ES480562A1 - Un procedimiento para la preparacion de un nuevo vincaderi- vado dimero. - Google Patents
Un procedimiento para la preparacion de un nuevo vincaderi- vado dimero.Info
- Publication number
- ES480562A1 ES480562A1 ES480562A ES480562A ES480562A1 ES 480562 A1 ES480562 A1 ES 480562A1 ES 480562 A ES480562 A ES 480562A ES 480562 A ES480562 A ES 480562A ES 480562 A1 ES480562 A1 ES 480562A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- preparation
- bridged
- formulations containing
- catharanthus alkaloid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Un procedimiento para la preparación de un nuevo vincaderivado dimero de fórmula R6- NH-CH2-(CH2)n-Q''(CH2)-n-CH2-NH2 donde R6 es una estructura parcial de indol- dihidroindol de fórmula:**(Fórmula)** donde R2 es CH3 o H; tomas dos individualmente, uno de los radicales R3 o R4 es OH y el otro es C2H5 y R5 es H y cuando se toman unidos, R4 y R5 forman un anillo alfa-epóxido y R3 es C2H5 y Q''es S, S-S, O, Se-se o (CH2)p'' donde n y p son 0, 1, 2, 3 o 4, dada uno de ellos, y sus sales de adición de ácidos farmacéuticamente aceptables; cuyo procedimiento se caracteriza por hacer reaccionar una azida de fórmula R6-N3, donde R6 es el resto de un indol-dihidroindol-alcaloide.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/905,667 US4199504A (en) | 1978-05-15 | 1978-05-15 | Bridged cathranthus alkaloid dimers |
Publications (1)
Publication Number | Publication Date |
---|---|
ES480562A1 true ES480562A1 (es) | 1980-04-01 |
Family
ID=25421234
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES480562A Expired ES480562A1 (es) | 1978-05-15 | 1979-05-14 | Un procedimiento para la preparacion de un nuevo vincaderi- vado dimero. |
ES480561A Expired ES480561A1 (es) | 1978-05-15 | 1979-05-14 | Un nuevo procedimiento para la preparacion de un compuesto vincadimero. |
ES480560A Expired ES480560A1 (es) | 1978-05-15 | 1979-05-14 | Un procedimiento para la preparacion de un vincaderivado di-mero puenteado. |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES480561A Expired ES480561A1 (es) | 1978-05-15 | 1979-05-14 | Un nuevo procedimiento para la preparacion de un compuesto vincadimero. |
ES480560A Expired ES480560A1 (es) | 1978-05-15 | 1979-05-14 | Un procedimiento para la preparacion de un vincaderivado di-mero puenteado. |
Country Status (21)
Country | Link |
---|---|
US (1) | US4199504A (es) |
EP (3) | EP0032756A3 (es) |
JP (1) | JPS54148798A (es) |
AU (1) | AU4691379A (es) |
BE (1) | BE876155A (es) |
CA (1) | CA1114816A (es) |
CS (1) | CS214792B2 (es) |
DD (3) | DD150467A5 (es) |
DK (1) | DK197579A (es) |
ES (3) | ES480562A1 (es) |
FI (1) | FI791519A (es) |
FR (2) | FR2435480A1 (es) |
GB (1) | GB2022080A (es) |
GR (1) | GR73047B (es) |
IL (1) | IL57434A0 (es) |
LU (1) | LU81254A1 (es) |
PH (3) | PH14999A (es) |
PL (2) | PL215593A1 (es) |
PT (1) | PT69589A (es) |
RO (1) | RO81682B (es) |
ZA (1) | ZA792271B (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4362664A (en) * | 1980-12-29 | 1982-12-07 | Eli Lilly And Company | Vinblastine oxazolidinedione disulfides and related compounds |
US4596676A (en) * | 1983-03-30 | 1986-06-24 | Lilly Industries Limited | Bifunctional ester derivatives of 4-desacetyl indole-dihydroindole alkaloids |
AU5240999A (en) * | 1998-07-31 | 2000-02-21 | Goldsmith Seeds Inc. | Trimeric and polymeric alkaloids |
EP2289549A3 (en) | 1999-10-01 | 2011-06-15 | Immunogen, Inc. | Immunoconjugates for treating cancer |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR204004A1 (es) * | 1973-04-02 | 1975-11-12 | Lilly Co Eli | Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina |
IL48685A (en) * | 1975-01-09 | 1980-03-31 | Lilly Co Eli | Amides of vincadioline and vinblastine |
GR69783B (es) * | 1976-09-08 | 1982-07-07 | Lilly Co Eli | |
US4115388A (en) * | 1977-03-30 | 1978-09-19 | Eli Lilly And Company | 3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds |
HU181874B (en) * | 1977-08-08 | 1983-11-28 | Lilly Co Eli | Process for preparing amides of deacetyl-leurosine and deacetyl-leuroformine |
-
1978
- 1978-05-15 US US05/905,667 patent/US4199504A/en not_active Expired - Lifetime
-
1979
- 1979-05-05 PH PH22464A patent/PH14999A/en unknown
- 1979-05-08 PT PT69589A patent/PT69589A/pt unknown
- 1979-05-09 AU AU46913/79A patent/AU4691379A/en not_active Abandoned
- 1979-05-10 FR FR7911882A patent/FR2435480A1/fr active Pending
- 1979-05-10 BE BE1/9386A patent/BE876155A/xx unknown
- 1979-05-10 CA CA327,351A patent/CA1114816A/en not_active Expired
- 1979-05-10 ZA ZA792271A patent/ZA792271B/xx unknown
- 1979-05-11 FI FI791519A patent/FI791519A/fi not_active Application Discontinuation
- 1979-05-12 GR GR59071A patent/GR73047B/el unknown
- 1979-05-14 GB GB7916702A patent/GB2022080A/en not_active Withdrawn
- 1979-05-14 EP EP81101927A patent/EP0032756A3/en not_active Withdrawn
- 1979-05-14 CS CS793284A patent/CS214792B2/cs unknown
- 1979-05-14 JP JP5962979A patent/JPS54148798A/ja active Pending
- 1979-05-14 ES ES480562A patent/ES480562A1/es not_active Expired
- 1979-05-14 EP EP79300826A patent/EP0005620A1/en not_active Withdrawn
- 1979-05-14 ES ES480561A patent/ES480561A1/es not_active Expired
- 1979-05-14 RO RO97514A patent/RO81682B/ro unknown
- 1979-05-14 ES ES480560A patent/ES480560A1/es not_active Expired
- 1979-05-14 EP EP81101924A patent/EP0033981A3/en not_active Withdrawn
- 1979-05-14 DK DK197579A patent/DK197579A/da unknown
- 1979-05-14 LU LU81254A patent/LU81254A1/xx unknown
- 1979-05-15 DD DD79217286A patent/DD150467A5/de unknown
- 1979-05-15 PL PL21559379A patent/PL215593A1/xx unknown
- 1979-05-15 DD DD79217285A patent/DD147543A5/de unknown
- 1979-05-15 DD DD79212894A patent/DD143618A5/de unknown
- 1979-05-15 PL PL1979222094A patent/PL120896B1/pl unknown
- 1979-05-30 IL IL57434A patent/IL57434A0/xx unknown
- 1979-10-31 FR FR7926971A patent/FR2438052A1/fr active Pending
-
1980
- 1980-03-06 PH PH23731A patent/PH14904A/en unknown
- 1980-03-06 PH PH23730A patent/PH14907A/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA1114816A (en) | 1981-12-22 |
PT69589A (en) | 1979-06-01 |
GR73047B (es) | 1984-01-26 |
RO81682A (ro) | 1983-04-29 |
FR2438052A1 (fr) | 1980-04-30 |
DD147543A5 (de) | 1981-04-08 |
DD143618A5 (de) | 1980-09-03 |
FI791519A (fi) | 1979-11-16 |
RO81682B (ro) | 1983-04-30 |
CS214792B2 (en) | 1982-05-28 |
EP0032756A3 (en) | 1981-09-09 |
LU81254A1 (fr) | 1979-09-10 |
EP0032756A2 (en) | 1981-07-29 |
PL222094A1 (es) | 1980-10-20 |
DD150467A5 (de) | 1981-09-02 |
GB2022080A (en) | 1979-12-12 |
AU4691379A (en) | 1979-11-22 |
EP0005620A1 (en) | 1979-11-28 |
EP0033981A3 (en) | 1981-09-09 |
PH14907A (en) | 1982-01-29 |
IL57434A0 (en) | 1979-09-30 |
PH14999A (en) | 1982-03-22 |
PL120896B1 (en) | 1982-03-31 |
US4199504A (en) | 1980-04-22 |
ZA792271B (en) | 1980-12-31 |
PL215593A1 (es) | 1980-06-16 |
PH14904A (en) | 1982-01-29 |
ES480561A1 (es) | 1980-04-01 |
JPS54148798A (en) | 1979-11-21 |
DK197579A (da) | 1979-11-16 |
BE876155A (fr) | 1979-11-12 |
EP0033981A2 (en) | 1981-08-19 |
FR2435480A1 (fr) | 1980-04-04 |
ES480560A1 (es) | 1980-04-01 |
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