CY1110919T1 - Μεθοδος για τον ενζυματικο διαχωρισμο εναντιομερων της 3(r)- kai 3(s)-υδροξυ-1-μεθυλο-4-(2,4,6-τριμεθοξυφαινυλο)-1,2,3,6-τετραϋδρο-πυριδινης ή των εστερων καρβοξυλικου οξεος αυτης. - Google Patents
Μεθοδος για τον ενζυματικο διαχωρισμο εναντιομερων της 3(r)- kai 3(s)-υδροξυ-1-μεθυλο-4-(2,4,6-τριμεθοξυφαινυλο)-1,2,3,6-τετραϋδρο-πυριδινης ή των εστερων καρβοξυλικου οξεος αυτης.Info
- Publication number
- CY1110919T1 CY1110919T1 CY20101100850T CY101100850T CY1110919T1 CY 1110919 T1 CY1110919 T1 CY 1110919T1 CY 20101100850 T CY20101100850 T CY 20101100850T CY 101100850 T CY101100850 T CY 101100850T CY 1110919 T1 CY1110919 T1 CY 1110919T1
- Authority
- CY
- Cyprus
- Prior art keywords
- hydroxy
- methyl
- trimethoxynyl
- entiometries
- enzymal
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/001—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by metabolizing one of the enantiomers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/814—Enzyme separation or purification
- Y10S435/816—Enzyme separation or purification by solubility
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyridine Compounds (AREA)
Abstract
Περιγράφεται μια μέθοδος για την παρασκευή οπτικώς καθαρών ενώσεων 3(R)- και 3(S)-υδροξυ-1-μεθυλο-4-(2,4,6-τριμεθοξυφαινυλο)-1,2,3,6-τετραϋδρο-πυριδίνης ή των εστέρων καρβοξυλικού οξέος αυτής δια της στερεοδιαφοροποιητικής μετατροπής των μιγμάτων εναντιομερών με τη βοήθεια ενός ενζύμου.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19809649A DE19809649A1 (de) | 1998-03-06 | 1998-03-06 | Verfahren zur enzymatischen Enantiomeren-Trennung von 3(R)- und 3(S)-Hydroxy-1-methyl-4-(2,4,6-trimethoxyphenyl)-1,2,3,6-tetrahydro-pyridin bzw. der Carbonsäureester |
| EP99910248A EP1071807B1 (de) | 1998-03-06 | 1999-02-20 | Verfahren zur enzymatischen enantiomeren-trennung von 3(r)- und 3(s)-hydroxy-1- methyl-4-(2,4, 6-trimethoxyphenyl)-1, 2,3,6- tetrahydro-pyridin bzw. der carbonsäureester |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1110919T1 true CY1110919T1 (el) | 2015-06-10 |
Family
ID=7859957
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20101100850T CY1110919T1 (el) | 1998-03-06 | 2010-09-22 | Μεθοδος για τον ενζυματικο διαχωρισμο εναντιομερων της 3(r)- kai 3(s)-υδροξυ-1-μεθυλο-4-(2,4,6-τριμεθοξυφαινυλο)-1,2,3,6-τετραϋδρο-πυριδινης ή των εστερων καρβοξυλικου οξεος αυτης. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6406912B1 (el) |
| EP (1) | EP1071807B1 (el) |
| JP (1) | JP4344089B2 (el) |
| KR (1) | KR100779864B1 (el) |
| CN (1) | CN1230554C (el) |
| AR (1) | AR018574A1 (el) |
| AT (1) | ATE474061T1 (el) |
| AU (1) | AU758106B2 (el) |
| BR (2) | BR9908557A (el) |
| CA (1) | CA2322842C (el) |
| CY (1) | CY1110919T1 (el) |
| CZ (1) | CZ301944B6 (el) |
| DE (2) | DE19809649A1 (el) |
| DK (1) | DK1071807T3 (el) |
| ES (1) | ES2348394T3 (el) |
| HK (1) | HK1035001A1 (el) |
| HU (1) | HU227994B1 (el) |
| ID (1) | ID27000A (el) |
| PL (1) | PL195006B1 (el) |
| PT (1) | PT1071807E (el) |
| RU (1) | RU2241040C2 (el) |
| TR (1) | TR200002576T2 (el) |
| WO (1) | WO1999045133A1 (el) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0010544A (pt) | 1999-05-13 | 2002-02-19 | Shell Int Research | Método para produzir hidrogênio e um produto hidroprocessado |
| US7153675B2 (en) * | 2001-05-15 | 2006-12-26 | Speedel Pharma Ag | Process for the preparation of substituted carboxylic esters |
| CN104278061A (zh) * | 2014-10-01 | 2015-01-14 | 青岛科技大学 | 一种生产氟苯基甲基丙酸甲酯的产朊酵母还原法 |
| CN104232700A (zh) * | 2014-10-01 | 2014-12-24 | 青岛科技大学 | 一种生物法生产(2r,3s)羟基丙酸甲酯的方法 |
| RU2717829C2 (ru) | 2015-04-20 | 2020-03-26 | Толеро Фармасьютикалз, Инк. | Прогнозирование ответа на альвоцидиб с помощью анализа профиля митохондрий |
| TR201911032T4 (tr) | 2015-05-18 | 2019-08-21 | Tolero Pharmaceuticals Inc | Artırılmış biyoyararlanıma sahip alvocıdıb ön ilaçları. |
| JP7083497B2 (ja) | 2015-08-03 | 2022-06-13 | スミトモ ファーマ オンコロジー， インコーポレイテッド | がんの処置のための併用療法 |
| US11279694B2 (en) | 2016-11-18 | 2022-03-22 | Sumitomo Dainippon Pharma Oncology, Inc. | Alvocidib prodrugs and their use as protein kinase inhibitors |
| CA3047557A1 (en) | 2016-12-19 | 2018-06-28 | Tolero Pharmaceuticals, Inc. | Profiling peptides and methods for sensitivity profiling |
| WO2019055579A1 (en) | 2017-09-12 | 2019-03-21 | Tolero Pharmaceuticals, Inc. | TREATMENT REGIME FOR CANCERS THAT ARE INSENSITIVE TO BCL-2 INHIBITORS USING THE MCL-1 ALVOCIDIB INHIBITOR |
| KR20210099066A (ko) | 2018-12-04 | 2021-08-11 | 스미토모 다이니폰 파마 온콜로지, 인크. | 암의 치료를 위한 작용제로서 사용하기 위한 cdk9 억제제 및 그의 다형체 |
| US11793802B2 (en) | 2019-03-20 | 2023-10-24 | Sumitomo Pharma Oncology, Inc. | Treatment of acute myeloid leukemia (AML) with venetoclax failure |
| CN110577974B (zh) * | 2019-09-10 | 2021-07-20 | 杭州澳赛诺生物科技有限公司 | 手性3-羟基-1,2,3,6-四氢吡啶的合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2691986B2 (ja) * | 1987-08-28 | 1997-12-17 | チッソ株式会社 | ピリジン骨格を有する光学活性化合物の製造法 |
| DE3743824C2 (de) | 1987-12-23 | 1997-03-06 | Hoechst Ag | Verfahren zur enzymatischen Racematspaltung von racemischen Alkoholen mit/in Vinylestern durch Umesterung |
| JPH0641075A (ja) * | 1990-09-01 | 1994-02-15 | Kazuo Achinami | 新規な１，４−ジヒドロピリジン化合物及びその製造方法 |
| CA2064676A1 (en) * | 1991-04-02 | 1992-10-03 | Manfred Schneider | Immobilized biocatalyst, its preparation and use for ester synthesis in a column reactor |
| JPH0690790A (ja) * | 1992-09-08 | 1994-04-05 | Mercian Corp | 光学活性１，４−ジヒドロピリジン−３，５−ジカルボン酸・モノエステル誘導体の製造方法 |
| DE19802449A1 (de) * | 1998-01-23 | 1999-07-29 | Hoechst Marion Roussel De Gmbh | Verfahren zur Herstellung von (-)cis-3-Hydroxy-1-methyl-4-(2,4,6-trimethoxypyhenyl)-piperidin |
-
1998
- 1998-03-06 DE DE19809649A patent/DE19809649A1/de not_active Withdrawn
-
1999
- 1999-02-20 PL PL342877A patent/PL195006B1/pl unknown
- 1999-02-20 HU HU0101795A patent/HU227994B1/hu unknown
- 1999-02-20 CZ CZ20003223A patent/CZ301944B6/cs not_active IP Right Cessation
- 1999-02-20 BR BR9908557-7A patent/BR9908557A/pt not_active IP Right Cessation
- 1999-02-20 PT PT99910248T patent/PT1071807E/pt unknown
- 1999-02-20 AU AU29275/99A patent/AU758106B2/en not_active Expired
- 1999-02-20 AT AT99910248T patent/ATE474061T1/de active
- 1999-02-20 CA CA2322842A patent/CA2322842C/en not_active Expired - Lifetime
- 1999-02-20 EP EP99910248A patent/EP1071807B1/de not_active Expired - Lifetime
- 1999-02-20 ID IDW20001691A patent/ID27000A/id unknown
- 1999-02-20 WO PCT/EP1999/001113 patent/WO1999045133A1/de active IP Right Grant
- 1999-02-20 DE DE59915183T patent/DE59915183D1/de not_active Expired - Lifetime
- 1999-02-20 US US09/623,563 patent/US6406912B1/en not_active Expired - Lifetime
- 1999-02-20 ES ES99910248T patent/ES2348394T3/es not_active Expired - Lifetime
- 1999-02-20 KR KR1020007009843A patent/KR100779864B1/ko not_active IP Right Cessation
- 1999-02-20 RU RU2000125273/13A patent/RU2241040C2/ru active
- 1999-02-20 TR TR2000/02576T patent/TR200002576T2/xx unknown
- 1999-02-20 CN CNB998035955A patent/CN1230554C/zh not_active Expired - Lifetime
- 1999-02-20 BR BRPI9908557A patent/BRPI9908557B8/pt unknown
- 1999-02-20 JP JP2000534664A patent/JP4344089B2/ja not_active Expired - Lifetime
- 1999-02-20 DK DK99910248.6T patent/DK1071807T3/da active
- 1999-03-04 AR ARP990100907A patent/AR018574A1/es active IP Right Grant
-
2001
- 2001-08-15 HK HK01105718A patent/HK1035001A1/xx not_active IP Right Cessation
-
2010
- 2010-09-22 CY CY20101100850T patent/CY1110919T1/el unknown
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