DD252608A5 - Neue zwischenprodukte zur herstellung von norfloxacin - Google Patents

Neue zwischenprodukte zur herstellung von norfloxacin Download PDF

Info

Publication number: DD252608A5
Authority: DD; German Democratic Republic
Prior art keywords: carbon atoms; general formula; compound; ethyl; pct
Prior art date: 1985-12-09

Application number

DD86297301A

Other languages

German (de)

English (en)

Inventor

Istvan Hermecz

Geza Kereszturi

Lelle Vasvari

Agnes Horvath

Maria Balogh

Gabor Kovacs

Zoltan Meszaros

Peter Ritli

Judit Sipos

Aniko Pajor

Original Assignee

��@��@��@��@��@��@��Kk��

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-12-09

Filing date

1986-12-09

Publication date

1987-12-23

1986-12-09 Application filed by ��@��@��@��@��@��@��Kk�� filed Critical ��@��@��@��@��@��@��Kk��

1987-12-23 Publication of DD252608A5 publication Critical patent/DD252608A5/de

Links

238000004519 manufacturing process Methods 0.000 title description 2
OGJPXUAPXNRGGI-UHFFFAOYSA-N norfloxacin Chemical compound C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCNCC1 OGJPXUAPXNRGGI-UHFFFAOYSA-N 0.000 title description 2
229960001180 norfloxacin Drugs 0.000 title description 2
239000013067 intermediate product Substances 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 claims abstract description 15
150000001875 compounds Chemical class 0.000 claims abstract description 11
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 9
238000000034 method Methods 0.000 claims abstract description 8
125000000217 alkyl group Chemical group 0.000 claims abstract description 6
125000003118 aryl group Chemical group 0.000 claims abstract description 5
125000004423 acyloxy group Chemical group 0.000 claims abstract description 4
125000005843 halogen group Chemical group 0.000 claims abstract description 4
238000002360 preparation method Methods 0.000 claims abstract description 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 3
239000001257 hydrogen Substances 0.000 claims abstract description 3
239000002904 solvent Substances 0.000 claims description 3
ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 claims 1
229910052736 halogen Inorganic materials 0.000 abstract description 3
150000001638 boron Chemical class 0.000 abstract description 2
125000001931 aliphatic group Chemical group 0.000 abstract 1
239000012450 pharmaceutical intermediate Substances 0.000 abstract 1
239000011541 reaction mixture Substances 0.000 description 14
WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 9
239000004327 boric acid Substances 0.000 description 6
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 5
150000008064 anhydrides Chemical class 0.000 description 4
239000013078 crystal Substances 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
239000000203 mixture Substances 0.000 description 3
DJXNJVFEFSWHLY-UHFFFAOYSA-N quinoline-3-carboxylic acid Chemical class C1=CC=CC2=CC(C(=O)O)=CN=C21 DJXNJVFEFSWHLY-UHFFFAOYSA-N 0.000 description 3
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
238000009835 boiling Methods 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
238000000354 decomposition reaction Methods 0.000 description 2
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
WYVAMUWZEOHJOQ-UHFFFAOYSA-N propionic anhydride Chemical compound CCC(=O)OC(=O)CC WYVAMUWZEOHJOQ-UHFFFAOYSA-N 0.000 description 2
230000035484 reaction time Effects 0.000 description 2
JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 2
-1 1-ethyl 6-fluoro-7-substituted-4-oxo-1,4-dihydro-quinoline-3-carboxylic acids Chemical class 0.000 description 1
150000008065 acid anhydrides Chemical class 0.000 description 1
150000001408 amides Chemical class 0.000 description 1
125000003277 amino group Chemical group 0.000 description 1
230000000844 anti-bacterial effect Effects 0.000 description 1
150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
229910052796 boron Inorganic materials 0.000 description 1
150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
238000001816 cooling Methods 0.000 description 1
230000007812 deficiency Effects 0.000 description 1
NGBZZCXZVDYZQK-UHFFFAOYSA-N ethyl 7-chloro-1-ethyl-6-fluoro-4-oxoquinoline-3-carboxylate Chemical compound ClC1=C(F)C=C2C(=O)C(C(=O)OCC)=CN(CC)C2=C1 NGBZZCXZVDYZQK-UHFFFAOYSA-N 0.000 description 1
238000001914 filtration Methods 0.000 description 1
150000002367 halogens Chemical group 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
239000000047 product Substances 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
150000003462 sulfoxides Chemical class 0.000 description 1
239000000725 suspension Substances 0.000 description 1
235000005074 zinc chloride Nutrition 0.000 description 1
239000011592 zinc chloride Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Plural Heterocyclic Compounds (AREA)
Quinoline Compounds (AREA)
Peptides Or Proteins (AREA)
Saccharide Compounds (AREA)
Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Thin Film Transistor (AREA)
Cephalosporin Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DD86297301A 1985-12-09 1986-12-09 Neue zwischenprodukte zur herstellung von norfloxacin DD252608A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HU854693A HU196218B (en)	1985-12-09	1985-12-09	Process for preparing quinoline carboxylic acid boric acid anhydrides

Publications (1)

Publication Number	Publication Date
DD252608A5 true DD252608A5 (de)	1987-12-23

Family

ID=10968688

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD86297301A DD252608A5 (de)	1985-12-09	1986-12-09	Neue zwischenprodukte zur herstellung von norfloxacin

Country Status (18)

Country	Link
US (1)	US4803274A (ko)
EP (1)	EP0250535B1 (ko)
JP (1)	JPH0742299B2 (ko)
KR (1)	KR940009028B1 (ko)
AT (1)	ATE53212T1 (ko)
CA (1)	CA1284800C (ko)
CS (1)	CS265228B2 (ko)
DD (1)	DD252608A5 (ko)
DE (1)	DE3671628D1 (ko)
DK (1)	DK412587A (ko)
FI (1)	FI84072C (ko)
HR (1)	HRP930558A2 (ko)
HU (1)	HU196218B (ko)
NO (1)	NO169076C (ko)
SI (1)	SI8612108A8 (ko)
SU (1)	SU1604156A3 (ko)
WO (1)	WO1987003595A1 (ko)
YU (1)	YU45388B (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI8810667A8 (en) *	1987-04-08	1996-04-30	Chinoin Gyogyszer Es Vegyeszet	Anhydride of quinoline carboxylic acid of boron acid and process for their production.
HU198709B (en) *	1987-04-08	1989-11-28	Chinoin Gyogyszer Es Vegyeszet	Process for producing quinoline-carboxylic acid derivatives
US5380845A (en) *	1987-06-24	1995-01-10	Chinoin Gyogyszer- Es Vegyeszeti Termekek Gyara Rt.	Process for the preparation of quinoline carboxylic acid derivatives
GR910100517A (el) *	1991-12-30	1993-08-31	Kyorin Seiyaku Kk	Δις(ακυλοξυ-ο) βορικος εστερας του (6,7-υποκατεστημενου-8-αλκοξυ-1- κυκλοπροπυλ-1,4,-διυδρο-4-οξο-3-κινολινοκαρβοξυλικου οξεως-ο3,ο4)και αλας αυτου, και μεθοδος παρασκευης αυτου.
ES2077490B1 (es) *	1992-11-18	1996-10-16	Marga Investigacion	Esteres trimetilsililicos y solvatos de quelatos de acidos quinolin-3-carboxilicos. preparacion y aplicacion al proceso de quinolonas.
ES2092963B1 (es) *	1995-04-12	1997-12-16	Sint Quimica Sa	Procedimiento para la preparacion del acido 1-ciclopropil-6-fluoro-1, 4-dihidro-7-(1s,4s)-5-metil-2,5-diazabiciclo(2.2.1) hept-2-il)-4-oxo-3-quinolincarboxilico y sus sales.

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1195749A (en) *	1966-12-19	1970-06-24	Lubrizol Corp	Sulfur-Containing Cycloaliphatic Reaction Products and their use in Lubricant Compositions
JPS53141286A (en)	1977-05-16	1978-12-08	Kyorin Seiyaku Kk	Novel substituted quinolinecarboxylic acid
SE444566B (sv)	1977-09-20	1986-04-21	Bellon Labor Sa Roger	7-dialkylamin-6-halogen-4-oxo-1,4-dihydrokinolin-3-karboxylsyra, forfarande for framstellning derav och farmaceutiskt preparat derav
JPS6011913B2 (ja) *	1977-12-27	1985-03-28	広栄化学工業株式会社	１，８−ナフチリジン誘導体ならびにその製造方法
JPS54138582A (en)	1978-04-19	1979-10-27	Kyorin Seiyaku Kk	Substituted quinolinecarboxylic acid
FR2424919B1 (fr)	1978-05-03	1980-10-31	Kyorin Seiyaku Kk	Acide quinoleinecarboxylique substitue et ses derives et leur utilisation comme agents antibacteriens
JPS5533453A (en)	1978-08-31	1980-03-08	Dainippon Pharmaceut Co Ltd	Preventive and remedy for infectious disease of fish
JPS5845426B2 (ja)	1978-09-29	1983-10-08	杏林製薬株式会社	置換キノリンカルボン酸誘導体
JPS5762259A (en)	1980-09-05	1982-04-15	Kyorin Pharmaceut Co Ltd	Preparation of substituted quinolinecarboxylic acid derivative
JPS59122470A (ja)	1982-12-27	1984-07-14	Dai Ichi Seiyaku Co Ltd	キノリン−３−カルボン酸誘導体の製造法
JPH0833453B2 (ja)	1987-05-30	1996-03-29	大阪瓦斯株式会社	金属管の接触位置の検出方法

1985
- 1985-12-09 HU HU854693A patent/HU196218B/hu not_active IP Right Cessation
1986
- 1986-12-08 CA CA000524725A patent/CA1284800C/en not_active Expired - Lifetime
- 1986-12-09 SI SI8612108A patent/SI8612108A8/sl unknown
- 1986-12-09 YU YU2108/86A patent/YU45388B/xx unknown
- 1986-12-09 US US07/105,298 patent/US4803274A/en not_active Expired - Fee Related
- 1986-12-09 EP EP87900246A patent/EP0250535B1/en not_active Expired - Lifetime
- 1986-12-09 KR KR1019870700687A patent/KR940009028B1/ko not_active IP Right Cessation
- 1986-12-09 JP JP62500207A patent/JPH0742299B2/ja not_active Expired - Lifetime
- 1986-12-09 CS CS869089A patent/CS265228B2/cs unknown
- 1986-12-09 WO PCT/HU1986/000068 patent/WO1987003595A1/en active IP Right Grant
- 1986-12-09 DD DD86297301A patent/DD252608A5/de not_active IP Right Cessation
- 1986-12-09 DE DE8787900246T patent/DE3671628D1/de not_active Expired - Fee Related
- 1986-12-09 AT AT87900246T patent/ATE53212T1/de not_active IP Right Cessation
1987
- 1987-08-03 NO NO873247A patent/NO169076C/no unknown
- 1987-08-07 DK DK412587A patent/DK412587A/da not_active Application Discontinuation
- 1987-08-07 FI FI873443A patent/FI84072C/fi not_active IP Right Cessation
- 1987-08-07 SU SU874203191A patent/SU1604156A3/ru active
1993
- 1993-03-26 HR HR930558A patent/HRP930558A2/hr not_active Application Discontinuation

Also Published As

Publication number	Publication date
FI873443A0 (fi)	1987-08-07
NO169076C (no)	1992-05-06
NO873247D0 (no)	1987-08-03
EP0250535B1 (en)	1990-05-30
FI873443A (fi)	1987-08-07
NO873247L (no)	1987-08-03
EP0250535A1 (en)	1988-01-07
HRP930558A2 (en)	1996-04-30
US4803274A (en)	1989-02-07
FI84072C (fi)	1991-10-10
CS908986A2 (en)	1988-03-15
CA1284800C (en)	1991-06-11
DK412587D0 (da)	1987-08-07
JPS63501955A (ja)	1988-08-04
KR880700803A (ko)	1988-04-12
SU1604156A3 (ru)	1990-10-30
JPH0742299B2 (ja)	1995-05-10
CS265228B2 (en)	1989-10-13
YU45388B (en)	1992-05-28
KR940009028B1 (ko)	1994-09-29
HU196218B (en)	1988-10-28
SI8612108A8 (en)	1996-10-31
YU210886A (en)	1987-12-31
ATE53212T1 (de)	1990-06-15
DK412587A (da)	1987-08-07
NO169076B (no)	1992-01-27
HUT44566A (en)	1988-03-28
DE3671628D1 (de)	1990-07-05
WO1987003595A1 (en)	1987-06-18
FI84072B (fi)	1991-06-28

Legal Events

Date	Code	Title	Description
1995-10-12	ENJ	Ceased due to non-payment of renewal fee

Publication	Publication Date	Title
EP0039482B1 (de)	1985-03-27	Perylen-3,4,9,10-tetracarbonsäuremonoanhydridmonoimide, Verfahren zur Herstellung solcher Verbindungen und ihre Verwendung
DE3876583T2 (de)	1993-04-15	Chinolincarbonsaeure-borsaeure-anhydride und verfahren zur herstellung.
EP0176846A2 (de)	1986-04-09	3-Amino-2-benzoyl-acrylsäurederivate und ein Verfahren zu ihrer Herstellung
DD280530A5 (de)	1990-07-11	Verfahren zur herstellung von l-tertiaer-alkyl-substituierten naphthyridin- und chinolin-carbonsaeuren und -carbonsaeurederivaten
DE2809720C2 (ko)	1992-01-16
DD252608A5 (de)	1987-12-23	Neue zwischenprodukte zur herstellung von norfloxacin
DE1966850B2 (de)	1978-08-03	Penicilline mit einer Sulfogruppe in a-Stellung de Acylrestes und Verfahren zu ihrer Herstellung
EP0045375A1 (de)	1982-02-10	Verfahren zur Herstellung von Chinolinen, Naphthyridinen und anderen Stickstoff-bi-heterocyclen
DD242042A5 (de)	1987-01-14	1-substituierte derivate von 6-flour-7-(pyrol-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxyl saeuren, ihre herstellung und ihre anwendung als arzneimittel
DD269848A5 (de)	1989-07-12	Verfahren zur herstellung von chinolincarbonsaeure
DD252607A5 (de)	1987-12-23	Neues zwischenprodukt zur herstellung von amifloxacin
DD252602A5 (de)	1987-12-23	Verfahren zur herstellung von 1-methylamino-chinolincarbonsaeuren
DE3538747C2 (ko)	1988-08-18
EP0511164B1 (de)	1996-05-08	Verfahren zur Herstellung von 5,6,11,12-Tetrathiotetracen
AT401648B (de)	1996-10-25	Verfahren zur herstellung von 1-subst.-6-fluor-
DE1795004A1 (de)	1972-05-10	Penicillansaeuren
DE951006C (de)	1956-10-18	Verfahren zur Herstellung von substituierten Oxazol-5-on-verbindungen
DE1935349C (de)	1973-01-18	Verfahren zur Herstellung von Aziridinomitosen-derivaten
DE69014852T2 (de)	1995-04-13	Phenylglycinderivate.
AT396105B (de)	1993-06-25	Verfahren zur herstellung von 1-substituierter 6-fluor-4-oxo-7-(1-piperazinyl)-1,4-dihydrochinolin-3-carbonsaeure und neue zwischenverbindung, verwendbar in diesem verfahren
DE2119396C3 (de)	1976-05-06	Thiazolo eckige Klammer auf 5,4-f eckige Klammer zu chinolinderivate und ein Verfahren zu deren Herstellung
DD250929A5 (de)	1987-10-28	Verfahren zur herstellung von chinolincarbonsaeuren
AT257610B (de)	1967-10-10	Verfahren zur Herstellung von neuen Estern substituierter 8-Hydroxychinoline
DE1470047C (de)	1972-01-05	Chinohndenvate und ein Verfahren zu ihrer Herstellung
DE2116159B2 (de)	1980-11-06	Verfahren zur Herstellung von 4-Pyridylthio-essigsäure