832A patent/EP1915466B1/de active Active
- 2006-08-18 DE DE602006018477T patent/DE602006018477D1/de active Active
Also Published As
Publication number | Publication date |
---|---|
US20090111094A1 (en) | 2009-04-30 |
ATE489482T1 (de) | 2010-12-15 |
WO2007024676A2 (en) | 2007-03-01 |
EP1915466B1 (de) | 2010-11-24 |
WO2007024676A3 (en) | 2007-06-07 |
EP1915466A2 (de) | 2008-04-30 |
JP2009505106A (ja) | 2009-02-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE602006018477D1 (de) | Dna und antikörpern sowie verwendungen davon | |
ATE425266T1 (de) | Aptamer-nanopartikelkonjugate und verwendungsverfahren zur detektion von zielanalyten | |
ATE541054T1 (de) | Bio-barcode erkennung für zielmoleküle | |
WO2010065781A3 (en) | Lateral flow strip assay with immobilized conjugate | |
NZ590161A (en) | Device and methods for detecting analytes in saliva by removing mucin before analysis | |
EP1978366A4 (de) | Fluoreszenzmarker für biologisches material und verfahren zur markierung von biologischem material mit fluoreszenzmarker | |
TW200720441A (en) | New labelling strategies for the sensitive detection of analytes | |
WO2005106036A3 (en) | Methods and compositions for assaying analytes | |
WO2006079049A3 (en) | Methods and compositions for increased dynamic range detection of nucleic acid molecules | |
WO2008039769A3 (en) | Methods and devices for analyzing small rna molecules | |
WO2009058902A3 (en) | Methods and devices for analyte detection | |
WO2006122311A3 (en) | Microfluidic chip | |
EP2177614A3 (de) | Zusammensetzung und Verfahren zur Diagnose von Speiseröhrenkrebs sowie der Metastasierung von Speiseröhrenkrebs | |
WO2006135818A8 (en) | Recirculating microfluidic device and methods of use | |
WO2008028160A3 (en) | Substrates, systems and methods for analyzing materials | |
WO2006078660A3 (en) | Nucleic acid enzyme ligation sensor | |
WO2008020823A3 (en) | Cooperative reporter systems, components, and methods for analyte detection | |
WO2007008276A3 (en) | Turnover probes and use thereof for nucleic acid detection | |
DK1788391T3 (da) | Biosensorindretning og fremgangsmåder til brug deraf | |
WO2008135862A3 (en) | Devices and methods for detecting analytes | |
WO2009121032A3 (en) | Sample preparation devices and methods for processing analytes | |
WO2007051863A3 (en) | Method and device for the detection of molecular interactions | |
WO2007078635A3 (en) | Method to detect small molecules binding to proteins using surface enhanced raman scattering (sers) | |
ATE431854T1 (de) | Auf bio-barcodes beruhender nachweis von zielanalyten | |
ATE462803T1 (de) | Kit und verfahren zum nachweis von urothelkarzinom |