CY1122708T1 - Ενωσεις οξα-διαζασπειρο με δραση εναντι του πονου - Google Patents

Ενωσεις οξα-διαζασπειρο με δραση εναντι του πονου

Info

Publication number
CY1122708T1
CY1122708T1 CY20201100183T CY201100183T CY1122708T1 CY 1122708 T1 CY1122708 T1 CY 1122708T1 CY 20201100183 T CY20201100183 T CY 20201100183T CY 201100183 T CY201100183 T CY 201100183T CY 1122708 T1 CY1122708 T1 CY 1122708T1
Authority
CY
Cyprus
Prior art keywords
compounds
oxa
diazaspire
action against
against pain
Prior art date
Application number
CY20201100183T
Other languages
English (en)
Inventor
Marina VIRGILI BERNADÓ
Carmen ALMANSA-ROSALES
Carlos ALEGRET-MOLINA
Original Assignee
Esteve Pharmaceuticals, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Pharmaceuticals, S.A. filed Critical Esteve Pharmaceuticals, S.A.
Publication of CY1122708T1 publication Critical patent/CY1122708T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Η παρούσα εφεύρεση αναφέρεται σε ενώσεις οξα-διαζασπειρο που έχουν φαρμακολογική δραστικότητα έναντι του υποδοχέα σίγμα (σ), σε μεθόδους παρασκευής αυτών των ενώσεων, σε φαρμακευτικές συνθέσεις που περιλαμβάνουν αυτές και στη χρήση αυτών για τη θεραπεία, συγκεκριμένα για την αγωγή του πόνου.
CY20201100183T 2015-10-23 2020-02-27 Ενωσεις οξα-διαζασπειρο με δραση εναντι του πονου CY1122708T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15382523 2015-10-23
PCT/EP2016/001742 WO2017067664A1 (en) 2015-10-23 2016-10-21 Oxa-diazaspiro compounds having activity against pain

Publications (1)

Publication Number Publication Date
CY1122708T1 true CY1122708T1 (el) 2021-03-12

Family

ID=54364221

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20201100183T CY1122708T1 (el) 2015-10-23 2020-02-27 Ενωσεις οξα-διαζασπειρο με δραση εναντι του πονου

Country Status (30)

Country Link
US (1) US10689398B2 (el)
EP (1) EP3365346B1 (el)
JP (1) JP6884973B2 (el)
KR (1) KR20180073638A (el)
CN (1) CN108349998B (el)
AR (1) AR106448A1 (el)
AU (1) AU2016343551A1 (el)
BR (1) BR112018007269A2 (el)
CA (1) CA2999925A1 (el)
CO (1) CO2018004803A2 (el)
CY (1) CY1122708T1 (el)
DK (1) DK3365346T3 (el)
ES (1) ES2775522T3 (el)
HR (1) HRP20200309T1 (el)
HU (1) HUE047997T2 (el)
IL (1) IL258370A (el)
LT (1) LT3365346T (el)
MA (1) MA43158B1 (el)
ME (1) ME03636B (el)
MX (1) MX2018004777A (el)
PH (1) PH12018500682A1 (el)
PL (1) PL3365346T3 (el)
PT (1) PT3365346T (el)
RS (1) RS59956B1 (el)
RU (1) RU2018118399A (el)
SG (1) SG11201802988XA (el)
SI (1) SI3365346T1 (el)
TN (1) TN2018000091A1 (el)
TW (1) TW201731853A (el)
WO (1) WO2017067664A1 (el)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201615643A (zh) 2014-06-02 2016-05-01 伊史帝夫博士實驗室股份有限公司 具有多重模式抗疼痛活性之１－氧雜－４，９－二氮雜螺十一烷化合物之烷基與芳基衍生物
TN2018000091A1 (en) 2015-10-23 2019-07-08 Esteve Labor Dr Oxa-diazaspiro compounds having activity against pain

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3481942A (en) 1968-09-06 1969-12-02 Smithkline Corp Oxa-diazaspiro(4.5)decane compounds
US4353900A (en) * 1981-10-19 1982-10-12 Syntex (U.S.A.) Inc. 9-(Arylalkyl or aroylalkyl)-1-oxa-4,9-diazaspiro(5.5)undecan-3-ones
WO1993013101A1 (en) * 1991-12-27 1993-07-08 Yoshitomi Pharmaceutical Industries, Ltd. Pyridonecarboxylate compound, pharmaceutical use thereof, and spiro compound
US6114541A (en) 1997-03-10 2000-09-05 Hoffmann-La Roche Inc. Method for the preparation of α-Bromo-Lactam derivatives
MXPA04006280A (es) 2001-12-28 2004-09-27 Acadia Pharm Inc Compuestos espiroazaciclicos como moduladores de receptor de monoamina.
JP4823914B2 (ja) * 2003-11-07 2011-11-24 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド Ｆｇｆｒ３の阻害および多発性骨髄腫の治療
EP1634873A1 (en) 2004-08-27 2006-03-15 Laboratorios Del Dr. Esteve, S.A. Sigma receptor inhibitors
DE102005030051A1 (de) 2005-06-27 2006-12-28 Grünenthal GmbH Substituierte 1-Oxa-3,8-diazaspiro[4,5]-decan-2-on-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
JP5217438B2 (ja) 2005-11-18 2013-06-19 小野薬品工業株式会社 塩基性基を含有する化合物およびその用途
EP1829869A1 (en) 2006-03-02 2007-09-05 Laboratorios Del Dr. Esteve, S.A. 4,5,6,7-Tetrahydrobenzo[b]thiophene derivatives and their use as sigma receptor ligands
WO2007124136A1 (en) 2006-04-19 2007-11-01 Acadia Pharmaceuticals, Inc. Use of 4-amino-piperidines for treating sleep disorders
EP1847542A1 (en) 2006-04-21 2007-10-24 Laboratorios del Dr. Esteve S.A. Spiro[benzopyran] or spiro[benzofuran] derivatives which inhibit the sigma receptor
EP2128154B1 (en) 2007-03-01 2015-04-08 Mitsubishi Tanabe Pharma Corporation Benzimidazole compound and pharmaceutical use thereof
EP1982714A1 (en) 2007-04-16 2008-10-22 Laboratorios del Dr. Esteve S.A. Pyrano-pyrazole-amines
EP2020414A1 (en) 2007-06-20 2009-02-04 Laboratorios del Dr. Esteve S.A. spiro[piperidine-4,4'-thieno[3,2-c]pyran] derivatives and related compounds as inhibitors of the sigma receptor for the treatment of psychosis
EP2197876A1 (en) 2007-08-29 2010-06-23 Glaxosmithkline LLC Thiazole and oxazole kinase inhibitors
EP2070933A1 (en) 2007-12-07 2009-06-17 Laboratorios del Dr. Esteve S.A. Tricyclic triazolic compounds
MY149731A (en) 2008-02-06 2013-10-14 Astrazeneca Ab Compounds
CN102668581A (zh) 2009-10-25 2012-09-12 Lg电子株式会社 用于处理广播节目信息的方法及广播接收器
CA2829803A1 (en) * 2011-03-14 2012-09-20 Vertex Pharmaceuticals Incorporated Morpholine-spirocyclic piperidine amides as modulators of ion channels
TWI623330B (zh) 2011-03-16 2018-05-11 通路實業集團國際公司 具紫外線消毒之增濕器及其方法
JP5964426B2 (ja) 2011-08-19 2016-08-03 グラクソスミスクライン、インテレクチュアル、プロパティー、ナンバー２、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｎｏ．２ Ｌｉｍｉｔｅｄ 脂肪酸シンターゼ阻害剤
US9751881B2 (en) 2013-07-31 2017-09-05 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
JP2017100951A (ja) 2014-04-04 2017-06-08 大正製薬株式会社 オキサゾリジノン及びオキサジナノン誘導体
TWI685497B (zh) 2014-06-02 2020-02-21 西班牙商伊史帝夫製藥公司 具有多重模式抗疼痛活性的１-氧雜-４,９-二氮雜螺十一烷化合物之烷基衍生物
TW201615642A (zh) 2014-06-02 2016-05-01 伊史帝夫博士實驗室股份有限公司 具有多重模式抗疼痛活性的１－氧雜－４，９－二氮雜螺十一烷化合物之醯胺衍生物
TW201615643A (zh) * 2014-06-02 2016-05-01 伊史帝夫博士實驗室股份有限公司 具有多重模式抗疼痛活性之１－氧雜－４，９－二氮雜螺十一烷化合物之烷基與芳基衍生物
JP2017535566A (ja) 2014-11-21 2017-11-30 ラボラトリオス・デル・ドクトル・エステベ・ソシエダッド・アノニマ 疼痛に対する多様な活性を有する１，９−ジアザスピロウンデカン化合物
TN2018000091A1 (en) 2015-10-23 2019-07-08 Esteve Labor Dr Oxa-diazaspiro compounds having activity against pain

Also Published As

Publication number Publication date
JP2018531263A (ja) 2018-10-25
IL258370A (en) 2018-05-31
HRP20200309T1 (hr) 2020-06-12
AU2016343551A1 (en) 2018-04-19
WO2017067664A9 (en) 2017-06-29
MX2018004777A (es) 2018-06-19
PL3365346T3 (pl) 2020-06-01
PH12018500682A1 (en) 2018-10-01
CA2999925A1 (en) 2017-04-27
JP6884973B2 (ja) 2021-06-09
RU2018118399A (ru) 2019-11-25
CO2018004803A2 (es) 2018-07-19
TW201731853A (zh) 2017-09-16
SI3365346T1 (sl) 2020-04-30
DK3365346T3 (da) 2020-03-09
RU2018118399A3 (el) 2020-01-31
EP3365346A1 (en) 2018-08-29
WO2017067664A1 (en) 2017-04-27
HUE047997T2 (hu) 2020-05-28
PT3365346T (pt) 2020-03-05
CN108349998A (zh) 2018-07-31
BR112018007269A2 (pt) 2018-10-30
AR106448A1 (es) 2018-01-17
ME03636B (me) 2020-07-20
SG11201802988XA (en) 2018-05-30
CN108349998B (zh) 2021-10-29
EP3365346B1 (en) 2019-12-04
US10689398B2 (en) 2020-06-23
RS59956B1 (sr) 2020-03-31
US20190002475A1 (en) 2019-01-03
MA43158B1 (fr) 2020-03-31
ES2775522T3 (es) 2020-07-27
LT3365346T (lt) 2020-04-10
TN2018000091A1 (en) 2019-07-08
KR20180073638A (ko) 2018-07-02

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