AR092247A1 - INHIBIDORES DE LA b-SECRETASA - Google Patents
INHIBIDORES DE LA b-SECRETASAInfo
- Publication number
- AR092247A1 AR092247A1 ARP130103032A ARP130103032A AR092247A1 AR 092247 A1 AR092247 A1 AR 092247A1 AR P130103032 A ARP130103032 A AR P130103032A AR P130103032 A ARP130103032 A AR P130103032A AR 092247 A1 AR092247 A1 AR 092247A1
- Authority
- AR
- Argentina
- Prior art keywords
- disorders
- secretase
- inhibitors
- cognitive
- bace1
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C229/50—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C313/02—Sulfinic acids; Derivatives thereof
- C07C313/06—Sulfinamides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
- C07C331/16—Isothiocyanates
- C07C331/26—Isothiocyanates having isothiocyanate groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
- C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/93—Spiro compounds
- C07C2603/94—Spiro compounds containing "free" spiro atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/93—Spiro compounds
- C07C2603/95—Spiro compounds containing "not free" spiro atoms
- C07C2603/96—Spiro compounds containing "not free" spiro atoms containing at least one ring with less than six members
- C07C2603/97—Spiro compounds containing "not free" spiro atoms containing at least one ring with less than six members containing five-membered rings
Abstract
Acilguanidinas espirocíclicas. Su uso como inhibidores de la actividad de la enzima b-secretasa (BACE1). Composiciones farmacéuticas que las comprenden. Métodos para usarlas como agentes terapéuticos en el tratamiento de los trastornos neurodegenerativos, de los trastornos caracterizados por un deterioro cognitivo, de las alteraciones cognitivas, de la demencia y de las enfermedades que se caracterizan por la producción de agregados b-amiloides. Reivindicación 1: Un compuesto caracterizado porque está representado por cualquiera de las fórmulas estructurales del Grupo (1), o una sal farmacéuticamente aceptable de éste.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261693512P | 2012-08-27 | 2012-08-27 | |
US201361788839P | 2013-03-15 | 2013-03-15 | |
US201361816458P | 2013-04-26 | 2013-04-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR092247A1 true AR092247A1 (es) | 2015-04-08 |
Family
ID=49162226
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP130103032A AR092247A1 (es) | 2012-08-27 | 2013-08-27 | INHIBIDORES DE LA b-SECRETASA |
Country Status (23)
Country | Link |
---|---|
US (2) | US9018391B2 (es) |
EP (1) | EP2888236A1 (es) |
JP (1) | JP2015529666A (es) |
KR (1) | KR20150046270A (es) |
CN (1) | CN104662005A (es) |
AP (1) | AP2015008261A0 (es) |
AR (1) | AR092247A1 (es) |
AU (1) | AU2013309157A1 (es) |
BR (1) | BR112015004303A2 (es) |
CA (1) | CA2879884A1 (es) |
EA (1) | EA201590410A1 (es) |
HK (1) | HK1211586A1 (es) |
IL (1) | IL236963A0 (es) |
IN (1) | IN2015DN01137A (es) |
MD (1) | MD20150030A2 (es) |
MX (1) | MX2015002570A (es) |
PE (1) | PE20150707A1 (es) |
PH (1) | PH12015500420A1 (es) |
SG (1) | SG11201500506YA (es) |
TN (1) | TN2015000032A1 (es) |
TW (1) | TW201422592A (es) |
UY (1) | UY34991A (es) |
WO (1) | WO2014035860A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG173466A1 (en) | 2009-03-13 | 2011-09-29 | Vitae Pharmaceuticals Inc | Inhibitors of beta-secretase |
SG11201406757SA (en) | 2012-04-26 | 2014-11-27 | Bristol Myers Squibb Co | Imidazothiadiazole and imidazopyrazine derivatives as protease activated receptor 4 (par4) inhibitors for treating platelet aggregation |
EP2847177B1 (en) | 2012-05-09 | 2017-10-11 | Boehringer Ingelheim International GmbH | Methods for making oxetan-3-ylmethanamines |
TWI568722B (zh) | 2012-06-15 | 2017-02-01 | 葛蘭馬克製藥公司 | 作爲mPGES-1抑制劑之***酮化合物 |
JP2015532282A (ja) | 2012-09-28 | 2015-11-09 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | β−セクレターゼの阻害剤 |
JP6288588B2 (ja) | 2012-11-21 | 2018-03-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | N−スルフィニル−α−アミノアミドの製造方法 |
JP2022547915A (ja) | 2019-09-06 | 2022-11-16 | 上海 インスティテュート オブ マテリア メディカ、チャイニーズ アカデミー オブ サイエンシーズ | Axlとc-Metキナーゼ阻害活性を有する化合物およびその製造と使用 |
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JP2008503460A (ja) | 2004-06-16 | 2008-02-07 | ワイス | β−セクレターゼのインヒビターとしてのジフェニルイミダゾピリミジンおよびイミダゾールアミン |
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WO2007005404A1 (en) | 2005-06-30 | 2007-01-11 | Wyeth | AMINO-5-(6-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR ß-SECRETASE MODULATION |
WO2007013002A2 (en) | 2005-07-29 | 2007-02-01 | Koninklijke Philips Electronics N.V. | Method for generating a burst of steam from a steam iron |
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BRPI0616757A2 (pt) | 2005-09-26 | 2011-06-28 | Wyeth Corp | composto da fórmula i; processo para o tratamento de uma doença ou de um distúrbio associado com a atividade excessiva de bace; processo para a modulação da atividade de bace; processo para o tratamento da doença de alzheimer; e composição farmacêutica |
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CA2634037A1 (en) | 2005-12-19 | 2007-07-12 | Wyeth | 2-amino-5-piperidinylimidazolone compounds and use thereof for .beta.-secretase modulation |
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WO2007100536A1 (en) | 2006-02-24 | 2007-09-07 | Wyeth | DIHYDROSPIRO[DIBENZO[A,D][7]ANNULENE-5,4'-IMIDAZOL] COMPOUNDS FOR THE INHIBITION OF β-SECRETASE |
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2013
- 2013-08-23 TW TW102130210A patent/TW201422592A/zh unknown
- 2013-08-26 CA CA2879884A patent/CA2879884A1/en not_active Abandoned
- 2013-08-26 UY UY34991A patent/UY34991A/es not_active Application Discontinuation
- 2013-08-26 CN CN201380044624.7A patent/CN104662005A/zh active Pending
- 2013-08-26 PE PE2015000250A patent/PE20150707A1/es not_active Application Discontinuation
- 2013-08-26 AP AP2015008261A patent/AP2015008261A0/xx unknown
- 2013-08-26 WO PCT/US2013/056566 patent/WO2014035860A1/en active Application Filing
- 2013-08-26 SG SG11201500506YA patent/SG11201500506YA/en unknown
- 2013-08-26 MD MDA20150030A patent/MD20150030A2/ro not_active Application Discontinuation
- 2013-08-26 JP JP2015529886A patent/JP2015529666A/ja active Pending
- 2013-08-26 BR BR112015004303A patent/BR112015004303A2/pt not_active IP Right Cessation
- 2013-08-26 IN IN1137DEN2015 patent/IN2015DN01137A/en unknown
- 2013-08-26 MX MX2015002570A patent/MX2015002570A/es unknown
- 2013-08-26 AU AU2013309157A patent/AU2013309157A1/en not_active Abandoned
- 2013-08-26 KR KR1020157007472A patent/KR20150046270A/ko not_active Application Discontinuation
- 2013-08-26 EP EP13760166.2A patent/EP2888236A1/en not_active Withdrawn
- 2013-08-26 EA EA201590410A patent/EA201590410A1/ru unknown
- 2013-08-27 AR ARP130103032A patent/AR092247A1/es unknown
- 2013-08-27 US US14/011,183 patent/US9018391B2/en not_active Expired - Fee Related
-
2015
- 2015-01-22 TN TNP2015000032A patent/TN2015000032A1/fr unknown
- 2015-01-28 IL IL236963A patent/IL236963A0/en unknown
- 2015-02-26 PH PH12015500420A patent/PH12015500420A1/en unknown
- 2015-03-19 US US14/662,553 patent/US20150239849A1/en not_active Abandoned
- 2015-12-17 HK HK15112443.1A patent/HK1211586A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
MX2015002570A (es) | 2015-10-05 |
TW201422592A (zh) | 2014-06-16 |
US9018391B2 (en) | 2015-04-28 |
IL236963A0 (en) | 2015-03-31 |
KR20150046270A (ko) | 2015-04-29 |
WO2014035860A8 (en) | 2015-01-15 |
JP2015529666A (ja) | 2015-10-08 |
CN104662005A (zh) | 2015-05-27 |
UY34991A (es) | 2014-03-31 |
PH12015500420B1 (en) | 2015-04-20 |
IN2015DN01137A (es) | 2015-06-26 |
PH12015500420A1 (en) | 2015-04-20 |
HK1211586A1 (en) | 2016-05-27 |
TN2015000032A1 (en) | 2016-06-29 |
PE20150707A1 (es) | 2015-06-14 |
AP2015008261A0 (en) | 2015-02-28 |
EP2888236A1 (en) | 2015-07-01 |
CA2879884A1 (en) | 2014-03-06 |
SG11201500506YA (en) | 2015-04-29 |
EA201590410A1 (ru) | 2015-06-30 |
US20150239849A1 (en) | 2015-08-27 |
AU2013309157A1 (en) | 2015-02-19 |
MD20150030A2 (ro) | 2015-08-31 |
US20140057927A1 (en) | 2014-02-27 |
BR112015004303A2 (pt) | 2017-08-08 |
WO2014035860A1 (en) | 2014-03-06 |
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