CU24399B1 - Nuevos compuestos macrocíclicos en calidad de inhibidores de cdk9, un proceso para su preparación y los compuestos intermediarios útiles en la preparación de estos compuestos - Google Patents
Nuevos compuestos macrocíclicos en calidad de inhibidores de cdk9, un proceso para su preparación y los compuestos intermediarios útiles en la preparación de estos compuestosInfo
- Publication number
- CU24399B1 CU24399B1 CU2016000152A CU20160152A CU24399B1 CU 24399 B1 CU24399 B1 CU 24399B1 CU 2016000152 A CU2016000152 A CU 2016000152A CU 20160152 A CU20160152 A CU 20160152A CU 24399 B1 CU24399 B1 CU 24399B1
- Authority
- CU
- Cuba
- Prior art keywords
- compounds
- preparation
- quality
- useful intermediate
- new macrocyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/529—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
- C07C53/16—Halogenated acetic acids
- C07C53/18—Halogenated acetic acids containing fluorine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Abstract
<p>Nuevos compuestos macrocíclicos de la fórmula general (I) como se los describe y se los define en la memoria descriptiva. Métodos para prepararlos. Su uso en el tratamiento y/o la profilaxis de diversos trastornos, particularmente de los trastornos hiperproliferativos, de las enfermedades infecciosas inducidas por virus y/o de las enfermedades cardiovasculares. Compuestos intermedios útiles para preparar los compuestos de la fórmula general (I).</p>
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2014000392 | 2014-04-11 | ||
PCT/EP2015/057546 WO2015155197A1 (en) | 2014-04-11 | 2015-04-08 | Novel macrocyclic compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
CU20160152A7 CU20160152A7 (es) | 2017-04-05 |
CU24399B1 true CU24399B1 (es) | 2019-04-04 |
Family
ID=52824234
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU2016000152A CU24399B1 (es) | 2014-04-11 | 2015-04-08 | Nuevos compuestos macrocíclicos en calidad de inhibidores de cdk9, un proceso para su preparación y los compuestos intermediarios útiles en la preparación de estos compuestos |
Country Status (28)
Country | Link |
---|---|
US (1) | US9963464B2 (es) |
EP (1) | EP3129387B1 (es) |
JP (1) | JP6605493B2 (es) |
KR (1) | KR102383938B1 (es) |
CN (1) | CN106459084B (es) |
AP (1) | AP2016009483A0 (es) |
AR (1) | AR099999A1 (es) |
AU (1) | AU2015243585B2 (es) |
BR (1) | BR112016023554B1 (es) |
CA (1) | CA2945237C (es) |
CL (1) | CL2016002577A1 (es) |
CR (1) | CR20160471A (es) |
CU (1) | CU24399B1 (es) |
DO (1) | DOP2016000278A (es) |
EA (1) | EA032541B1 (es) |
ES (1) | ES2743799T3 (es) |
IL (1) | IL247966B (es) |
MX (1) | MX2016013362A (es) |
PE (1) | PE20161379A1 (es) |
PH (1) | PH12016501968A1 (es) |
SG (1) | SG11201608430RA (es) |
SV (1) | SV2016005301A (es) |
TN (1) | TN2016000435A1 (es) |
TW (1) | TW201623312A (es) |
UA (1) | UA119349C2 (es) |
UY (1) | UY36072A (es) |
WO (1) | WO2015155197A1 (es) |
ZA (1) | ZA201607765B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6847099B2 (ja) * | 2015-09-29 | 2021-03-24 | バイエル ファーマ アクチエンゲゼルシャフト | 新規な大環状スルホンジイミン化合物 |
US10214542B2 (en) | 2015-10-08 | 2019-02-26 | Bayer Pharma Aktiengesellschaft | Modified macrocyclic compounds |
CA3020378A1 (en) * | 2016-04-22 | 2017-10-26 | Astrazeneca Ab | Macrocyclic mcl1 inhibitors for treating cancer |
AU2017345367A1 (en) * | 2016-10-20 | 2019-04-04 | Pfizer Inc. | Anti-proliferative agents for treating PAH |
EP3601253B1 (en) | 2017-03-28 | 2021-09-15 | Bayer Aktiengesellschaft | Novel ptefb inhibiting macrocyclic compounds |
EP3601236A1 (en) | 2017-03-28 | 2020-02-05 | Bayer Aktiengesellschaft | Novel ptefb inhibiting macrocyclic compounds |
CN109251212A (zh) * | 2017-07-14 | 2019-01-22 | 上海长森药业有限公司 | 内环硫醚酰胺-芳基酰胺类化合物及其治疗乙型肝炎的用途 |
CN111434665B (zh) * | 2019-01-11 | 2023-03-10 | 上海长森药业有限公司 | 内环硫脒酰胺-芳基酰胺类化合物及其治疗乙型肝炎的用途 |
CN112321604A (zh) * | 2019-08-05 | 2021-02-05 | 华东理工大学 | 大环类jak2抑制剂及其应用 |
WO2023057812A1 (en) | 2021-10-04 | 2023-04-13 | Vincerx Pharma Gmbh | Compounds, pharmaceutical compositions, and methods for the treatment, prevention, or management of hyperproliferative disorder |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7105530B2 (en) | 2000-12-21 | 2006-09-12 | Smithkline Beecham Corporation | Pyrimidineamines as angiogenesis modulators |
DE10239042A1 (de) | 2002-08-21 | 2004-03-04 | Schering Ag | Makrozyclische Pyrimidine, deren Herstellung und Verwendung als Arzneimittel |
DE10349423A1 (de) | 2003-10-16 | 2005-06-16 | Schering Ag | Sulfoximinsubstituierte Parimidine als CDK- und/oder VEGF-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel |
NZ555474A (en) | 2004-12-17 | 2010-10-29 | Astrazeneca Ab | 4-(4-(imidazol-4-yl) pyrimidin-2-ylamino) benzamides as CDK inhibitors |
DE102006042143A1 (de) | 2006-09-08 | 2008-03-27 | Bayer Healthcare Aktiengesellschaft | Neue substituierte Bipyridin-Derivate und ihre Verwendung |
WO2008060248A1 (en) * | 2006-11-15 | 2008-05-22 | S*Bio Pte Ltd. | Indole sustituted pyrimidines and use thereof in the treatment of cancer |
CA2672639A1 (en) | 2006-12-22 | 2008-07-03 | Novartis Ag | Indol-4-yl-pyrimidinyl-2-yl-amine derivatives and use thereof as cyclin dependant kinase inhibitors |
US20100048597A1 (en) | 2006-12-22 | 2010-02-25 | Novartis Ag | Organic Compounds and Their Uses |
EP2137166B1 (en) | 2007-04-24 | 2012-05-30 | Ingenium Pharmaceuticals GmbH | 4, 6-disubstituted aminopyrimidine derivatives as inhibitors of protein kinases |
WO2008129071A1 (en) | 2007-04-24 | 2008-10-30 | Ingenium Pharmaceuticals Gmbh | Inhibitors of protein kinases |
ES2539518T3 (es) | 2007-04-24 | 2015-07-01 | Astrazeneca Ab | Inhibidores de proteínas quinasas |
WO2008132138A1 (en) | 2007-04-25 | 2008-11-06 | Ingenium Pharmaceuticals Gmbh | Derivatives of 4,6-disubstituted aminopyrimidines |
WO2009029998A1 (en) | 2007-09-06 | 2009-03-12 | Cytopia Research Pty Ltd | Retrometabolic compounds |
GB0805477D0 (en) | 2008-03-26 | 2008-04-30 | Univ Nottingham | Pyrimidines triazines and their use as pharmaceutical agents |
US8415381B2 (en) | 2009-07-30 | 2013-04-09 | Novartis Ag | Heteroaryl compounds and their uses |
WO2011116951A1 (en) | 2010-03-22 | 2011-09-29 | Lead Discovery Center Gmbh | Pharmaceutically active disubstituted triazine derivatives |
CN103562184B (zh) | 2011-03-02 | 2016-04-27 | 利德探索中心有限公司 | 药学活性的二取代的吡啶衍生物 |
EP2527332A1 (en) | 2011-05-24 | 2012-11-28 | Bayer Intellectual Property GmbH | 4-Aryl-N-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group as CDK9 inhibitors |
WO2013037894A1 (en) | 2011-09-16 | 2013-03-21 | Bayer Intellectual Property Gmbh | Disubstituted 5-fluoro pyrimidine derivatives containing a sulfoximine group |
CN103917527B (zh) * | 2011-09-16 | 2017-05-31 | 拜耳知识产权有限责任公司 | 二取代的5‑氟‑嘧啶 |
CN105102434A (zh) | 2012-10-18 | 2015-11-25 | 拜耳药业股份公司 | 含砜基团的4-(邻)-氟苯基-5-氟嘧啶-2-基胺 |
EA027226B1 (ru) | 2012-11-15 | 2017-07-31 | Байер Фарма Акциенгезельшафт | Производные 5-фтор-n-(пиридин-2-ил)пиридин-2-амина, содержащие сульфоксиминовую группу |
JP6300818B2 (ja) | 2012-11-15 | 2018-03-28 | バイエル ファーマ アクチエンゲゼルシャフト | スルホキシイミン基を含有する4−(オルト)−フルオロフェニル−5−フルオロピリミジン−2−イルアミン |
EP3016945B1 (en) | 2013-07-04 | 2017-05-03 | Bayer Pharma Aktiengesellschaft | Sulfoximine substituted 5-fluoro-n-(pyridin-2-yl)pyridin-2-amine derivatives and their use as cdk9 kinase inhibitors |
CN106232596A (zh) | 2014-03-13 | 2016-12-14 | 拜耳医药股份有限公司 | 含有砜基团的5‑氟‑n‑(吡啶‑2‑基)吡啶‑2‑胺衍生物 |
-
2015
- 2015-04-08 SG SG11201608430RA patent/SG11201608430RA/en unknown
- 2015-04-08 CU CU2016000152A patent/CU24399B1/es unknown
- 2015-04-08 MX MX2016013362A patent/MX2016013362A/es active IP Right Grant
- 2015-04-08 AP AP2016009483A patent/AP2016009483A0/en unknown
- 2015-04-08 CR CR20160471A patent/CR20160471A/es unknown
- 2015-04-08 PE PE2016001962A patent/PE20161379A1/es unknown
- 2015-04-08 BR BR112016023554-1A patent/BR112016023554B1/pt active IP Right Grant
- 2015-04-08 KR KR1020167031177A patent/KR102383938B1/ko active IP Right Grant
- 2015-04-08 JP JP2016561318A patent/JP6605493B2/ja active Active
- 2015-04-08 EP EP15715715.7A patent/EP3129387B1/en active Active
- 2015-04-08 TN TN2016000435A patent/TN2016000435A1/en unknown
- 2015-04-08 WO PCT/EP2015/057546 patent/WO2015155197A1/en active Application Filing
- 2015-04-08 AU AU2015243585A patent/AU2015243585B2/en active Active
- 2015-04-08 CA CA2945237A patent/CA2945237C/en active Active
- 2015-04-08 CN CN201580030721.XA patent/CN106459084B/zh active Active
- 2015-04-08 EA EA201692034A patent/EA032541B1/ru not_active IP Right Cessation
- 2015-04-08 ES ES15715715T patent/ES2743799T3/es active Active
- 2015-04-08 US US15/303,212 patent/US9963464B2/en active Active
- 2015-04-09 UY UY0001036072A patent/UY36072A/es not_active Application Discontinuation
- 2015-04-10 TW TW104111701A patent/TW201623312A/zh unknown
- 2015-04-10 AR ARP150101081A patent/AR099999A1/es unknown
- 2015-08-04 UA UAA201611295A patent/UA119349C2/uk unknown
-
2016
- 2016-09-22 IL IL247966A patent/IL247966B/en active IP Right Grant
- 2016-10-04 PH PH12016501968A patent/PH12016501968A1/en unknown
- 2016-10-11 DO DO2016000278A patent/DOP2016000278A/es unknown
- 2016-10-11 SV SV2016005301A patent/SV2016005301A/es unknown
- 2016-10-11 CL CL2016002577A patent/CL2016002577A1/es unknown
- 2016-11-10 ZA ZA2016/07765A patent/ZA201607765B/en unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CU24399B1 (es) | Nuevos compuestos macrocíclicos en calidad de inhibidores de cdk9, un proceso para su preparación y los compuestos intermediarios útiles en la preparación de estos compuestos | |
DOP2015000118A (es) | Derivados de 5-fluoro-n-(piridin-2-il)piridin-2-amina que contienen un grupo sulfoximina | |
ECSP13013040A (es) | 4-aril-n-fenil-1,3,5-triazin-2-aminas que contienen un grupo sulfoximina | |
GT201700189A (es) | Derivados de nucleósidos sustituidos útiles como agentes antineoplásicos | |
NI201700096A (es) | Derivados de 4h-pirrol[3, 2-c]piridin-4-ona | |
CL2017000712A1 (es) | Pirimidinonas como inhibidores del factor xia | |
CL2016001963A1 (es) | Heteroarilos inhibidores de syk | |
EA201790630A1 (ru) | Способы получения рибозидов | |
ECSP13013021A (es) | Compuestos de benzotiazol y su uso farmacéutico | |
EA201791304A1 (ru) | Производные изохинолина для лечения вич | |
UY35139A (es) | 4- (orto) -fluorofenil-5-fluoropirimidin-2-ilaminas que contienen un grupo sulfoximina | |
DOP2015000117A (es) | Derivados de n-(piridin-2-il)pirimidin-4-amina que contienen un grupo sulfoximina | |
ECSP18074962A (es) | Derivados de aminotiazol útiles como agentes antivíricos | |
CR20160016A (es) | Pirazolpiridinas sustituidas | |
UY36923A (es) | Nuevos compuestos macrocíclicos de sulfondiimina | |
CL2017000707A1 (es) | Derivados de nucleosidos sustituidos de 4'-vinilo como inhibidores de la replicación del arn del virus sincicial respiratorio | |
SV2016005282A (es) | Nuevos compuestos | |
UY36284A (es) | Método para la preparación de imidazopiridazinas sustituidas | |
EA201691191A1 (ru) | Полиморфные формы n-карбамоилметил-4(r)-фенил-2-пирролидона |