CY1124130T1 - Παραγωγο 2.2-διφθοροπροπιοναμιδιου απο μεθυλικη βαρδοξολονη, φαρμακευτικες συνθεσεις και πολυμορφικες μορφες τους για χρηση στη θεραπευτικη αντιμετωπιση συγκεκριμενων παθησεων - Google Patents
Παραγωγο 2.2-διφθοροπροπιοναμιδιου απο μεθυλικη βαρδοξολονη, φαρμακευτικες συνθεσεις και πολυμορφικες μορφες τους για χρηση στη θεραπευτικη αντιμετωπιση συγκεκριμενων παθησεωνInfo
- Publication number
- CY1124130T1 CY1124130T1 CY20211100266T CY211100266T CY1124130T1 CY 1124130 T1 CY1124130 T1 CY 1124130T1 CY 20211100266 T CY20211100266 T CY 20211100266T CY 211100266 T CY211100266 T CY 211100266T CY 1124130 T1 CY1124130 T1 CY 1124130T1
- Authority
- CY
- Cyprus
- Prior art keywords
- pharmaceutical compositions
- vardoxolone
- polymorphines
- difluoropropionamide
- methylate
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C255/47—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of rings being part of condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Abstract
Η παρούσα εφεύρεση σχετίζεται γενικά με την ένωση: Ν-((4aS,6aR,6bS,8aR,12aS, 14aR, 14bS)-11-κυαν-2,2,6a,6b,9,9, 12a-επταμεθυλο-10, 14-διοξο-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9, 10, 12a, 14, 14a, 14b-οκταδεκαϋδροπισεν-4a-υλο)-2,2-διφθοροπροπαναμίδιο και πολυμορφικές μορφές και φαρμακευτικές σύνθεσης αυτής για χρήση στη θεραπευτική αντιμετώπιση του καρκίνου σε συνδυασμό με ανοσοθεραπεία, για χρήση στη θεραπευτική αντιμετώπιση παθήσεων που συνδέονται με οξειδωτικό στρες το οποίο προκαλείται από μιτοχονδριακή δυσλειτουργία και για χρήση στη θεραπευτική αντιμετώπιση διαταραχών κρίσεων.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261687669P | 2012-04-27 | 2012-04-27 | |
US201361775288P | 2013-03-08 | 2013-03-08 | |
US201361780444P | 2013-03-13 | 2013-03-13 | |
EP13720708.0A EP2841445B1 (en) | 2012-04-27 | 2013-04-24 | 2.2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof |
PCT/US2013/038064 WO2013163344A1 (en) | 2012-04-27 | 2013-04-24 | 2.2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
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CY1124130T1 true CY1124130T1 (el) | 2022-05-27 |
Family
ID=49483867
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20171100959T CY1119333T1 (el) | 2012-04-27 | 2017-09-12 | Παραγωγα 2.2-διφθοροπροπιοναμιδιου απο μεθυλικη βαρδοξολονη, πολυμορφικες μορφες και μεθοδοι χρησης αυτων |
CY20211100266T CY1124130T1 (el) | 2012-04-27 | 2021-03-26 | Παραγωγο 2.2-διφθοροπροπιοναμιδιου απο μεθυλικη βαρδοξολονη, φαρμακευτικες συνθεσεις και πολυμορφικες μορφες τους για χρηση στη θεραπευτικη αντιμετωπιση συγκεκριμενων παθησεων |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20171100959T CY1119333T1 (el) | 2012-04-27 | 2017-09-12 | Παραγωγα 2.2-διφθοροπροπιοναμιδιου απο μεθυλικη βαρδοξολονη, πολυμορφικες μορφες και μεθοδοι χρησης αυτων |
Country Status (39)
Country | Link |
---|---|
US (4) | US8993640B2 (el) |
EP (2) | EP2841445B1 (el) |
JP (2) | JP6410710B2 (el) |
KR (1) | KR102101774B1 (el) |
CN (1) | CN104395332B (el) |
AR (1) | AR092823A1 (el) |
AU (1) | AU2013251602B2 (el) |
BR (1) | BR112014026640B1 (el) |
CA (1) | CA2869783C (el) |
CL (1) | CL2014002886A1 (el) |
CO (1) | CO7170182A2 (el) |
CY (2) | CY1119333T1 (el) |
DK (2) | DK3444261T3 (el) |
DO (1) | DOP2014000236A (el) |
EA (1) | EA030468B1 (el) |
ES (2) | ES2861393T3 (el) |
FI (1) | FIC20240012I1 (el) |
FR (1) | FR24C1015I1 (el) |
HK (2) | HK1207086A1 (el) |
HR (1) | HRP20171275T1 (el) |
HU (3) | HUE035673T2 (el) |
IL (1) | IL235275B (el) |
LT (2) | LT2841445T (el) |
ME (1) | ME02926B (el) |
MX (1) | MX357060B (el) |
MY (1) | MY172750A (el) |
NL (1) | NL301276I2 (el) |
NZ (1) | NZ630222A (el) |
PE (1) | PE20150160A1 (el) |
PL (2) | PL2841445T3 (el) |
PT (2) | PT3444261T (el) |
RS (2) | RS56154B1 (el) |
SG (1) | SG11201406868XA (el) |
SI (2) | SI3444261T1 (el) |
TW (2) | TWI623548B (el) |
UA (1) | UA116209C2 (el) |
UY (1) | UY34764A (el) |
WO (1) | WO2013163344A1 (el) |
ZA (1) | ZA201407326B (el) |
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WO2013163344A1 (en) | 2012-04-27 | 2013-10-31 | Reata Pharmaceuticals, Inc. | 2.2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof |
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DK2892912T3 (da) | 2012-09-10 | 2019-06-24 | Reata Pharmaceuticals Inc | C17-alkandiyl og alkenediylderivater af oleanolsyre og fremgangsmåder til anvendelse deraf |
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