CS214792B2 - Method of making the dimeric compounds of indol-dihydroindole derivatives genus vinca connected by the bridge - Google Patents

Method of making the dimeric compounds of indol-dihydroindole derivatives genus vinca connected by the bridge Download PDF

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Publication number
CS214792B2
CS214792B2 CS793284A CS328479A CS214792B2 CS 214792 B2 CS214792 B2 CS 214792B2 CS 793284 A CS793284 A CS 793284A CS 328479 A CS328479 A CS 328479A CS 214792 B2 CS214792 B2 CS 214792B2
Authority
CS
Czechoslovakia
Prior art keywords
vlb
deacetyl
bis
formula
ethyl
Prior art date
Application number
CS793284A
Other languages
Czech (cs)
English (en)
Inventor
Robert A Conrad
Koert Gerzon
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Priority to CS806477A priority Critical patent/CS214794B2/cs
Priority to CS806476A priority patent/CS214793B2/cs
Publication of CS214792B2 publication Critical patent/CS214792B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CS793284A 1978-05-15 1979-05-14 Method of making the dimeric compounds of indol-dihydroindole derivatives genus vinca connected by the bridge CS214792B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CS806477A CS214794B2 (cs) 1978-05-15 1980-09-25 Způsob výroby poloamidů dimerních indol-dihydroindolových derivátů z rodu Vinca, spojených můstkem
CS806476A CS214793B2 (en) 1978-05-15 1980-09-25 New method of making the dimeric disulphides of indol-dihydroindole derivatives genus vinca connected by the bridge

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/905,667 US4199504A (en) 1978-05-15 1978-05-15 Bridged cathranthus alkaloid dimers

Publications (1)

Publication Number Publication Date
CS214792B2 true CS214792B2 (en) 1982-05-28

Family

ID=25421234

Family Applications (1)

Application Number Title Priority Date Filing Date
CS793284A CS214792B2 (en) 1978-05-15 1979-05-14 Method of making the dimeric compounds of indol-dihydroindole derivatives genus vinca connected by the bridge

Country Status (21)

Country Link
US (1) US4199504A (de)
EP (3) EP0005620A1 (de)
JP (1) JPS54148798A (de)
AU (1) AU4691379A (de)
BE (1) BE876155A (de)
CA (1) CA1114816A (de)
CS (1) CS214792B2 (de)
DD (3) DD147543A5 (de)
DK (1) DK197579A (de)
ES (3) ES480560A1 (de)
FI (1) FI791519A (de)
FR (2) FR2435480A1 (de)
GB (1) GB2022080A (de)
GR (1) GR73047B (de)
IL (1) IL57434A0 (de)
LU (1) LU81254A1 (de)
PH (3) PH14999A (de)
PL (2) PL215593A1 (de)
PT (1) PT69589A (de)
RO (1) RO81682B (de)
ZA (1) ZA792271B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4362664A (en) * 1980-12-29 1982-12-07 Eli Lilly And Company Vinblastine oxazolidinedione disulfides and related compounds
EP0123441B1 (de) * 1983-03-30 1990-10-03 Lilly Industries Limited Vincaleukoblastin-Derivate
AU5240999A (en) * 1998-07-31 2000-02-21 Goldsmith Seeds Inc. Trimeric and polymeric alkaloids
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR204004A1 (es) * 1973-04-02 1975-11-12 Lilly Co Eli Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina
IL48685A (en) * 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine
GR69783B (de) * 1976-09-08 1982-07-07 Lilly Co Eli
US4115388A (en) * 1977-03-30 1978-09-19 Eli Lilly And Company 3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds
HU181874B (en) * 1977-08-08 1983-11-28 Lilly Co Eli Process for preparing amides of deacetyl-leurosine and deacetyl-leuroformine

Also Published As

Publication number Publication date
CA1114816A (en) 1981-12-22
JPS54148798A (en) 1979-11-21
LU81254A1 (fr) 1979-09-10
ES480560A1 (es) 1980-04-01
GR73047B (de) 1984-01-26
RO81682A (ro) 1983-04-29
PH14999A (en) 1982-03-22
DK197579A (da) 1979-11-16
AU4691379A (en) 1979-11-22
PL120896B1 (en) 1982-03-31
PL222094A1 (de) 1980-10-20
EP0032756A3 (de) 1981-09-09
PH14904A (en) 1982-01-29
PT69589A (en) 1979-06-01
EP0005620A1 (de) 1979-11-28
PH14907A (en) 1982-01-29
ES480562A1 (es) 1980-04-01
EP0032756A2 (de) 1981-07-29
PL215593A1 (de) 1980-06-16
FR2438052A1 (fr) 1980-04-30
DD147543A5 (de) 1981-04-08
EP0033981A3 (de) 1981-09-09
US4199504A (en) 1980-04-22
GB2022080A (en) 1979-12-12
ZA792271B (en) 1980-12-31
FR2435480A1 (fr) 1980-04-04
DD143618A5 (de) 1980-09-03
FI791519A (fi) 1979-11-16
RO81682B (ro) 1983-04-30
EP0033981A2 (de) 1981-08-19
BE876155A (fr) 1979-11-12
DD150467A5 (de) 1981-09-02
ES480561A1 (es) 1980-04-01
IL57434A0 (en) 1979-09-30

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