DD209478A5 - Testsystem und verfahren zur bestimmung von substanzen in fluessigkeiten - Google Patents

Testsystem und verfahren zur bestimmung von substanzen in fluessigkeiten Download PDF

Info

Publication number: DD209478A5
Authority: DD; German Democratic Republic
Prior art keywords: test system; glucose; enzyme; determination; dehydrogenase
Prior art date: 1982-03-26

Application number

DD83249136A

Other languages

German (de)

English (en)

Inventor

Berthold Limbach

Roland Helger

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-03-26

Filing date

1983-03-24

Publication date

1984-05-09

1983-03-24 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

1984-05-09 Publication of DD209478A5 publication Critical patent/DD209478A5/de

Links

238000012360 testing method Methods 0.000 title claims abstract description 28
239000000126 substance Substances 0.000 title claims abstract description 21
238000000034 method Methods 0.000 title claims abstract description 15
239000007788 liquid Substances 0.000 title claims abstract description 8
102000004190 Enzymes Human genes 0.000 claims description 44
108090000790 Enzymes Proteins 0.000 claims description 44
229940088598 enzyme Drugs 0.000 claims description 44
BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 claims description 24
229950006238 nadide Drugs 0.000 claims description 24
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 19
239000008103 glucose Substances 0.000 claims description 19
108010050375 Glucose 1-Dehydrogenase Proteins 0.000 claims description 18
108010015776 Glucose oxidase Proteins 0.000 claims description 9
239000004366 Glucose oxidase Substances 0.000 claims description 9
239000005515 coenzyme Substances 0.000 claims description 9
229940116332 glucose oxidase Drugs 0.000 claims description 9
235000019420 glucose oxidase Nutrition 0.000 claims description 9
238000005259 measurement Methods 0.000 claims description 9
102000003992 Peroxidases Human genes 0.000 claims description 6
239000007795 chemical reaction product Substances 0.000 claims description 6
229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 claims description 5
101710088194 Dehydrogenase Proteins 0.000 claims description 4
239000012488 sample solution Substances 0.000 claims description 4
241000194107 Bacillus megaterium Species 0.000 claims description 3
125000003831 tetrazolyl group Chemical group 0.000 claims description 3
241000588624 Acinetobacter calcoaceticus Species 0.000 claims description 2
108020005199 Dehydrogenases Proteins 0.000 claims description 2
108010046301 glucose peroxidase Proteins 0.000 claims description 2
239000000370 acceptor Substances 0.000 claims 2
XJLXINKUBYWONI-NNYOXOHSSA-N NADP zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-NNYOXOHSSA-N 0.000 claims 1
235000001727 glucose Nutrition 0.000 description 19
238000006243 chemical reaction Methods 0.000 description 18
230000001419 dependent effect Effects 0.000 description 9
FBWADIKARMIWNM-UHFFFAOYSA-N N-3,5-dichloro-4-hydroxyphenyl-1,4-benzoquinone imine Chemical compound C1=C(Cl)C(O)=C(Cl)C=C1N=C1C=CC(=O)C=C1 FBWADIKARMIWNM-UHFFFAOYSA-N 0.000 description 8
230000008878 coupling Effects 0.000 description 8
238000010168 coupling process Methods 0.000 description 8
238000005859 coupling reaction Methods 0.000 description 8
239000011541 reaction mixture Substances 0.000 description 7
238000013459 approach Methods 0.000 description 6
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
230000001575 pathological effect Effects 0.000 description 5
108010021809 Alcohol dehydrogenase Proteins 0.000 description 4
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
238000006911 enzymatic reaction Methods 0.000 description 4
108040007629 peroxidase activity proteins Proteins 0.000 description 4
210000002966 serum Anatomy 0.000 description 4
239000000758 substrate Substances 0.000 description 4
YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 4
102000003855 L-lactate dehydrogenase Human genes 0.000 description 3
108700023483 L-lactate dehydrogenases Proteins 0.000 description 3
JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 3
229910019142 PO4 Inorganic materials 0.000 description 3
238000002835 absorbance Methods 0.000 description 3
238000007357 dehydrogenase reaction Methods 0.000 description 3
238000003745 diagnosis Methods 0.000 description 3
238000011156 evaluation Methods 0.000 description 3
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
239000010452 phosphate Substances 0.000 description 3
239000008363 phosphate buffer Substances 0.000 description 3
239000000243 solution Substances 0.000 description 3
102000007698 Alcohol dehydrogenase Human genes 0.000 description 2
240000004808 Saccharomyces cerevisiae Species 0.000 description 2
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 description 2
239000000654 additive Substances 0.000 description 2
210000001124 body fluid Anatomy 0.000 description 2
239000010839 body fluid Substances 0.000 description 2
239000000872 buffer Substances 0.000 description 2
239000003153 chemical reaction reagent Substances 0.000 description 2
230000002255 enzymatic effect Effects 0.000 description 2
235000011187 glycerol Nutrition 0.000 description 2
239000000463 material Substances 0.000 description 2
BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 2
230000003287 optical effect Effects 0.000 description 2
238000011197 physicochemical method Methods 0.000 description 2
150000004053 quinones Chemical class 0.000 description 2
239000000376 reactant Substances 0.000 description 2
239000012898 sample dilution Substances 0.000 description 2
238000012216 screening Methods 0.000 description 2
230000035945 sensitivity Effects 0.000 description 2
WNMXBIHCTDWWGR-BTVCFUMJSA-N 2,3-dihydroxypropyl dihydrogen phosphate (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal Chemical compound OCC(O)COP(O)(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O WNMXBIHCTDWWGR-BTVCFUMJSA-N 0.000 description 1
QITPSLQLANKSGE-UHFFFAOYSA-N 2-aminoacetic acid;2-hydroxypropanoic acid Chemical compound NCC(O)=O.CC(O)C(O)=O QITPSLQLANKSGE-UHFFFAOYSA-N 0.000 description 1
125000006306 4-iodophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1I 0.000 description 1
VDJKJPMLWJWQIH-UHFFFAOYSA-M 5-ethylphenazin-5-ium;ethyl sulfate Chemical compound CCOS([O-])(=O)=O.C1=CC=C2[N+](CC)=C(C=CC=C3)C3=NC2=C1 VDJKJPMLWJWQIH-UHFFFAOYSA-M 0.000 description 1
RXGJTUSBYWCRBK-UHFFFAOYSA-M 5-methylphenazinium methyl sulfate Chemical compound COS([O-])(=O)=O.C1=CC=C2[N+](C)=C(C=CC=C3)C3=NC2=C1 RXGJTUSBYWCRBK-UHFFFAOYSA-M 0.000 description 1
102100031126 6-phosphogluconolactonase Human genes 0.000 description 1
108010029731 6-phosphogluconolactonase Proteins 0.000 description 1
MBAJNQDWJUHYOF-UHFFFAOYSA-N 7h-purin-6-amine;pyridine-3-carboxamide Chemical compound NC(=O)C1=CC=CN=C1.NC1=NC=NC2=C1NC=N2 MBAJNQDWJUHYOF-UHFFFAOYSA-N 0.000 description 1
239000004382 Amylase Substances 0.000 description 1
102000013142 Amylases Human genes 0.000 description 1
108010065511 Amylases Proteins 0.000 description 1
241000193830 Bacillus <bacterium> Species 0.000 description 1
101000950981 Bacillus subtilis (strain 168) Catabolic NAD-specific glutamate dehydrogenase RocG Proteins 0.000 description 1
102000018832 Cytochromes Human genes 0.000 description 1
108010052832 Cytochromes Proteins 0.000 description 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
108010018962 Glucosephosphate Dehydrogenase Proteins 0.000 description 1
102000016901 Glutamate dehydrogenase Human genes 0.000 description 1
102000057621 Glycerol kinases Human genes 0.000 description 1
102000005548 Hexokinase Human genes 0.000 description 1
108700040460 Hexokinases Proteins 0.000 description 1
229930195725 Mannitol Natural products 0.000 description 1
101710163410 Probable glycerol kinase Proteins 0.000 description 1
241000589774 Pseudomonas sp. Species 0.000 description 1
108010046334 Urease Proteins 0.000 description 1
239000002250 absorbent Substances 0.000 description 1
230000002745 absorbent Effects 0.000 description 1
230000000996 additive effect Effects 0.000 description 1
235000019418 amylase Nutrition 0.000 description 1
150000004054 benzoquinones Chemical class 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
238000002405 diagnostic procedure Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000003792 electrolyte Substances 0.000 description 1
150000002211 flavins Chemical class 0.000 description 1
GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
229940020947 fluorescein sodium Drugs 0.000 description 1
150000002304 glucoses Chemical class 0.000 description 1
238000007654 immersion Methods 0.000 description 1
UETZVSHORCDDTH-UHFFFAOYSA-N iron(2+);hexacyanide Chemical compound [Fe+2].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] UETZVSHORCDDTH-UHFFFAOYSA-N 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
CXKWCBBOMKCUKX-UHFFFAOYSA-M methylene blue Chemical compound [Cl-].C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 CXKWCBBOMKCUKX-UHFFFAOYSA-M 0.000 description 1
229960000907 methylthioninium chloride Drugs 0.000 description 1
238000012544 monitoring process Methods 0.000 description 1
230000036651 mood Effects 0.000 description 1
238000006395 oxidase reaction Methods 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
239000000047 product Substances 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
238000010998 test method Methods 0.000 description 1
150000003626 triacylglycerols Chemical class 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
210000002700 urine Anatomy 0.000 description 1
230000000007 visual effect Effects 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/805—Test papers
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Microbiology (AREA)
Biochemistry (AREA)
Physics & Mathematics (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Biophysics (AREA)
Analytical Chemistry (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Emergency Medicine (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)

DD83249136A 1982-03-26 1983-03-24 Testsystem und verfahren zur bestimmung von substanzen in fluessigkeiten DD209478A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19823211167 DE3211167A1 (de)	1982-03-26	1982-03-26	Testsystem und verfahren zur bestimmung von substanzen in fluessigkeiten

Publications (1)

Publication Number	Publication Date
DD209478A5 true DD209478A5 (de)	1984-05-09

Family

ID=6159381

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD83249136A DD209478A5 (de)	1982-03-26	1983-03-24	Testsystem und verfahren zur bestimmung von substanzen in fluessigkeiten

Country Status (8)

Country	Link
US (1)	US4490465A (xx)
EP (1)	EP0090223B1 (xx)
JP (1)	JPS58175498A (xx)
CS (1)	CS250227B2 (xx)
DD (1)	DD209478A5 (xx)
DE (2)	DE3211167A1 (xx)
IL (1)	IL68198A (xx)
ZA (1)	ZA832105B (xx)

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US7244264B2 (en) *	2002-12-03	2007-07-17	Roche Diagnostics Operations, Inc.	Dual blade lancing test strip
US7582258B2 (en)	2002-12-23	2009-09-01	Roche Diagnostics Operations, Inc.	Body fluid testing device
ES2522972T3 (es)	2002-12-23	2014-11-19	F.Hoffmann-La Roche Ag	Dispositivo para ensayar fluidos corporales
US20040127818A1 (en)	2002-12-27	2004-07-01	Roe Steven N.	Precision depth control lancing tip
ATE445360T1 (de) *	2002-12-30	2009-10-15	Hoffmann La Roche	Blutaquisitionssuspensionssystem
EP1581114B1 (en) *	2002-12-30	2014-04-30	Roche Diagnostics GmbH	Flexible test strip lancet device
US7214200B2 (en) *	2002-12-30	2007-05-08	Roche Diagnostics Operations, Inc.	Integrated analytical test element
EP1589873B1 (en) *	2003-01-29	2011-12-21	Roche Diagnostics GmbH	Integrated lancing test strip
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DE2905708A1 (de) *	1979-02-15	1980-08-28	Vitatron Scientific Bv	Verfahren zur photometrischen bestimmung von zwei oder mehr bestandteilen einer fluessigkeitsprobe sowie reagenzsatz zur durchfuehrung dieser photometrischen bestimmung
US4259440A (en) *	1979-05-21	1981-03-31	Miles Laboratories, Inc.	Hydrolysis and assay of triglycerides
SU857874A1 (ru) *	1979-07-23	1981-08-23	Ордена Ленина Институт Химической Физики Ан Ссср	Способ количественного определени глюкозы
DE2950381A1 (de) *	1979-12-14	1981-06-19	Boehringer Mannheim Gmbh, 6800 Mannheim	Verfahren und reagens zur bestimmulng von triglyceriden
US4309502A (en) *	1980-06-30	1982-01-05	Beckman Instruments, Inc.	Enzymatic assay for glycerol and triglycerides and a reagent for use therein
US4340669A (en) *	1981-02-12	1982-07-20	Miles Laboratories, Inc.	System for the determination of glucose in fluids
DE3210095A1 (de) *	1982-03-19	1983-09-29	Boehringer Mannheim Gmbh, 6800 Mannheim	Verfahren und reagenz zur bestimmung von glycerin

1982
- 1982-03-26 DE DE19823211167 patent/DE3211167A1/de not_active Withdrawn
1983
- 1983-03-11 EP EP83102388A patent/EP0090223B1/de not_active Expired
- 1983-03-11 DE DE8383102388T patent/DE3373314D1/de not_active Expired
- 1983-03-22 IL IL68198A patent/IL68198A/xx unknown
- 1983-03-23 CS CS831987A patent/CS250227B2/cs unknown
- 1983-03-24 ZA ZA832105A patent/ZA832105B/xx unknown
- 1983-03-24 DD DD83249136A patent/DD209478A5/de not_active IP Right Cessation
- 1983-03-25 JP JP58049099A patent/JPS58175498A/ja active Pending
- 1983-03-25 US US06/478,765 patent/US4490465A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JPS58175498A (ja)	1983-10-14
EP0090223B1 (de)	1987-09-02
US4490465A (en)	1984-12-25
EP0090223A3 (en)	1985-08-14
IL68198A (en)	1986-09-30
CS250227B2 (en)	1987-04-16
DE3373314D1 (en)	1987-10-08
ZA832105B (en)	1983-12-28
EP0090223A2 (de)	1983-10-05
DE3211167A1 (de)	1983-09-29
IL68198A0 (en)	1983-06-15

Legal Events

Date	Code	Title	Description
1996-05-23	ENJ	Ceased due to non-payment of renewal fee

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