DE2460537A1 - Cephalosporin-antibiotika - Google Patents

Cephalosporin-antibiotika

Info

Publication number
DE2460537A1
DE2460537A1 DE19742460537 DE2460537A DE2460537A1 DE 2460537 A1 DE2460537 A1 DE 2460537A1 DE 19742460537 DE19742460537 DE 19742460537 DE 2460537 A DE2460537 A DE 2460537A DE 2460537 A1 DE2460537 A1 DE 2460537A1
Authority
DE
Germany
Prior art keywords
fur
ceph
carboxylic acid
alkyl
acetamido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19742460537
Other languages
German (de)
English (en)
Other versions
DE2460537C2 (da
Inventor
Janice Bradshaw
St Peter Buckinghamsh Chalfont
John Derek Cocker
Martin Christopher Cook
Gordon Ian Gregory
Derek Ronald Sutherland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB59517/73A external-priority patent/GB1496757A/en
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Publication of DE2460537A1 publication Critical patent/DE2460537A1/de
Application granted granted Critical
Publication of DE2460537C2 publication Critical patent/DE2460537C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE19742460537 1973-12-21 1974-12-20 Cephalosporin-antibiotika Granted DE2460537A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB59517/73A GB1496757A (en) 1973-12-21 1973-12-21 Cephalosporin derivatives
GB4300574 1974-10-03

Publications (2)

Publication Number Publication Date
DE2460537A1 true DE2460537A1 (de) 1975-07-03
DE2460537C2 DE2460537C2 (da) 1987-01-22

Family

ID=26265028

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19742460537 Granted DE2460537A1 (de) 1973-12-21 1974-12-20 Cephalosporin-antibiotika

Country Status (15)

Country Link
JP (1) JPS5844675B2 (da)
AT (1) AT344888B (da)
CH (1) CH617703A5 (da)
DE (1) DE2460537A1 (da)
DK (1) DK674674A (da)
ES (2) ES433226A1 (da)
FI (1) FI65258C (da)
FR (1) FR2255076B1 (da)
HU (1) HU172234B (da)
IE (1) IE42144B1 (da)
IL (1) IL46302A (da)
LU (1) LU71550A1 (da)
NL (1) NL7416665A (da)
NO (1) NO744621L (da)
SE (1) SE7416195L (da)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2706360A1 (de) * 1976-02-16 1977-08-18 Glaxo Lab Ltd Cephalosporinantibiotika, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen
DE2730377A1 (de) * 1976-07-12 1978-01-19 Smithkline Corp 7-beta-(2-oxyimino-2-arylacetamido)- cephalosporine
DE2730376A1 (de) * 1976-07-12 1978-01-19 Smithkline Corp 7-beta-(2-oxyimino-2-arylacetamido)- cephalosporine
US4103084A (en) 1973-12-21 1978-07-25 Glaxo Laboratories Limited 7-(Carboxy substituted α-etherified oximino arylacetamido) cephalosporins having a 3-vinyl or substituted vinyl group
DE2810922A1 (de) 1977-03-14 1978-09-21 Fujisawa Pharmaceutical Co Neue cephem- und cepham-verbindungen, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
DE2812625A1 (de) * 1977-03-25 1978-09-28 Roussel Uclaf Oximderivate der 3-acetoxymethyl-7- aminothiazolyl-acetamido-cephalosporansaeure, ihre herstellung und pharmazeutische mittel
US4144392A (en) 1973-12-21 1979-03-13 Glaxo Laboratories Limited Cephalosporins having at position-7 a carboxy substituted α-etherified hydroxyimino-arylacetamido group and at position-3 the residue of a sulphur nucleophile
US4165430A (en) 1976-03-19 1979-08-21 Glaxo Laboratories Limited Cephalosporins having a 7-carboxy substituted α-etherified oximinoarylacetamido) group
US4168309A (en) 1976-10-01 1979-09-18 Glaxo Laboratories Limited Cephalosporins having a 7-(carboxy substituted α-etherified oximinoarylacetamido) group
DE3019462A1 (de) * 1979-05-23 1980-12-04 Rhone Poulenc Ind Neue 3-vinyl-cephalosporin-derivate und verfahren zu deren herstellung
US4304770A (en) 1976-04-12 1981-12-08 Fujisawa Pharmaceutical Co., Ltd. Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation thereof
US4385177A (en) 1976-11-30 1983-05-24 Glaxo Laboratories, Ltd. Cephalosporins having a carbamoylalkoxyiminoarylacetamido group at 7-position
US7211366B2 (en) 2003-02-21 2007-05-01 Az Electronic Materials Usa Corp. Photoresist composition for deep ultraviolet lithography

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1555471A (en) * 1975-06-19 1979-11-14 Glaxo Lab Ltd 7 carbamoylalkoxyimino acetamido 3 em 4 carboxylic acidsand derivatives thereof
ES485441A1 (es) * 1978-10-27 1980-07-01 Glaxo Group Ltd Un procedimiento para la preparacion de antibioticos de ce- falosporina
FR2552432B2 (fr) * 1983-09-27 1985-10-25 Roussel Uclaf Nouvelles oximes derivees de l'acide 2-amino thiazol- 4-yl acetique, procede de preparation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2018600A1 (de) * 1969-04-18 1970-11-05 Lilly Co Eli 3-Mercatothiazol- oder -Mercaptotetrazoloephalosporine und Verfahren zu ihrer Herstellung
DE2129675A1 (de) * 1970-06-16 1971-12-23 Merck & Co Inc Antibiotika und Verfahren zu deren Herstellung
DE2223375A1 (de) * 1971-05-14 1972-11-23 Glaxo Lab Ltd Antibiotika und Verfahren zu ihrer Herstellung

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2018600A1 (de) * 1969-04-18 1970-11-05 Lilly Co Eli 3-Mercatothiazol- oder -Mercaptotetrazoloephalosporine und Verfahren zu ihrer Herstellung
DE2129675A1 (de) * 1970-06-16 1971-12-23 Merck & Co Inc Antibiotika und Verfahren zu deren Herstellung
DE2223375A1 (de) * 1971-05-14 1972-11-23 Glaxo Lab Ltd Antibiotika und Verfahren zu ihrer Herstellung

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Arzneim.-Forsch. 28, 1978, 1541-1545 *
Chem.Abstr. 77, 1972, 126629 *
Demain - Solomon: Antibiotics, 1983, S. 94, 95, 101, 157 *
J.Pharm.Sci. 64, 1975, 1917 *
Med.Klin. 76, 1981, 55/20 *

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4144393A (en) 1973-12-21 1979-03-13 Glaxo Laboratories Limited 3-Acetoxymethyl cephalosporins having at position-7 a carboxy substituted α-etherified hydroxyiminoarylacetamido group
US4144392A (en) 1973-12-21 1979-03-13 Glaxo Laboratories Limited Cephalosporins having at position-7 a carboxy substituted α-etherified hydroxyimino-arylacetamido group and at position-3 the residue of a sulphur nucleophile
US4103084A (en) 1973-12-21 1978-07-25 Glaxo Laboratories Limited 7-(Carboxy substituted α-etherified oximino arylacetamido) cephalosporins having a 3-vinyl or substituted vinyl group
DE2706360A1 (de) * 1976-02-16 1977-08-18 Glaxo Lab Ltd Cephalosporinantibiotika, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen
US4165430A (en) 1976-03-19 1979-08-21 Glaxo Laboratories Limited Cephalosporins having a 7-carboxy substituted α-etherified oximinoarylacetamido) group
US4304770A (en) 1976-04-12 1981-12-08 Fujisawa Pharmaceutical Co., Ltd. Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation thereof
DE2730377A1 (de) * 1976-07-12 1978-01-19 Smithkline Corp 7-beta-(2-oxyimino-2-arylacetamido)- cephalosporine
DE2730376A1 (de) * 1976-07-12 1978-01-19 Smithkline Corp 7-beta-(2-oxyimino-2-arylacetamido)- cephalosporine
US4168309A (en) 1976-10-01 1979-09-18 Glaxo Laboratories Limited Cephalosporins having a 7-(carboxy substituted α-etherified oximinoarylacetamido) group
US4385177A (en) 1976-11-30 1983-05-24 Glaxo Laboratories, Ltd. Cephalosporins having a carbamoylalkoxyiminoarylacetamido group at 7-position
DE2810922A1 (de) 1977-03-14 1978-09-21 Fujisawa Pharmaceutical Co Neue cephem- und cepham-verbindungen, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
DE2812625A1 (de) * 1977-03-25 1978-09-28 Roussel Uclaf Oximderivate der 3-acetoxymethyl-7- aminothiazolyl-acetamido-cephalosporansaeure, ihre herstellung und pharmazeutische mittel
DE3019462A1 (de) * 1979-05-23 1980-12-04 Rhone Poulenc Ind Neue 3-vinyl-cephalosporin-derivate und verfahren zu deren herstellung
US7211366B2 (en) 2003-02-21 2007-05-01 Az Electronic Materials Usa Corp. Photoresist composition for deep ultraviolet lithography

Also Published As

Publication number Publication date
CH617703A5 (en) 1980-06-13
JPS50105689A (da) 1975-08-20
FR2255076B1 (da) 1978-11-10
NL7416665A (nl) 1975-06-24
FI371374A (da) 1975-06-22
ATA1020174A (de) 1977-12-15
NO744621L (da) 1975-07-21
ES433226A1 (es) 1977-07-01
DK674674A (da) 1975-09-08
SE7416195L (sv) 1975-09-22
HU172234B (hu) 1978-07-28
FR2255076A1 (da) 1975-07-18
FI65258C (fi) 1984-04-10
IE42144L (en) 1975-06-21
FI65258B (fi) 1983-12-30
LU71550A1 (da) 1976-04-13
ES451604A1 (es) 1977-12-16
IE42144B1 (en) 1980-06-18
IL46302A (en) 1978-09-29
AT344888B (de) 1978-08-10
IL46302A0 (en) 1975-03-13
AU7673574A (en) 1976-06-24
DE2460537C2 (da) 1987-01-22
JPS5844675B2 (ja) 1983-10-04

Similar Documents

Publication Publication Date Title
DE2837264C2 (da)
DE2460537A1 (de) Cephalosporin-antibiotika
DE2223375A1 (de) Antibiotika und Verfahren zu ihrer Herstellung
DE2439880C3 (de) (6R, 7R)-3-Carbamoyloxymethyl-7- [2-(fur-2-yl)-2methoxyiminoacetamido] -ceph-S-em^carbonsäure und Verfahren zur ihrer Herstellung
DE2744135A1 (de) Cephalosporinderivate, verfahren zu deren herstellung und diese enthaltende arzneimittel
AT369749B (de) Verfahren zur herstellung von neuen cephalosporinantibiotika
DE2204060A1 (de) Cephalosporin- und Penicillin-Antibiotika
CH625526A5 (da)
EP0009008A2 (de) Cephalosporinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
DE2356388A1 (de) Cephalosporine und verfahren zu ihrer herstellung
CH647784A5 (de) Cephalosporinantibiotika.
CH644868A5 (de) In 3- und 7-stellung substituierte cephemcarbonsaeure(ester).
CH626370A5 (en) Process for the preparation of the syn isomer or of a mixture of syn and anti isomers of 7beta-acylamidoceph-3-em-4-carboxylic acids with antibiotic activity
DE2753182A1 (de) Neue cephalosporine, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen
DE3011038A1 (de) Cephalosporinantibiotika
CH649557A5 (de) Cephalosporinantibiotika.
CH649298A5 (de) Cephalosporin-antibiotika.
DE2943437A1 (de) Cephalosporinverbindungen
EP0035161B1 (de) Cephalosporine, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
AT362500B (de) Verfahren zur herstellung von neuen cephalos- porin-antibiotika
DE3516777A1 (de) Cephalosporin-antibiotika
AT367061B (de) Verfahren zur herstellung von neuen antibiotischen verbindungen
AT371474B (de) Verfahren zur herstellung von neuen cephalosporinantibiotika
DE3342317A1 (de) Cephalosporin-antibiotika
AT375663B (de) Verfahren zur herstellung von neuen cephalosporinantibiotika

Legal Events

Date Code Title Description
8128 New person/name/address of the agent

Representative=s name: ZUMSTEIN SEN., F., DR. ASSMANN, E., DIPL.-CHEM. DR

D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee