GT200600105A - Derivados de pirimidina para el tratamiento de trastornos hiperproliferativos. - Google Patents

Derivados de pirimidina para el tratamiento de trastornos hiperproliferativos.

Info

Publication number
GT200600105A
GT200600105A GT200600105A GT200600105A GT200600105A GT 200600105 A GT200600105 A GT 200600105A GT 200600105 A GT200600105 A GT 200600105A GT 200600105 A GT200600105 A GT 200600105A GT 200600105 A GT200600105 A GT 200600105A
Authority
GT
Guatemala
Prior art keywords
oxi
trifluorometil
phenyl
pirimidine
diamine
Prior art date
Application number
GT200600105A
Other languages
English (en)
Inventor
Julie A Dixon
Dhanapalan Nagarathnam
Lei Zhang
Chunguang Wang
Lin Yi
Yuanwei Chen
Jianging Chen
Brian R Bear
Michael Brands
Alexander Hillisch
Donald Bierer
Ming Wang
Weniang Fu
Martin F Hentemann
Ann-Marie Bullion
Manoj Patel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36624969&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GT200600105(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of GT200600105A publication Critical patent/GT200600105A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Abstract

ESTA SOLICITUD ESTÁ RELACIONADA CON COMPUESTOS FARMACÉUTICOS HETEROCÍCLICOS DE MOLÉCULA PEQUEÑA Y, MÁS ESPECÍFICAMENTE, CON DERIVADOS DE PIRIMIDINA AMINOSUSTITUIDA, DE FÓRMULA GENERAL (I), CON ACTIVIDAD CITOTÓXICA DEL GRUPO INTEGRADO POR: 6-(2,6-DIMETILFENIL)-N-(4-((2-(TRIFLUOROMETIL)-PIRIDIN-4-IL)-OXI-FENIL)-PIRIMIDINA-2,4-DIAMINA), (6-(6-AMINOPIRIDIN-3-IL)-N-(4-((2-METILPIRIDIN-4-IL)-OXI)-FENIL)-PIRIMIDINA-2,4-DIAMINA), (N-(4-(2-(TRIFLUOROMETIL)-PIRIDIN-4-IL)-OXI)-FENIL)-4,5´-BIPIRIMIDINA-2,5-DIAMINA), (6-FENIL-N-(4-((2-TRIFLUOROMETIL)-PIRIMIDIN-4-IL)-OXI-FENIL)PIRIMIDINA-2,4-DIAMINA), (6-(6-AMINOPIRIDIN-3-IL)-N-(4-((2-(TRIFLUOROMETIL)-PIRIMIDIN-4-IL)-OXI)-FENIL)-PIRIMIDINA-2,4-DIAMINA), COMPOSICIONES FARMACÉUTICAS, PROCEDIMIENTOS DE PREPARACIÓN Y MÉTODO PARA TRATAR TRASTORNOS HIPERPROLIFERATIVOS. T2006
GT200600105A 2005-03-10 2006-03-09 Derivados de pirimidina para el tratamiento de trastornos hiperproliferativos. GT200600105A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US66056105P 2005-03-10 2005-03-10

Publications (1)

Publication Number Publication Date
GT200600105A true GT200600105A (es) 2007-02-14

Family

ID=36624969

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200600105A GT200600105A (es) 2005-03-10 2006-03-09 Derivados de pirimidina para el tratamiento de trastornos hiperproliferativos.

Country Status (23)

Country Link
US (1) US20110098301A1 (es)
EP (1) EP1858882A1 (es)
JP (1) JP2008533042A (es)
KR (1) KR20080004488A (es)
CN (1) CN101151258A (es)
AR (1) AR053554A1 (es)
AU (1) AU2006223199A1 (es)
BR (1) BRPI0609022A2 (es)
CA (1) CA2601257A1 (es)
CR (1) CR9347A (es)
DO (1) DOP2006000061A (es)
EA (1) EA200701930A1 (es)
GT (1) GT200600105A (es)
IL (1) IL185498A0 (es)
MA (1) MA29377B1 (es)
MX (1) MX2007010102A (es)
NO (1) NO20074964L (es)
PE (1) PE20061067A1 (es)
TN (1) TNSN07322A1 (es)
TW (1) TW200724537A (es)
UY (1) UY29414A1 (es)
WO (1) WO2006099231A1 (es)
ZA (1) ZA200708591B (es)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2001477A4 (en) * 2006-03-20 2010-07-21 Bayer Healthcare Llc COMBINATION OF PACLITAXEL
EP2173722B1 (en) * 2007-07-26 2012-08-29 Novartis AG Pyrimidine derivatives useful for the treatment of inflammatory or allergic conditions
DE102008015033A1 (de) 2008-03-17 2009-09-24 Aicuris Gmbh & Co. Kg Substituierte (Pyrazolyl-carbonyl)imidazolidinone und ihre Verwendung
DE102008015032A1 (de) * 2008-03-17 2009-09-24 Aicuris Gmbh & Co. Kg Substituierte Pyrazolamide und ihre Verwendung
DE102008062863A1 (de) 2008-12-17 2010-06-24 Aicuris Gmbh & Co. Kg Substituierte (Thiophenyl-carbonyl)imidazolidinone und ihre Verwendung
DE102008062878A1 (de) 2008-12-17 2010-06-24 Aicuris Gmbh & Co. Kg Substituierte Furancarboxamide und ihre Verwendung
KR20130099117A (ko) 2010-10-01 2013-09-05 바이엘 인텔렉쳐 프로퍼티 게엠베하 치환된 ｎ-(2-아릴아미노)아릴 설폰아미드 함유 배합물
EA201390917A1 (ru) 2010-12-21 2013-12-30 Новартис Аг Дигетероарильные соединения в качестве ингибиторов vps34
RU2697712C2 (ru) 2011-04-22 2019-08-19 СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи Замещенные диаминокарбоксамидные и диаминокарбонитрильные производные пиримидинов, их композиции и способы лечения с их помощью
EA035349B1 (ru) 2012-11-21 2020-05-29 ПиТиСи ТЕРАПЬЮТИКС, ИНК. ЗАМЕЩЕННЫЕ ПИРИМИДИНОВЫЕ ОБРАТНЫЕ ИНГИБИТОРЫ Bmi-1
CN103408573B (zh) * 2013-07-12 2015-12-23 上海工程技术大学 硼酸衍生物及其制备方法和应用
AU2013399092A1 (en) * 2013-08-30 2016-03-17 Ptc Therapeutics, Inc. Substituted pyrimidine Bmi-1 inhibitors
EP3071553A4 (en) 2013-11-21 2017-08-02 PTC Therapeutics, Inc. Substituted pyridine and pyrazine bmi-1 inhibitors
NZ715903A (en) 2014-01-30 2017-06-30 Signal Pharm Llc Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use
US9638690B2 (en) 2014-11-07 2017-05-02 The University Of British Columbia Compounds and compositions for use as alkylating agent sensors and methods of use thereof
CA2975260A1 (en) 2015-01-29 2016-08-04 Signal Pharmaceuticals Llc Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide
MX2018001004A (es) 2015-07-24 2018-06-07 Celgene Corp Metodos de sintesis de clorhidrato de (1r,2r,5r)-5-amino-2-metilci clohexanol e intermedios utiles en este.
TWI609028B (zh) 2016-05-06 2017-12-21 財團法人工業技術研究院 共聚物與含其之樹脂組合物、封裝膜及封裝結構
CN111518078B (zh) * 2020-05-30 2021-02-26 南方医科大学 一种含氨基吡啶的嘧啶类化合物及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3089480B2 (ja) * 1990-09-20 2000-09-18 ソニー株式会社 フリットシール装置
JP4469179B2 (ja) * 2002-01-23 2010-05-26 バイエル ファーマセチカル コーポレーション Ｒｈｏキナーゼ阻害剤としてのピリミジン誘導体
WO2003062227A1 (en) * 2002-01-23 2003-07-31 Bayer Pharmaceuticals Corporation Rho-kinase inhibitors
EP1689722A2 (en) * 2003-10-10 2006-08-16 Bayer Pharmaceuticals Corporation 4-aminopyrimidine derivatives for treatment of hyperproliferative disorders

Also Published As

Publication number Publication date
PE20061067A1 (es) 2006-11-30
TW200724537A (en) 2007-07-01
BRPI0609022A2 (pt) 2010-01-12
AU2006223199A1 (en) 2006-09-21
NO20074964L (no) 2007-12-06
WO2006099231A1 (en) 2006-09-21
TNSN07322A1 (en) 2008-12-31
EA200701930A1 (ru) 2008-02-28
MX2007010102A (es) 2007-10-12
IL185498A0 (en) 2008-01-06
MA29377B1 (fr) 2008-04-01
ZA200708591B (en) 2009-01-28
JP2008533042A (ja) 2008-08-21
DOP2006000061A (es) 2006-09-30
EP1858882A1 (en) 2007-11-28
UY29414A1 (es) 2006-10-02
CA2601257A1 (en) 2006-09-21
AR053554A1 (es) 2007-05-09
CR9347A (es) 2007-12-17
CN101151258A (zh) 2008-03-26
US20110098301A1 (en) 2011-04-28
KR20080004488A (ko) 2008-01-09

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