CY1113423T1 - Συστημα παροχης φαρμακου για την υποεπιπεφυκοτικη χορηγηση λεπτων κοκκων - Google Patents
Συστημα παροχης φαρμακου για την υποεπιπεφυκοτικη χορηγηση λεπτων κοκκωνInfo
- Publication number
- CY1113423T1 CY1113423T1 CY20121101142T CY121101142T CY1113423T1 CY 1113423 T1 CY1113423 T1 CY 1113423T1 CY 20121101142 T CY20121101142 T CY 20121101142T CY 121101142 T CY121101142 T CY 121101142T CY 1113423 T1 CY1113423 T1 CY 1113423T1
- Authority
- CY
- Cyprus
- Prior art keywords
- drug
- ophthalmic
- fine particles
- delivery system
- posterior half
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Transplantation (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Η παρούσα εφεύρεση παρέχει ένα εξαιρετικό σύστημα παροχής φαρμάκου σε οπίσθια ημιμόρια. Μια ένεση σύμφωνα με την παρούσα εφεύρεση είναι μια περιοφθαλμική ένεση η οποία περιλαμβάνει λεπτά σωματίδια τα οποία περιέχουν ένα φάρμακο και η οποία καθιστά δυνατή την παροχή στα οπίσθια ημιμόρια. Το φάρμακο μπορεί να παρασχεθεί αποτελεσματικά στα οπίσθια ημιμόρια (όπως έναν αμφιβληστροειδή, έναν χοριοειδή και ένα οπτικό νεύρο) ενώ τραυματίζει ελάχιστα τους οφθαλμικούς ιστούς με χορήγηση των λεπτών σωματιδίων που περιέχουν το φάρμακο περιοφθαλμικά. Προτιμητέα λεπτά σωματίδια φτιάχνονται από ένα συνθετικό βιοαποικοδομήσιμο πολυμερές, η μέση τους σωματιδιακή διάμετρος είναι 50 nm έως 150 μm, και το φάρμακο είναι διεσπαρμένο στα λεπτά σωματίδια ομοιογενώς. Προτιμητέα φάρμακα είναι αντι-φλεγμονώδη, ανοσοκατασταλτικά, αναστολείς της αγγειογένεσης, προστατευτικά του οπτικού νεύρου, αντιμικροβιακά και αντιμυκητιακοί παράγοντες.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002046355 | 2002-02-22 | ||
EP03705377A EP1484054B1 (en) | 2002-02-22 | 2003-02-21 | Drug delivery system for the subconjunctival administration of fine grains |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1113423T1 true CY1113423T1 (el) | 2016-06-22 |
Family
ID=27750627
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20121101142T CY1113423T1 (el) | 2002-02-22 | 2012-11-27 | Συστημα παροχης φαρμακου για την υποεπιπεφυκοτικη χορηγηση λεπτων κοκκων |
Country Status (13)
Country | Link |
---|---|
US (1) | US20050089545A1 (el) |
EP (1) | EP1484054B1 (el) |
KR (2) | KR20100102749A (el) |
CN (1) | CN1638734A (el) |
AU (1) | AU2003211238A1 (el) |
CA (1) | CA2476935C (el) |
CY (1) | CY1113423T1 (el) |
DK (1) | DK1484054T3 (el) |
ES (1) | ES2393086T3 (el) |
PT (1) | PT1484054E (el) |
SI (1) | SI1484054T1 (el) |
TW (1) | TWI290835B (el) |
WO (1) | WO2003070219A1 (el) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
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ATE501766T1 (de) * | 2003-05-20 | 2011-04-15 | James F Collins | Ophthalmisches arzneimittelabgabesystem |
US8012136B2 (en) | 2003-05-20 | 2011-09-06 | Optimyst Systems, Inc. | Ophthalmic fluid delivery device and method of operation |
TWI347847B (en) * | 2003-08-20 | 2011-09-01 | Santen Pharmaceutical Co Ltd | Drug delivery system for sub-tenon administration of fine particles |
AU2005209201B2 (en) * | 2004-01-20 | 2010-06-03 | Allergan, Inc. | Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid |
US20060110428A1 (en) | 2004-07-02 | 2006-05-25 | Eugene Dejuan | Methods and devices for the treatment of ocular conditions |
CN101119733A (zh) * | 2005-02-18 | 2008-02-06 | 参天制药株式会社 | 减轻或避免甾族化合物副作用的方法 |
US8003124B2 (en) | 2005-04-08 | 2011-08-23 | Surmodics, Inc. | Sustained release implants and methods for subretinal delivery of bioactive agents to treat or prevent retinal disease |
JP4982839B2 (ja) * | 2005-06-22 | 2012-07-25 | 国立大学法人京都大学 | 硝子体可視化剤 |
EP1930028A4 (en) * | 2005-07-29 | 2010-11-17 | Santen Pharmaceutical Co Ltd | NON-INVASIVE DRUG DELIVERY SYSTEM THAT TARGETS THE EARLY CLOTH OF THE EYE USING A SOLID COMPOSITION |
CN1771913B (zh) * | 2005-10-30 | 2011-07-20 | 沈阳药科大学 | 用乳化溶剂扩散法制备掩味微球的制备方法 |
US20070202186A1 (en) | 2006-02-22 | 2007-08-30 | Iscience Interventional Corporation | Apparatus and formulations for suprachoroidal drug delivery |
CN101959503A (zh) * | 2008-02-29 | 2011-01-26 | 财团法人名古屋产业科学研究所 | 眼后节到达用脂质体和眼后节疾病用医药组合物 |
WO2010093873A2 (en) | 2009-02-12 | 2010-08-19 | Incept, Llc | Drug delivery through hydrogel plugs |
EP2593056B1 (en) | 2010-07-15 | 2020-10-21 | Eyenovia, Inc. | Drop generating device |
US10154923B2 (en) | 2010-07-15 | 2018-12-18 | Eyenovia, Inc. | Drop generating device |
WO2012009702A1 (en) | 2010-07-15 | 2012-01-19 | Corinthian Ophthalmic, Inc. | Method and system for performing remote treatment and monitoring |
ES2787254T3 (es) | 2010-07-15 | 2020-10-15 | Eyenovia Inc | Suministro de fármacos oftálmicos |
JP5996544B2 (ja) | 2010-10-15 | 2016-09-21 | クリアサイド・バイオメディカル・インコーポレーテッドClearside Biomedical Incorporated | 眼球アクセス用装置 |
EP2787973B1 (en) | 2011-12-05 | 2019-10-09 | Incept, LLC | Medical organogel processes and compositions |
US20130172830A1 (en) | 2011-12-12 | 2013-07-04 | Corinthian Ophthalmic, Inc. | Ejector mechanism, ejector device, and methods of use |
MX2015005839A (es) | 2012-11-08 | 2015-12-17 | Clearside Biomedical Inc | Metodos y dispositivos para el tratamiento de trastornos oculares en sujetos humanos. |
WO2014179615A2 (en) * | 2013-05-01 | 2014-11-06 | Dae Won Park | Biodegradable copolymers, systems including the copolymers, and methods of forming and using same |
CN110302004B (zh) | 2013-05-03 | 2023-04-28 | 科尼尔赛德生物医学公司 | 用于眼部注射的设备和方法 |
US10010447B2 (en) | 2013-12-18 | 2018-07-03 | Novartis Ag | Systems and methods for subretinal delivery of therapeutic agents |
BR112017001017A2 (pt) | 2014-07-18 | 2018-01-23 | Allergan Inc | composições em suspensão de ciclosporina a para injeção subconjuntival e periocular |
GB201522441D0 (en) | 2015-12-18 | 2016-02-03 | Midatech Pharma Wales Ltd | Sustained release cyclosporine-loaded microparticles |
WO2017139375A1 (en) | 2016-02-10 | 2017-08-17 | Clearside Biomedical, Inc. | Ocular injection kit, packaging, and methods of use |
CA3062845A1 (en) | 2016-05-02 | 2017-11-09 | Clearside Biomedical, Inc. | Systems and methods for ocular drug delivery |
US10973681B2 (en) | 2016-08-12 | 2021-04-13 | Clearside Biomedical, Inc. | Devices and methods for adjusting the insertion depth of a needle for medicament delivery |
WO2018227190A1 (en) | 2017-06-10 | 2018-12-13 | Eyenovia, Inc. | Methods and devices for handling a fluid and delivering the fluid to the eye |
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US5185152A (en) * | 1990-01-10 | 1993-02-09 | Peyman Gholam A | Method and apparatus for controlled release drug delivery to the cornea and anterior chamber of the eye |
US5384333A (en) * | 1992-03-17 | 1995-01-24 | University Of Miami | Biodegradable injectable drug delivery polymer |
US5178635A (en) * | 1992-05-04 | 1993-01-12 | Allergan, Inc. | Method for determining amount of medication in an implantable device |
US5700485A (en) * | 1992-09-10 | 1997-12-23 | Children's Medical Center Corporation | Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid |
US5922340A (en) * | 1992-09-10 | 1999-07-13 | Children's Medical Center Corporation | High load formulations and methods for providing prolonged local anesthesia |
DK0694310T3 (da) * | 1993-04-16 | 2000-06-05 | Wakamoto Pharma Co Ltd | Reversibelt, termisk gelatinerende, vandbaseret, medicinsk præparat |
SE9401108D0 (sv) * | 1994-03-31 | 1994-03-31 | Leiras Oy | Ophthalmic composition I |
US5466233A (en) * | 1994-04-25 | 1995-11-14 | Escalon Ophthalmics, Inc. | Tack for intraocular drug delivery and method for inserting and removing same |
JPH08176016A (ja) * | 1994-12-19 | 1996-07-09 | Univ Miami | 生分解可能で注射可能な薬物運搬ポリマー |
US5869079A (en) * | 1995-06-02 | 1999-02-09 | Oculex Pharmaceuticals, Inc. | Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents |
US6264970B1 (en) * | 1996-06-26 | 2001-07-24 | Takeda Chemical Industries, Ltd. | Sustained-release preparation |
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US6378526B1 (en) * | 1998-08-03 | 2002-04-30 | Insite Vision, Incorporated | Methods of ophthalmic administration |
JP2000247871A (ja) | 1999-02-25 | 2000-09-12 | Santen Pharmaceut Co Ltd | 網膜または硝子体への薬物放出制御システム |
US6395294B1 (en) * | 2000-01-13 | 2002-05-28 | Gholam A. Peyman | Method of visualization of the vitreous during vitrectomy |
JP2002326962A (ja) * | 2000-04-03 | 2002-11-15 | Santen Pharmaceut Co Ltd | 送達性物質およびそれを利用した薬物デリバリーシステム |
US20030194421A1 (en) * | 2001-12-28 | 2003-10-16 | Angiotech Pharmaceuticals, Inc. | Treatment of uveitis |
-
2003
- 2003-02-21 TW TW092103600A patent/TWI290835B/zh not_active IP Right Cessation
- 2003-02-21 CN CNA038044064A patent/CN1638734A/zh active Pending
- 2003-02-21 PT PT03705377T patent/PT1484054E/pt unknown
- 2003-02-21 SI SI200332201T patent/SI1484054T1/sl unknown
- 2003-02-21 DK DK03705377.4T patent/DK1484054T3/da active
- 2003-02-21 US US10/505,393 patent/US20050089545A1/en not_active Abandoned
- 2003-02-21 KR KR1020107019620A patent/KR20100102749A/ko not_active Application Discontinuation
- 2003-02-21 AU AU2003211238A patent/AU2003211238A1/en not_active Abandoned
- 2003-02-21 EP EP03705377A patent/EP1484054B1/en not_active Expired - Lifetime
- 2003-02-21 WO PCT/JP2003/001897 patent/WO2003070219A1/ja active Application Filing
- 2003-02-21 KR KR10-2004-7013018A patent/KR20040084931A/ko active Search and Examination
- 2003-02-21 CA CA2476935A patent/CA2476935C/en not_active Expired - Fee Related
- 2003-02-21 ES ES03705377T patent/ES2393086T3/es not_active Expired - Lifetime
-
2012
- 2012-11-27 CY CY20121101142T patent/CY1113423T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU2003211238A1 (en) | 2003-09-09 |
EP1484054A1 (en) | 2004-12-08 |
CA2476935C (en) | 2013-05-28 |
DK1484054T3 (da) | 2012-11-26 |
KR20100102749A (ko) | 2010-09-24 |
TWI290835B (en) | 2007-12-11 |
KR20040084931A (ko) | 2004-10-06 |
CA2476935A1 (en) | 2003-08-28 |
EP1484054B1 (en) | 2012-08-29 |
PT1484054E (pt) | 2012-11-28 |
US20050089545A1 (en) | 2005-04-28 |
EP1484054A4 (en) | 2007-12-12 |
ES2393086T3 (es) | 2012-12-18 |
SI1484054T1 (sl) | 2012-12-31 |
WO2003070219A1 (fr) | 2003-08-28 |
CN1638734A (zh) | 2005-07-13 |
TW200303218A (en) | 2003-09-01 |
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