CR9277A - Piperacinil y piperadinil ureas como moduladores de la amida hidrolasa de acido graso - Google Patents
Piperacinil y piperadinil ureas como moduladores de la amida hidrolasa de acido grasoInfo
- Publication number
- CR9277A CR9277A CR9277A CR9277A CR9277A CR 9277 A CR9277 A CR 9277A CR 9277 A CR9277 A CR 9277A CR 9277 A CR9277 A CR 9277A CR 9277 A CR9277 A CR 9277A
- Authority
- CR
- Costa Rica
- Prior art keywords
- 4alkyl
- alkyl
- pyrimidinyl
- disorders
- compounds
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 150000003672 ureas Chemical class 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 6
- -1 2-thiazolyl Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 102100029111 Fatty-acid amide hydrolase 1 Human genes 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 108010046094 fatty-acid amide hydrolase Proteins 0.000 abstract 2
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 208000030814 Eating disease Diseases 0.000 abstract 1
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000016285 Movement disease Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 235000014632 disordered eating Nutrition 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000003940 fatty acid amidase inhibitor Substances 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- XSXHWVKGUXMUQE-UHFFFAOYSA-N osmium dioxide Inorganic materials O=[Os]=O XSXHWVKGUXMUQE-UHFFFAOYSA-N 0.000 abstract 1
- 230000036407 pain Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 abstract 1
- 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 abstract 1
- 125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/195—Radicals derived from nitrogen analogues of carboxylic acids
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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Abstract
Los compuestos de formula (I): en donde Z es -N o >CH; R1 es -H o alquilo de c1-4; Ar1 es 2-tiazolilo, 2-p6iridilo, 3-piridilo, 4-piridilo, 2-pirimidinilo, 4-pirimidinilo, 5-pirimidinilo o fenilo, cada uno no sustituido o sustituido en un miembro del anillo del carbono con uno o dos porciones de Ra, en donde cada porcion de Ra se selecciona de manera independiente del grupo que consiste de alquilo de C1-4, alquenilo de c2-4, -OH, -Oalquilo de C1-4, halo, -CF3, -OCF3, -SCF3, -SH, -S(O)0-2alquilo de C1-4, -OSO2alquilo de C1-4, -CO2alquilo de C1-4, -CO2H, -COalquilo de C1-4, -N(Rb)Rc, -SO2NRbRc, -NRbSO2Rc, -C(=O)NRbRc, -NO2, y -CN, en donde Rb y Rc son cada uno de manera independiente -H o alquilo de C1-4; y Ar2 se define en las reivindicaciones, son utiles como inhibidores de la FAAH; tales compuestos pueden utilizarse en composiciones farmaceuticas y metodos para el tratamiento de estados de enfermedad, trastornos y condiciones mediadas por la actividad de la amida hidrolasa del acido graso (FAAH); asi, los compuestos pueden administrarse para tratar, por ejemplo, ansiedad, dolor, inflamacion, trastornos del sueno. trastornos de la alimentacion o trastornos del movimiento (tales como esclerosis multiple).
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CR9277A CR9277A (es) | 2004-12-30 | 2007-07-27 | Piperacinil y piperadinil ureas como moduladores de la amida hidrolasa de acido graso |
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US (3) | US7598249B2 (es) |
EP (2) | EP1836179B1 (es) |
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KR (1) | KR101287955B1 (es) |
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Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
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TW200633990A (en) * | 2004-11-18 | 2006-10-01 | Takeda Pharmaceuticals Co | Amide compound |
SI1836179T1 (sl) * | 2004-12-30 | 2015-07-31 | Janssen Pharmaceutica N.V. | Amidni derivati piperidin- in piperazin-1-karboksilne kisline in sorodne spojine kot modulatorji maščobnokislinske amidne hidrolaze (faah) za zdravljenje tesnobe, bolečine in drugih stanj |
GB0503056D0 (en) * | 2005-02-14 | 2005-03-23 | Smithkline Beecham Corp | Chemical compounds |
PE20070099A1 (es) * | 2005-06-30 | 2007-02-06 | Janssen Pharmaceutica Nv | N-heteroarilpiperazinil ureas como moduladores de la amida hidrolasa del acido graso |
WO2007020888A1 (ja) * | 2005-08-12 | 2007-02-22 | Takeda Pharmaceutical Company Limited | 脳・神経細胞保護剤および睡眠障害治療薬 |
WO2007086584A1 (ja) * | 2006-01-30 | 2007-08-02 | Meiji Seika Kaisha, Ltd. | 新規FabKおよびFabI/K阻害剤 |
ITRM20060090A1 (it) * | 2006-02-22 | 2007-08-23 | Sigma Tau Ind Farmaceuti | Nuovi composti inibitori cpt a livello del snc come farmaci antidiabetici e o antiobesita |
EP2023728A4 (en) * | 2006-05-26 | 2010-11-24 | Janssen Pharmaceutica Nv | OXAZOLYLPIPERIDINES AS MODULATORS OF FATTY ACID AMIDHYDROLASE |
CA2665804A1 (en) | 2006-08-23 | 2008-02-28 | Astellas Pharma Inc. | Urea compound or salt thereof |
ES2357340T3 (es) | 2006-10-18 | 2011-04-25 | Pfizer Products Inc. | Compuestos de biaril éter urea. |
RU2009148304A (ru) * | 2007-05-25 | 2011-06-27 | Янссен Фармацевтика Н.В. (Be) | Модуляторы гидролазы амидов жирных кислот на основе гетероарилзамещенной мочевины |
WO2009105220A1 (en) * | 2008-02-19 | 2009-08-27 | Janssen Pharmaceutica N.V. | Aryl-hydroxyethylamino-pyrimidines and triazines as modulators of fatty acid amide hydrolase |
EP2276738A1 (en) * | 2008-04-17 | 2011-01-26 | Pfizer Inc. | Ether benzylidene piperidine 5-membered aryl carboxamide compounds useful as faah inhibitors |
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