AR204004A1 - Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina - Google Patents

Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina

Info

Publication number: AR204004A1
Authority: AR; Argentina
Prior art keywords: leurocristine; leurosidine; vinblastin; procedures; derivatives
Prior art date: 1973-04-02

Application number

AR253105A

Other languages

English (en)

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1973-04-02

Filing date

1974-01-01

Publication date

1975-11-12

1974-01-01 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1975-11-12 Application granted granted Critical

1975-11-12 Publication of AR204004A1 publication Critical patent/AR204004A1/es

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Fodder In General (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

AR253105A 1973-04-02 1974-01-01 Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina AR204004A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US34727573A	1973-04-02	1973-04-02

Publications (1)

Publication Number	Publication Date
AR204004A1 true AR204004A1 (es)	1975-11-12

Family

ID=23363051

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AR253105A AR204004A1 (es)	1973-04-02	1974-01-01	Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina
AR257228A AR203882A1 (es)	1973-04-02	1975-01-08	Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AR257228A AR203882A1 (es)	1973-04-02	1975-01-08	Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina

Country Status (28)

Country	Link
JP (2)	JPS5919117B2 (es)
AR (2)	AR204004A1 (es)
AT (1)	AT340605B (es)
BE (1)	BE813168A (es)
BG (3)	BG22831A3 (es)
CA (1)	CA1042428A (es)
CH (1)	CH603669A5 (es)
CS (1)	CS185223B2 (es)
CY (1)	CY1044A (es)
DD (1)	DD113538A5 (es)
DE (1)	DE2415980A1 (es)
DK (1)	DK141511B (es)
ES (2)	ES424882A1 (es)
FR (1)	FR2223044B1 (es)
GB (1)	GB1463575A (es)
HK (1)	HK20180A (es)
HU (1)	HU171572B (es)
IE (1)	IE39071B1 (es)
IL (1)	IL44415A (es)
KE (1)	KE3028A (es)
MY (1)	MY8100025A (es)
NL (1)	NL181079C (es)
PH (1)	PH13623A (es)
RO (2)	RO77533A (es)
SE (1)	SE416206B (es)
SU (4)	SU731900A3 (es)
YU (3)	YU39719B (es)
ZA (1)	ZA741674B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL48685A (en) *	1975-01-09	1980-03-31	Lilly Co Eli	Amides of vincadioline and vinblastine
GR69783B (es) *	1976-09-08	1982-07-07	Lilly Co Eli
US4096148A (en) *	1976-12-06	1978-06-20	Eli Lilly And Company	Oxazolidinedione derivatives of Vinca alkaloids
USRE30560E (en) *	1976-12-06	1981-03-31	Eli Lilly And Company	Oxazolidinedione derivatives of Vinca alkaloids
USRE30561E (en)	1976-12-06	1981-03-31	Eli Lilly And Company	Vinca alkaloid intermediates
US4203898A (en)	1977-08-29	1980-05-20	Eli Lilly And Company	Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids
US4199504A (en) *	1978-05-15	1980-04-22	Eli Lilly And Company	Bridged cathranthus alkaloid dimers
US4357334A (en)	1980-03-20	1982-11-02	Eli Lilly And Company	Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms
OA06421A (fr) *	1980-06-10	1981-09-30	Omnium Chimique Sa	Procédé de préparation de dérivés N-(vinblastinoyl-23) d'acides aminés et de peptides.
LU83822A1 (fr) *	1981-12-08	1983-09-01	Omnichem Sa	Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique
FR2623504B1 (fr) *	1987-11-25	1990-03-09	Adir	Nouveaux derives n-(vinblastinoyl-23) d'acide amino-1 methylphosphonique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
HUT76925A (hu) *	1995-04-04	1998-01-28	MTA Enzimológiai Intézet	Bisz-indol-származékok, eljárás előállításukra és az azokat tartalmazó gyógyszerkészítmények
US5948750A (en) *	1996-10-30	1999-09-07	Merck & Co., Inc.	Conjugates useful in the treatment of prostate cancer
US6326402B1 (en)	1998-08-12	2001-12-04	Octamer, Inc.	Methods for treating viral infections using a compound capable of inhibiting microtubules
KR101345002B1 (ko)	2005-01-21	2013-12-31	아스텍스 테라퓨틱스 리미티드	제약 화합물
NZ587586A (en)	2005-07-18	2012-04-27	Bipar Sciences Inc	Treatment of cancer
US8143447B2 (en)	2006-09-05	2012-03-27	Bipar Sciences, Inc.	Treatment of cancer
CN101534836B (zh)	2006-09-05	2011-09-28	彼帕科学公司	Parp抑制剂在制备治疗肥胖症的药物中的用途
EP2073807A1 (en)	2006-10-12	2009-07-01	Astex Therapeutics Limited	Pharmaceutical combinations
US8916552B2 (en)	2006-10-12	2014-12-23	Astex Therapeutics Limited	Pharmaceutical combinations
NZ586125A (en)	2007-11-12	2012-12-21	Bipar Sciences Inc	Treatment of breast cancer with a parp inhibitor alone or in combination with anti-tumor agents
US10377774B2 (en) *	2013-04-19	2019-08-13	Jinan University	Vinblastine derivatives, preparation method therefor and application thereof
CN113456797B (zh) *	2021-06-18	2024-03-08	暨南大学	长春碱类衍生物在制备治疗骨肉瘤和/或软组织肉瘤药物中的应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3097137A (en) *	1960-05-19	1963-07-09	Canadian Patents Dev	Vincaleukoblastine

1974
- 1974-01-01 AR AR253105A patent/AR204004A1/es active
- 1974-03-13 IE IE532/74A patent/IE39071B1/xx unknown
- 1974-03-13 IL IL44415A patent/IL44415A/xx unknown
- 1974-03-13 ZA ZA00741674A patent/ZA741674B/xx unknown
- 1974-03-22 CA CA195,760A patent/CA1042428A/en not_active Expired
- 1974-03-25 CY CY1044A patent/CY1044A/xx unknown
- 1974-03-25 GB GB1310174A patent/GB1463575A/en not_active Expired
- 1974-03-25 YU YU817/74A patent/YU39719B/xx unknown
- 1974-03-29 CH CH446374A patent/CH603669A5/xx active Protection Beyond IP Right Term
- 1974-03-29 FR FR7411519A patent/FR2223044B1/fr not_active Expired
- 1974-03-29 PH PH15676A patent/PH13623A/en unknown
- 1974-04-01 SU SU742013753A patent/SU731900A3/ru active
- 1974-04-01 HU HU74EI00000538A patent/HU171572B/hu unknown
- 1974-04-01 AT AT267974A patent/AT340605B/de not_active IP Right Cessation
- 1974-04-01 SE SE7404380A patent/SE416206B/xx not_active IP Right Cessation
- 1974-04-01 CS CS7400002335A patent/CS185223B2/cs unknown
- 1974-04-01 NL NLAANVRAGE7404423,A patent/NL181079C/xx not_active IP Right Cessation
- 1974-04-01 DK DK178774AA patent/DK141511B/da not_active IP Right Cessation
- 1974-04-02 RO RO7498695A patent/RO77533A/ro unknown
- 1974-04-02 BE BE1005847A patent/BE813168A/xx not_active IP Right Cessation
- 1974-04-02 RO RO78274A patent/RO73524B/ro unknown
- 1974-04-02 BG BG26279A patent/BG22831A3/xx unknown
- 1974-04-02 JP JP49037765A patent/JPS5919117B2/ja not_active Expired
- 1974-04-02 DE DE2415980A patent/DE2415980A1/de active Granted
- 1974-04-02 DD DD177632A patent/DD113538A5/xx unknown
- 1974-04-02 BG BG28513A patent/BG21612A3/xx unknown
- 1974-04-02 ES ES424882A patent/ES424882A1/es not_active Expired
- 1974-04-02 BG BG28514A patent/BG21235A3/xx unknown
1975
- 1975-01-08 AR AR257228A patent/AR203882A1/es active
- 1975-07-04 SU SU752151512A patent/SU784783A3/ru active
- 1975-07-09 SU SU752152020A patent/SU652896A3/ru active
1976
- 1976-03-31 ES ES446571A patent/ES446571A1/es not_active Expired
- 1976-12-20 SU SU762429453A patent/SU623522A3/ru active
1980
- 1980-02-27 KE KE3028A patent/KE3028A/xx unknown
- 1980-04-17 HK HK201/80A patent/HK20180A/xx unknown
- 1980-04-25 YU YU1139/80A patent/YU39876B/xx unknown
- 1980-04-25 YU YU1138/80A patent/YU39875B/xx unknown
1981
- 1981-12-30 MY MY25/81A patent/MY8100025A/xx unknown
1983
- 1983-12-16 JP JP58238722A patent/JPS6033837B2/ja not_active Expired

Also Published As

Publication number	Publication date
JPS49128000A (es)	1974-12-07
BG21235A3 (es)	1976-03-20
NL181079C (nl)	1987-06-16
YU81774A (en)	1982-05-31
IE39071B1 (en)	1978-08-02
BG22831A3 (es)	1977-04-20
SU731900A3 (ru)	1980-04-30
YU39719B (en)	1985-04-30
YU39876B (en)	1985-04-30
ES424882A1 (es)	1976-12-16
NL7404423A (es)	1974-10-04
DK141511B (da)	1980-04-08
BG21612A3 (es)	1976-07-20
FR2223044A1 (es)	1974-10-25
JPS5919117B2 (ja)	1984-05-02
BE813168A (fr)	1974-10-02
GB1463575A (en)	1977-02-02
AR203882A1 (es)	1975-10-31
AT340605B (de)	1977-12-27
DE2415980A1 (de)	1974-10-10
CS185223B2 (en)	1978-09-15
ATA267974A (de)	1977-04-15
MY8100025A (en)	1981-12-31
YU113880A (en)	1982-05-31
SU652896A3 (ru)	1979-03-15
AU6671974A (en)	1975-09-18
RO77533A (ro)	1982-02-01
SE416206B (sv)	1980-12-08
YU113980A (en)	1982-05-31
SU623522A3 (ru)	1978-09-05
DD113538A5 (es)	1975-06-12
RO73524B (ro)	1984-11-30
YU39875B (en)	1985-04-30
DE2415980C2 (es)	1989-11-09
IL44415A (en)	1978-08-31
CH603669A5 (es)	1978-08-31
DK141511C (es)	1980-09-29
IE39071L (en)	1974-10-02
JPS6033837B2 (ja)	1985-08-05
CA1042428A (en)	1978-11-14
RO73524A (ro)	1984-10-31
HU171572B (hu)	1978-02-28
SU784783A3 (ru)	1980-11-30
IL44415A0 (en)	1974-06-30
JPS59193895A (ja)	1984-11-02
ZA741674B (en)	1975-10-29
KE3028A (en)	1980-03-28
NL181079B (nl)	1987-01-16
HK20180A (en)	1980-04-25
ES446571A1 (es)	1977-06-16
CY1044A (en)	1980-08-01
FR2223044B1 (es)	1978-06-30
PH13623A (en)	1980-08-07

Publication	Publication Date	Title
AR204004A1 (es)	1975-11-12	Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina
AR206908A1 (es)	1976-08-31	Procedimiento mejorado para preparar derivados 1-aciloxicarbonilicos
AR205129A1 (es)	1976-04-05	Procedimiento para preparar nuevos derivados de chalcona
RO68793A (ro)	1980-12-30	Procedeu pentru prepararea unor copoliamide
SE415261B (sv)	1980-09-22	Forfarande for framstellning av berarbundna polypeptider
SE397530B (sv)	1977-11-07	Forfarande for framstellning av 1-pyrazolylalkyl-4-arylpiperazinderivat
AR195314A1 (es)	1973-09-28	Procedimiento para preparar derivados de piperidinoalcanol alfa-aril-4-sustituidos
AR200387A1 (es)	1974-11-08	Procedimiento para preparar derivados de trifluorometilfenilpiperazina
SE415354B (sv)	1980-09-29	Forfarande for framstellning av xantinderivat
NO151585C (no)	1985-05-08	Fremgangsmaate for fremstilling 6-deoksyoksytetracyklin
SE387344B (sv)	1976-09-06	Forfarande for framstellning av pyrazin-4-oxidderivat
AR201506A1 (es)	1975-03-21	Procedimiento para preparar derivados de 4-hidroxi-3-nitrocarboestirilo
RO87769A (ro)	1985-12-20	Procedeu pentru prepararea unor derivati de tiazolidina
NL7415177A (nl)	1975-06-03	Werkwijze ter bereiding van xantheen- en thioxantheenderivaten.
AR205398A1 (es)	1976-04-30	Procedimiento para preparar derivados de cefalosporina
SE415100B (sv)	1980-09-08	Forfarande for framstellning av kinuklidin-kinolinderivat
AR200962A1 (es)	1974-12-27	Procedimiento para preparar nuevos derivados de alfa-l-arabinosido de digitoxigenina
AR210132A1 (es)	1977-06-30	Procedimiento para preparar nuevos derivados de 3-amino-4-acetil-5-metil-pirrol
TR18287A (tr)	1976-12-09	Triasetonamin hazirlamaya mahsus usul
SE417966B (sv)	1981-04-27	Forfarande for framstellning av pyrimidinoaminometyl-ergolinderivat
AR206652A1 (es)	1976-08-06	Procedimiento para preparar nuevos derivados de n-amino-alquil-2-aminoindano
RO67060A (ro)	1982-10-26	Procedeu pentru prepararea unor peniciline
AR201666A1 (es)	1975-04-08	Procedimiento para preparar derivados de dimetiltetrahidronaftodioxolil-oxi-propanoles
SE416550B (sv)	1981-01-19	5-hydroxi-4-oxa-polycykloalken-3-on-derivat samt forfarande for framstellning derav
RO70190A (ro)	1982-09-09	Procedeu pentru prepararea unor derivati de netroimidazol