CS211364B2 - Method of making the oxymorfone - Google Patents

Method of making the oxymorfone Download PDF

Info

Publication number
CS211364B2
CS211364B2 CS797115A CS711579A CS211364B2 CS 211364 B2 CS211364 B2 CS 211364B2 CS 797115 A CS797115 A CS 797115A CS 711579 A CS711579 A CS 711579A CS 211364 B2 CS211364 B2 CS 211364B2
Authority
CS
Czechoslovakia
Prior art keywords
mixture
boron compound
reaction
oxycodone
hours
Prior art date
Application number
CS797115A
Other languages
Czech (cs)
English (en)
Inventor
Michael L Wilson
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of CS211364B2 publication Critical patent/CS211364B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polarising Elements (AREA)
CS797115A 1978-10-19 1979-10-19 Method of making the oxymorfone CS211364B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95305678A 1978-10-19 1978-10-19

Publications (1)

Publication Number Publication Date
CS211364B2 true CS211364B2 (en) 1982-02-26

Family

ID=25493512

Family Applications (1)

Application Number Title Priority Date Filing Date
CS797115A CS211364B2 (en) 1978-10-19 1979-10-19 Method of making the oxymorfone

Country Status (16)

Country Link
JP (1) JPS55501025A (es)
AU (1) AU5189779A (es)
BE (1) BE879494A (es)
CA (1) CA1108132A (es)
CS (1) CS211364B2 (es)
DK (1) DK258280A (es)
ES (1) ES485154A1 (es)
FI (1) FI793235A (es)
FR (1) FR2439201A1 (es)
GB (1) GB2049680A (es)
IL (1) IL58489A0 (es)
IT (1) IT7969032A0 (es)
NL (1) NL7920126A (es)
NO (1) NO793297L (es)
SE (1) SE8004454L (es)
WO (1) WO1980000841A1 (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795813A (en) * 1981-08-17 1989-01-03 The Florida Board Of Regents On Behalf Of The Florida State University Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US5668285A (en) * 1986-10-31 1997-09-16 The United States Of America As Represented By The Department Of Health And Human Services Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates
FR2636330B1 (fr) * 1988-09-13 1990-11-30 Sanofi Sa Procede de preparation de derives de morphinane
JP2694156B2 (ja) * 1989-10-16 1997-12-24 アメリカ合衆国 Ｎ−ノル中間体を介するノルテバイン、ノルモルフィン、ノルオキシモルフォン鏡像異性体の全合成
US8329216B2 (en) 2001-07-06 2012-12-11 Endo Pharmaceuticals Inc. Oxymorphone controlled release formulations
WO2003004030A1 (en) 2001-07-06 2003-01-16 Endo Pharmaceuticals, Inc. Oxymorphone controlled release formulations
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
MX2008010921A (es) 2006-03-02 2008-09-03 Mallinckrodt Inc Procesos para preparar productos de morfinan-6-ona con bajos niveles de compuestos de cetona alfa, beta-insaturados.
CA2713128C (en) 2008-01-25 2016-04-05 Gruenenthal Gmbh Pharmaceutical dosage form
KR101690094B1 (ko) 2008-05-09 2016-12-27 그뤼넨탈 게엠베하 분무 응결 단계의 사용하에 중간 분말 제형 및 최종 고체 제형을 제조하는 방법
BR112012001466A2 (pt) 2009-07-22 2020-08-11 Grünenthal GmbH forma de dosagem resistente à falsificação para opioides sensíveis à oxidação, seu processo de fabricação, e embalagem
NZ596667A (en) 2009-07-22 2013-09-27 Gruenenthal Chemie Hot-melt extruded controlled release dosage form
PE20131126A1 (es) 2010-09-02 2013-10-21 Gruenenthal Chemie Forma de dosificacion resistente a alteracion que comprende un polimero anionico
CA2808219C (en) 2010-09-02 2019-05-14 Gruenenthal Gmbh Tamper resistant dosage form comprising inorganic salt
CA2839123A1 (en) 2011-07-29 2013-02-07 Grunenthal Gmbh Tamper-resistant tablet providing immediate drug release
MX348054B (es) 2011-07-29 2017-05-25 Gruenenthal Gmbh Tableta a prueba de alteracion que proporciona liberacion inmediata del farmaco.
EP2819656A1 (en) 2012-02-28 2015-01-07 Grünenthal GmbH Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
SI2838512T1 (sl) 2012-04-18 2018-11-30 Gruenenthal Gmbh Pred posegi in prehitrim sproščanjem odporna farmacevtska oblika odmerka
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
US10154966B2 (en) 2013-05-29 2018-12-18 Grünenthal GmbH Tamper-resistant dosage form containing one or more particles
CA2913209A1 (en) 2013-05-29 2014-12-04 Grunenthal Gmbh Tamper resistant dosage form with bimodal release profile
KR20160031526A (ko) 2013-07-12 2016-03-22 그뤼넨탈 게엠베하 에틸렌-비닐 아세테이트 중합체를 함유하는 템퍼 내성 투여형
BR112016010482B1 (pt) 2013-11-26 2022-11-16 Grünenthal GmbH Preparação de uma composição farmacêutica em pó por meio de criomoagem
CN106572980A (zh) 2014-05-12 2017-04-19 格吕伦塔尔有限公司 包含他喷他多的防篡改即释胶囊制剂
EP3148512A1 (en) 2014-05-26 2017-04-05 Grünenthal GmbH Multiparticles safeguarded against ethanolic dose-dumping
CA2983642A1 (en) 2015-04-24 2016-10-27 Grunenthal Gmbh Tamper-resistant dosage form with immediate release and resistance against solvent extraction
US10842750B2 (en) 2015-09-10 2020-11-24 Grünenthal GmbH Protecting oral overdose with abuse deterrent immediate release formulations
EP3252055B1 (en) 2016-05-31 2018-09-19 Alcaliber Investigacion Desarrollo e Innovacion SLU Process for obtaining 3,14-diacetyloxymorphone from oripavine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3249616A (en) * 1966-05-03 Ix-dfflydroxy-g-oxo-n-phenethylmor- phinan (cis) and production thereof
US2806033A (en) * 1955-08-03 1957-09-10 Lewenstein Morphine derivative
US3775414A (en) * 1972-05-10 1973-11-27 Bristol Myers Co Process for the preparation of 14-hydroxymorphinan derivatives

Also Published As

Publication number Publication date
DK258280A (da) 1980-06-17
NO793297L (no) 1980-04-22
BE879494A (fr) 1980-02-15
FI793235A (fi) 1980-04-20
NL7920126A (nl) 1980-08-29
FR2439201A1 (fr) 1980-05-16
WO1980000841A1 (en) 1980-05-01
SE8004454L (sv) 1980-06-16
AU5189779A (en) 1980-04-24
CA1108132A (en) 1981-09-01
IT7969032A0 (it) 1979-10-18
GB2049680A (en) 1980-12-31
IL58489A0 (en) 1980-01-31
JPS55501025A (es) 1980-11-27
ES485154A1 (es) 1980-06-16

Similar Documents

Publication Publication Date Title
CS211364B2 (en) Method of making the oxymorfone
CA2040927C (en) Sucrose-6-ester production process
IE911343A1 (en) Process for recovery of organotin esters from reaction mixtures containing the same and re-use of the recovered organotin compounds
JPH0212478B2 (es)
CN1015104B (zh) 烯丙基酯类和醚类的脱保护方法
WO2005115954A2 (en) Process for prepariing 1,3-dibromoacetone, 1-3-dichloroacetone and epichlorohydrin
EP0079447B1 (en) Deazapurine derivatives
US6049014A (en) Process for the manufacture of tetrabromobisphenol-A with co-production of n-propyl bromide
EP0327473A2 (fr) Procédé de préparation de métaborate d'aryle et son application à la préparation des alcools orthohydroxybenzyliques
JP3446899B2 (ja) ハロピリジル−アザビシクロヘプタン誘導体の製造法および中間体
US5162570A (en) Process for producing 1,4-dihydroxy-2-arylnaphthoate
US5241103A (en) Process for producing 1,4-dihydroxy-2-arylnaphthoate
US5157156A (en) Process for preparing an intermediate useful in the syntheis of probucol
EP0297783B1 (en) A method of producing 4-alkoxypyridine-1-oxides
CA1134839A (en) Preparation of 5-hydroxymethylimidazoles
US4709059A (en) Process for selective halogenation of primary hydroxyl groups
EP0062068B1 (en) N-phthalidyl-5-fluorouracil derivatives
EP0222172A2 (en) N-Glycolylneuraminic acid derivative
EP0423991B1 (en) Process for the preparation of 2-trifluoromethyl-4-hydroxybenzoic acid
EP0524959B1 (en) Process for sultamicillin intermediate
KR900008126B1 (ko) 할로겐화 페놀-알데히드 축합생성물 유도체의 제조방법
JP2688437B2 (ja) ヒドロキシメチル―ジハロ―ジアルキルフェノールの合成法
US20040034213A1 (en) Process for producing a ribofuranose
EP0074837A1 (en) 4-Substituted pyridine catalysts
JPH0710833B2 (ja) ５−（１−カルボキシエチル）−２−フエニルチオフエニル酢酸の製造方法