PH12016500978A1 - Piperazine derivatives having multimodal activity against pain - Google Patents
Piperazine derivatives having multimodal activity against painInfo
- Publication number
- PH12016500978A1 PH12016500978A1 PH12016500978A PH12016500978A PH12016500978A1 PH 12016500978 A1 PH12016500978 A1 PH 12016500978A1 PH 12016500978 A PH12016500978 A PH 12016500978A PH 12016500978 A PH12016500978 A PH 12016500978A PH 12016500978 A1 PH12016500978 A1 PH 12016500978A1
- Authority
- PH
- Philippines
- Prior art keywords
- activity against
- piperazine derivatives
- against pain
- multimodal activity
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Abstract
The present invention relates to compounds having dual pharmacological activity towards both the sigma (s) receptor, and the m-opiod receptor and more particularly to piperazine compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13384006 | 2013-12-20 | ||
PCT/EP2014/078852 WO2015092009A1 (en) | 2013-12-20 | 2014-12-19 | Piperazine derivatives having multimodal activity against pain |
Publications (1)
Publication Number | Publication Date |
---|---|
PH12016500978A1 true PH12016500978A1 (en) | 2016-06-20 |
Family
ID=49998042
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PH12016500978A PH12016500978A1 (en) | 2013-12-20 | 2016-05-25 | Piperazine derivatives having multimodal activity against pain |
Country Status (17)
Country | Link |
---|---|
US (2) | US10351535B2 (en) |
EP (1) | EP3083563A1 (en) |
JP (1) | JP6553615B2 (en) |
KR (1) | KR20160098506A (en) |
CN (1) | CN105829287B (en) |
AU (1) | AU2014368368C1 (en) |
CA (1) | CA2932051A1 (en) |
IL (1) | IL245808B (en) |
MA (1) | MA39145B1 (en) |
MX (1) | MX2016008130A (en) |
MY (1) | MY179509A (en) |
PH (1) | PH12016500978A1 (en) |
RU (1) | RU2709482C1 (en) |
SG (1) | SG10201805267UA (en) |
TN (1) | TN2016000203A1 (en) |
UA (1) | UA120754C2 (en) |
WO (1) | WO2015092009A1 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2018000418A (en) * | 2015-07-29 | 2018-08-14 | Esteve Labor Dr | Amide derivatives having multimodal activity against pain. |
TW201718533A (en) | 2015-07-29 | 2017-06-01 | 艾斯提夫博士實驗股份有限公司 | Substituted amide derivatives having multimodal activity against pain |
TN2018000355A1 (en) * | 2016-05-20 | 2020-06-15 | Esteve Pharmaceuticals Sa | Tetrahydropyran and thiopyran derivatives having multimodal activity against pain. |
EP3600289A4 (en) * | 2017-03-21 | 2020-08-05 | Temple University - Of The Commonwealth System of Higher Education | 5-hydroxytryptamine receptor 7 modulators and their use as therapeutic agents |
US10961249B2 (en) | 2017-03-21 | 2021-03-30 | Temple University-Of The Commonwealth System Of Higher Education | Modulators of the sigma-2 receptor and their method of use |
ES2910071T3 (en) | 2018-03-08 | 2022-05-11 | Incyte Corp | Aminopyrazine diol compounds as PI3K-Y inhibitors |
WO2020010003A1 (en) | 2018-07-02 | 2020-01-09 | Incyte Corporation | AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS |
EP3753932A1 (en) * | 2019-06-17 | 2020-12-23 | Esteve Pharmaceuticals, S.A. | Substituted bicyclic derivatives having multimodal activity against pain |
WO2022187206A1 (en) * | 2021-03-01 | 2022-09-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Dual-target mu opioid and dopamine d3 receptors ligands; preparation and use thereof |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2580648B1 (en) * | 1985-04-17 | 1987-05-15 | Adir | NOVEL TRIAZOLE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
DE3782525T2 (en) * | 1986-02-27 | 1993-05-27 | Duphar Int Res | ARYL-SUBSTITUTED (N-PIPERIDINYL) METHYL AND (N-PIPERAZINYL) METHYLAZOLES WITH ANTIPSYCHOTIC EFFECT. |
SE0103818D0 (en) | 2001-11-15 | 2001-11-15 | Astrazeneca Ab | Chemical compounds |
US7262194B2 (en) | 2002-07-26 | 2007-08-28 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
EP2009005A4 (en) * | 2006-04-19 | 2010-06-02 | Astellas Pharma Inc | Azolecarboxamide derivative |
US7678791B2 (en) * | 2006-07-12 | 2010-03-16 | Cumbre Ip Ventures, L.P. | Nitroheteroaryl-containing rifamycin derivatives |
EP2057124A2 (en) * | 2006-07-21 | 2009-05-13 | Irm, Llc | Compounds and compositions as itpkb inhibitors |
CN101578275A (en) | 2006-10-31 | 2009-11-11 | 先灵公司 | Anilinopiperazine derivatives and methods of use thereof |
CA2673918C (en) * | 2006-12-27 | 2015-02-17 | Sanofi-Aventis | Substituted isoquinoline and isoquinolinone derivatives |
WO2008125342A2 (en) * | 2007-04-16 | 2008-10-23 | Grünenthal GmbH | Novel vanilloid receptor ligands and the use thereof for the production of pharmaceuticals |
EP1982714A1 (en) * | 2007-04-16 | 2008-10-22 | Laboratorios del Dr. Esteve S.A. | Pyrano-pyrazole-amines |
DK2155717T3 (en) | 2007-05-11 | 2012-11-19 | Lilly Co Eli | 2- [4- (PYRAZOL-4-YLALKYL) PIPERAZIN-1-YL] -3-PHENYL-PYRAZINES AND PYRIDINES AND 3- [4- (PYRAZOL-4-YLALKYL) PIPERAZIN-1-YL] -2-PHENYL -PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS |
US7842696B2 (en) | 2007-06-21 | 2010-11-30 | Forest Laboratories Holdings Limited | Piperazine derivatives as inhibitors of stearoyl-CoA desaturase |
TW200914020A (en) * | 2007-08-28 | 2009-04-01 | Lilly Co Eli | Substituted piperazinyl pyrazines and pyridines as 5-HT7 receptor antagonists |
TWI448289B (en) | 2007-08-31 | 2014-08-11 | Purdue Pharma Lp | Substituted-quinoxaline-type piperidine compounds and the uses thereof |
WO2010046780A2 (en) | 2008-10-22 | 2010-04-29 | Institut Pasteur Korea | Anti viral compounds |
US8853202B2 (en) * | 2008-11-04 | 2014-10-07 | Chemocentryx, Inc. | Modulators of CXCR7 |
KR101701367B1 (en) * | 2008-11-04 | 2017-02-02 | 케모센트릭스, 인크. | Modulators of cxcr7 |
JP5683489B2 (en) | 2009-01-12 | 2015-03-11 | アレイ バイオファーマ、インコーポレイテッド | Piperidine-containing compounds and uses thereof |
ES2625637T3 (en) | 2010-02-12 | 2017-07-20 | Pharmascience Inc. | BIR IAP domain binding compounds |
EP2395003A1 (en) * | 2010-05-27 | 2011-12-14 | Laboratorios Del. Dr. Esteve, S.A. | Pyrazole compounds as sigma receptor inhibitors |
CN102918031A (en) * | 2010-05-28 | 2013-02-06 | 通用电气健康护理有限公司 | Radiolabeled compounds and methods thereof |
-
2014
- 2014-12-19 RU RU2016129110A patent/RU2709482C1/en not_active IP Right Cessation
- 2014-12-19 CA CA2932051A patent/CA2932051A1/en not_active Abandoned
- 2014-12-19 CN CN201480069503.2A patent/CN105829287B/en not_active Expired - Fee Related
- 2014-12-19 MY MYPI2016701867A patent/MY179509A/en unknown
- 2014-12-19 UA UAA201607879A patent/UA120754C2/en unknown
- 2014-12-19 MA MA39145A patent/MA39145B1/en unknown
- 2014-12-19 KR KR1020167019809A patent/KR20160098506A/en not_active Application Discontinuation
- 2014-12-19 SG SG10201805267UA patent/SG10201805267UA/en unknown
- 2014-12-19 WO PCT/EP2014/078852 patent/WO2015092009A1/en active Application Filing
- 2014-12-19 AU AU2014368368A patent/AU2014368368C1/en not_active Ceased
- 2014-12-19 MX MX2016008130A patent/MX2016008130A/en unknown
- 2014-12-19 JP JP2016539896A patent/JP6553615B2/en not_active Expired - Fee Related
- 2014-12-19 US US15/106,423 patent/US10351535B2/en not_active Expired - Fee Related
- 2014-12-19 EP EP14815384.4A patent/EP3083563A1/en not_active Withdrawn
- 2014-12-19 TN TN2016000203A patent/TN2016000203A1/en unknown
-
2016
- 2016-05-24 IL IL245808A patent/IL245808B/en active IP Right Grant
- 2016-05-25 PH PH12016500978A patent/PH12016500978A1/en unknown
-
2019
- 2019-05-30 US US16/426,024 patent/US10745361B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
MX2016008130A (en) | 2016-10-13 |
RU2016129110A (en) | 2018-01-23 |
CN105829287B (en) | 2019-08-27 |
MY179509A (en) | 2020-11-09 |
AU2014368368B2 (en) | 2019-01-31 |
EP3083563A1 (en) | 2016-10-26 |
JP2016540792A (en) | 2016-12-28 |
KR20160098506A (en) | 2016-08-18 |
US20170001967A1 (en) | 2017-01-05 |
IL245808B (en) | 2020-03-31 |
AU2014368368A1 (en) | 2016-07-07 |
US10351535B2 (en) | 2019-07-16 |
SG10201805267UA (en) | 2018-07-30 |
US20190276415A1 (en) | 2019-09-12 |
UA120754C2 (en) | 2020-02-10 |
RU2709482C1 (en) | 2019-12-18 |
MA39145B1 (en) | 2018-05-31 |
AU2014368368C1 (en) | 2019-06-27 |
WO2015092009A1 (en) | 2015-06-25 |
IL245808A0 (en) | 2016-08-02 |
US10745361B2 (en) | 2020-08-18 |
MA39145A1 (en) | 2017-10-31 |
CN105829287A (en) | 2016-08-03 |
CA2932051A1 (en) | 2015-06-25 |
JP6553615B2 (en) | 2019-07-31 |
TN2016000203A1 (en) | 2017-10-06 |
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