CY1118928T1 - Αντι-οχ40 αντισωματα και μεθοδοι χρησης τους - Google Patents
Αντι-οχ40 αντισωματα και μεθοδοι χρησης τουςInfo
- Publication number
- CY1118928T1 CY1118928T1 CY20171100363T CY171100363T CY1118928T1 CY 1118928 T1 CY1118928 T1 CY 1118928T1 CY 20171100363 T CY20171100363 T CY 20171100363T CY 171100363 T CY171100363 T CY 171100363T CY 1118928 T1 CY1118928 T1 CY 1118928T1
- Authority
- CY
- Cyprus
- Prior art keywords
- antibodies
- receptor
- human antibodies
- recombinant human
- antibody
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
Abstract
Ανθρώπινα αντισώματα, κατά προτίμηση ανασυνδυασμένα ανθρώπινα αντισώματα, αμφότερα ανθρωποποιημένα και χιμαιρικά, τα οποία δεσμεύονται ειδικά με ανθρώπινο ΟΧ40 γνωστοποιούνται. Προτιμητέα αντισώματα έχουν υψηλή συγγένεια για ΟΧ40 υποδοχέα και ενεργοποιούν τον υποδοχέα in vitro και in vivo. Το αντίσωμα μπορεί να είναι ένα πλήρους-μήκους αντίσωμα ή ένα αντιγονοδεσμευτικό τμήμα αυτού. Τα αντισώματα, ή τμήματα αντισωμάτων, είναι χρήσιμα για διαμόρφωση της δραστικότητας του υποδοχέα, π.χ., σε έναν άνθρωπο ο οποίος πάσχει από μία διαταραχή στην οποία η ΟΧ40 δραστικότητα είναι επιβλαβής. Νουκλεϊκά οξέα, φορείς και κύτταρα ξενιστές για έκφραση των ανασυνδυασμένων ανθρώπινων αντισωμάτων παρέχονται, και μέθοδοι σύνθεσης των ανασυνδυασμένων ανθρώπινων αντισωμάτων, επίσης παρέχονται.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37599910P | 2010-08-23 | 2010-08-23 | |
US38082710P | 2010-09-08 | 2010-09-08 | |
PCT/US2011/048752 WO2012027328A2 (en) | 2010-08-23 | 2011-08-23 | Anti-ox40 antibodies and methods of using the same |
Publications (1)
Publication Number | Publication Date |
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CY1118928T1 true CY1118928T1 (el) | 2018-01-10 |
Family
ID=45724011
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20171100363T CY1118928T1 (el) | 2010-08-23 | 2017-03-22 | Αντι-οχ40 αντισωματα και μεθοδοι χρησης τους |
Country Status (34)
Country | Link |
---|---|
US (6) | US9006399B2 (el) |
EP (2) | EP2609118B1 (el) |
JP (2) | JP5984810B2 (el) |
KR (2) | KR101704865B1 (el) |
CN (2) | CN106554417B (el) |
AP (1) | AP2013006771A0 (el) |
AU (1) | AU2011293558B2 (el) |
BR (2) | BR112013004266A8 (el) |
CA (1) | CA2809089C (el) |
CL (3) | CL2013000545A1 (el) |
CO (1) | CO6680693A2 (el) |
CR (1) | CR20130126A (el) |
CY (1) | CY1118928T1 (el) |
DK (1) | DK2609118T3 (el) |
DO (1) | DOP2013000045A (el) |
EA (2) | EA029793B1 (el) |
ES (2) | ES2649155T3 (el) |
HK (1) | HK1213272A1 (el) |
HR (1) | HRP20170568T1 (el) |
HU (1) | HUE031371T2 (el) |
IL (2) | IL224886A (el) |
LT (1) | LT2609118T (el) |
ME (1) | ME02678B (el) |
MX (1) | MX339964B (el) |
MY (1) | MY171312A (el) |
NZ (3) | NZ608033A (el) |
PE (2) | PE20131403A1 (el) |
PL (1) | PL2609118T3 (el) |
PT (1) | PT2609118T (el) |
RS (1) | RS55952B1 (el) |
SG (1) | SG187945A1 (el) |
SI (1) | SI2609118T1 (el) |
WO (1) | WO2012027328A2 (el) |
ZA (1) | ZA201301442B (el) |
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