CY1121972T1 - Mono- ή διυποκατεστημενα ινδολια ως αναστολεις του αναδιπλασιασμου του ιου του δαγκειου πυρετου - Google Patents
Mono- ή διυποκατεστημενα ινδολια ως αναστολεις του αναδιπλασιασμου του ιου του δαγκειου πυρετουInfo
- Publication number
- CY1121972T1 CY1121972T1 CY20191100171T CY191100171T CY1121972T1 CY 1121972 T1 CY1121972 T1 CY 1121972T1 CY 20191100171 T CY20191100171 T CY 20191100171T CY 191100171 T CY191100171 T CY 191100171T CY 1121972 T1 CY1121972 T1 CY 1121972T1
- Authority
- CY
- Cyprus
- Prior art keywords
- mono
- chemical compounds
- dengue virus
- inhibitors
- virus replication
- Prior art date
Links
- 241000725619 Dengue virus Species 0.000 title 1
- 150000002475 indoles Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000029812 viral genome replication Effects 0.000 title 1
- 206010012310 Dengue fever Diseases 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000025729 dengue disease Diseases 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 3
- 208000001490 Dengue Diseases 0.000 abstract 2
- 208000036142 Viral infection Diseases 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 230000009385 viral infection Effects 0.000 abstract 2
- -1 di-substituted indole chemical compounds Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N2030/022—Column chromatography characterised by the kind of separation mechanism
- G01N2030/027—Liquid chromatography
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Η παρούσα εφεύρεση αφορά μονο- ή διυποκατεστημένες χημικές ενώσεις ινδολίου τύπου (I), οι οποίες είναι χρήσιμες για την πρόληψη ή την αντιμετώπιση ιικών λοιμώξεων του δάγκειου πυρετού και σχετίζονται, επίσης, με τις υπάρχουσες χημικές ενώσεις για χρήση ως φάρμακο, κατά προτίμηση για χρήση ως φάρμακο για την πρόληψη ή την αντιμετώπιση ιικών λοιμώξεων του δάγκειου πυρετού. Η παρούσα εφεύρεση αναφέρεται περαιτέρω σε φαρμακευτικές συνθέσεις ή συνδυαστικά παρασκευάσματα των χημικών ενώσεων, στις συνθέσεις ή στα παρασκευάσματα για χρήση ως φάρμακο, κατά για την πρόληψη ή την αντιμετώπιση ιικών λοιμώξεων του δάγκειου πυρετού. Η εφεύρεση αναφέρεται, επίσης, σε μεθόδους παρασκευής των χημικών ενώσεων.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14187373 | 2014-10-01 | ||
| EP15156073 | 2015-02-23 | ||
| PCT/EP2015/072534 WO2016050831A1 (en) | 2014-10-01 | 2015-09-30 | Mono- or di-substituted indoles as dengue viral replication inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1121972T1 true CY1121972T1 (el) | 2020-10-14 |
Family
ID=54207512
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20191100171T CY1121972T1 (el) | 2014-10-01 | 2019-02-08 | Mono- ή διυποκατεστημενα ινδολια ως αναστολεις του αναδιπλασιασμου του ιου του δαγκειου πυρετου |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US10206902B2 (el) |
| EP (1) | EP3201177B1 (el) |
| JP (1) | JP6701185B2 (el) |
| KR (1) | KR102478309B1 (el) |
| CN (1) | CN107001265B (el) |
| AU (1) | AU2015326920A1 (el) |
| BR (1) | BR112017006708A2 (el) |
| CA (1) | CA2958022A1 (el) |
| CL (1) | CL2017000742A1 (el) |
| CY (1) | CY1121972T1 (el) |
| DK (1) | DK3201177T3 (el) |
| EA (1) | EA033845B1 (el) |
| ES (1) | ES2711117T3 (el) |
| HR (1) | HRP20190139T1 (el) |
| HU (1) | HUE042628T2 (el) |
| IL (1) | IL251401A0 (el) |
| LT (1) | LT3201177T (el) |
| MA (1) | MA40769B1 (el) |
| ME (1) | ME03344B (el) |
| MX (1) | MX2017004298A (el) |
| PH (1) | PH12017500503A1 (el) |
| PL (1) | PL3201177T3 (el) |
| PT (1) | PT3201177T (el) |
| RS (1) | RS58394B1 (el) |
| SG (1) | SG11201702464WA (el) |
| SI (1) | SI3201177T1 (el) |
| TW (1) | TW201619130A (el) |
| UY (1) | UY36339A (el) |
| WO (1) | WO2016050831A1 (el) |
| ZA (1) | ZA201702299B (el) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| US9453018B2 (en) | 2014-10-01 | 2016-09-27 | Bristol-Myers Squibb Company | Pyrimidinones as factor XIa inhibitors |
| MY186911A (en) | 2014-10-01 | 2021-08-26 | Merck Patent Gmbh | Boronic acid derivatives |
| JOP20160086B1 (ar) * | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) * | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| BR112018069601A2 (pt) | 2016-03-31 | 2019-01-29 | Janssen Pharmaceuticals Inc | derivados de indolina substituídos como inibidores da replicação viral da dengue |
| CR20180495A (es) | 2016-03-31 | 2018-12-06 | Univ Leuven Kath | Deribados de indol sustituidos como inhibidores de replicación viral del dengue |
| MA44502A (fr) * | 2016-04-01 | 2019-02-06 | Janssen Pharmaceuticals Inc | Dérivés d'indole substitués utilisés en tant qu'inhibiteurs de réplication du virus de la dengue |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| IL270727B2 (en) | 2017-05-22 | 2023-03-01 | Janssen Pharmaceuticals Inc | Transduced indulin derivatives as inhibitors of dengue virus replication |
| KR102625988B1 (ko) | 2017-05-22 | 2024-01-16 | 얀센 파마슈티칼즈, 인코포레이티드 | 뎅기 바이러스 복제 억제제로서의 치환 인돌린 유도체 |
| CN114989131B (zh) * | 2022-05-30 | 2023-10-24 | 云南大学 | N’-(2-(苯并[1,3]二氧戊烷-5-基)酰基)芳酰肼类化合物及其合成和用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2928645A1 (fr) * | 2008-03-14 | 2009-09-18 | Sanofi Aventis Sa | Nouveaux derives de carbazole inhibiteurs d'hsp90, compositions les contenant et utilisation |
| EP2326631A4 (en) * | 2008-08-18 | 2012-03-21 | Univ Yale | MODULATORS OF MIF |
| GB201116559D0 (en) * | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| PT3201176T (pt) * | 2014-10-01 | 2019-03-04 | Janssen Pharmaceuticals Inc | Derivados indol mono- ou dissubstituídos como inibidores da replicação viral do dengue |
-
2015
- 2015-09-30 KR KR1020177009096A patent/KR102478309B1/ko active IP Right Grant
- 2015-09-30 CA CA2958022A patent/CA2958022A1/en not_active Abandoned
- 2015-09-30 BR BR112017006708A patent/BR112017006708A2/pt not_active Application Discontinuation
- 2015-09-30 RS RS20190141A patent/RS58394B1/sr unknown
- 2015-09-30 SI SI201530583T patent/SI3201177T1/sl unknown
- 2015-09-30 CN CN201580053468.XA patent/CN107001265B/zh active Active
- 2015-09-30 DK DK15771593.9T patent/DK3201177T3/en active
- 2015-09-30 JP JP2017517658A patent/JP6701185B2/ja active Active
- 2015-09-30 AU AU2015326920A patent/AU2015326920A1/en not_active Abandoned
- 2015-09-30 PL PL15771593T patent/PL3201177T3/pl unknown
- 2015-09-30 PT PT15771593T patent/PT3201177T/pt unknown
- 2015-09-30 TW TW104132007A patent/TW201619130A/zh unknown
- 2015-09-30 MX MX2017004298A patent/MX2017004298A/es unknown
- 2015-09-30 LT LTEP15771593.9T patent/LT3201177T/lt unknown
- 2015-09-30 MA MA40769A patent/MA40769B1/fr unknown
- 2015-09-30 SG SG11201702464WA patent/SG11201702464WA/en unknown
- 2015-09-30 ES ES15771593T patent/ES2711117T3/es active Active
- 2015-09-30 EP EP15771593.9A patent/EP3201177B1/en active Active
- 2015-09-30 US US15/515,563 patent/US10206902B2/en active Active
- 2015-09-30 EA EA201790700A patent/EA033845B1/ru not_active IP Right Cessation
- 2015-09-30 WO PCT/EP2015/072534 patent/WO2016050831A1/en active Application Filing
- 2015-09-30 HU HUE15771593A patent/HUE042628T2/hu unknown
- 2015-09-30 ME MEP-2019-37A patent/ME03344B/me unknown
- 2015-10-01 UY UY0001036339A patent/UY36339A/es unknown
-
2017
- 2017-03-16 PH PH12017500503A patent/PH12017500503A1/en unknown
- 2017-03-27 IL IL251401A patent/IL251401A0/en unknown
- 2017-03-28 CL CL2017000742A patent/CL2017000742A1/es unknown
- 2017-03-31 ZA ZA2017/02299A patent/ZA201702299B/en unknown
-
2019
- 2019-01-21 HR HRP20190139TT patent/HRP20190139T1/hr unknown
- 2019-02-08 CY CY20191100171T patent/CY1121972T1/el unknown
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