ES485154A1 - Procedimiento para preparar oximorfona - Google Patents
Procedimiento para preparar oximorfonaInfo
- Publication number
- ES485154A1 ES485154A1 ES485154A ES485154A ES485154A1 ES 485154 A1 ES485154 A1 ES 485154A1 ES 485154 A ES485154 A ES 485154A ES 485154 A ES485154 A ES 485154A ES 485154 A1 ES485154 A1 ES 485154A1
- Authority
- ES
- Spain
- Prior art keywords
- oxymorphone
- producing
- producing oxymorphone
- utilizing
- lewis base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Polarising Elements (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedimiento para preparar oximorfona, mediante reacción de oxicodona con una cantidad desmetilante de un compuesto de boro elegido del grupo consistente en tribromuro de boro, tricloruro de boro y el producto de reacción de cualquiera de estos haluros con un alcohol inferior, en un medio de reacción que contiene disolvente orgánico, bajo condiciones desmetilantes; caracterizado porque dicho medio de reacción contiene una cantidad atenuante de un agente atenuador para atenuar la actividad del compuesto de boro, siendo dicho agente atenuante una base débil de Lewis que no es reactiva con dicho agente desmetilante, con lo cual se obtiene oximorfona en buenos rendimientos y sin prácticamente subproductos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95305678A | 1978-10-19 | 1978-10-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES485154A1 true ES485154A1 (es) | 1980-06-16 |
Family
ID=25493512
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES485154A Expired ES485154A1 (es) | 1978-10-19 | 1979-10-18 | Procedimiento para preparar oximorfona |
Country Status (16)
Country | Link |
---|---|
JP (1) | JPS55501025A (es) |
AU (1) | AU5189779A (es) |
BE (1) | BE879494A (es) |
CA (1) | CA1108132A (es) |
CS (1) | CS211364B2 (es) |
DK (1) | DK258280A (es) |
ES (1) | ES485154A1 (es) |
FI (1) | FI793235A (es) |
FR (1) | FR2439201A1 (es) |
GB (1) | GB2049680A (es) |
IL (1) | IL58489A0 (es) |
IT (1) | IT7969032A0 (es) |
NL (1) | NL7920126A (es) |
NO (1) | NO793297L (es) |
SE (1) | SE8004454L (es) |
WO (1) | WO1980000841A1 (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4795813A (en) * | 1981-08-17 | 1989-01-03 | The Florida Board Of Regents On Behalf Of The Florida State University | Synthesis of derivatives of codeine and other 3-O-alkylmorphines |
US5668285A (en) * | 1986-10-31 | 1997-09-16 | The United States Of America As Represented By The Department Of Health And Human Services | Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates |
FR2636330B1 (fr) * | 1988-09-13 | 1990-11-30 | Sanofi Sa | Procede de preparation de derives de morphinane |
ES2129395T3 (es) * | 1989-10-16 | 1999-06-16 | Us Health | Sintesis total de enantiomeros de nortebaina, normorfina, noroximorfona y sus derivados a traves de productos intermedios n-nor. |
WO2003004031A1 (en) | 2001-07-06 | 2003-01-16 | Endo Pharmaceuticals, Inc. | Parenteral administration of 6-hydroxy-oxymorphone for use as an analgesic |
US8329216B2 (en) | 2001-07-06 | 2012-12-11 | Endo Pharmaceuticals Inc. | Oxymorphone controlled release formulations |
US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
CA2644095A1 (en) | 2006-03-02 | 2007-09-13 | Mallinckrodt Inc. | Processes for preparing morphinan-6-one products with low levels of alpha, beta-unsaturated ketone compounds |
BRPI0906467C1 (pt) | 2008-01-25 | 2021-05-25 | Gruenenthal Gmbh | forma de dosagem farmacêutica com formato exterior modificado resistente à ruptura e com liberação controlada |
LT2273983T (lt) | 2008-05-09 | 2016-10-25 | Grünenthal GmbH | Tarpinės miltelių kompozicijos gamybos būdas ir galutinė kieta dozavimo forma naudojant purškalo kietinimo stadija |
AU2010275754B2 (en) | 2009-07-22 | 2014-05-15 | Grünenthal GmbH | Tamper-resistant dosage form for oxidation-sensitive opioids |
EP2456427B1 (en) | 2009-07-22 | 2015-03-04 | Grünenthal GmbH | Hot-melt extruded controlled release dosage form |
MX2013002293A (es) | 2010-09-02 | 2013-05-09 | Gruenenthal Gmbh | Forma de dosificacion resistente a alteracion que comprende un polimero anionico. |
WO2012028319A1 (en) | 2010-09-02 | 2012-03-08 | Grünenthal GmbH | Tamper resistant dosage form comprising inorganic salt |
BR112014002022A2 (pt) | 2011-07-29 | 2017-02-21 | Gruenenthal Gmbh | comprimido resistente à violação proporcionando liberação de fármaco imediata |
LT2736497T (lt) | 2011-07-29 | 2017-11-10 | Grünenthal GmbH | Sugadinimui atspari tabletė, pasižyminti greitu vaisto atpalaidavimu |
US20130225697A1 (en) | 2012-02-28 | 2013-08-29 | Grunenthal Gmbh | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer |
AU2013248351B2 (en) | 2012-04-18 | 2018-04-26 | Grunenthal Gmbh | Tamper resistant and dose-dumping resistant pharmaceutical dosage form |
US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
CA2907950A1 (en) | 2013-05-29 | 2014-12-04 | Grunenthal Gmbh | Tamper-resistant dosage form containing one or more particles |
JP6466417B2 (ja) | 2013-05-29 | 2019-02-06 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 二峰性放出プロファイルを有する改変防止(tamper−resistant)剤形 |
EA032465B1 (ru) | 2013-07-12 | 2019-05-31 | Грюненталь Гмбх | Защищенная от применения не по назначению пероральная фармацевтическая лекарственная форма, содержащая этиленвинилацетатный полимер, и способ ее изготовления |
AU2014356581C1 (en) | 2013-11-26 | 2020-05-28 | Grunenthal Gmbh | Preparation of a powdery pharmaceutical composition by means of cryo-milling |
CN106572980A (zh) | 2014-05-12 | 2017-04-19 | 格吕伦塔尔有限公司 | 包含他喷他多的防篡改即释胶囊制剂 |
CN106456550A (zh) | 2014-05-26 | 2017-02-22 | 格吕伦塔尔有限公司 | 避免乙醇剂量倾泻的多颗粒 |
AU2016251854A1 (en) | 2015-04-24 | 2017-10-19 | Grunenthal Gmbh | Tamper-resistant dosage form with immediate release and resistance against solvent extraction |
JP2018526414A (ja) | 2015-09-10 | 2018-09-13 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 乱用抑止性の即放性製剤を用いた経口過剰摂取に対する保護 |
ES2701855T3 (es) | 2016-05-31 | 2019-02-26 | Alcaliber Investig Desarrollo E Innovacion Slu | Proceso para la obtención de 3,14-diacetiloximorfona a partir de oripavina |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3249616A (en) * | 1966-05-03 | Ix-dfflydroxy-g-oxo-n-phenethylmor- phinan (cis) and production thereof | ||
US2806033A (en) * | 1955-08-03 | 1957-09-10 | Lewenstein | Morphine derivative |
US3775414A (en) * | 1972-05-10 | 1973-11-27 | Bristol Myers Co | Process for the preparation of 14-hydroxymorphinan derivatives |
-
1979
- 1979-10-12 NO NO793297A patent/NO793297L/no unknown
- 1979-10-18 BE BE0/197710A patent/BE879494A/fr unknown
- 1979-10-18 ES ES485154A patent/ES485154A1/es not_active Expired
- 1979-10-18 WO PCT/US1979/000862 patent/WO1980000841A1/en unknown
- 1979-10-18 GB GB8014422A patent/GB2049680A/en not_active Withdrawn
- 1979-10-18 NL NL7920126A patent/NL7920126A/nl unknown
- 1979-10-18 IT IT7969032A patent/IT7969032A0/it unknown
- 1979-10-18 FR FR7925895A patent/FR2439201A1/fr not_active Withdrawn
- 1979-10-18 AU AU51897/79A patent/AU5189779A/en not_active Abandoned
- 1979-10-18 FI FI793235A patent/FI793235A/fi not_active Application Discontinuation
- 1979-10-18 JP JP50190279A patent/JPS55501025A/ja active Pending
- 1979-10-18 IL IL58489A patent/IL58489A0/xx unknown
- 1979-10-18 CA CA337,908A patent/CA1108132A/en not_active Expired
- 1979-10-19 CS CS797115A patent/CS211364B2/cs unknown
-
1980
- 1980-06-16 SE SE8004454A patent/SE8004454L/xx not_active Application Discontinuation
- 1980-06-17 DK DK258280A patent/DK258280A/da unknown
Also Published As
Publication number | Publication date |
---|---|
WO1980000841A1 (en) | 1980-05-01 |
SE8004454L (sv) | 1980-06-16 |
NL7920126A (nl) | 1980-08-29 |
AU5189779A (en) | 1980-04-24 |
IT7969032A0 (it) | 1979-10-18 |
GB2049680A (en) | 1980-12-31 |
CS211364B2 (en) | 1982-02-26 |
CA1108132A (en) | 1981-09-01 |
BE879494A (fr) | 1980-02-15 |
JPS55501025A (es) | 1980-11-27 |
NO793297L (no) | 1980-04-22 |
DK258280A (da) | 1980-06-17 |
IL58489A0 (en) | 1980-01-31 |
FI793235A (fi) | 1980-04-20 |
FR2439201A1 (fr) | 1980-05-16 |
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