CU20160152A7 - Nuevos compuestos macrocíclicos en calidad de inhibidores de cdk9, un proceso para su preparación y los compuestos intermediarios útiles en la preparación de estos compuestos - Google Patents
Nuevos compuestos macrocíclicos en calidad de inhibidores de cdk9, un proceso para su preparación y los compuestos intermediarios útiles en la preparación de estos compuestosInfo
- Publication number
- CU20160152A7 CU20160152A7 CUP2016000152A CU20160152A CU20160152A7 CU 20160152 A7 CU20160152 A7 CU 20160152A7 CU P2016000152 A CUP2016000152 A CU P2016000152A CU 20160152 A CU20160152 A CU 20160152A CU 20160152 A7 CU20160152 A7 CU 20160152A7
- Authority
- CU
- Cuba
- Prior art keywords
- compounds
- preparation
- quality
- useful intermediate
- new macrocyclic
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/529—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim forming part of bridged ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
- C07C53/16—Halogenated acetic acids
- C07C53/18—Halogenated acetic acids containing fluorine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
Abstract
Nuevos compuestos macrocíclicos de la fórmula general (I) como se los describe y se los define en la memoria descriptiva. Métodos para prepararlos. Su uso en el tratamiento y/o la profilaxis de diversos trastornos, particularmente de los trastornos hiperproliferativos, de las enfermedades infecciosas inducidas por virus y/o de las enfermedades cardiovasculares. Compuestos intermedios útiles para preparar los compuestos de la fórmula general (I).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2014000392 | 2014-04-11 | ||
PCT/EP2015/057546 WO2015155197A1 (en) | 2014-04-11 | 2015-04-08 | Novel macrocyclic compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
CU20160152A7 true CU20160152A7 (es) | 2017-04-05 |
CU24399B1 CU24399B1 (es) | 2019-04-04 |
Family
ID=52824234
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU2016000152A CU24399B1 (es) | 2014-04-11 | 2015-04-08 | Nuevos compuestos macrocíclicos en calidad de inhibidores de cdk9, un proceso para su preparación y los compuestos intermediarios útiles en la preparación de estos compuestos |
Country Status (28)
Country | Link |
---|---|
US (1) | US9963464B2 (es) |
EP (1) | EP3129387B1 (es) |
JP (1) | JP6605493B2 (es) |
KR (1) | KR102383938B1 (es) |
CN (1) | CN106459084B (es) |
AP (1) | AP2016009483A0 (es) |
AR (1) | AR099999A1 (es) |
AU (1) | AU2015243585B2 (es) |
BR (1) | BR112016023554B1 (es) |
CA (1) | CA2945237C (es) |
CL (1) | CL2016002577A1 (es) |
CR (1) | CR20160471A (es) |
CU (1) | CU24399B1 (es) |
DO (1) | DOP2016000278A (es) |
EA (1) | EA032541B1 (es) |
ES (1) | ES2743799T3 (es) |
IL (1) | IL247966B (es) |
MX (1) | MX2016013362A (es) |
PE (1) | PE20161379A1 (es) |
PH (1) | PH12016501968A1 (es) |
SG (1) | SG11201608430RA (es) |
SV (1) | SV2016005301A (es) |
TN (1) | TN2016000435A1 (es) |
TW (1) | TW201623312A (es) |
UA (1) | UA119349C2 (es) |
UY (1) | UY36072A (es) |
WO (1) | WO2015155197A1 (es) |
ZA (1) | ZA201607765B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108290903B (zh) * | 2015-09-29 | 2021-09-03 | 拜耳医药股份有限公司 | 新的大环磺酰二亚胺化合物 |
CN108368129B (zh) * | 2015-10-08 | 2021-08-17 | 拜耳医药股份有限公司 | 改性大环化合物 |
PT3445767T (pt) * | 2016-04-22 | 2020-05-13 | Astrazeneca Ab | Inibidores de mcl-1 macrocíclicos para o tratamento de cancro |
RU2019111887A (ru) * | 2016-10-20 | 2020-11-20 | Пфайзер Инк. | Антипролиферативные средства для лечения лаг |
US11242356B2 (en) | 2017-03-28 | 2022-02-08 | Bayer Aktiengesellschaft | PTEFb inhibiting macrocyclic compounds |
PL3601253T3 (pl) | 2017-03-28 | 2022-01-17 | Bayer Aktiengesellschaft | Nowe hamujące ptefb związki makrocykliczne |
CN109251212A (zh) * | 2017-07-14 | 2019-01-22 | 上海长森药业有限公司 | 内环硫醚酰胺-芳基酰胺类化合物及其治疗乙型肝炎的用途 |
CN111434665B (zh) * | 2019-01-11 | 2023-03-10 | 上海长森药业有限公司 | 内环硫脒酰胺-芳基酰胺类化合物及其治疗乙型肝炎的用途 |
CN112321604A (zh) * | 2019-08-05 | 2021-02-05 | 华东理工大学 | 大环类jak2抑制剂及其应用 |
WO2023057812A1 (en) | 2021-10-04 | 2023-04-13 | Vincerx Pharma Gmbh | Compounds, pharmaceutical compositions, and methods for the treatment, prevention, or management of hyperproliferative disorder |
Family Cites Families (25)
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ES2556946T3 (es) | 2000-12-21 | 2016-01-21 | Novartis Ag | Pirimidinaminas como moduladores de la angiogénesis |
DE10239042A1 (de) * | 2002-08-21 | 2004-03-04 | Schering Ag | Makrozyclische Pyrimidine, deren Herstellung und Verwendung als Arzneimittel |
DE10349423A1 (de) | 2003-10-16 | 2005-06-16 | Schering Ag | Sulfoximinsubstituierte Parimidine als CDK- und/oder VEGF-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel |
KR20070091018A (ko) | 2004-12-17 | 2007-09-06 | 아스트라제네카 아베 | Cdk 억제제로서의4-(4-(이미다졸-4-일)피리미딘-2-일아미노)벤즈아미드 |
DE102006042143A1 (de) | 2006-09-08 | 2008-03-27 | Bayer Healthcare Aktiengesellschaft | Neue substituierte Bipyridin-Derivate und ihre Verwendung |
WO2008060248A1 (en) | 2006-11-15 | 2008-05-22 | S*Bio Pte Ltd. | Indole sustituted pyrimidines and use thereof in the treatment of cancer |
KR20090101905A (ko) | 2006-12-22 | 2009-09-29 | 노파르티스 아게 | 인돌-4-일-피리미디닐-일-아민 유도체 및 사이클린 의존성 키나제 억제제로서의 그의 용도 |
CA2672518A1 (en) | 2006-12-22 | 2008-07-03 | Novartis Ag | Organic compounds and their uses |
JP5566880B2 (ja) | 2007-04-24 | 2014-08-06 | インゲニウム ファーマシューティカルズ ジーエムビーエイチ | プロテインキナーゼの阻害剤としての4,6−二置換アミノピリミジン誘導体 |
JP5379787B2 (ja) | 2007-04-24 | 2013-12-25 | インゲニウム ファーマシューティカルズ ジーエムビーエイチ | プロテインキナーゼの阻害剤 |
ES2539518T3 (es) | 2007-04-24 | 2015-07-01 | Astrazeneca Ab | Inhibidores de proteínas quinasas |
WO2008132138A1 (en) | 2007-04-25 | 2008-11-06 | Ingenium Pharmaceuticals Gmbh | Derivatives of 4,6-disubstituted aminopyrimidines |
WO2009029998A1 (en) | 2007-09-06 | 2009-03-12 | Cytopia Research Pty Ltd | Retrometabolic compounds |
GB0805477D0 (en) | 2008-03-26 | 2008-04-30 | Univ Nottingham | Pyrimidines triazines and their use as pharmaceutical agents |
US8415381B2 (en) | 2009-07-30 | 2013-04-09 | Novartis Ag | Heteroaryl compounds and their uses |
AU2011231975B2 (en) | 2010-03-22 | 2014-07-03 | Bayer Intellectual Property Gmbh | Pharmaceutically active disubstituted triazine derivatives |
CN103562184B (zh) | 2011-03-02 | 2016-04-27 | 利德探索中心有限公司 | 药学活性的二取代的吡啶衍生物 |
EP2527332A1 (en) | 2011-05-24 | 2012-11-28 | Bayer Intellectual Property GmbH | 4-Aryl-N-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group as CDK9 inhibitors |
JP5976814B2 (ja) | 2011-09-16 | 2016-08-24 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH | スルホキシイミン基を含有する二置換5−フルオロピリミジン誘導体 |
WO2013037896A1 (en) * | 2011-09-16 | 2013-03-21 | Bayer Intellectual Property Gmbh | Disubstituted 5-fluoro-pyrimidines |
CN105102434A (zh) | 2012-10-18 | 2015-11-25 | 拜耳药业股份公司 | 含砜基团的4-(邻)-氟苯基-5-氟嘧啶-2-基胺 |
CN104918918B (zh) | 2012-11-15 | 2017-10-24 | 拜耳药业股份公司 | 含磺亚胺基团的4‑(邻)‑氟苯基‑5‑氟嘧啶‑2‑基胺 |
LT2928878T (lt) | 2012-11-15 | 2016-11-25 | Bayer Pharma Aktiengesellschaft | 5-fluor-n-(piridin-2-il)piridin-2-amino dariniai, turintys sulfoksimino grupę |
WO2015001021A1 (en) | 2013-07-04 | 2015-01-08 | Bayer Pharma Aktiengesellschaft | Sulfoximine substituted 5-fluoro-n-(pyridin-2-yl)pyridin-2-amine derivatives and their use as cdk9 kinase inhibitors |
US9856242B2 (en) | 2014-03-13 | 2018-01-02 | Bayer Pharma Aktiengesellscaft | 5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfone group |
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2015
- 2015-04-08 EP EP15715715.7A patent/EP3129387B1/en active Active
- 2015-04-08 TN TN2016000435A patent/TN2016000435A1/en unknown
- 2015-04-08 EA EA201692034A patent/EA032541B1/ru not_active IP Right Cessation
- 2015-04-08 JP JP2016561318A patent/JP6605493B2/ja active Active
- 2015-04-08 CR CR20160471A patent/CR20160471A/es unknown
- 2015-04-08 AP AP2016009483A patent/AP2016009483A0/en unknown
- 2015-04-08 KR KR1020167031177A patent/KR102383938B1/ko active IP Right Grant
- 2015-04-08 ES ES15715715T patent/ES2743799T3/es active Active
- 2015-04-08 WO PCT/EP2015/057546 patent/WO2015155197A1/en active Application Filing
- 2015-04-08 MX MX2016013362A patent/MX2016013362A/es active IP Right Grant
- 2015-04-08 BR BR112016023554-1A patent/BR112016023554B1/pt active IP Right Grant
- 2015-04-08 AU AU2015243585A patent/AU2015243585B2/en active Active
- 2015-04-08 CU CU2016000152A patent/CU24399B1/es unknown
- 2015-04-08 PE PE2016001962A patent/PE20161379A1/es unknown
- 2015-04-08 CA CA2945237A patent/CA2945237C/en active Active
- 2015-04-08 US US15/303,212 patent/US9963464B2/en active Active
- 2015-04-08 SG SG11201608430RA patent/SG11201608430RA/en unknown
- 2015-04-08 CN CN201580030721.XA patent/CN106459084B/zh active Active
- 2015-04-09 UY UY0001036072A patent/UY36072A/es not_active Application Discontinuation
- 2015-04-10 AR ARP150101081A patent/AR099999A1/es unknown
- 2015-04-10 TW TW104111701A patent/TW201623312A/zh unknown
- 2015-08-04 UA UAA201611295A patent/UA119349C2/uk unknown
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2016
- 2016-09-22 IL IL247966A patent/IL247966B/en active IP Right Grant
- 2016-10-04 PH PH12016501968A patent/PH12016501968A1/en unknown
- 2016-10-11 CL CL2016002577A patent/CL2016002577A1/es unknown
- 2016-10-11 DO DO2016000278A patent/DOP2016000278A/es unknown
- 2016-10-11 SV SV2016005301A patent/SV2016005301A/es unknown
- 2016-11-10 ZA ZA2016/07765A patent/ZA201607765B/en unknown
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