FR2439201A1 - Procede de fabrication de l'oxymorphone - Google Patents

Procede de fabrication de l'oxymorphone

Info

Publication number
FR2439201A1
FR2439201A1 FR7925895A FR7925895A FR2439201A1 FR 2439201 A1 FR2439201 A1 FR 2439201A1 FR 7925895 A FR7925895 A FR 7925895A FR 7925895 A FR7925895 A FR 7925895A FR 2439201 A1 FR2439201 A1 FR 2439201A1
Authority
FR
France
Prior art keywords
oxymorphone
boron
agent
manufacturing process
boron compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7925895A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of FR2439201A1 publication Critical patent/FR2439201A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Polarising Elements (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDE DE FABRICATION DE L'OXYMORPHONE CONSISTANT A FAIRE REAGIR L'OXYCODONE AVEC UNE QUANTITE DEMETHYLANTE D'UN COMPOSE DU BORE QUI EST LE TRIBROMURE DE BORE, LE TRICHLORURE DE BORE OU LE PRODUIT DE LA REACTION DE L'UN DE CES DEUX HALOGENURES AVEC UN ALCOOL INFERIEUR, DANS UN MILIEU REACTIONNEL CONTENANT UN SOLVANT ORGANIQUE, DANS DES CONDITIONS DE DEMETHYLATION. LE MILIEU REACTIONNEL CONTIENT UNE QUANTITE SUFFISANTE D'UN AGENT D'ATTENUATION POUR AFFAIBLIR L'ACTIVITE DU COMPOSE DU BORE, CET AGENT D'ATTENUATION ETANT UNE BASE DE LEWIS FAIBLE QUI NE PEUT REAGIR AVEC LEDIT AGENT DEMETHYLANT, CE QUI PERMET D'OBTENIR L'OXYMORPHONE AVEC UN BON RENDEMENT ET PRATIQUEMENT SANS SOUS-PRODUITS. L'OXYMORPHONE EST UNE SUBSTANCE NARCOTIQUE TRES UTILISEE COMME ANALGESIQUE.
FR7925895A 1978-10-19 1979-10-18 Procede de fabrication de l'oxymorphone Withdrawn FR2439201A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95305678A 1978-10-19 1978-10-19

Publications (1)

Publication Number Publication Date
FR2439201A1 true FR2439201A1 (fr) 1980-05-16

Family

ID=25493512

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7925895A Withdrawn FR2439201A1 (fr) 1978-10-19 1979-10-18 Procede de fabrication de l'oxymorphone

Country Status (16)

Country Link
JP (1) JPS55501025A (fr)
AU (1) AU5189779A (fr)
BE (1) BE879494A (fr)
CA (1) CA1108132A (fr)
CS (1) CS211364B2 (fr)
DK (1) DK258280A (fr)
ES (1) ES485154A1 (fr)
FI (1) FI793235A (fr)
FR (1) FR2439201A1 (fr)
GB (1) GB2049680A (fr)
IL (1) IL58489A0 (fr)
IT (1) IT7969032A0 (fr)
NL (1) NL7920126A (fr)
NO (1) NO793297L (fr)
SE (1) SE8004454L (fr)
WO (1) WO1980000841A1 (fr)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795813A (en) * 1981-08-17 1989-01-03 The Florida Board Of Regents On Behalf Of The Florida State University Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US5668285A (en) * 1986-10-31 1997-09-16 The United States Of America As Represented By The Department Of Health And Human Services Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates
FR2636330B1 (fr) * 1988-09-13 1990-11-30 Sanofi Sa Procede de preparation de derives de morphinane
ES2129395T3 (es) * 1989-10-16 1999-06-16 Us Health Sintesis total de enantiomeros de nortebaina, normorfina, noroximorfona y sus derivados a traves de productos intermedios n-nor.
WO2003004031A1 (fr) 2001-07-06 2003-01-16 Endo Pharmaceuticals, Inc. Administration parenterale de 6-hydroxy-oxymorphone destinee a etre utilisee en tant qu'analgesique
US8329216B2 (en) 2001-07-06 2012-12-11 Endo Pharmaceuticals Inc. Oxymorphone controlled release formulations
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
CA2644095A1 (fr) 2006-03-02 2007-09-13 Mallinckrodt Inc. Procedes de preparation de produits a base de morphinan-6-one avec de faibles niveaux de composes de cetones alpha, beta-insaturees
BRPI0906467C1 (pt) 2008-01-25 2021-05-25 Gruenenthal Gmbh forma de dosagem farmacêutica com formato exterior modificado resistente à ruptura e com liberação controlada
LT2273983T (lt) 2008-05-09 2016-10-25 Grünenthal GmbH Tarpinės miltelių kompozicijos gamybos būdas ir galutinė kieta dozavimo forma naudojant purškalo kietinimo stadija
AU2010275754B2 (en) 2009-07-22 2014-05-15 Grünenthal GmbH Tamper-resistant dosage form for oxidation-sensitive opioids
EP2456427B1 (fr) 2009-07-22 2015-03-04 Grünenthal GmbH Formule de dosage pharmaceutique extrudée thermofusible à libération prolongée
MX2013002293A (es) 2010-09-02 2013-05-09 Gruenenthal Gmbh Forma de dosificacion resistente a alteracion que comprende un polimero anionico.
WO2012028319A1 (fr) 2010-09-02 2012-03-08 Grünenthal GmbH Forme pharmaceutique inviolable comportant un sel inorganique
BR112014002022A2 (pt) 2011-07-29 2017-02-21 Gruenenthal Gmbh comprimido resistente à violação proporcionando liberação de fármaco imediata
LT2736497T (lt) 2011-07-29 2017-11-10 Grünenthal GmbH Sugadinimui atspari tabletė, pasižyminti greitu vaisto atpalaidavimu
US20130225697A1 (en) 2012-02-28 2013-08-29 Grunenthal Gmbh Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
AU2013248351B2 (en) 2012-04-18 2018-04-26 Grunenthal Gmbh Tamper resistant and dose-dumping resistant pharmaceutical dosage form
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
CA2907950A1 (fr) 2013-05-29 2014-12-04 Grunenthal Gmbh Forme pharmaceutique inviolable contenant une ou plusieurs particules
JP6466417B2 (ja) 2013-05-29 2019-02-06 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 二峰性放出プロファイルを有する改変防止（ｔａｍｐｅｒ−ｒｅｓｉｓｔａｎｔ）剤形
EA032465B1 (ru) 2013-07-12 2019-05-31 Грюненталь Гмбх Защищенная от применения не по назначению пероральная фармацевтическая лекарственная форма, содержащая этиленвинилацетатный полимер, и способ ее изготовления
AU2014356581C1 (en) 2013-11-26 2020-05-28 Grunenthal Gmbh Preparation of a powdery pharmaceutical composition by means of cryo-milling
CN106572980A (zh) 2014-05-12 2017-04-19 格吕伦塔尔有限公司 包含他喷他多的防篡改即释胶囊制剂
CN106456550A (zh) 2014-05-26 2017-02-22 格吕伦塔尔有限公司 避免乙醇剂量倾泻的多颗粒
AU2016251854A1 (en) 2015-04-24 2017-10-19 Grunenthal Gmbh Tamper-resistant dosage form with immediate release and resistance against solvent extraction
JP2018526414A (ja) 2015-09-10 2018-09-13 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 乱用抑止性の即放性製剤を用いた経口過剰摂取に対する保護
ES2701855T3 (es) 2016-05-31 2019-02-26 Alcaliber Investig Desarrollo E Innovacion Slu Proceso para la obtención de 3,14-diacetiloximorfona a partir de oripavina

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2806033A (en) * 1955-08-03 1957-09-10 Lewenstein Morphine derivative
US3249616A (en) * 1966-05-03 Ix-dfflydroxy-g-oxo-n-phenethylmor- phinan (cis) and production thereof
US3775414A (en) * 1972-05-10 1973-11-27 Bristol Myers Co Process for the preparation of 14-hydroxymorphinan derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3249616A (en) * 1966-05-03 Ix-dfflydroxy-g-oxo-n-phenethylmor- phinan (cis) and production thereof
US2806033A (en) * 1955-08-03 1957-09-10 Lewenstein Morphine derivative
US3775414A (en) * 1972-05-10 1973-11-27 Bristol Myers Co Process for the preparation of 14-hydroxymorphinan derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EXBK/77 *

Also Published As

Publication number Publication date
WO1980000841A1 (fr) 1980-05-01
SE8004454L (sv) 1980-06-16
NL7920126A (nl) 1980-08-29
ES485154A1 (es) 1980-06-16
AU5189779A (en) 1980-04-24
IT7969032A0 (it) 1979-10-18
GB2049680A (en) 1980-12-31
CS211364B2 (en) 1982-02-26
CA1108132A (fr) 1981-09-01
BE879494A (fr) 1980-02-15
JPS55501025A (fr) 1980-11-27
NO793297L (no) 1980-04-22
DK258280A (da) 1980-06-17
IL58489A0 (en) 1980-01-31
FI793235A (fi) 1980-04-20

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Legal Events

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