MX348862B - Derivados c4-monometil triterpenoides y sus metodos de uso. - Google Patents

Derivados c4-monometil triterpenoides y sus metodos de uso.

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Publication number
MX348862B
MX348862B MX2013010429A MX2013010429A MX348862B MX 348862 B MX348862 B MX 348862B MX 2013010429 A MX2013010429 A MX 2013010429A MX 2013010429 A MX2013010429 A MX 2013010429A MX 348862 B MX348862 B MX 348862B
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MX
Mexico
Prior art keywords
methods
compounds
monomethyl
triterpenoid derivatives
derivatives
Prior art date
Application number
MX2013010429A
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English (en)
Other versions
MX2013010429A (es
Inventor
Anderson Eric
Jiang Xin
Visnick Melean
bender Christopher
Liu Xioafeng
Original Assignee
Reata Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reata Pharmaceuticals Inc filed Critical Reata Pharmaceuticals Inc
Publication of MX2013010429A publication Critical patent/MX2013010429A/es
Publication of MX348862B publication Critical patent/MX348862B/es

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    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P37/08—Antiallergic agents
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    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring

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  • Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • Immunology (AREA)
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  • Psychiatry (AREA)
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Abstract

Nuevos compuestos C4-monometil triterpenoides y derivados de los mismos, incluso los de la siguiente fórmula: (Ver Formula) en donde las variables son como se definieron en la presente. También se proveen composiciones farmacéuticas, conjuntos de elementos y artículos de manufactura que comprenden dichos compuestos. Se proveen asimismo métodos e intermediarios que son de utilidad para elaborar los compuestos, y métodos para utilizar los compuestos, por ejemplo como moduladores antioxidantes de inflamación, y composiciones con los mismos.
MX2013010429A 2011-03-11 2012-03-09 Derivados c4-monometil triterpenoides y sus metodos de uso. MX348862B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161452017P 2011-03-11 2011-03-11
PCT/US2012/028569 WO2012125488A1 (en) 2011-03-11 2012-03-09 C4-monomethyl triterpenoid derivatives and methods of use thereof

Publications (2)

Publication Number Publication Date
MX2013010429A MX2013010429A (es) 2013-10-03
MX348862B true MX348862B (es) 2017-07-03

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ID=45856041

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MX2013010429A MX348862B (es) 2011-03-11 2012-03-09 Derivados c4-monometil triterpenoides y sus metodos de uso.

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US (1) US9290536B2 (es)
EP (1) EP2683731B1 (es)
JP (1) JP6129084B2 (es)
KR (1) KR101956399B1 (es)
CN (1) CN103619866B (es)
AR (1) AR085666A1 (es)
AU (1) AU2012229244B2 (es)
BR (1) BR112013023174B1 (es)
CA (1) CA2829618C (es)
CL (1) CL2013002612A1 (es)
CO (1) CO6801741A2 (es)
CY (1) CY1121744T1 (es)
DK (1) DK2683731T3 (es)
EA (1) EA026847B1 (es)
ES (1) ES2729405T3 (es)
HR (1) HRP20191164T1 (es)
HU (1) HUE044081T2 (es)
IL (1) IL228297B (es)
LT (1) LT2683731T (es)
ME (1) ME03469B (es)
MX (1) MX348862B (es)
PL (1) PL2683731T3 (es)
PT (1) PT2683731T (es)
RS (1) RS59200B1 (es)
SG (1) SG193404A1 (es)
SI (1) SI2683731T1 (es)
TR (1) TR201909788T4 (es)
TW (1) TWI535731B (es)
UY (1) UY33946A (es)
WO (1) WO2012125488A1 (es)

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