CU20110225A7 - Derivados de l-(piperidin-4-il)-pirazol como moduladores de gpr 119 - Google Patents

Derivados de l-(piperidin-4-il)-pirazol como moduladores de gpr 119

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Publication number
CU20110225A7
CU20110225A7 CU2011000225A CU20110225A CU20110225A7 CU 20110225 A7 CU20110225 A7 CU 20110225A7 CU 2011000225 A CU2011000225 A CU 2011000225A CU 20110225 A CU20110225 A CU 20110225A CU 20110225 A7 CU20110225 A7 CU 20110225A7
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CU
Cuba
Prior art keywords
pirazol
gpr
piperidin
modulators
derivatives
Prior art date
Application number
CU2011000225A
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English (en)
Inventor
Vincent Mascitti
Kim Francis Mcclure
Michael John Munchhof
Ralph Pelton Robinson Jr
Michael Paul Deninno
Kentaro Futatsugi
Kung Daniel Wei-Shung
Bruce Allen Lefker
Original Assignee
Pfizer
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Application filed by Pfizer filed Critical Pfizer
Publication of CU20110225A7 publication Critical patent/CU20110225A7/es

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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Abstract

En la presente memoria se describen compuestos de fórmula I que modulan la actividad del receptor acoplado a proteína G GPR119 y sus usos en el tratamiento de enfermedades ligadas a la modulación del receptor acoplado a proteína G GPR119 en animales.
CU2011000225A 2009-06-05 2011-12-02 Derivados de l-(piperidin-4-il)-pirazol como moduladores de gpr 119 CU20110225A7 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18435509P 2009-06-05 2009-06-05
US25762109P 2009-11-03 2009-11-03
PCT/IB2010/052377 WO2010140092A1 (en) 2009-06-05 2010-05-27 L- ( piperidin-4-yl) -pyrazole derivatives as gpr 119 modulators

Publications (1)

Publication Number Publication Date
CU20110225A7 true CU20110225A7 (es) 2013-01-30

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Family Applications (1)

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CU2011000225A CU20110225A7 (es) 2009-06-05 2011-12-02 Derivados de l-(piperidin-4-il)-pirazol como moduladores de gpr 119

Country Status (33)

Country Link
US (1) US20110020460A1 (es)
EP (1) EP2438051A1 (es)
JP (1) JP2012528847A (es)
KR (1) KR20120061063A (es)
CN (1) CN102459222B (es)
AP (1) AP2799A (es)
AR (1) AR076985A1 (es)
AU (1) AU2010255422B2 (es)
BR (1) BRPI1014636A2 (es)
CA (1) CA2764021C (es)
CL (1) CL2011003085A1 (es)
CO (1) CO6470897A2 (es)
CR (1) CR20110623A (es)
CU (1) CU20110225A7 (es)
DO (1) DOP2011000371A (es)
EA (1) EA020106B1 (es)
EC (1) ECSP11011493A (es)
GE (1) GEP20135907B (es)
GT (1) GT201100308A (es)
HN (1) HN2011003195A (es)
IL (1) IL216772A0 (es)
MA (1) MA33334B1 (es)
MX (1) MX2011013034A (es)
NI (1) NI201100204A (es)
NZ (1) NZ596467A (es)
PE (1) PE20120399A1 (es)
SG (1) SG175995A1 (es)
SV (1) SV2011004063A (es)
TN (1) TN2012000073A1 (es)
TW (1) TWI411611B (es)
UY (1) UY32683A (es)
WO (1) WO2010140092A1 (es)
ZA (1) ZA201108481B (es)

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